🐠 New pre-print from the lab! 🐠
Neural microexons fine-tune protein function - but how do they impact arousal states and underlying neuronal signaling pathways?
www.biorxiv.org/content/10.1...
Check out our latest pre-print by @tahneema.bsky.social et al, @upf.edu @crg.eu. 🧵👇 1/9
Neural microexons fine-tune protein function - but how do they impact arousal states and underlying neuronal signaling pathways?
www.biorxiv.org/content/10.1...
Check out our latest pre-print by @tahneema.bsky.social et al, @upf.edu @crg.eu. 🧵👇 1/9
Neural microexons modulate arousal states via cAMP signalling in zebrafish
Arousal states, often dysregulated in neurodevelopmental disorders, shape how organisms perceive and respond to their environment. Here, we show that srrm3, a master regulator of neural microexons, is...
www.biorxiv.org
April 28, 2025 at 9:24 AM
🐠 New pre-print from the lab! 🐠
Neural microexons fine-tune protein function - but how do they impact arousal states and underlying neuronal signaling pathways?
www.biorxiv.org/content/10.1...
Check out our latest pre-print by @tahneema.bsky.social et al, @upf.edu @crg.eu. 🧵👇 1/9
Neural microexons fine-tune protein function - but how do they impact arousal states and underlying neuronal signaling pathways?
www.biorxiv.org/content/10.1...
Check out our latest pre-print by @tahneema.bsky.social et al, @upf.edu @crg.eu. 🧵👇 1/9
🐟 Our new paper "Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish" is out in @elife.bsky.social 🐟
A nearly 10-year tour-de-force by Laura Lopez-Blanch and many others in the lab @crg.eu & @upf.edu
elifesciences.org/reviewed-pre...
Thread 👇1/9
A nearly 10-year tour-de-force by Laura Lopez-Blanch and many others in the lab @crg.eu & @upf.edu
elifesciences.org/reviewed-pre...
Thread 👇1/9
Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish
elifesciences.org
December 30, 2024 at 4:07 PM
🐟 Our new paper "Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish" is out in @elife.bsky.social 🐟
A nearly 10-year tour-de-force by Laura Lopez-Blanch and many others in the lab @crg.eu & @upf.edu
elifesciences.org/reviewed-pre...
Thread 👇1/9
A nearly 10-year tour-de-force by Laura Lopez-Blanch and many others in the lab @crg.eu & @upf.edu
elifesciences.org/reviewed-pre...
Thread 👇1/9
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
July 23, 2025 at 2:28 PM
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Very excited to finally share my PhD! 🎉
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish
Loss of the conserved splicing factor for neuronal microexons disrupts neuromodulatory signaling and drives hyperarousal.
www.science.org
June 28, 2026 at 4:37 PM
Very excited to finally share my PhD! 🎉
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
MEPDB: Database of microExons in plants
A #CommunityResource by Islamov, et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
A #CommunityResource by Islamov, et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
September 5, 2025 at 6:35 AM
MEPDB: Database of microExons in plants
A #CommunityResource by Islamov, et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
A #CommunityResource by Islamov, et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
🚀 Check out our new review article “From Tiny Exons to Big Insights: The Expanding Field of #Microexons” now out in Annual Review of Genomics and Human Genetics!
doi.org/10.1146/annu...
Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!
doi.org/10.1146/annu...
Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!
August 31, 2025 at 1:42 PM
🚀 Check out our new review article “From Tiny Exons to Big Insights: The Expanding Field of #Microexons” now out in Annual Review of Genomics and Human Genetics!
doi.org/10.1146/annu...
Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!
doi.org/10.1146/annu...
Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!
Mighty microexons!
MICROEXONS! 💪
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Regulated microexon alternative splicing in single neurons tunes synaptic function | EMBO reports
imageimageAlternative splicing of a conserved microexon in the unc-13 synaptic gene is regulated
by a pair of cell-specific RNA binding proteins. Microexon-included and microexon-skipped
isoforms are ...
www.embopress.org
June 17, 2025 at 6:54 AM
Mighty microexons!
🧬 Neural microexons (3–51 nt) are tiny but highly conserved across vertebrates, and frequently mis-spliced in neurological disorders like autism and schizophrenia. A key master regulator of microexons is SRRM3. 3/9
April 28, 2025 at 9:24 AM
🧬 Neural microexons (3–51 nt) are tiny but highly conserved across vertebrates, and frequently mis-spliced in neurological disorders like autism and schizophrenia. A key master regulator of microexons is SRRM3. 3/9
Thrilled to share my 1st PhD paper exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬(and first post at @bsky.app :)
Finally published in
@natcomms.nature.com
nature.com/articles/s41... .
