Hi there, I wanted to share Jahseh’s story. At just 19 months old, he’s already fighting JMML cancer, and his family is facing overwhelming expenses. If you’re able, please donate or share to help support Jahseh’s treatment and his family during this tough time — every bit makes a difference. 💙
August 24, 2026 at 5:44 PM
Hi there, I wanted to share Jahseh’s story. At just 19 months old, he’s already fighting JMML cancer, and his family is facing overwhelming expenses. If you’re able, please donate or share to help support Jahseh’s treatment and his family during this tough time — every bit makes a difference. 💙
Dr. Stieglitz will study daraxonrasib in JMML (juvenile myelomonocytic leukemia).
JMML is associated with certain PTPN11 variants in Noonan syndrome.
#pediatrics #oncosky
lnkd.in/p/eDZZ32-x
JMML is associated with certain PTPN11 variants in Noonan syndrome.
#pediatrics #oncosky
lnkd.in/p/eDZZ32-x
Daraxonrasib: A Promising Cancer Drug for 2026 | Elliot Stieglitz posted on the topic | LinkedIn
What is the most important cancer drug of 2026?
Hands down, that's daraxonrasib. A first-in-class, direct inhibitor of RAS (previously thought to be impossible) that has transformed the field of panc...
lnkd.in
August 13, 2026 at 4:29 PM
Dr. Stieglitz will study daraxonrasib in JMML (juvenile myelomonocytic leukemia).
JMML is associated with certain PTPN11 variants in Noonan syndrome.
#pediatrics #oncosky
lnkd.in/p/eDZZ32-x
JMML is associated with certain PTPN11 variants in Noonan syndrome.
#pediatrics #oncosky
lnkd.in/p/eDZZ32-x
youtube.com/watch?v=jMmL...
@xyliegetsreal.bsky.social @xyliegetsbiased.bsky.social AKA Crylie is a miserable haggot.
& Tommy C is doing just fine, especially how he entertain us with...oh I don't know....JOKES!!
Get over it Xy....I mean Crylie because booo hooo for you.😒
#lolcow #lolcows #LCU
@xyliegetsreal.bsky.social @xyliegetsbiased.bsky.social AKA Crylie is a miserable haggot.
& Tommy C is doing just fine, especially how he entertain us with...oh I don't know....JOKES!!
Get over it Xy....I mean Crylie because booo hooo for you.😒
#lolcow #lolcows #LCU
Lolcow's Tommy C. & Xylie’s Brutal Confrontation Ends in Rage Quitting (Yo Mama Causes Crashout) 🪦
YouTube video by Huggy Show
youtube.com
July 30, 2026 at 4:32 AM
youtube.com/watch?v=jMmL...
@xyliegetsreal.bsky.social @xyliegetsbiased.bsky.social AKA Crylie is a miserable haggot.
& Tommy C is doing just fine, especially how he entertain us with...oh I don't know....JOKES!!
Get over it Xy....I mean Crylie because booo hooo for you.😒
#lolcow #lolcows #LCU
@xyliegetsreal.bsky.social @xyliegetsbiased.bsky.social AKA Crylie is a miserable haggot.
& Tommy C is doing just fine, especially how he entertain us with...oh I don't know....JOKES!!
Get over it Xy....I mean Crylie because booo hooo for you.😒
#lolcow #lolcows #LCU
to be fair to the translator, this is the first diagram in the original Chinese PDF. I have a degree in computer science and can read Chinese and certainly have no idea what's going on here.
April 22, 2026 at 11:12 AM
to be fair to the translator, this is the first diagram in the original Chinese PDF. I have a degree in computer science and can read Chinese and certainly have no idea what's going on here.
Editors’ Pick by Cancer Research Catalyst @aacrjournals.bsky.social
RAS-driven plasticity and oncofetal reprogramming as a key mechanism and vulnerability in JMML.
The article is freely available for a limited time:
www.aacr.org/blog/2026/03...
#hematology
#oncology
#epigenetics
#development
RAS-driven plasticity and oncofetal reprogramming as a key mechanism and vulnerability in JMML.
The article is freely available for a limited time:
www.aacr.org/blog/2026/03...
