@cellcellpress.bsky.social spotlight
Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41...
Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41...
October 17, 2025 at 4:41 PM
@cellcellpress.bsky.social spotlight
Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41...
Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41...
My thesis paper is out in @elife.bsky.social! We look forward to making it even better as we respond to our (very kind) reviewer comments. Till then, see how we created a novel microglia replacement system & showed that brain macs can drive brain interferonopathy!
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology
elifesciences.org
January 6, 2025 at 7:58 PM
My thesis paper is out in @elife.bsky.social! We look forward to making it even better as we respond to our (very kind) reviewer comments. Till then, see how we created a novel microglia replacement system & showed that brain macs can drive brain interferonopathy!
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
ICYMI: Type I interferonopathy in ATR-X syndrome reveals a transcriptional role for cGAS
Type I interferonopathy in ATR-X syndrome reveals a transcriptional role for cGAS
Nature Reviews Immunology, Published online: 28 January 2026; doi:10.1038/s41577-026-01275-5A preprint by El-Daher et al. describes an interferonopathy-associated mutation in the chromatin remodeller ATRX, which identifies an unexpected role for nuclear cGAS in transcriptional regulation.
dlvr.it
January 31, 2026 at 10:58 AM
ICYMI: Type I interferonopathy in ATR-X syndrome reveals a transcriptional role for cGAS
Interesting review by Russell Vance
"The major difference, for which we lack a satisfying explanation, is that innate immunity is able to sterilize a dose of 10^6 Legionella within a few days, whereas innate immunity fails to eliminate even a single bacillus of Mtb" #ImmunoSky
"The major difference, for which we lack a satisfying explanation, is that innate immunity is able to sterilize a dose of 10^6 Legionella within a few days, whereas innate immunity fails to eliminate even a single bacillus of Mtb" #ImmunoSky
Tuberculosis as an unconventional interferonopathy
Tuberculosis is caused by Mycobacterium tuberculosis, a bacterium that accounts for more human mortality than any other. Evidence is accumulating for …
www.sciencedirect.com
December 16, 2024 at 7:32 PM
Interesting review by Russell Vance
"The major difference, for which we lack a satisfying explanation, is that innate immunity is able to sterilize a dose of 10^6 Legionella within a few days, whereas innate immunity fails to eliminate even a single bacillus of Mtb" #ImmunoSky
"The major difference, for which we lack a satisfying explanation, is that innate immunity is able to sterilize a dose of 10^6 Legionella within a few days, whereas innate immunity fails to eliminate even a single bacillus of Mtb" #ImmunoSky
Superb Review of an interesting type I interferonopathy !
Spondyloenchondrodysplasia: An enigmatic immuno-osseus type I interferonopathy url:https://rupress.org/jhi/article/1/2/e20250035/277993/Spondyloenchondrodysplasia-An-enigmatic-immuno
Spondyloenchondrodysplasia: An enigmatic immuno-osseus type I interferonopathy url:https://rupress.org/jhi/article/1/2/e20250035/277993/Spondyloenchondrodysplasia-An-enigmatic-immuno
June 3, 2025 at 4:10 PM
Superb Review of an interesting type I interferonopathy !
Spondyloenchondrodysplasia: An enigmatic immuno-osseus type I interferonopathy url:https://rupress.org/jhi/article/1/2/e20250035/277993/Spondyloenchondrodysplasia-An-enigmatic-immuno
Spondyloenchondrodysplasia: An enigmatic immuno-osseus type I interferonopathy url:https://rupress.org/jhi/article/1/2/e20250035/277993/Spondyloenchondrodysplasia-An-enigmatic-immuno
Köhlmeier-Degos disease is an interferonopathy characterized by type I and II interferon-driven inflammatory vasculopathy @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
July 30, 2026 at 7:44 PM
Köhlmeier-Degos disease is an interferonopathy characterized by type I and II interferon-driven inflammatory vasculopathy @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Newcastle University, Newcastle upon Tyne (@newcastleuni.bsky.social) is hiring:
Research Assistant / Associate in Interferonopathy
#researcher #phd #medicine #immunology
Research Assistant / Associate in Interferonopathy
#researcher #phd #medicine #immunology
September 27, 2026 at 6:09 PM
Newcastle University, Newcastle upon Tyne (@newcastleuni.bsky.social) is hiring:
Research Assistant / Associate in Interferonopathy
#researcher #phd #medicine #immunology
Research Assistant / Associate in Interferonopathy
#researcher #phd #medicine #immunology
Spondyloenchondrodysplasia: An enigmatic immuno-osseus type I #interferonopathy. New review from Callie Wong, Tifenn Wauquier, Yanick Crow and colleagues @institutimagine.bsky.social @uoe-igc.bsky.social: rupress.org/jhi/article/...
