Beautiful paper from Burkhard Ludewig’s group showing the importance of immunoregulatory stroma to support anti-tumour immunity.
www.cell.com/action/showP...
www.cell.com/action/showP...
www.cell.com
November 19, 2024 at 8:50 PM
Beautiful paper from Burkhard Ludewig’s group showing the importance of immunoregulatory stroma to support anti-tumour immunity.
www.cell.com/action/showP...
www.cell.com/action/showP...
“Immunoregulatory role of quercetin in lung cancer”
Quercetin exerts potent #Antioxidant, #AntiProliferative, and #Immunomodulatory effects ⤵️
nature.com/articles/s41...
Quercetin exerts potent #Antioxidant, #AntiProliferative, and #Immunomodulatory effects ⤵️
nature.com/articles/s41...
Immunoregulatory role of quercetin in lung cancer - Cell Death Discovery
Cell Death Discovery - Immunoregulatory role of quercetin in lung cancer
nature.com
September 23, 2026 at 10:52 AM
“Immunoregulatory role of quercetin in lung cancer”
Quercetin exerts potent #Antioxidant, #AntiProliferative, and #Immunomodulatory effects ⤵️
nature.com/articles/s41...
Quercetin exerts potent #Antioxidant, #AntiProliferative, and #Immunomodulatory effects ⤵️
nature.com/articles/s41...
January 8, 2025 at 5:40 AM
FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
October 15, 2025 at 5:59 PM
FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
Will have a more detailed post soon, but sharing advanced online pre-proof version of our new study
- Single cell profiling of Hematopoietic Stem Cell Transplant recipients reveals TGF-β1 and IL-2 confer immunoregulatory functions to NK cells: www.cell.com/iscience/ful...
- Single cell profiling of Hematopoietic Stem Cell Transplant recipients reveals TGF-β1 and IL-2 confer immunoregulatory functions to NK cells: www.cell.com/iscience/ful...
Single cell profiling of Hematopoietic Stem Cell Transplant recipients reveals TGF-β1 and IL-2 confer immunoregulatory functions to NK cells
Natural Killer (NK) cell activity is influenced by cytokines and microenvironment
factors, resulting in remarkably diverse functions, by contributing to inflammatory
responses or serving as rheostats ...
www.cell.com
November 18, 2024 at 5:15 PM
Will have a more detailed post soon, but sharing advanced online pre-proof version of our new study
- Single cell profiling of Hematopoietic Stem Cell Transplant recipients reveals TGF-β1 and IL-2 confer immunoregulatory functions to NK cells: www.cell.com/iscience/ful...
- Single cell profiling of Hematopoietic Stem Cell Transplant recipients reveals TGF-β1 and IL-2 confer immunoregulatory functions to NK cells: www.cell.com/iscience/ful...
Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
July 3, 2025 at 1:47 PM
Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Congrats to our Immunology program student Ani in the @igal78.bsky.social lab:
Wnt-activated immunoregulatory myeloid cells prevent relapse in EAE, offering a potential therapeutic strategy for multiple sclerosis
doi.org/10.1101/2025...
Wnt-activated immunoregulatory myeloid cells prevent relapse in EAE, offering a potential therapeutic strategy for multiple sclerosis
doi.org/10.1101/2025...
February 23, 2025 at 2:54 AM
Congrats to our Immunology program student Ani in the @igal78.bsky.social lab:
Wnt-activated immunoregulatory myeloid cells prevent relapse in EAE, offering a potential therapeutic strategy for multiple sclerosis
doi.org/10.1101/2025...
Wnt-activated immunoregulatory myeloid cells prevent relapse in EAE, offering a potential therapeutic strategy for multiple sclerosis
doi.org/10.1101/2025...
Notch2−expressing CD4+ T cells attain immunoregulatory functions during autoimmune inflammation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 23, 2025 at 6:56 PM
Notch2−expressing CD4+ T cells attain immunoregulatory functions during autoimmune inflammation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
December 1, 2024 at 11:12 PM
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
New paper from the lab:
Bianca Morejon defines the regulatory protease network that governs #mosquito #immunity
www.pnas.org/doi/10.1073/...
