Localized delivery tools can help researchers perturb defined regions of living plant tissue without treating the whole plant. Li et al. develop a phytoinjector combining open-side microneedles with a speaker-driven micropump for tunable fluid delivery and active Agrobacterium transport into tobacco leaves. The platform supports externally controlled plant intervention and provides a foundation for future sensor-triggered delivery.

Dissolving microneedles developed by ArrayPatch could take the pain out of injections

The Microneedles Needle-Free Injection Systems Market is expected to grow from 1,100 USD Million in 2025 to 3,200 USD Million by 2035. The Microneedles Needle-Free Injection Systems Market CAGR (growt...

「注射💉が怖い」は過去のもの!? NEDOが支援したスタートアップ・シンクランドは、薬液を注入できる「中空型マイクロニードル」を開発。 美容用途ではすでに製品化を実現！次の目標は医療用途での実用化です。 人々の負担を減らす技術はこうした挑戦から生まれています✨ #FocusNEDO 記事はこちら👉 https://t.co/ngok0lczRK

The invention is directed to a nasal delivery device comprising one or more microneedles, and to methods of nasally administering a composition with a nasal delivery device comprising one or more micr...

The invention is directed to a nasal delivery device comprising one or more microneedles, and to methods of nasally administering a composition with a nasal delivery device comprising one or more micr...

Georgia Tech researchers have developed biodegradable polymer STAR particles that painlessly create micropores in the skin, enhancing topical drug absorption for conditions like eczema and psoriasis…

**Authors:** Milana Tesfamarian, Michael Heisig, Gabriel Wittum, Rolf Krause In this work, we present a computational model to investigate transdermal insulin delivery using coated microneedles. A detailed skin geometry incorporating a coated microneedles was developed to analyze insulin release through the different skin layers and to evaluate the influence of key transport parameters. The model represents the major skin layers: the stratum corneum, viable epidermis, and dermis. Unstructured grids were used to achieve a reliable resolution of the model. The simulations provide insights into the permeation of insulin from the coated microneedles and the transport and distribution across the different skin layers. Finally, the simulation results were compared with experimental data to evaluate the predictive capability of the model.

'on patient medical records' - sounds great - On-patient medical record and mRNA therapeutics using intradermal microneedles https://www.nature.com/articles/s41563-024-02115-4

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d9041799e112">Ocular drug delivery systems are essential for treating various eye conditions. Ocular conventional drug delivery techniques, such as eye drops (topical administration), often face challenges, like rapid drainage and low bioavailability. To overcome these challenges, scientists have developed ocular inserts with sustained delivery systems. Biocompatible materials, such as hydrogels, polymers, and biodegradable nanoparticles, have been investigated for insert manufacturing. These materials provide controlled release, improved retention time in the outer surface of the eye, and enhanced penetration of active pharmaceutical ingredients passing through the corneal barrier. Innovations in contact lens technology have made it possible to develop drug-loaded lenses that can deliver drugs in a sustained manner directly to the ocular surface by enhancing drug retention time and therapeutic efficacy. Microneedle-based ocular delivery, a relatively new methodology, has made progress by open-hollow and biodegradable microneedles that permit minimally invasive penetration to the sclera or cornea. Microneedle-based ocular delivery provides high bioavailability with prolonged release of drugs. The introduction of smart polymers, nanotechnology, and 3D printing with these systems has enhanced accuracy, patient comfort, and therapeutic efficacy. Together, these advances represent an evolution from current topical ocular treatment options to long-acting, patient-comfort ocular therapies with high efficacy and accuracy. </p>

Researchers from Queen’s University Belfast have developed an innovative dissolvable 3D-printed patch that could help improve treatment for localised skin cancer.