Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...

Lipids are complex molecules crucial for life. The authors developed MS-DIAL 5, a tool that enhances in-depth structure elucidations and the spatial mapping of lipidome. Using advanced techniques, the...

The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...

Clarke et al. presents a framework for spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging. Applying this approach, they revealed reg...

Nature Methods - uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.

This paper presents a comprehensive synthesis of current knowledge on plant lipidome responses to heat and cold stresses through a systematic review and me

The integrative multiomics characterization of minute amounts of clinical tissue specimens has become increasingly important. Here, we present an approach called Integral-Omics, which enables sequenti...

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Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...

Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...

DZNE researchers have generated new insights into how the human genome shapes the chemical composition and concentration of blood lipids. Across the genome, they identified more than 50 regions whose relevance to lipid metabolism was not been known before. The findings are based on blood samples from more than 8,000 individuals and may provide a better understanding of aging processes and pathological conditions like Alzheimer’s disease, diabetes, and cardiovascular dysfunctions. The results have been published in the scientific journal Nature Communications. They are based on samples from the Rhineland Study, a population-based study in Bonn, Germany, and additional study data. Fatty molecules, also called „lipids”, occur in the human body in a vast number of forms. They serve not only as structural components, for instance in cell membranes, but also participate in metabolism and in particular in signaling pathways. “Lipids are much more than the ‘good’ and ‘bad’ cholesterol we often hear about. In fact, thousands of different lipids circulate in our bodies. Some of them are presumed to play an important role in aging and in the development of diseases. This is a complex molecular world. Yet the genetic basis of many lipids remains poorly understood,” says Dr. Mohammed...

Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...