Bianca Morejon defines the regulatory protease network that governs #mosquito #immunity
www.pnas.org/doi/10.1073/...
The expanded immunoregulatory protease network in mosquitoes is governed by gene coexpression | PNAS
Serine protease cascades regulate key innate immune responses. Their activation cleaves
a series of inactive protease zymogens, which then activate...
www.pnas.org
May 2, 2025 at 3:02 PM
New paper from the lab:
Bianca Morejon defines the regulatory protease network that governs #mosquito #immunity
www.pnas.org/doi/10.1073/...
Bianca Morejon defines the regulatory protease network that governs #mosquito #immunity
www.pnas.org/doi/10.1073/...
Excited to share our latest study
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung
infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential
role of nerve- and airway-associated...
www.cell.com
April 25, 2025 at 2:38 PM
Excited to share our latest study
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...
Three immunoregulatory signatures define non-productive HIV infection in CD4+ T memory stem cells @biorxivpreprint.bsky.social
biorxiv.org/content/10.6...
biorxiv.org/content/10.6...
March 23, 2026 at 5:32 PM
Three immunoregulatory signatures define non-productive HIV infection in CD4+ T memory stem cells @biorxivpreprint.bsky.social
biorxiv.org/content/10.6...
biorxiv.org/content/10.6...
Nature research paper: Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
go.nature.com/48fgQ7H
go.nature.com/48fgQ7H
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and developing more effective myeloid-targeting therapies.
go.nature.com
September 14, 2025 at 3:28 PM
Nature research paper: Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
go.nature.com/48fgQ7H
go.nature.com/48fgQ7H
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
www.nature.com
September 22, 2025 at 12:41 PM
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A protective CD56bright HELIOS & HOBIT expressing TGF-β1-secreting immunoregulatory NK cell subset associated with Hematopoietic Stem Cell Transplantation & promoted by IL-2/TGF-β1 combo
@sarahcrome.bsky.social
www.cell.com/iscience/ful...
@sarahcrome.bsky.social
www.cell.com/iscience/ful...
November 19, 2024 at 5:27 PM
A protective CD56bright HELIOS & HOBIT expressing TGF-β1-secreting immunoregulatory NK cell subset associated with Hematopoietic Stem Cell Transplantation & promoted by IL-2/TGF-β1 combo
@sarahcrome.bsky.social
www.cell.com/iscience/ful...
@sarahcrome.bsky.social
www.cell.com/iscience/ful...
Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬
BrainChild-03 Trial Supports Safety of B7-H3 CAR T-cell Therapy for DIPG
Main Finding: A phase I trial supported the safety and feasibility of repeated intracranial infusions of B7-H3 CAR T cells for DIPG.Concept: B7-H3 is an immunoregulatory protein expressed on the surfa...
aacrjournals.org
January 28, 2025 at 6:48 PM
Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬
ICYMI: Graft rejection limits survival rates in patients with lung transplantation. buff.ly/poRtG4Q
Daniel Kreisel & team now show lung transplant tolerance is critically dependent on the maintenance of a graft-resident immunoregulatory cell population.
Daniel Kreisel & team now show lung transplant tolerance is critically dependent on the maintenance of a graft-resident immunoregulatory cell population.
May 24, 2025 at 12:04 PM
ICYMI: Graft rejection limits survival rates in patients with lung transplantation. buff.ly/poRtG4Q
Daniel Kreisel & team now show lung transplant tolerance is critically dependent on the maintenance of a graft-resident immunoregulatory cell population.
Daniel Kreisel & team now show lung transplant tolerance is critically dependent on the maintenance of a graft-resident immunoregulatory cell population.
And so this is what the brilliant @payalyokota.bsky.social does in her free time when she is not organising the #gdTcellClub.
😉
😉
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung
infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential
role of nerve- and airway-associated...
www.cell.com
April 27, 2025 at 7:35 AM
And so this is what the brilliant @payalyokota.bsky.social does in her free time when she is not organising the #gdTcellClub.
😉
😉
It’s finally out!
