Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
September 25, 2025 at 4:27 PM
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
#Medsky🧪 #IDsky #immunosky #virosky #Publichealth Role of MAPK in #LongCOVID Pathophysiology . The mitogen-activated protein kinase (MAPK) pathway is a critical intracellular signaling network that regulates inflammation, cell survival & stress responses.
#Medsky🧪 #immunosky New preclinical work in @science.org reveals how #Tcells respond in real time to signaling inputs of varying intensities & could shed further light on how these cells become activated in the context of #immunity & inflammation.
January 17, 2026 at 6:13 AM
#Medsky🧪 #IDsky #immunosky #virosky #Publichealth Role of MAPK in #LongCOVID Pathophysiology . The mitogen-activated protein kinase (MAPK) pathway is a critical intracellular signaling network that regulates inflammation, cell survival & stress responses.
krebsrelevante Signalwege stört und damit Bedingungen schafft, die die Entstehung oder das Fortschreiten von Tumoren in anfälligen Geweben begünstigen können. Virale Proteine können p53 und pRb [Tumorsuppressor] hemmen, die Zellzykluskontrolle stören und die MAPK-, NF-B-,
„Kombiniert könnten diese Faktoren - Virus-Protein-Interaktion, anhaltende Entzündung, epigenetische Veränderungen und verminderte Immunabwehr - über Monate oder Jahre das Risiko für die Entstehung von Krebs steigern.“ Ein Mega-🧵.
February 8, 2026 at 4:44 PM
krebsrelevante Signalwege stört und damit Bedingungen schafft, die die Entstehung oder das Fortschreiten von Tumoren in anfälligen Geweben begünstigen können. Virale Proteine können p53 und pRb [Tumorsuppressor] hemmen, die Zellzykluskontrolle stören und die MAPK-, NF-B-,
Main Finding 9: The immune response triggered by the spike protein may activate the MAPK-JNK signaling pathway, leading to neuronal stress and inflammation.
November 29, 2024 at 4:01 PM
Main Finding 9: The immune response triggered by the spike protein may activate the MAPK-JNK signaling pathway, leading to neuronal stress and inflammation.
Finally, the excellent postdoc work of Emmanuel Haillot is out, where he dissected the integration of Wnt, MAPK and Notch signaling in defining mesoderm and endoderm identities in the diploblast Nematostella. Strikingly similar to sea urchins. www.nature.com/articles/s41...
August 29, 2025 at 9:04 PM
Finally, the excellent postdoc work of Emmanuel Haillot is out, where he dissected the integration of Wnt, MAPK and Notch signaling in defining mesoderm and endoderm identities in the diploblast Nematostella. Strikingly similar to sea urchins. www.nature.com/articles/s41...
How do cells communicate? They use Sms1 ! 🙂
More seriously, Sms1 is the scaffold of the pheromone-MAPK signalling cascade in fission yeast, which @borissieber.bsky.social et al discovered.
Have a look at the paper 👇
@biology-unige.bsky.social
More seriously, Sms1 is the scaffold of the pheromone-MAPK signalling cascade in fission yeast, which @borissieber.bsky.social et al discovered.
Have a look at the paper 👇
@biology-unige.bsky.social
May 12, 2026 at 4:03 PM
How do cells communicate? They use Sms1 ! 🙂
More seriously, Sms1 is the scaffold of the pheromone-MAPK signalling cascade in fission yeast, which @borissieber.bsky.social et al discovered.
Have a look at the paper 👇
@biology-unige.bsky.social
More seriously, Sms1 is the scaffold of the pheromone-MAPK signalling cascade in fission yeast, which @borissieber.bsky.social et al discovered.
Have a look at the paper 👇
@biology-unige.bsky.social
MAPK cascades play crucial roles in #plant #growth, #reproduction, and responses to biotic and abiotic stresses.
This🔥new #OpenAccess #review in #JIPB explores their role as an essential signaling hub in activating plant immunity.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci
This🔥new #OpenAccess #review in #JIPB explores their role as an essential signaling hub in activating plant immunity.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci
Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation
This review focuses on mitogen-activated protein kinase (MAPK) activation and summarizes how plants regulate and integrate MAPK signaling in modulating plant immune responses. It also examines the ef...
doi.org
July 29, 2026 at 1:05 PM
MAPK cascades play crucial roles in #plant #growth, #reproduction, and responses to biotic and abiotic stresses.
This🔥new #OpenAccess #review in #JIPB explores their role as an essential signaling hub in activating plant immunity.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci
This🔥new #OpenAccess #review in #JIPB explores their role as an essential signaling hub in activating plant immunity.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci
Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com!
@biology-unige.bsky.social
www.nature.com/articles/s41...
@biology-unige.bsky.social
www.nature.com/articles/s41...
May 12, 2026 at 2:44 PM
Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com!