With @mirimiam.bsky.social, @maradierssen.bsky.social,
@crg.eu
Details below:
Finally published in
@natcomms.nature.com
nature.com/articles/s41... .
With @mirimiam.bsky.social, @maradierssen.bsky.social,
@crg.eu
Details below:
A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation - Nature Communications
Actin is crucial for nervous system function yet the role of microexons in its modulation is unclear. Here, the authors show that a microexon in DAAM1 has a role in actin dynamics, neuronal function a...
nature.com
May 9, 2025 at 9:35 AM
Thrilled to share my 1st PhD paper exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬(and first post at @bsky.app :)
Finally published in
@natcomms.nature.com
nature.com/articles/s41... .
With @mirimiam.bsky.social, @maradierssen.bsky.social,
@crg.eu
Details below:
Finally published in
@natcomms.nature.com
nature.com/articles/s41... .
With @mirimiam.bsky.social, @maradierssen.bsky.social,
@crg.eu
Details below:
This story is published back-to-back with @sthyme.bsky.social lab, who deleted 45 microexons (only two in common with us) and assessed larval brain activity, morphology and behavior. They also found that most individual mutants had minimal or no phenotypes: elifesciences.org/reviewed-pre.... 9/9
Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function
elifesciences.org
December 30, 2024 at 4:07 PM
This story is published back-to-back with @sthyme.bsky.social lab, who deleted 45 microexons (only two in common with us) and assessed larval brain activity, morphology and behavior. They also found that most individual mutants had minimal or no phenotypes: elifesciences.org/reviewed-pre.... 9/9
MICROEXONS! 💪
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Regulated microexon alternative splicing in single neurons tunes synaptic function | EMBO reports
imageimageAlternative splicing of a conserved microexon in the unc-13 synaptic gene is regulated
by a pair of cell-specific RNA binding proteins. Microexon-included and microexon-skipped
isoforms are ...
www.embopress.org
June 16, 2025 at 3:43 PM
MICROEXONS! 💪
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Finally, we asked whether this recurrent evolution was functionally relevant. We deleted two recurrent neural microexons in Drosophila: loss of the spg exon impaired climbing and strongly reduced lifespan, while loss of the syd exon caused age-dependent hyperactivity and reduced offspring. 10/11
October 5, 2026 at 10:38 AM
Finally, we asked whether this recurrent evolution was functionally relevant. We deleted two recurrent neural microexons in Drosophila: loss of the spg exon impaired climbing and strongly reduced lifespan, while loss of the syd exon caused age-dependent hyperactivity and reduced offspring. 10/11
🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
September 1, 2025 at 10:20 AM
🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
@rodrigomorec.bsky.social & @uribelab.bsky.social (Enteric nervous system)
https://www.biorxiv.org/content/10.1101/2025.04.17.649413v1
@tahneema.bsky.social & @mirimiam.bsky.social (Neural microexons/ Neuronal signaling)
https://www.biorxiv.org/content/10.1101/2025.04.24.650407v1
(22/36)
https://www.biorxiv.org/content/10.1101/2025.04.17.649413v1
@tahneema.bsky.social & @mirimiam.bsky.social (Neural microexons/ Neuronal signaling)
https://www.biorxiv.org/content/10.1101/2025.04.24.650407v1
(22/36)
May 26, 2025 at 12:15 PM
@rodrigomorec.bsky.social & @uribelab.bsky.social (Enteric nervous system)
https://www.biorxiv.org/content/10.1101/2025.04.17.649413v1
@tahneema.bsky.social & @mirimiam.bsky.social (Neural microexons/ Neuronal signaling)
https://www.biorxiv.org/content/10.1101/2025.04.24.650407v1
(22/36)
https://www.biorxiv.org/content/10.1101/2025.04.17.649413v1
@tahneema.bsky.social & @mirimiam.bsky.social (Neural microexons/ Neuronal signaling)
https://www.biorxiv.org/content/10.1101/2025.04.24.650407v1
(22/36)
3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons and the ability to put together amazing teams of collaborators. Somehow, CureSearch for Children's Cancer had faith in us! www.cell.com/cell-reports...