#hematology
#oncology
#epigenetics
#development
Editors’ Picks, March 2026: Pediatric Leukemia Development, Low-dose Tamoxifen Use, and More
In March, AACR's journals editors highlighted studies on the development of pediatric leukemia, the use of low-dose tamoxifen, and more.
www.aacr.org
April 9, 2026 at 4:31 PM
Editors’ Pick by Cancer Research Catalyst @aacrjournals.bsky.social
RAS-driven plasticity and oncofetal reprogramming as a key mechanism and vulnerability in JMML.
The article is freely available for a limited time:
www.aacr.org/blog/2026/03...
#hematology
#oncology
#epigenetics
#development
RAS-driven plasticity and oncofetal reprogramming as a key mechanism and vulnerability in JMML.
The article is freely available for a limited time:
www.aacr.org/blog/2026/03...
#hematology
#oncology
#epigenetics
#development
【注目プレスリリース】超高感度次世代シーケンスで若年性骨髄単球性白血病の「微小クローン」を可視化～見逃されてきた遺伝子変異が予後不良と強く関連～ / 名古屋大学
https://research-er.jp/articles/view/154880
https://research-er.jp/articles/view/154880
超高感度次世代シーケンスで若年性骨髄単球性白血病の「微小クローン」を可視化～見逃されてきた遺伝子変異が予後不良と強く関連～
2026.04.09 名古屋大学 プレスリリース 【本研究のポイント】若年性骨髄単球性白血病（JMML）は、乳幼児に発症する治療が難しい希少な白血病です。本研究では...
research-er.jp
April 9, 2026 at 1:30 AM
【注目プレスリリース】超高感度次世代シーケンスで若年性骨髄単球性白血病の「微小クローン」を可視化～見逃されてきた遺伝子変異が予後不良と強く関連～ / 名古屋大学
https://research-er.jp/articles/view/154880
https://research-er.jp/articles/view/154880
"By the Poplar", a #Ukrainian song commemorating those that gave their lives in the #RussiaUkraineWar, performed by Daniela, another Ukrainian girl.
www.youtube.com/watch?v=JmmL...
www.youtube.com/watch?v=JmmL...
Trident Muzyka Presents 'By the Poplar' (Біля тополі, Bilia topoli) - Ukrainian Patriotic Song
YouTube video by Hand-in-Shot Productions
www.youtube.com
April 5, 2026 at 3:02 AM
"By the Poplar", a #Ukrainian song commemorating those that gave their lives in the #RussiaUkraineWar, performed by Daniela, another Ukrainian girl.
www.youtube.com/watch?v=JmmL...
www.youtube.com/watch?v=JmmL...
Hey Red Wings fans - donate if you can, share if you can't. Mickey Redmond's grandson needs a helping hand.
gofund.me/08ea5c16d
gofund.me/08ea5c16d
Donate to Support Teddy’s Fight Against JMML Leukemia, organized by Logan Wonfor
Our world changed when our 3-year-old son, Teddy, was diagnosed with JMML, an… Logan Wonfor needs your support for Support Teddy’s Fight Against JMML Leukemia
gofund.me
February 25, 2026 at 7:19 AM
Hey Red Wings fans - donate if you can, share if you can't. Mickey Redmond's grandson needs a helping hand.
gofund.me/08ea5c16d
gofund.me/08ea5c16d
JMML stem cells aren’t epigenetically “stuck” in a fetal state.
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
AbstractPersistent fetal gene expression in childhood neoplasms is usually explained by a maturation block originating in the prenatal phase. In contrast, reactivation of fetal genes in adult malignan...
doi.org
February 4, 2026 at 6:28 PM
JMML stem cells aren’t epigenetically “stuck” in a fetal state.
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
Myeloproliferative diseases vary widely and require different treatment approaches. To help clarify, Dr. Elliot Stieglitz (University of California) will present on two primary subtypes tomorrow (Feb 4): us02web.zoom.us/webinar/regi...
February 3, 2026 at 4:47 PM
Myeloproliferative diseases vary widely and require different treatment approaches. To help clarify, Dr. Elliot Stieglitz (University of California) will present on two primary subtypes tomorrow (Feb 4): us02web.zoom.us/webinar/regi...
