Catalytic, intramolecular N-heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium-sized heterobiaryl atropisomeri...

Communications Chemistry, Published online: 24 September 2026; doi:10.1038/s42004-026-02194-1Non-peptidic macrocycles present a promising avenue for drug development, yet their conformational flexibility complicates membrane permeability prediction. Here, the authors introduce MEGPNM, a model that utilizes multilayer edge-aware graph attention, outperforms existing methods in predicting effective permeability, and reveals structural motifs linked to permeability, with a web server facilitating early-stage drug screening.

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Orbis Medicines and Novo ink up to $1.4B deal to develop macrocycles for cardiometabolic diseases, marking Orbis' first pharma partnership. Novo also investing directly in the startup.

Abstract. Selective extraction of sulfate anions (SO42–) from aqueous media is highly desirable but remains challenging, largely due to the high hydration

A triangle association strategy (TAS) uses shared chemical reactants to systematically predict new reactions and overcome the limitations of traditional serendipity. Guided by a condition-correlation metric, this approach discovered six unprecedented catalytic reactions and enables efficient synthesis of structurally complex rings and macrocycles for drug discovery.