#ligandreceptor
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ipiproteins.bsky.social
Just published: A new review from Rob Meijers, Shaotong Zhu and Alex Jaworski explores the landscape of #ligandreceptor interactions in #axon pathfinding. Get the lay of the land in our #axonguidance explainer 🧠🟦
#neuroskyence #proteinscience
proteininnovation.org/2025/03/axon...
Axon Guidance: Explained
In the late 19th century, neuroscientist Santiago Ramón y Cajal peered through a microscope at the spinal cords of three-day-old chick embryos and drew
proteininnovation.org
March 21, 2025 at 5:01 PM
genesndiseases.bsky.social
This review summarizes the autocrine and paracrine pathways in the #Glioblastoma (GBM) microenvironment, along with related #ligandreceptor interactions that induce proneural-mesenchymal transition (PMT), and discusses current therapies targeting PMT-related pathways. #medsky

buff.ly/Ou1U232
Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions
May 27, 2025 at 3:30 PM
genesndiseases.bsky.social
This review examines #GPR126's expression, #ligandreceptor interactions, signaling, and roles in development/diseases, highlighting small molecule, #peptide, and #monobody modulators as promising #aGPCRs-targeted therapies.

#OpenAccess: doi.org/10.1016/j.ge...
December 6, 2025 at 5:25 PM
alicefrolov.bsky.social
Rewiring of intercellular ligand-receptor communication in aged tissue

I am sharing a visualization exploring how intercellular signaling architecture is remodeled with chronological age.

#CellCommunication #LigandReceptor #SingleCellTranscriptomics #SpatialTranscriptomics #Stromalniche
Rewiring of intercellular ligand-receptor communication in aged tissue I am sharing a visualization exploring how intercellular signaling architecture is remodeled with chronological age. The figure ("Log2 fold-change (old vs young) in signaling pair activity across niches; simulated data") uses a diverging lollipop layout with a dual-panel mirror, presenting ligand-side and receptor-side activity shifts in vertically aligned registers. This mirror design allows direct visual comparison of whether a given signaling pair is being driven predominantly by altered ligand availability, receptor expression, or coordinated changes in both. I want to emphasize at the outset that the underlying data are simulated. The magnitudes and directionality, however, are parameterized to reflect trends repeatedly reported in the CellChat and CellPhoneDB-based literature on aged niches, so the figure is intended as an illustrative scaffold rather than an empirical claim. Several patterns are worth highlighting for discussion. Pro-inflammatory axes such as TNF-TNFRSF1A and CCL2-CCR2 display positive log2 fold-changes, consistent with the inflammatory remodeling and myeloid recruitment characteristic of aged stromal compartments. Conversely, WNT and NOTCH ligand-receptor pairs trend negative, mirroring reported attenuation of niche-derived regenerative and self-renewal cues. TGFB1-TGFBR2 shows a positive shift concordant with fibrotic reprogramming. The mirror arrangement makes clear that certain pairs are receptor-limited in the aged condition, which has implications for how one interprets deconvolved communication probabilities. Methodologically, I would welcome perspectives on normalization strategies for cross-niche comparison, particularly how to control for compositional shifts in cell-type abundance that can confound inferred communication strength.
August 31, 2026 at 5:03 PM
exo-beyondthecell.bsky.social
Can we map how cells and tissues communicate?
🎙️EXO Chats Ep03 explores how #genetics, AI and #singlecell data are making ligand–receptor discovery more systematic.
🔗Listen: sciexplor.com/exo/podcast/3
#LigandReceptor #Secretome #Biochemistry
August 11, 2026 at 6:12 AM
exo-beyondthecell.bsky.social
How do cells talk to each other?
Researchers from Harvard Medical School lay out a roadmap to identify orphan signaling receptors using synthetic biology, AI, and spatial omics.
📰 www.eurekalert.org/news-release...
🔗 sciexplor.com/exo/articles...
#LigandReceptor #Deorphanization #SpatialOmics
June 8, 2026 at 9:05 AM
exo-beyondthecell.bsky.social
🔬Decoding the Secretome: From orphan ligands to inter-organ networks.
Harvard University's Norbert Perrimon lab reviews how multi-omics & AI decode the secretome's receptor code in spatial context.
🔗Welcome to Read: sciexplor.com/exo/articles...
#Secretome #LigandReceptor #SpatialTranscriptomics
May 19, 2026 at 10:19 AM