Online Now: KRASG12D-targeted therapy sensitivity depends on interferon signaling activation in pancreatic cancer
KRASG12D-targeted therapy sensitivity depends on interferon signaling activation in pancreatic cancer
Zhang et al. show that intrinsic resistance to KRASG12D-targeted therapy in pancreatic cancer is driven by suppressed interferon signaling associated with sustained MYC activity. Activation of interferon pathways, particularly via IFN-β, resensitizes resistant tumors and synergizes with KRAS inhibitors, revealing interferon signaling as an actionable target.
dlvr.it
October 30, 2026 at 11:52 AM
Online Now: KRASG12D-targeted therapy sensitivity depends on interferon signaling activation in pancreatic cancer
Intrinsic resistance to KRAS inhibition: Interfering with interferon www.cell.com/cancer-cell...
November 1, 2026 at 2:45 PM
Intrinsic resistance to KRAS inhibition: Interfering with interferon www.cell.com/cancer-cell...
Defective Viral Genomes Reveal History-dependent Self-regulation of Type I Interferon Dynamics https://www.biorxiv.org/content/10.64898/2026.10.30.763053v1
November 1, 2026 at 2:18 AM
Defective Viral Genomes Reveal History-dependent Self-regulation of Type I Interferon Dynamics https://www.biorxiv.org/content/10.64898/2026.10.30.763053v1
RHs can order broader Immuno-panels , gamma interferon infusions, do MRIs, prescribe steroids ( often a 1st line treatment ) .
November 3, 2026 at 3:42 AM
RHs can order broader Immuno-panels , gamma interferon infusions, do MRIs, prescribe steroids ( often a 1st line treatment ) .
Listen to this podcast to explore how type 1 interferon drives CLE and how emerging therapies may disrupt this pathway: https://www.vindicocme.com/1cutaneous-lupus-conversations-interferon-focused-strategies-to-treat-cle-with-drs-victoria-werth-and-maria-dall-era-blt12dec68dd5ff6941/overview
#CME
#CME
November 1, 2026 at 2:18 PM
Listen to this podcast to explore how type 1 interferon drives CLE and how emerging therapies may disrupt this pathway: https://www.vindicocme.com/1cutaneous-lupus-conversations-interferon-focused-strategies-to-treat-cle-with-drs-victoria-werth-and-maria-dall-era-blt12dec68dd5ff6941/overview
#CME
#CME
🦋 “Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis” #genyo.
👉 Disponible en #risalud hdl.handle.net/10668/30225
#BVSSPA #Interferon #LupusNephritis
👉 Disponible en #risalud hdl.handle.net/10668/30225
#BVSSPA #Interferon #LupusNephritis
November 3, 2026 at 12:13 PM
🦋 “Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis” #genyo.
👉 Disponible en #risalud hdl.handle.net/10668/30225
#BVSSPA #Interferon #LupusNephritis
👉 Disponible en #risalud hdl.handle.net/10668/30225
#BVSSPA #Interferon #LupusNephritis
Aberrant thymic architecture and enhanced interferon signaling in Down syndrome @natcomms.nature.com @stjuderesearch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 30, 2026 at 4:48 PM
Aberrant thymic architecture and enhanced interferon signaling in Down syndrome @natcomms.nature.com @stjuderesearch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coevolutionary constraints of Zika virus nonstructural protein 5 replication and interferon antagonism activities
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
October 30, 2026 at 1:31 PM
Coevolutionary constraints of Zika virus nonstructural protein 5 replication and interferon antagonism activities
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Intranasal HSV‑1 infection drives region‑specific interferon‑dominant microglial remodeling
"Herpes simplex virus type 1 (HSV-1) is a neurotropic pathogen capable of invading the central nervous system (CNS) and is associated with chronic neuroinflammation,1/2
journals.plos.org/plospathogen...
"Herpes simplex virus type 1 (HSV-1) is a neurotropic pathogen capable of invading the central nervous system (CNS) and is associated with chronic neuroinflammation,1/2
journals.plos.org/plospathogen...
Intranasal HSV‑1 infection drives region‑specific interferon‑dominant microglial remodeling
Author summary Herpes simplex virus type 1 (HSV-1) infects nearly 60% of the population and establishes latency within the nervous system. Growing evidence links HSV-1 infection and reactivation to Al...
journals.plos.org
November 2, 2026 at 4:22 PM
Intranasal HSV‑1 infection drives region‑specific interferon‑dominant microglial remodeling
"Herpes simplex virus type 1 (HSV-1) is a neurotropic pathogen capable of invading the central nervous system (CNS) and is associated with chronic neuroinflammation,1/2
journals.plos.org/plospathogen...