#Autoinflammation
#Autoinflammation
June 11, 2025 at 2:50 PM
Spondyloenchondrodysplasia: An enigmatic immuno-osseus type I #interferonopathy. New review from Callie Wong, Tifenn Wauquier, Yanick Crow and colleagues @institutimagine.bsky.social @uoe-igc.bsky.social: rupress.org/jhi/article/...
#Autoinflammation
#Autoinflammation
ADAR1 haploinsufficiency and sustained viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy https://www.biorxiv.org/content/10.1101/2025.01.21.634124v1
January 23, 2025 at 12:16 AM
ADAR1 haploinsufficiency and sustained viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy https://www.biorxiv.org/content/10.1101/2025.01.21.634124v1
Excited to highlight this preprint by lead author Marie-Thérèse El-Daher and the Crow Lab @uoe-igc.bsky.social @edinburgh-uni.bsky.social
The authors describe a novel Type I Interferonopathy condition and a non-canonical role for cGAS in transcriptional regulation 🧬
The authors describe a novel Type I Interferonopathy condition and a non-canonical role for cGAS in transcriptional regulation 🧬
January 30, 2026 at 2:47 PM
Excited to highlight this preprint by lead author Marie-Thérèse El-Daher and the Crow Lab @uoe-igc.bsky.social @edinburgh-uni.bsky.social
The authors describe a novel Type I Interferonopathy condition and a non-canonical role for cGAS in transcriptional regulation 🧬
The authors describe a novel Type I Interferonopathy condition and a non-canonical role for cGAS in transcriptional regulation 🧬
@biorxivpreprint.bsky.social Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
May 29, 2026 at 5:56 PM
@biorxivpreprint.bsky.social Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Nouvelle publication au Limos : 'Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy' - https://hal.science/hal-05762907v1
September 25, 2026 at 10:30 PM
Nouvelle publication au Limos : 'Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy' - https://hal.science/hal-05762907v1
I have a pet theory that sarcoidosis is also an interferonopathy.
Maybe someday we will treat TB with antibiotics AND immunosuppressants?
Maybe someday we will treat TB with antibiotics AND immunosuppressants?
December 16, 2024 at 7:36 PM
I have a pet theory that sarcoidosis is also an interferonopathy.
Maybe someday we will treat TB with antibiotics AND immunosuppressants?
Maybe someday we will treat TB with antibiotics AND immunosuppressants?
Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy
Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy
In a recent Nature paper, Kelepouras et al. uncover how STING licenses ZBP1-driven necroptosis through transcriptional priming and Z-nucleic acid amplification, revealing a pathogenic circuit in SAVI and highlighting the ZBP1-RIPK3-MLKL axis as a therapeutic target.
dlvr.it
October 20, 2025 at 7:15 PM
Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy
'Some emphasize how Mtb can be thought of as a stealth pathogen that evades or suppresses immune recognition. Others emphasize essentially the opposite — that Mtb elicits a robust inflammatory response that it exploits for its benefit. Both views have validity & the challenge is to reconcile them.'
Tuberculosis as an unconventional interferonopathy
Tuberculosis is caused by Mycobacterium tuberculosis, a bacterium that accounts for more human mortality than any other. Evidence is accumulating for …
www.sciencedirect.com
December 22, 2024 at 4:26 PM
'Some emphasize how Mtb can be thought of as a stealth pathogen that evades or suppresses immune recognition. Others emphasize essentially the opposite — that Mtb elicits a robust inflammatory response that it exploits for its benefit. Both views have validity & the challenge is to reconcile them.'
Familial pulmonary alveolar proteinosis and type I #interferonopathy by mutation of #STAT2 (TIMS2). New study from Conor Gruber, Dusan Bogunovic @bogunoviclab.bsky.social @columbiamed.bsky.social and colleagues: rupress.org/jem/article/...
#HumanDiseaseGenetics #Immunodeficiency #InnateImmunity
#HumanDiseaseGenetics #Immunodeficiency #InnateImmunity
July 23, 2026 at 1:15 PM
Familial pulmonary alveolar proteinosis and type I #interferonopathy by mutation of #STAT2 (TIMS2). New study from Conor Gruber, Dusan Bogunovic @bogunoviclab.bsky.social @columbiamed.bsky.social and colleagues: rupress.org/jem/article/...
