🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 8, 2025 at 8:27 PM
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
#NatureMicroPicks
Microbial integrons in focus 🦠🧬
Two studies showing microbial integrons encoding phage defense systems
#MicroSky
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Microbial integrons in focus 🦠🧬
Two studies showing microbial integrons encoding phage defense systems
#MicroSky
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 14, 2025 at 3:55 PM
#NatureMicroPicks
Microbial integrons in focus 🦠🧬
Two studies showing microbial integrons encoding phage defense systems
#MicroSky
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Microbial integrons in focus 🦠🧬
Two studies showing microbial integrons encoding phage defense systems
#MicroSky
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Our paper on how integrons are biobanks of novel minimal defense systems is now out www.science.org/doi/10.1126/... Two main conclusions on this excellent work led by @eloilittner.bsky.social @baptistedarracq.bsky.social 1/n
May 9, 2025 at 1:07 PM
Our paper on how integrons are biobanks of novel minimal defense systems is now out www.science.org/doi/10.1126/... Two main conclusions on this excellent work led by @eloilittner.bsky.social @baptistedarracq.bsky.social 1/n
It’s out! Brand new work from my PostDoc in @themaxwelllab.bsky.social exploring anti-phage defence in V. parahaemolyticus: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
rdcu.be/d7EsN
rdcu.be/d7EsN
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
Nature Microbiology - Integrons are genetic elements that capture and store gene cassettes in Vibrio species. Bioinformatic and molecular techniques show that these regions can be hotspots of phage...
rdcu.be
January 27, 2025 at 3:48 PM
It’s out! Brand new work from my PostDoc in @themaxwelllab.bsky.social exploring anti-phage defence in V. parahaemolyticus: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
rdcu.be/d7EsN
rdcu.be/d7EsN
🧫🦠🔬🧬 @science.org Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems | Science www.science.org/doi/10.1126/...
@baptistedarracq.bsky.social @eloilittner.bsky.social @celineloot.bsky.social @epcrocha.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky
@baptistedarracq.bsky.social @eloilittner.bsky.social @celineloot.bsky.social @epcrocha.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 11, 2025 at 1:25 AM
🧫🦠🔬🧬 @science.org Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems | Science www.science.org/doi/10.1126/...
@baptistedarracq.bsky.social @eloilittner.bsky.social @celineloot.bsky.social @epcrocha.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky
@baptistedarracq.bsky.social @eloilittner.bsky.social @celineloot.bsky.social @epcrocha.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky
🧫🦠🔬🧬 @science.org Mobile integrons encode phage defense systems | Science www.science.org/doi/10.1126/...
@jaescudero.bsky.social @albertohca.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky
@jaescudero.bsky.social @albertohca.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 11, 2025 at 1:25 AM
🧫🦠🔬🧬 @science.org Mobile integrons encode phage defense systems | Science www.science.org/doi/10.1126/...
@jaescudero.bsky.social @albertohca.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky
@jaescudero.bsky.social @albertohca.bsky.social et al.
#microbiology #phage #immunity #phagesky #MicroSky
OUT NOW: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
@themaxwelllab.bsky.social
www.nature.com/articles/s41...
@themaxwelllab.bsky.social
www.nature.com/articles/s41...
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus - Nature Microbiology
Integrons are genetic elements that capture and store gene cassettes in Vibrio species. Bioinformatic and molecular techniques show that these regions can be hotspots of phage defence systems.
www.nature.com
January 27, 2025 at 3:40 PM
OUT NOW: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
@themaxwelllab.bsky.social
www.nature.com/articles/s41...
@themaxwelllab.bsky.social
www.nature.com/articles/s41...
Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity.
academic.oup.com/nar/article/... 1/5
academic.oup.com/nar/article/... 1/5
Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons
Abstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti
academic.oup.com
November 17, 2025 at 3:44 PM
Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity.
academic.oup.com/nar/article/... 1/5
academic.oup.com/nar/article/... 1/5
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 8, 2025 at 8:27 PM
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
April 16, 2025 at 7:14 AM
New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
Excited to share our new paper out today in @science.org 🎉
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
www.science.org
April 10, 2026 at 10:46 AM
Excited to share our new paper out today in @science.org 🎉
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) !
In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones.
www.science.org/doi/10.1126/...
In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones.
www.science.org/doi/10.1126/...
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 9, 2025 at 11:41 AM
White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) !
In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones.
www.science.org/doi/10.1126/...
In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones.
www.science.org/doi/10.1126/...
Mobile Elements Starter Pack on BlueSky!
Interested in plasmids, phages, ICEs, transposons, integrons, and all things accessory genome? Follow this curated list of researchers and labs doing exciting work in mobile elements.
Interested in plasmids, phages, ICEs, transposons, integrons, and all things accessory genome? Follow this curated list of researchers and labs doing exciting work in mobile elements.
