Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Paternal exercise confers endurance capacity to offspring through sperm microRNAs
Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic
health via sperm microRNAs that reprogram gene expression in early embryos, revealing
how exercise benefits c...
www.cell.com
October 6, 2025 at 3:17 PM
Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
MicroRNAs
From their role in cancer
jci.org/articles/vie...
to
Rejuvenating aged mice, w/ enhanced physical and cognitive function, and longevity
sciencedirect.com/science/arti...
+ explainer
nature.com/articles/d41...
From their role in cancer
jci.org/articles/vie...
to
Rejuvenating aged mice, w/ enhanced physical and cognitive function, and longevity
sciencedirect.com/science/arti...
+ explainer
nature.com/articles/d41...
January 17, 2025 at 9:08 PM
MicroRNAs
From their role in cancer
jci.org/articles/vie...
to
Rejuvenating aged mice, w/ enhanced physical and cognitive function, and longevity
sciencedirect.com/science/arti...
+ explainer
nature.com/articles/d41...
From their role in cancer
jci.org/articles/vie...
to
Rejuvenating aged mice, w/ enhanced physical and cognitive function, and longevity
sciencedirect.com/science/arti...
+ explainer
nature.com/articles/d41...
MicroRNAs control gene expression by modulating the output and stability of messenger RNAs. How are these crucial regulators kept in check?
go.nature.com/4bIecb0
go.nature.com/4bIecb0
Quirky base pairing attracts rule-breaking enzymes to destroy microRNAs
MicroRNAs control gene expression by modulating the output and stability of messenger RNAs. How are these crucial regulators kept in check?
go.nature.com
March 20, 2026 at 9:21 AM
MicroRNAs control gene expression by modulating the output and stability of messenger RNAs. How are these crucial regulators kept in check?
go.nature.com/4bIecb0
go.nature.com/4bIecb0
From DC.
The drawing is of the famous research worm C. elegans, in which microRNAs were discovered.
C. elegans has neither a brain nor a spine. 🧪
The drawing is of the famous research worm C. elegans, in which microRNAs were discovered.
C. elegans has neither a brain nor a spine. 🧪
March 8, 2025 at 3:22 AM
From DC.
The drawing is of the famous research worm C. elegans, in which microRNAs were discovered.
C. elegans has neither a brain nor a spine. 🧪
The drawing is of the famous research worm C. elegans, in which microRNAs were discovered.
C. elegans has neither a brain nor a spine. 🧪
Great #Nobelprize lectures @karolinskainst @NobelPrize
A marvelous unfolding story of microRNAs
Victor Ambros, UMass Chan Med
A vast and ancient hidden world of microRNAs across the eukaryotes
Gary Ruvkun, Massachusetts General Hospital, Harvard Med
A marvelous unfolding story of microRNAs
Victor Ambros, UMass Chan Med
A vast and ancient hidden world of microRNAs across the eukaryotes
Gary Ruvkun, Massachusetts General Hospital, Harvard Med
December 7, 2024 at 5:20 PM
Great #Nobelprize lectures @karolinskainst @NobelPrize
A marvelous unfolding story of microRNAs
Victor Ambros, UMass Chan Med
A vast and ancient hidden world of microRNAs across the eukaryotes
Gary Ruvkun, Massachusetts General Hospital, Harvard Med
A marvelous unfolding story of microRNAs
Victor Ambros, UMass Chan Med
A vast and ancient hidden world of microRNAs across the eukaryotes
Gary Ruvkun, Massachusetts General Hospital, Harvard Med
Type 2 Diabetes increases metastasis of triple-negative breast cancer via exosomal microRNAs. The findings could lead to personalized treatment plans for breast cancer patients with metabolic conditions. 🩷🧪
BU Researchers Discover Connection Between Metabolism and Aggressive Breast
In a groundbreaking study conducted by the researchers at Boston University’s Chobanian & Avedisian School of Medicine, important insights into the relationship between diabetes and t
bioengineer.org
March 10, 2025 at 3:10 AM
Type 2 Diabetes increases metastasis of triple-negative breast cancer via exosomal microRNAs. The findings could lead to personalized treatment plans for breast cancer patients with metabolic conditions. 🩷🧪
New lab paper out! 😀
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors
Author summary MicroRNAs (miRNAs) are small RNAs that silence messenger RNAs (mRNAs) by binding to partially complementary sequences. They play a crucial role in cell type specification during develop...
journals.plos.org
April 30, 2025 at 4:50 PM
New lab paper out! 😀
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
New computational modeling paper w/
Josu Egea-Carro, Salvador Mafe, Javier Cervera
pubs.aip.org/aip/jcp/arti...
"Bioelectrical regionalization of multicellular aggregates by microRNAs"
Josu Egea-Carro, Salvador Mafe, Javier Cervera
pubs.aip.org/aip/jcp/arti...