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung
infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential
role of nerve- and airway-associated...
www.cell.com
April 25, 2025 at 7:19 PM
It’s finally out!
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
So cool!
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung
infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential
role of nerve- and airway-associated...
www.cell.com
April 26, 2025 at 12:14 AM
So cool!
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
"Interest in researching immunoglobulin (IgG) therapy in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) began in the mid-1980s, prompted by emerging evidence of immunoregulatory defects including disordered cell-mediated immunity and immunoglobulin subclass deficiencies.">
August 7, 2025 at 11:34 AM
"Interest in researching immunoglobulin (IgG) therapy in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) began in the mid-1980s, prompted by emerging evidence of immunoregulatory defects including disordered cell-mediated immunity and immunoglobulin subclass deficiencies.">
Check out our updated preprint!
Using functional #metabolomics, we link reduced EWSR1::ETS activity in Ewing #sarcoma to poor outcome and activation of the AHR pathway, which promotes immune evasion characterized by impaired NK cell function and immunoregulatory infiltrates.
tinyurl.com/2b6cry3m
Using functional #metabolomics, we link reduced EWSR1::ETS activity in Ewing #sarcoma to poor outcome and activation of the AHR pathway, which promotes immune evasion characterized by impaired NK cell function and immunoregulatory infiltrates.
tinyurl.com/2b6cry3m
September 4, 2025 at 9:23 AM
Check out our updated preprint!
Using functional #metabolomics, we link reduced EWSR1::ETS activity in Ewing #sarcoma to poor outcome and activation of the AHR pathway, which promotes immune evasion characterized by impaired NK cell function and immunoregulatory infiltrates.
tinyurl.com/2b6cry3m
Using functional #metabolomics, we link reduced EWSR1::ETS activity in Ewing #sarcoma to poor outcome and activation of the AHR pathway, which promotes immune evasion characterized by impaired NK cell function and immunoregulatory infiltrates.
tinyurl.com/2b6cry3m
New paper out today in @microbiomej.bsky.social: “Environmental microbiota transfer from forest soil into urban homes: a proof-of-principle study.” We show that a simple soil-on-rug intervention can shift bacterial microbiota in house dust in urban homes. link.springer.com/article/10.1...
Environmental microbiota transfer from forest soil into urban homes: a proof-of-principle study - Microbiome
Background Urban lifestyles are characterized by reduced encounters of environmental microbe stimuli that activate immunoregulatory pathways. This has been linked to an increased risk of inflammatory ...
link.springer.com
March 30, 2026 at 3:19 AM
New paper out today in @microbiomej.bsky.social: “Environmental microbiota transfer from forest soil into urban homes: a proof-of-principle study.” We show that a simple soil-on-rug intervention can shift bacterial microbiota in house dust in urban homes. link.springer.com/article/10.1...
Complementary immunoregulatory effects of #Bifidobacterium longum 1714TM associated exopolysaccharide and tryptophan metabolism
www.sciencedirect.com/science/arti... #OpenAccess #immunology #MicroSky #IDSky
www.sciencedirect.com/science/arti... #OpenAccess #immunology #MicroSky #IDSky
September 30, 2025 at 8:22 AM
Complementary immunoregulatory effects of #Bifidobacterium longum 1714TM associated exopolysaccharide and tryptophan metabolism
www.sciencedirect.com/science/arti... #OpenAccess #immunology #MicroSky #IDSky
www.sciencedirect.com/science/arti... #OpenAccess #immunology #MicroSky #IDSky
Slc13a3, the Itaconate transporter, improves hepatic antibacterial innate immunity
www.cell.com/developmenta...
www.cell.com/developmenta...
Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity
It has been reported that itaconate is an immunoregulatory metabolite secreted by
activated myeloid cells, including neutrophils and macrophages. Here, Chen et al.
demonstrate that SLC13A3 is an itaco...
www.cell.com
November 17, 2024 at 11:11 PM
Slc13a3, the Itaconate transporter, improves hepatic antibacterial innate immunity
www.cell.com/developmenta...
www.cell.com/developmenta...