@biology-unige.bsky.social
www.nature.com/articles/s41...
@biology-unige.bsky.social
www.nature.com/articles/s41...
Time for an intro!
I'm a cell biologist interested in GPCR and MAPK signalling across evolution.
Postdoc in Sophie Martin lab where I study the pheromone signalling pathway using biochemistry, especially to identify MAPK scaffolds.
Previously in Freeman lab #rhomboid and Raff lab #centriole
I'm a cell biologist interested in GPCR and MAPK signalling across evolution.
Postdoc in Sophie Martin lab where I study the pheromone signalling pathway using biochemistry, especially to identify MAPK scaffolds.
Previously in Freeman lab #rhomboid and Raff lab #centriole
August 24, 2023 at 9:28 AM
Time for an intro!
I'm a cell biologist interested in GPCR and MAPK signalling across evolution.
Postdoc in Sophie Martin lab where I study the pheromone signalling pathway using biochemistry, especially to identify MAPK scaffolds.
Previously in Freeman lab #rhomboid and Raff lab #centriole
I'm a cell biologist interested in GPCR and MAPK signalling across evolution.
Postdoc in Sophie Martin lab where I study the pheromone signalling pathway using biochemistry, especially to identify MAPK scaffolds.
Previously in Freeman lab #rhomboid and Raff lab #centriole
New Article: "A feedback regulatory loop by MAPK–CCA1 engages auxin signalling to stimulate root foraging for nitrate" rdcu.be/e39v1
Nitrate sensing by NLP7 engages a MEKK–MAPK cascade to phosphorylate the circadian clock protein CCA1, establishing a + feedback loop...
Nitrate sensing by NLP7 engages a MEKK–MAPK cascade to phosphorylate the circadian clock protein CCA1, establishing a + feedback loop...
February 16, 2026 at 5:21 AM
New Article: "A feedback regulatory loop by MAPK–CCA1 engages auxin signalling to stimulate root foraging for nitrate" rdcu.be/e39v1
Nitrate sensing by NLP7 engages a MEKK–MAPK cascade to phosphorylate the circadian clock protein CCA1, establishing a + feedback loop...
Nitrate sensing by NLP7 engages a MEKK–MAPK cascade to phosphorylate the circadian clock protein CCA1, establishing a + feedback loop...
Interesting paper from @LalDennis group. More evidence of #RAS #MAPK pathway genes in epilepsy.
nature.com/articles/s41...
nature.com/articles/s41...
December 1, 2024 at 8:41 PM
Interesting paper from @LalDennis group. More evidence of #RAS #MAPK pathway genes in epilepsy.
nature.com/articles/s41...
nature.com/articles/s41...
Euan Cawston on investigating the role of Mst7 and identifying potential scaffolds of the Pmk1 MAPK pathway #Magnafest26 #Fungal26 @thesainsburylab.bsky.social
March 17, 2026 at 8:45 PM
Euan Cawston on investigating the role of Mst7 and identifying potential scaffolds of the Pmk1 MAPK pathway #Magnafest26 #Fungal26 @thesainsburylab.bsky.social
Wellness influencers: cancer is caused by a dysregulated gut!
Actual science: this particular type of cancer is commonly caused by a mutation in codons 5-10 in the RAS-MAPK signaling pathway which contributes to oncogenesis by turning off the GTP phosphorylation
Actual science: this particular type of cancer is commonly caused by a mutation in codons 5-10 in the RAS-MAPK signaling pathway which contributes to oncogenesis by turning off the GTP phosphorylation
June 2, 2025 at 7:42 PM
Wellness influencers: cancer is caused by a dysregulated gut!
Actual science: this particular type of cancer is commonly caused by a mutation in codons 5-10 in the RAS-MAPK signaling pathway which contributes to oncogenesis by turning off the GTP phosphorylation
Actual science: this particular type of cancer is commonly caused by a mutation in codons 5-10 in the RAS-MAPK signaling pathway which contributes to oncogenesis by turning off the GTP phosphorylation
I want US Marshalls in JP Morgan. I want 5th Fleet invading corporate offices in Panama. I want 10th Mountain in Bern. I want Marines occupying Deutsche Bank. I want SEALs raiding the Canaries.
April 14, 2025 at 5:11 PM
Exciting new finding about the role of PP2A molecular glues in overcoming resistant to broad classes of MAPK inhibitors in KRAS driven cancers
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...
JCI -
A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer
www.jci.org
October 21, 2025 at 2:00 PM
Exciting new finding about the role of PP2A molecular glues in overcoming resistant to broad classes of MAPK inhibitors in KRAS driven cancers
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...
Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
Real time characterization of the MAPK pathway using native mass spectrometry - Communications Biology
Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics.
doi.org
April 17, 2025 at 9:45 PM
Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
🍵 Matcha green tea vs radiation
A new study found matcha reduces DNA damage and oxidative stress in bone marrow after gamma radiation exposure – potentially offering radioprotective benefits.