November 10, 2024 at 8:45 AM
Mobile Elements Starter Pack on BlueSky!
Interested in plasmids, phages, ICEs, transposons, integrons, and all things accessory genome? Follow this curated list of researchers and labs doing exciting work in mobile elements.
Interested in plasmids, phages, ICEs, transposons, integrons, and all things accessory genome? Follow this curated list of researchers and labs doing exciting work in mobile elements.
Congrats @baptistedarracq.bsky.social & @marialopopolo.bsky.social two Pasteurians awarded the Academy of Sciences' "Major Advances in Biology" Prize for groundbreaking Science publications on bacterial defense & ancient leprosy.
pubmed.ncbi.nlm.nih.gov/40339013/
pubmed.ncbi.nlm.nih.gov/40440428/
pubmed.ncbi.nlm.nih.gov/40339013/
pubmed.ncbi.nlm.nih.gov/40440428/
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems - PubMed
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
pubmed.ncbi.nlm.nih.gov
June 17, 2026 at 2:51 PM
Congrats @baptistedarracq.bsky.social & @marialopopolo.bsky.social two Pasteurians awarded the Academy of Sciences' "Major Advances in Biology" Prize for groundbreaking Science publications on bacterial defense & ancient leprosy.
pubmed.ncbi.nlm.nih.gov/40339013/
pubmed.ncbi.nlm.nih.gov/40440428/
pubmed.ncbi.nlm.nih.gov/40339013/
pubmed.ncbi.nlm.nih.gov/40440428/
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus www.nature.com/articles/s41... #jcampubs
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus - Nature Microbiology
Integrons are genetic elements that capture and store gene cassettes in Vibrio species. Bioinformatic and molecular techniques show that these regions can be hotspots of phage defence systems.
www.nature.com
January 27, 2025 at 1:50 PM
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus www.nature.com/articles/s41... #jcampubs
At least 10% of the V. cholerae integron cassettes have novel antiphage activities (see below). Considering that there are 25,000 distinct cassettes of unknown function, integrons constitute an extraordinary and almost inexhaustible reservoir of antiphage functions!
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 9, 2025 at 3:26 PM
At least 10% of the V. cholerae integron cassettes have novel antiphage activities (see below). Considering that there are 25,000 distinct cassettes of unknown function, integrons constitute an extraordinary and almost inexhaustible reservoir of antiphage functions!
Have also a look at our back-to-back study for mobile integrons by Nicolas Kieffer from @jaescudero.bsky.social group !
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 9, 2025 at 11:41 AM
Have also a look at our back-to-back study for mobile integrons by Nicolas Kieffer from @jaescudero.bsky.social group !
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
Soyons de meilleur.e.s écologistes : Intégrons les autres animaux sentients dans notre sphère de considération.
Ne pas le faire nous expose à reproduire les oppressions contre lesquelles nous prétendons lutter.
Ne pas le faire nous expose à reproduire les oppressions contre lesquelles nous prétendons lutter.
🔥🎬 Qui dit nouvelle Quinzaine de la #Sentience dit : NOUVELLE VIDÉO ! 🎬🔥
👉 Cette année, le thème de notre campagne est l’invisibilisation de l'individualité des animaux non-humains et donc… de leur sentience ❗️
youtu.be/aVWZCdfqheI
youtu.be/aVWZCdfqheI
youtu.be/aVWZCdfqheI
#QuinzaineSentience
👉 Cette année, le thème de notre campagne est l’invisibilisation de l'individualité des animaux non-humains et donc… de leur sentience ❗️
youtu.be/aVWZCdfqheI
youtu.be/aVWZCdfqheI
youtu.be/aVWZCdfqheI
#QuinzaineSentience
Effacé·e
YouTube video by Projet Méduses
youtu.be
May 15, 2025 at 1:14 PM
Soyons de meilleur.e.s écologistes : Intégrons les autres animaux sentients dans notre sphère de considération.
Ne pas le faire nous expose à reproduire les oppressions contre lesquelles nous prétendons lutter.
Ne pas le faire nous expose à reproduire les oppressions contre lesquelles nous prétendons lutter.
Really cool work from @mblokesch.bsky.social et al Competence-mediated DNA uptake diversifies Vibrio cholerae sedentary chromosomal integrons www.science.org/doi/10.1126/...
Competence-mediated DNA uptake diversifies Vibrio cholerae sedentary chromosomal integrons
Bacteria often survive viral attack and environmental stress by sharing genes that enhance their defenses. The cholera pathogen Vibrio cholerae carries a sedentary chromosomal integron (SCI), a genetic element containing hundreds of mostly promoterless ...
www.science.org
April 10, 2026 at 8:51 AM
Really cool work from @mblokesch.bsky.social et al Competence-mediated DNA uptake diversifies Vibrio cholerae sedentary chromosomal integrons www.science.org/doi/10.1126/...