"Bioelectrical regionalization of multicellular aggregates by microRNAs"
Bioelectrical regionalization of multicellular aggregates by microRNAs
We theoretically explore how microRNAs (miRNAs) can modulate the expression of ion channel proteins and the resulting cell membrane potentials in multicellular
pubs.aip.org
August 15, 2026 at 6:00 PM
New computational modeling paper w/
Josu Egea-Carro, Salvador Mafe, Javier Cervera
pubs.aip.org/aip/jcp/arti...
"Bioelectrical regionalization of multicellular aggregates by microRNAs"
Josu Egea-Carro, Salvador Mafe, Javier Cervera
pubs.aip.org/aip/jcp/arti...
"Bioelectrical regionalization of multicellular aggregates by microRNAs"
Nobel de Medicina 2024 vai para Victor Ambros e Gary Ruvkun pela descoberta dos microRNAs glo.bo/4gUFWKX #g1
Nobel de Medicina 2024 vai para Victor Ambros e Gary Ruvkun pela descoberta dos microRNAs
Vencedores, dois norte-americanos, levam o prêmio de 11 milhões de coroas suecas (cerca de R$ 5,8 milhões). As láureas em Física, Química, Literatura e Paz serão entregues ao longo da semana; já a de ...
glo.bo
October 7, 2024 at 10:17 AM
Nobel de Medicina 2024 vai para Victor Ambros e Gary Ruvkun pela descoberta dos microRNAs glo.bo/4gUFWKX #g1
🩸 Obesity switches on liver microRNAs
Researchers in Germany found a cluster of microRNAs raised in the livers of people with obesity, and in mouse models of metabolic disease. It points to a new drug target for diabetes.
🔗 doi.org/10.1038/s41467-026-77808-2
#Diabetes #Obesity #Science 🧪
Researchers in Germany found a cluster of microRNAs raised in the livers of people with obesity, and in mouse models of metabolic disease. It points to a new drug target for diabetes.
🔗 doi.org/10.1038/s41467-026-77808-2
#Diabetes #Obesity #Science 🧪
Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity - Nature Communications
Hepatic-specific repression of the miR-379/miR-410 cluster in adult mice impacts hepatic insulin signalling and affects whole-body glucose and lipid metabolism, improving glycemic control and dyslipid...
doi.org
September 25, 2026 at 5:59 AM
🩸 Obesity switches on liver microRNAs
Researchers in Germany found a cluster of microRNAs raised in the livers of people with obesity, and in mouse models of metabolic disease. It points to a new drug target for diabetes.
🔗 doi.org/10.1038/s41467-026-77808-2
#Diabetes #Obesity #Science 🧪
Researchers in Germany found a cluster of microRNAs raised in the livers of people with obesity, and in mouse models of metabolic disease. It points to a new drug target for diabetes.
🔗 doi.org/10.1038/s41467-026-77808-2
#Diabetes #Obesity #Science 🧪
Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation.
rdcu.be/fj8Er
#Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu
rdcu.be/fj8Er
#Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu
Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny - Nature Structural & Molecular Biology
In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...
www.nature.com
May 22, 2026 at 11:36 AM
Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation.
rdcu.be/fj8Er
#Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu
rdcu.be/fj8Er
#Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu
The Lipp Lab (@lippilab.bsky.social) has uncovered how microRNAs guide the development of Purkinje cells—rare neurons tied to movement and autism.
Published in Neuron, a @cellpress.bsky.social journal, the study maps how precise timing and gene regulation shape these cells’ identity and structure.
Published in Neuron, a @cellpress.bsky.social journal, the study maps how precise timing and gene regulation shape these cells’ identity and structure.
How microRNAs act as a “blueprint” for the developing brain
www.scripps.edu
April 3, 2025 at 6:24 PM
The Lipp Lab (@lippilab.bsky.social) has uncovered how microRNAs guide the development of Purkinje cells—rare neurons tied to movement and autism.
Published in Neuron, a @cellpress.bsky.social journal, the study maps how precise timing and gene regulation shape these cells’ identity and structure.
Published in Neuron, a @cellpress.bsky.social journal, the study maps how precise timing and gene regulation shape these cells’ identity and structure.
No doubt microRNAs play important roles in gene regulation and protein expression (ahem, Nobel Prize-worthy) but the literature is swamped by (IMHO) a ton of poor quality studies that pollute and dilute the field. Here's a preprint that may help clean things up. www.biorxiv.org/content/10.1...
Chasing non-existent “microRNAs” in cancer
MicroRNAs (miRNAs) are important regulators of gene expression whose dysregulation is widely linked to tumourigenesis, tumour progression and Epithelial-Mesenchymal Transition (EMT), a developmental p...
www.biorxiv.org
December 12, 2024 at 9:30 PM
No doubt microRNAs play important roles in gene regulation and protein expression (ahem, Nobel Prize-worthy) but the literature is swamped by (IMHO) a ton of poor quality studies that pollute and dilute the field. Here's a preprint that may help clean things up. www.biorxiv.org/content/10.1...