🔗 doi.org/10.1007/s110...
#SciComm #Matcha #Radiation 🧪
A new study found matcha reduces DNA damage and oxidative stress in bone marrow after gamma radiation exposure – potentially offering radioprotective benefits.
🔗 doi.org/10.1007/s110...
#SciComm #Matcha #Radiation 🧪
Matcha Green Tea (Camellia sinensis) Inhibits Gamma Radiation-Induced Genotoxic Damage and Oxidative Stress Via Modulating P38 MAPK Pathway and ROS Generation in Murine Bone Marrow - Pharmaceutical Ch...
The present study investigates the efficacy of matcha green tea in mitigating genotoxic damage and oxidative stress induced by gamma radiation exposure through modulation of the P38/MAPK pathway and R...
doi.org
March 17, 2025 at 5:52 AM
🍵 Matcha green tea vs radiation
A new study found matcha reduces DNA damage and oxidative stress in bone marrow after gamma radiation exposure – potentially offering radioprotective benefits.
🔗 doi.org/10.1007/s110...
#SciComm #Matcha #Radiation 🧪
A new study found matcha reduces DNA damage and oxidative stress in bone marrow after gamma radiation exposure – potentially offering radioprotective benefits.
🔗 doi.org/10.1007/s110...
#SciComm #Matcha #Radiation 🧪
We described a novel role of the MAPK signaling pathway in shaping CAF phenotype in #PancreaticCancer, providing new insights into tumor-stromal cell interactions @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer - Nature Communications
Phenotypic and functional heterogeneity of cancer associated fibroblasts (CAFs) has been reported in pancreatic ductal adenocarcinoma (PDAC). Here the authors show that epithelial MAPK activity promot...
www.nature.com
December 4, 2024 at 11:15 AM
We described a novel role of the MAPK signaling pathway in shaping CAF phenotype in #PancreaticCancer, providing new insights into tumor-stromal cell interactions @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 9:55 PM
Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!
An RNA editing enzyme restrains the excessive proliferation of intestinal stem cells—a major hallmark of #aging in humans and other organisms—according to recent work in #ScienceSignaling involving fruit flies and data from mice and human samples. https://scim.ag/4g2RNr3
A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging
The RNA editing enzyme ADAR slows intestinal stem cell aging by reducing proliferative MAPK signaling.
scim.ag
August 7, 2026 at 3:00 PM
An RNA editing enzyme restrains the excessive proliferation of intestinal stem cells—a major hallmark of #aging in humans and other organisms—according to recent work in #ScienceSignaling involving fruit flies and data from mice and human samples. https://scim.ag/4g2RNr3
I’m thrilled to share the first preprint from the Piacentino Lab @hopkinsmedicine.bsky.social! We show that developing inner ear requires a secreted lipid chaperone, APOD, working in a positive feedback loop to amplify FGF/MAPK signaling. 👂 #DevBio Check it out! www.biorxiv.org/content/10.6...
Lipid-mediated reinforcement of FGF/MAPK signaling enables robust otic placode specification
The formation of cranial placodes requires groups of ectodermal cells to interpret inductive signals in a robust and organized manner, yet how signaling responses are coordinated across a developing f...
www.biorxiv.org
January 8, 2026 at 10:56 PM
I’m thrilled to share the first preprint from the Piacentino Lab @hopkinsmedicine.bsky.social! We show that developing inner ear requires a secreted lipid chaperone, APOD, working in a positive feedback loop to amplify FGF/MAPK signaling. 👂 #DevBio Check it out! www.biorxiv.org/content/10.6...
A spatial map of MAPK-activated immunosuppressive myeloid populations in pediatric low-grade glioma @natimmunol.nature.com @ucalgary.bsky.social @mcgilluniversity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 15, 2025 at 4:24 PM
A spatial map of MAPK-activated immunosuppressive myeloid populations in pediatric low-grade glioma @natimmunol.nature.com @ucalgary.bsky.social @mcgilluniversity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Why don't you just boycott the f*ckers? Just quit Amazon and shut up!
April 30, 2025 at 9:21 AM
Gisela Cairo @giselacairobaza.bsky.social, Muhammad Haseeb @muhammad-haseeb.bsky.social, Soni Lacefield @lacefieldlab.bsky.social & team find that the MOS-MAPK pathway regulates polar body fate in mouse oocytes.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
March 12, 2026 at 2:11 PM
Gisela Cairo @giselacairobaza.bsky.social, Muhammad Haseeb @muhammad-haseeb.bsky.social, Soni Lacefield @lacefieldlab.bsky.social & team find that the MOS-MAPK pathway regulates polar body fate in mouse oocytes.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...