Lee Min Leong and colleagues provide evidence that #interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse #olfactory bulb 🧠 💉

Read the #research👇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...

2/ We uncover a novel mechanism for signal decorrelation which is based on intraglomerular excitation and works in synergism with lateral interglomerular inhibition. This intraglomerular excitation is mediated by mAChR-B and it only occurs at high neuronal activity.

Manoim-Wolkovitz, J. E., Camchy, T., Rozenfeld, E., Chang, H. H., Lerner, H., Chou, Y. H., Darshan, R., Parnas, M. (2025). Nonlinear high-activity neuronal excitation enhances odor discrimination. Curr Biol, 35(7):1521-1538. www.cell.com/current-biol...