"Herpes simplex virus type 1 (HSV-1) is a neurotropic pathogen capable of invading the central nervous system (CNS) and is associated with chronic neuroinflammation,1/2
journals.plos.org/plospathogen...
If My Neurologist believed me initially , i could have gotten gamma interferon or plasma pharesis to stop it.
( I didnt know that/ he didnt tell me that)
But I sure did make em do every possible test that was on wikipedia
( I didnt know that/ he didnt tell me that)
But I sure did make em do every possible test that was on wikipedia
November 2, 2026 at 5:55 PM
If My Neurologist believed me initially , i could have gotten gamma interferon or plasma pharesis to stop it.
( I didnt know that/ he didnt tell me that)
But I sure did make em do every possible test that was on wikipedia
( I didnt know that/ he didnt tell me that)
But I sure did make em do every possible test that was on wikipedia
Interferon-activated neutrophils characterize coronary microvascular dysfunction in women with ANOCA #SingleCell 🧪🧬🖥️
https://www.medrxiv.org/content/10.64898/2026.10.30.26366961v1
https://www.medrxiv.org/content/10.64898/2026.10.30.26366961v1
November 3, 2026 at 5:00 AM
Interferon-activated neutrophils characterize coronary microvascular dysfunction in women with ANOCA #SingleCell 🧪🧬🖥️
https://www.medrxiv.org/content/10.64898/2026.10.30.26366961v1
https://www.medrxiv.org/content/10.64898/2026.10.30.26366961v1
#CME podcast with Drs. Victoria P. Werth, Maria Dall'Era, and Kenneth Carekin Kalunian explores emerging therapeutic insights for cutaneous lupus erythematosus.
Find it here: https://www.vindicocme.com/cutaneous-lupus-erythematosus-emerging-therapeutic-insights-for-interferon-driven-disease
Find it here: https://www.vindicocme.com/cutaneous-lupus-erythematosus-emerging-therapeutic-insights-for-interferon-driven-disease
October 30, 2026 at 7:26 PM
#CME podcast with Drs. Victoria P. Werth, Maria Dall'Era, and Kenneth Carekin Kalunian explores emerging therapeutic insights for cutaneous lupus erythematosus.
Find it here: https://www.vindicocme.com/cutaneous-lupus-erythematosus-emerging-therapeutic-insights-for-interferon-driven-disease
Find it here: https://www.vindicocme.com/cutaneous-lupus-erythematosus-emerging-therapeutic-insights-for-interferon-driven-disease
Defective Viral Genomes Reveal History-dependent Self-regulation of Type I Interferon Dynamics https://www.biorxiv.org/content/10.64898/2026.10.30.763053v1
November 1, 2026 at 2:18 AM
Defective Viral Genomes Reveal History-dependent Self-regulation of Type I Interferon Dynamics https://www.biorxiv.org/content/10.64898/2026.10.30.763053v1
Online Now: Intrinsic resistance to KRAS inhibition: Interfering with interferon
Intrinsic resistance to KRAS inhibition: Interfering with interferon
In this issue of Cancer Cell, Zhang et al. perform multi-omics profiling on a large collection of patient-derived pancreatic ductal adenocarcinoma organoids to elucidate the mechanisms underlying intrinsic resistance to KRAS inhibition. This work identifies suppression of innate immune signaling through sustained MYC activity as the principal driver of intrinsic resistance.
dlvr.it
October 29, 2026 at 6:51 PM
Online Now: Intrinsic resistance to KRAS inhibition: Interfering with interferon
Congrats to Yimei Li with this interesting preprint! The impact of viral RNA on the innate immune response depends on the immune context and may lead to local immune suppression to stimulate viral growth: www.biorxiv.org/content/10.6...
Defective Viral Genomes Reveal History-dependent Self-regulation of Type I Interferon Dynamics
Type I interferons (IFN) help clear a viral infection, but IFN levels can then decline to reset the antiviral state and avoid innate immune dysregulation. Such dysregulation can occur following infect...
www.biorxiv.org
November 1, 2026 at 5:46 PM
Congrats to Yimei Li with this interesting preprint! The impact of viral RNA on the innate immune response depends on the immune context and may lead to local immune suppression to stimulate viral growth: www.biorxiv.org/content/10.6...
🔬 Can optical tweezers show what interferon does to red blood cells?
Short-term IFN-α exposure reduced RBC aggregation forces in vitro — a biophysical angle on a drug usually framed as immune-only.
🔗 https://imrpress.com/journal/IJP/22/6/10.31083/IJP54887
#Pharmacology #Interferon
Short-term IFN-α exposure reduced RBC aggregation forces in vitro — a biophysical angle on a drug usually framed as immune-only.