Very cool paper, on my reading list! We were desperate to get hold of some primary JMML samples for this very reason but not a resource widely available in the UK.
We'd be very interested in hearing more about this. Perhaps we could talk more offline?
We'd be very interested in hearing more about this. Perhaps we could talk more offline?
January 28, 2026 at 2:15 PM
Very cool paper, on my reading list! We were desperate to get hold of some primary JMML samples for this very reason but not a resource widely available in the UK.
We'd be very interested in hearing more about this. Perhaps we could talk more offline?
We'd be very interested in hearing more about this. Perhaps we could talk more offline?
Absolutely, we see pronounced fetal signatures in JMML, too:
aacrjournals.org/bloodcancerd...
Unfortunately, LIN28B is not well captured in the scRNA data. However, I remember clusters revealing pronounced b-catenin expression patterns.
Will check this again… maybe we can find shared programs.
aacrjournals.org/bloodcancerd...
Unfortunately, LIN28B is not well captured in the scRNA data. However, I remember clusters revealing pronounced b-catenin expression patterns.
Will check this again… maybe we can find shared programs.
Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
Abstract. Persistent fetal gene expression in childhood neoplasms is usually explained by a maturation block originating in the prenatal phase. In contrast, reactivation of fetal genes in adult malign...
aacrjournals.org
January 28, 2026 at 1:21 PM
Absolutely, we see pronounced fetal signatures in JMML, too:
aacrjournals.org/bloodcancerd...
Unfortunately, LIN28B is not well captured in the scRNA data. However, I remember clusters revealing pronounced b-catenin expression patterns.
Will check this again… maybe we can find shared programs.
aacrjournals.org/bloodcancerd...
Unfortunately, LIN28B is not well captured in the scRNA data. However, I remember clusters revealing pronounced b-catenin expression patterns.
Will check this again… maybe we can find shared programs.
American foreign policy IS all about “transactions”. Something for Trump;
ALL FOR PUTIN.
ZERO for US little people.
ZERO. I fkng HATE this liar.
youtube.com/watch?v=JmMl...
ALL FOR PUTIN.
ZERO for US little people.
ZERO. I fkng HATE this liar.
youtube.com/watch?v=JmMl...
youtube.com
December 29, 2025 at 7:48 PM
American foreign policy IS all about “transactions”. Something for Trump;
ALL FOR PUTIN.
ZERO for US little people.
ZERO. I fkng HATE this liar.
youtube.com/watch?v=JmMl...
ALL FOR PUTIN.
ZERO for US little people.
ZERO. I fkng HATE this liar.
youtube.com/watch?v=JmMl...
Merry Griftmas! How 6 countries bribed Canks and what they got in return #USpol #IHIP youtube.com/watch?v=JmMl...
IHIP News: Trump EXPOSED For BRIBING World Leaders?! He's GRIFTING in Plain Sight!
YouTube video by I've Had It
youtube.com
December 25, 2025 at 10:20 PM
Merry Griftmas! How 6 countries bribed Canks and what they got in return #USpol #IHIP youtube.com/watch?v=JmMl...
youtube.com/watch?v=JmMl...
The Trump regime is a criminal organization; the evidence is clear.👇
The Trump regime is a criminal organization; the evidence is clear.👇
IHIP News: Trump EXPOSED For BRIBING World Leaders?! He's GRIFTING in Plain Sight!
YouTube video by I've Had It
youtube.com
December 25, 2025 at 9:11 PM
youtube.com/watch?v=JmMl...
The Trump regime is a criminal organization; the evidence is clear.👇
The Trump regime is a criminal organization; the evidence is clear.👇
(342) IHIP News: Trump EXPOSED For BRIBING World Leaders?! He's GRIFTING in Plain Sight! - YouTube www.youtube.com/watch?v=JmMl...
IHIP News: Trump EXPOSED For BRIBING World Leaders?! He's GRIFTING in Plain Sight!
YouTube video by I've Had It
www.youtube.com
December 25, 2025 at 8:21 PM
(342) IHIP News: Trump EXPOSED For BRIBING World Leaders?! He's GRIFTING in Plain Sight! - YouTube www.youtube.com/watch?v=JmMl...