I had fun using pangenome graphs to explore the global epidemiology of blaGES-5-associated integrons 🔎
The next challenge: can we integrate pangenome graphs into the routine surveillance of integrons?
New preprint with #LiamShaw and #NicoleStoesser
www.biorxiv.org/content/10.1...
The next challenge: can we integrate pangenome graphs into the routine surveillance of integrons?
New preprint with #LiamShaw and #NicoleStoesser
www.biorxiv.org/content/10.1...
Global genomic epidemiology of blaGES-5 carbapenemase-associated integrons
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
February 11, 2024 at 10:25 AM
I had fun using pangenome graphs to explore the global epidemiology of blaGES-5-associated integrons 🔎
The next challenge: can we integrate pangenome graphs into the routine surveillance of integrons?
New preprint with #LiamShaw and #NicoleStoesser
www.biorxiv.org/content/10.1...
The next challenge: can we integrate pangenome graphs into the routine surveillance of integrons?
New preprint with #LiamShaw and #NicoleStoesser
www.biorxiv.org/content/10.1...
New preprint alert!!! 🚀🤓 We are very happy to finally share this with the world — the result of seven years of work and a new tool to study integrons and discover new functions encoded in these bacterial platforms.
If you want to know more, here is a thread 🧵
www.biorxiv.org/content/10.6...
If you want to know more, here is a thread 🧵
www.biorxiv.org/content/10.6...
www.biorxiv.org
March 20, 2026 at 4:01 PM
New preprint alert!!! 🚀🤓 We are very happy to finally share this with the world — the result of seven years of work and a new tool to study integrons and discover new functions encoded in these bacterial platforms.
If you want to know more, here is a thread 🧵
www.biorxiv.org/content/10.6...
If you want to know more, here is a thread 🧵
www.biorxiv.org/content/10.6...
🔻 Dans notre combat #syndical, intégrons cette riposte indispensable face à l’empire #bolloré. Nous ne sommes pas seul•es sur ce champs de lutte ; des alliances sont primordiales.
✊Nous les renforcerons en #2025. @lessoulevements.bsky.social @solidaires.org
✊Nous les renforcerons en #2025. @lessoulevements.bsky.social @solidaires.org
January 17, 2025 at 7:48 PM
🔻 Dans notre combat #syndical, intégrons cette riposte indispensable face à l’empire #bolloré. Nous ne sommes pas seul•es sur ce champs de lutte ; des alliances sont primordiales.
✊Nous les renforcerons en #2025. @lessoulevements.bsky.social @solidaires.org
✊Nous les renforcerons en #2025. @lessoulevements.bsky.social @solidaires.org
Mobile Integrons Encode Phage Defense Systems | bioRxiv https://www.biorxiv.org/content/10.1101/2024.07.02.601719v4
Mobile Integrons Encode Phage Defense Systems
Integrons are bacterial genetic elements that capture, stockpile and modulate the expression of genes encoded in integron cassettes. Mobile Integrons (MI) are borne on plasmids, acting as a vehicle for hundreds of antimicrobial resistance genes among key pathogens. These elements also carry gene cassettes of unknown function ( gcu s) whose role and adaptive value remains unexplored. Here we show that gcu s encode phage resistance systems, many of which are novel. Bacteriophage resistance integron cassettes (BRiCs) can be combined and mixed with resistance cassettes to produce multiphage or drug/phage-resistance. The fitness costs of BRiCs are variable, dependent on the genetic context, and can be modulated by changing the order of cassettes in the array. Hence, MIs act as highly mobile, low-cost defense islands. ![Summary Figure][1]</img> Summary Figure Novel phage defense systems identified in Mobile Integrons. We confronted genes of unknown function from mobile integrons against a panel of phage. We characterized 13 Bacteriophage Resistance integron Cassettes (BRiCs) and confirmed their function in Klebsiella pneumoniae and Pseudomonas aeruginosa . Combined with other cassettes, BRiCs produce multi-phage/antibiotic resistance. Additionally, their cost can be reduced in an array. ### Competing Interest Statement The authors have declared no competing interest. [1]: pending:yes
www.biorxiv.org
April 8, 2025 at 7:23 AM
Mobile Integrons Encode Phage Defense Systems | bioRxiv https://www.biorxiv.org/content/10.1101/2024.07.02.601719v4
What a milestone!!! I’m really glad I got to add my two cents to the growing knowledge about integrons — this paper is totally worth checking out!
🧪
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉
Short 🧵
www.science.org/doi/10.1126/...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 9, 2025 at 1:16 AM
What a milestone!!! I’m really glad I got to add my two cents to the growing knowledge about integrons — this paper is totally worth checking out!
Bah intégrons tous les autres jours fériés des autres cultes alors. Et guillotinons Bayrou et Macron
July 15, 2025 at 4:41 PM
Bah intégrons tous les autres jours fériés des autres cultes alors. Et guillotinons Bayrou et Macron