Exosome Derived MicroRNAs in Hypertrophic Cardiomyopathy - Thailand Medical News
www.thailandmedical.news
February 10, 2025 at 2:12 AM
This is very exciting! A small clinical trial using gene therapy for Huntington's disease has been successful. microRNAs were used to edit the Huntington mRNA, stopping it making mutant protein that can damage neurons. Huge hopes now for treating such a devastating condition
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.co.uk
September 24, 2025 at 12:48 PM
This is very exciting! A small clinical trial using gene therapy for Huntington's disease has been successful. microRNAs were used to edit the Huntington mRNA, stopping it making mutant protein that can damage neurons. Huge hopes now for treating such a devastating condition
Posts about #microRNAs can be found here in the future
November 9, 2024 at 1:16 PM
Posts about #microRNAs can be found here in the future
#1. A huge number of "microRNAs" are not microRNAs. They will not act like microRNAs and should not be studied as microRNAs. Any studies of these "microRNAs" are dubious and likely erroneous and/or misinterpreted studies. MicroRNA studies should start with confirming it is in MirGeneDB.
October 22, 2025 at 4:26 PM
#1. A huge number of "microRNAs" are not microRNAs. They will not act like microRNAs and should not be studied as microRNAs. Any studies of these "microRNAs" are dubious and likely erroneous and/or misinterpreted studies. MicroRNA studies should start with confirming it is in MirGeneDB.
Two days of teaching everything about microRNAs in Oslo (#OsloBioinformaticsWeek) ahead.
December 8, 2025 at 10:04 AM
Two days of teaching everything about microRNAs in Oslo (#OsloBioinformaticsWeek) ahead.
Also props to the author for a very good explanation of microRNAs for a general audience
September 24, 2025 at 3:03 PM
Also props to the author for a very good explanation of microRNAs for a general audience
Plant-parasitic nematode microRNAs hijack plant AGO1 to induce host-cell reprogramming https://www.biorxiv.org/content/10.64898/2026.02.13.705329v1
February 16, 2026 at 5:01 PM
Plant-parasitic nematode microRNAs hijack plant AGO1 to induce host-cell reprogramming https://www.biorxiv.org/content/10.64898/2026.02.13.705329v1
Micro-Proteine, deren Existenz noch nicht so lange bekannt ist, scheinen in interessante Wechselwirkungen mit Krebszellen zu treten. Das könnte die Krebsforschung und - Therapien revolutionieren.
microRNAs: Wie kleine RNAs Proteine steuern und Krebs mitprägen
Was sind microRNAs? Der Leitartikel erklärt, wie kleine RNAs Gene dämpfen, Entwicklung ordnen, Biomarker liefern und warum Krebs oft eine Frage falscher Dosierung ist.
wissenschaftswelle.de
August 6, 2026 at 9:23 AM
Micro-Proteine, deren Existenz noch nicht so lange bekannt ist, scheinen in interessante Wechselwirkungen mit Krebszellen zu treten. Das könnte die Krebsforschung und - Therapien revolutionieren.
Can combining blood signals improve detection? A study of 1,785 people tested microRNAs + CA19-9 for pancreatic cancer. PANXEON showed promise, but larger prospective studies are still needed.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 20, 2026 at 2:09 PM
Can combining blood signals improve detection? A study of 1,785 people tested microRNAs + CA19-9 for pancreatic cancer. PANXEON showed promise, but larger prospective studies are still needed.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Weirdly, nearly all >2000 types of microRNAs rely on a single protein called Dicer for maturation. So do microRNAs compete for Dicer? Sofia Raak (co-supervised by Jon Hanley) studied this using computational modelling, and confirmed the predictions in data: royalsocietypublishing.org/doi/10.1098/...
February 19, 2025 at 10:59 AM
Weirdly, nearly all >2000 types of microRNAs rely on a single protein called Dicer for maturation. So do microRNAs compete for Dicer? Sofia Raak (co-supervised by Jon Hanley) studied this using computational modelling, and confirmed the predictions in data: royalsocietypublishing.org/doi/10.1098/...
Nobel prize time! 🧪 microRNAs take the prize. Congratulations to Ruvkun and Ambrose!
October 7, 2024 at 11:44 AM
Nobel prize time! 🧪 microRNAs take the prize. Congratulations to Ruvkun and Ambrose!
O desenvolvimento do câncer e de outras doenças está ligado a problemas nessas moléculas. Por isso, a descoberta pode levar a novos tratamentos. #JN
Nobel de Medicina 2024 vai para Victor Ambros e Gary Ruvkun pela descoberta dos microRNAs
O desenvolvimento do câncer e de outras doenças está ligado a problemas nessas moléculas. E, por isso, a descoberta pode levar a novos tratamentos.
g1.globo.com
October 8, 2024 at 2:13 AM
O desenvolvimento do câncer e de outras doenças está ligado a problemas nessas moléculas. Por isso, a descoberta pode levar a novos tratamentos. #JN