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas
Aberrant splicing of microexons yields non-canonical surface receptors, such as the
neuronal cell adhesion molecule (NRCAM) lacking amino acids encoded by exons 5 and
19. Sehgal et al. show that Δex5Δ...
www.cell.com
August 8, 2025 at 3:30 PM
3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons and the ability to put together amazing teams of collaborators. Somehow, CureSearch for Children's Cancer had faith in us! www.cell.com/cell-reports...
⚡️ Arousal states govern how animals respond to the world around them. Too much arousal may manifest as hyperactivity, anxiety, sensory overload and sleep loss. But how do neurodevelopmental processes shape arousal regulation? Are neural microexons part of the answer? 2/9
April 28, 2025 at 9:24 AM
⚡️ Arousal states govern how animals respond to the world around them. Too much arousal may manifest as hyperactivity, anxiety, sensory overload and sleep loss. But how do neurodevelopmental processes shape arousal regulation? Are neural microexons part of the answer? 2/9
🚨 New paper alert! 🚨
Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !
journals.plos.org/plosbiology/...
#splicing #microexons #NMJ #Ciona
🧵👇
Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !
journals.plos.org/plosbiology/...
#splicing #microexons #NMJ #Ciona
🧵👇
Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates
Neuron-specific splicing of Agrin by Nova RNA-binding proteins is essential for neuromuscular synapse formation via acetylcholine receptor clustering. This study shows that this RNA splicing pathway i...
journals.plos.org
September 16, 2025 at 6:54 PM
🚨 New paper alert! 🚨
Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !
journals.plos.org/plosbiology/...
#splicing #microexons #NMJ #Ciona
🧵👇
Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !
journals.plos.org/plosbiology/...
#splicing #microexons #NMJ #Ciona
🧵👇
Beautiful work on mis-splicing, microexons and molecular mechanisms of autism.
By the labs of @xsalvatella1.bsky.social and #Raul_Mendez at the @irbbarcelona.bsky.social , and the collaboration of #Jose_Lucas lab at the @cbm-csic-uam.bsky.social .
www.nature.com/articles/s41...
By the labs of @xsalvatella1.bsky.social and #Raul_Mendez at the @irbbarcelona.bsky.social , and the collaboration of #Jose_Lucas lab at the @cbm-csic-uam.bsky.social .
www.nature.com/articles/s41...
December 4, 2024 at 4:23 PM
Beautiful work on mis-splicing, microexons and molecular mechanisms of autism.
By the labs of @xsalvatella1.bsky.social and #Raul_Mendez at the @irbbarcelona.bsky.social , and the collaboration of #Jose_Lucas lab at the @cbm-csic-uam.bsky.social .
www.nature.com/articles/s41...
By the labs of @xsalvatella1.bsky.social and #Raul_Mendez at the @irbbarcelona.bsky.social , and the collaboration of #Jose_Lucas lab at the @cbm-csic-uam.bsky.social .
www.nature.com/articles/s41...
The importance of being small: only microexons are conserved between vertebrates and invertebrates.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Regulated microexon alternative splicing in single neurons tunes synaptic function | EMBO reports
imageimageAlternative splicing of a conserved microexon in the unc-13 synaptic gene is regulated
by a pair of cell-specific RNA binding proteins. Microexon-included and microexon-skipped
isoforms are ...
www.embopress.org
July 24, 2025 at 9:41 AM
The importance of being small: only microexons are conserved between vertebrates and invertebrates.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
The preprint is finally out! Microexons to the rescue, and potentially targetable in deadly high-grade gliomas. www.biorxiv.org/content/10.1...
Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade glioma
To overcome the paucity of known tumor-specific surface antigens in pediatric high-grade glioma (pHGG), we contrasted splicing patterns in pHGGs and normal brain samples. Among alternative splicing ev...
www.biorxiv.org
January 23, 2025 at 9:37 PM
The preprint is finally out! Microexons to the rescue, and potentially targetable in deadly high-grade gliomas. www.biorxiv.org/content/10.1...
🧬 RNA-seq of FACS-sorted neurons revealed large-scale mis-splicing of conserved neural microexons. Interestingly, many microexon-harboring genes, for example involved in calcium ion homeostasis or synapse organization, were upregulated, suggesting a compensatory response to mis-splicing. 7/9
April 28, 2025 at 9:24 AM
🧬 RNA-seq of FACS-sorted neurons revealed large-scale mis-splicing of conserved neural microexons. Interestingly, many microexon-harboring genes, for example involved in calcium ion homeostasis or synapse organization, were upregulated, suggesting a compensatory response to mis-splicing. 7/9