🔗 https://imrpress.com/journal/IJP/22/6/10.31083/IJP54887
#Pharmacology #Interferon
November 2, 2026 at 1:35 PM
🔬 Can optical tweezers show what interferon does to red blood cells?
Short-term IFN-α exposure reduced RBC aggregation forces in vitro — a biophysical angle on a drug usually framed as immune-only.
🔗 https://imrpress.com/journal/IJP/22/6/10.31083/IJP54887
#Pharmacology #Interferon
Short-term IFN-α exposure reduced RBC aggregation forces in vitro — a biophysical angle on a drug usually framed as immune-only.
🔗 https://imrpress.com/journal/IJP/22/6/10.31083/IJP54887
#Pharmacology #Interferon
Antineoplastic Interferon Drug Market Analysis & Forecast 2035 | WiseGuyReports www.wiseguyreports.com/reports/anti...
Antineoplastic Interferon Drug Market Analysis & Forecast 2035
Antineoplastic Interferon Drug Market Size was estimated at 14.9 (USD Billion) in 2023. The Antineoplastic Interferon Drug Market Industry is expected to grow from 15.59(USD Billion) in 2024 to 22.5 (...
www.wiseguyreports.com
October 29, 2026 at 9:21 AM
Antineoplastic Interferon Drug Market Analysis & Forecast 2035 | WiseGuyReports www.wiseguyreports.com/reports/anti...
MDTP Seminar this week: Doran Goldman from the Mo Lab and Autumn Sanders from the Gaglia Lab will be presenting!
#UWMadison
#UWMadison
November 2, 2026 at 7:50 PM
MDTP Seminar this week: Doran Goldman from the Mo Lab and Autumn Sanders from the Gaglia Lab will be presenting!
#UWMadison
#UWMadison
The authors included RRIDs in their in Molecular Cancer Therapeutics paper! We value the author's support of reproducibility. #reproducibility #OpenResearch #BetterScience
Targeting SUMOylation triggers interferon-β-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid Leukemia
Read the full paper: Targeting SUMOylation triggers interferon-β-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid Leukemia
doi.org
November 1, 2026 at 7:00 AM
The authors included RRIDs in their in Molecular Cancer Therapeutics paper! We value the author's support of reproducibility. #reproducibility #OpenResearch #BetterScience
In @jhumimmunity.org: Liu et al. identify NBAS deficiency as an underrecognized cause of immune dysregulation and reveal myeloid-driven type I interferon activation, linking impaired intracellular trafficking to interferonopathy. rupress.org/jhi/article/...
October 28, 2026 at 5:00 PM
In @jhumimmunity.org: Liu et al. identify NBAS deficiency as an underrecognized cause of immune dysregulation and reveal myeloid-driven type I interferon activation, linking impaired intracellular trafficking to interferonopathy. rupress.org/jhi/article/...
An interferon-like off-switch in invertebrates: Vago4 downregulates Domeless to restrain JAK/STAT signaling https://www.biorxiv.org/content/10.64898/2026.10.26.761873v1
October 31, 2026 at 2:17 AM
An interferon-like off-switch in invertebrates: Vago4 downregulates Domeless to restrain JAK/STAT signaling https://www.biorxiv.org/content/10.64898/2026.10.26.761873v1
An interferon-like off-switch in invertebrates: Vago4 downregulates Domeless to restrain JAK/STAT signaling https://www.biorxiv.org/content/10.64898/2026.10.26.761873v1
October 31, 2026 at 2:17 AM
An interferon-like off-switch in invertebrates: Vago4 downregulates Domeless to restrain JAK/STAT signaling https://www.biorxiv.org/content/10.64898/2026.10.26.761873v1
Coma sempre me dan reacción (síntomas de interferón coma febre, dor muscular...) o ano pasado tomei paracetamol 500mg cada 8h, 2 días e foime xenial, cun ibuprofeno 400mg solto o 1° día. Repetirei
October 29, 2026 at 10:04 PM
Coma sempre me dan reacción (síntomas de interferón coma febre, dor muscular...) o ano pasado tomei paracetamol 500mg cada 8h, 2 días e foime xenial, cun ibuprofeno 400mg solto o 1° día. Repetirei
Liu et al. identify NBAS deficiency as an underrecognized cause of immune dysregulation. They reveal myeloid-driven type I #interferon activation, linking impaired intracellular trafficking to #interferonopathy and suggesting therapeutic potential for JAK inhibition. rupress.org/jhi/article/...
October 28, 2026 at 4:00 PM
Liu et al. identify NBAS deficiency as an underrecognized cause of immune dysregulation. They reveal myeloid-driven type I #interferon activation, linking impaired intracellular trafficking to #interferonopathy and suggesting therapeutic potential for JAK inhibition. rupress.org/jhi/article/...