#HumanDiseaseGenetics #Immunodeficiency #InnateImmunity
#HumanDiseaseGenetics #Immunodeficiency #InnateImmunity
ME/CFS & Long COVID Research Monitor — Mar 17–24, 2026
Key papers: cGAS inhibitor on SAMHD1 cells, SAMHD1 phenotype study, IFN-γ as LC biomarker, immune exhaustion (Nat Immunol)
🧵 #MECFS #LongCovid #interferonopathy
Key papers: cGAS inhibitor on SAMHD1 cells, SAMHD1 phenotype study, IFN-γ as LC biomarker, immune exhaustion (Nat Immunol)
🧵 #MECFS #LongCovid #interferonopathy
March 25, 2026 at 6:28 AM
ME/CFS & Long COVID Research Monitor — Mar 17–24, 2026
Key papers: cGAS inhibitor on SAMHD1 cells, SAMHD1 phenotype study, IFN-γ as LC biomarker, immune exhaustion (Nat Immunol)
🧵 #MECFS #LongCovid #interferonopathy
Key papers: cGAS inhibitor on SAMHD1 cells, SAMHD1 phenotype study, IFN-γ as LC biomarker, immune exhaustion (Nat Immunol)
🧵 #MECFS #LongCovid #interferonopathy
And surprise!! we found three deleterious heterozygous mutants of the AZI2 gene (which encodes the NAP1 protein) in three patients suffering from lupus or a severe interferonopathy (a disease linked to the uncontrolled production of type-1 interferon).
September 7, 2026 at 7:52 AM
And surprise!! we found three deleterious heterozygous mutants of the AZI2 gene (which encodes the NAP1 protein) in three patients suffering from lupus or a severe interferonopathy (a disease linked to the uncontrolled production of type-1 interferon).
Parvaneh et al. study patients with STAT2 p.R148Q variant, who present with life-threatening #neuroinflammation, respiratory failure, & high mortality rate. Early genetic recognition & treatment with high-dose JAK inhibitors may improve outcomes in this #interferonopathy. rupress.org/jhi/article/...
May 27, 2026 at 4:01 PM
Parvaneh et al. study patients with STAT2 p.R148Q variant, who present with life-threatening #neuroinflammation, respiratory failure, & high mortality rate. Early genetic recognition & treatment with high-dose JAK inhibitors may improve outcomes in this #interferonopathy. rupress.org/jhi/article/...
Congratulations to Dr. Kelly Sullivan, director of the Crnic Institute’s Experimental Models Program and associate professor at @cupediatrics.bsky.social, on presenting ”The Interferonopathy of Down Syndrome,” and to Rachel Shropshire for winning Top Student Poster at this year’s DSMIG Symposium!
August 1, 2025 at 8:38 PM
Congratulations to Dr. Kelly Sullivan, director of the Crnic Institute’s Experimental Models Program and associate professor at @cupediatrics.bsky.social, on presenting ”The Interferonopathy of Down Syndrome,” and to Rachel Shropshire for winning Top Student Poster at this year’s DSMIG Symposium!
My interpretation: as we age we lose tert expression and our telomeres fray, requiring tert to activate the immune response to damaged telomeres prevents massive autoimmunity. Not so much moonlighting as a fail safe, raising the threshold to trigger interferonopathy.
August 7, 2025 at 1:34 AM
My interpretation: as we age we lose tert expression and our telomeres fray, requiring tert to activate the immune response to damaged telomeres prevents massive autoimmunity. Not so much moonlighting as a fail safe, raising the threshold to trigger interferonopathy.
Type I interferonopathy in ATR-X syndrome reveals a transcriptional role for cGAS
Type I interferonopathy in ATR-X syndrome reveals a transcriptional role for cGAS
Nature Reviews Immunology, Published online: 28 January 2026; doi:10.1038/s41577-026-01275-5A preprint by El-Daher et al. describes an interferonopathy-associated mutation in the chromatin remodeller ATRX, which identifies an unexpected role for nuclear cGAS in transcriptional regulation.
dlvr.it
January 30, 2026 at 10:57 AM
Type I interferonopathy in ATR-X syndrome reveals a transcriptional role for cGAS
Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy https://www.biorxiv.org/content/10.64898/2026.05.27.728148v1
May 29, 2026 at 8:16 AM
Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy https://www.biorxiv.org/content/10.64898/2026.05.27.728148v1