Very cool! Includes molecularly-defined CA2 👀 #keepCA2weird
Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @princetonneuro.bsky.social. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s415... #hippocampus But my personal favorite is (1/2)
Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells - Nature Neuroscience
The authors present a dense connectomic reconstruction of a 0.1 mm3 hippocampal CA3 volume and reveal spatial gradients, high convergence and cell-type-selective feedforward inhibition of inputs to py...
doi.org
August 13, 2026 at 2:52 PM
Very cool! Includes molecularly-defined CA2 👀 #keepCA2weird
Couldn't wait for #FluorescenceFriday to share our cover image @SfNJournals Article is pretty cool too #keepCA2weird #PNNs www.jneurosci.org/content/45/6...
Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory
Perineuronal nets (PNNs) are a specialized extracellular matrix that surrounds certain populations of neurons, including (inhibitory) parvalbumin (PV)-expressing interneurons throughout the brain and ...
www.jneurosci.org
February 5, 2025 at 8:18 PM
Couldn't wait for #FluorescenceFriday to share our cover image @SfNJournals Article is pretty cool too #keepCA2weird #PNNs www.jneurosci.org/content/45/6...
Understanding how MR makes CA2 weird...using spatial transcriptomics! 🧠🧬 Huge thank you to Serena and Basak for getting this across the finish line - I'm so happy this work is published! #keepCA2weird
@commsbio.nature.com
@commsbio.nature.com
Now officially out! What do CA2 neurons become in an Nr3c2 KO? We used spatial transcriptomics to find out.
With @neuroerin.bsky.social and @jmw86069.bsky.social
Lots in the suppl data rdcu.be/evGGh
With @neuroerin.bsky.social and @jmw86069.bsky.social
Lots in the suppl data rdcu.be/evGGh
Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1
Communications Biology - Spatial transcriptomics reveals that the molecular phenotype of hippocampal area CA2, which is critical for many social behaviors, is profoundly altered upon knock-out of...
rdcu.be
July 10, 2025 at 11:11 PM
Understanding how MR makes CA2 weird...using spatial transcriptomics! 🧠🧬 Huge thank you to Serena and Basak for getting this across the finish line - I'm so happy this work is published! #keepCA2weird
@commsbio.nature.com
@commsbio.nature.com
Super interesting to think about the different ‘contactomes’ of cell types with lower densities like CA2, which should def have many fewer ‘cuddle buddies’ than CA1. 🧐 #keepCA2weird
I first got excited about this ~8y ago when I started seeing a pattern in #microns and other datasets at bossdb.org @alleninstitute.org @bcmhouston.bsky.social @princeton.edu @mit.edu
Usually neuron cell bodies are spread out... But every so often, you get what I call "cuddle buddies". wtf?
Usually neuron cell bodies are spread out... But every so often, you get what I call "cuddle buddies". wtf?
June 16, 2026 at 2:11 AM
Super interesting to think about the different ‘contactomes’ of cell types with lower densities like CA2, which should def have many fewer ‘cuddle buddies’ than CA1. 🧐 #keepCA2weird
Happy this one is finally out! 🙌 Virginia Tech scientists discover a role for mitochondria in shaping memory circuits. #keepCA2weird @fralinbiomed.bsky.social www.eurekalert.org/news-release...
Virginia Tech scientists discover mitochondria’s role in shaping memory circuits
Virginia Tech neuroscientists have uncovered a mitochondrial process that helps brain cells adapt and strengthen connections, supporting learning, memory, and social recognition. Their research, focus...
www.eurekalert.org
February 9, 2025 at 8:17 PM
Happy this one is finally out! 🙌 Virginia Tech scientists discover a role for mitochondria in shaping memory circuits. #keepCA2weird @fralinbiomed.bsky.social www.eurekalert.org/news-release...
#sfn25 Come say in the late break poster section! Showing live mito calcium imaging data from our new collab with Sharon Swangers lab! #keepCA2weird 🧪
November 16, 2025 at 8:53 PM
#sfn25 Come say in the late break poster section! Showing live mito calcium imaging data from our new collab with Sharon Swangers lab! #keepCA2weird 🧪
Thanks to @serenadudette.bsky.social for an amazing visit with the NSB program at @umassamherst.bsky.social! We were so busy with great #keepCA2weird science that I forgot to take photos, so I'll share some of the amazing results that she presented (from PMC12246475 with @neuroerin.bsky.social).
May 8, 2026 at 2:00 PM
Thanks to @serenadudette.bsky.social for an amazing visit with the NSB program at @umassamherst.bsky.social! We were so busy with great #keepCA2weird science that I forgot to take photos, so I'll share some of the amazing results that she presented (from PMC12246475 with @neuroerin.bsky.social).
Amazing paper, exactly what spatial transcriptomics is made for, and look at this system! Each hippocampus region lit up, it’s stunning.
I was thrilled to play a part!
#keepCA2weird
I was thrilled to play a part!
#keepCA2weird
Now officially out! What do CA2 neurons become in an Nr3c2 KO? We used spatial transcriptomics to find out.
With @neuroerin.bsky.social and @jmw86069.bsky.social
Lots in the suppl data rdcu.be/evGGh
With @neuroerin.bsky.social and @jmw86069.bsky.social
Lots in the suppl data rdcu.be/evGGh
Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1
Communications Biology - Spatial transcriptomics reveals that the molecular phenotype of hippocampal area CA2, which is critical for many social behaviors, is profoundly altered upon knock-out of...
rdcu.be
July 11, 2025 at 3:54 AM
Amazing paper, exactly what spatial transcriptomics is made for, and look at this system! Each hippocampus region lit up, it’s stunning.
I was thrilled to play a part!
#keepCA2weird
I was thrilled to play a part!
#keepCA2weird
Check out the paper-kinda cool no? #keepCA2weird
November 17, 2024 at 3:54 AM
Check out the paper-kinda cool no? #keepCA2weird
Big thanks to authors @shannonfarris.bsky.social, @mikels-mitos.bsky.social, @danielagilia.bsky.social, and several others not on this site for their contributions! #keepCA2weird
February 7, 2025 at 4:04 PM
Big thanks to authors @shannonfarris.bsky.social, @mikels-mitos.bsky.social, @danielagilia.bsky.social, and several others not on this site for their contributions! #keepCA2weird