We previously showed that an upstream CM1 autoinhibition domain is required to prevent binding and activation of g-TuRCs by #Drosophila Centrosomin (Cnn) to avoid ectopic cytosolic #microtubule nucleation and major #cell and #developmental defects
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Autoinhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects
We show that autoinhibition regulates the binding between microtubule nucleating complexes and proteins that tether them to sites of microtubule nucleation
rupress.org
October 1, 2026 at 8:28 AM
We previously showed that an upstream CM1 autoinhibition domain is required to prevent binding and activation of g-TuRCs by #Drosophila Centrosomin (Cnn) to avoid ectopic cytosolic #microtubule nucleation and major #cell and #developmental defects
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Abir Elfarkouchi, Arthur Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...
September 30, 2026 at 4:00 PM
Abir Elfarkouchi, Arthur Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...
In @jcborg, Elfarkouchi, Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...
September 30, 2026 at 4:00 PM
In @jcborg, Elfarkouchi, Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...
Mitotic phosphorylation of the microtubule nucleator γ-tubulin regulates spindle assembly
Mitotic phosphorylation of the microtubule nucleator γ-tubulin regulates spindle assembly
Li et al. reveal that mitotic phosphorylation of γ-tubulin at Ser364 suppresses cytoplasmic microtubule nucleation, while preserving the microtubule-nucleating activity of spindle-associated γTuRC. This mechanism ensures accurate spindle assembly and chromosome segregation, thereby supporting proper mitotic progression.
dlvr.it
July 10, 2026 at 12:36 PM
Mitotic phosphorylation of the microtubule nucleator γ-tubulin regulates spindle assembly
The centriculum, a membrane reticulum that surrounds C. elegans centrosomes, may serve as a microtubule filter journals.biologists.com/jcs/article/...
The centriculum, a membrane reticulum that surrounds C. elegans centrosomes, may serve as a microtubule filter
Centrosomes are cytoplasmic microtubule-nucleating structures. They are considered membraneless organelles, but in several cell types they are surrounded by ER-derived membrane. In C. elegans early em...
journals.biologists.com
June 12, 2026 at 3:42 PM
The centriculum, a membrane reticulum that surrounds C. elegans centrosomes, may serve as a microtubule filter journals.biologists.com/jcs/article/...
Using a point mutant that disrupts autoregulation (γ-tubulin R3H), we revealed deregulated protein levels and microtubule-nucleating activity. These changes led to a loss of mitotic fidelity, highlighting the importance of precise γ-tubulin dosage.
January 10, 2026 at 11:24 AM
Using a point mutant that disrupts autoregulation (γ-tubulin R3H), we revealed deregulated protein levels and microtubule-nucleating activity. These changes led to a loss of mitotic fidelity, highlighting the importance of precise γ-tubulin dosage.
Manolo Rios, Jeffrey Woodruff and colleagues use purified human proteins to define the minimal modules for centrosome scaffold assembly and microtubule aster nucleation.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
July 8, 2025 at 7:50 AM
Manolo Rios, Jeffrey Woodruff and colleagues use purified human proteins to define the minimal modules for centrosome scaffold assembly and microtubule aster nucleation.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
💬 New preprint evaluation by @arcadiascience.bsky.social of
Mechanical Centrosome Fracturing during Cell Navigation
https://sciety.org/articles/activity/10.1101/2024.10.01.615992?utm_source=bluesky&utm_medium=social&utm_campaign=preprint_review
#PreprintEvaluation
Mechanical Centrosome Fracturing during Cell Navigation
https://sciety.org/articles/activity/10.1101/2024.10.01.615992?utm_source=bluesky&utm_medium=social&utm_campaign=preprint_review
#PreprintEvaluation
Mechanical Centrosome Fracturing during Cell Navigation
Abstract
The centrosome is the primary microtubule orchestrator in most eukaryotic cells, nucleating and anchoring microtubules that grow radially and exert forces on cargos
sciety.org
October 7, 2024 at 9:00 AM
💬 New preprint evaluation by @arcadiascience.bsky.social of
Mechanical Centrosome Fracturing during Cell Navigation
https://sciety.org/articles/activity/10.1101/2024.10.01.615992?utm_source=bluesky&utm_medium=social&utm_campaign=preprint_review
#PreprintEvaluation
Mechanical Centrosome Fracturing during Cell Navigation
https://sciety.org/articles/activity/10.1101/2024.10.01.615992?utm_source=bluesky&utm_medium=social&utm_campaign=preprint_review
#PreprintEvaluation
Mechanical Centrosome Fracturing during Cell Navigation https://www.biorxiv.org/content/10.1101/2024.10.01.615992v1
Mechanical Centrosome Fracturing during Cell Navigation https://www.biorxiv.org/content/10.1101/2024.10.01.615992v1
The centrosome is the primary microtubule orchestrator in most eukaryotic cells, nucleating and anch
www.biorxiv.org
October 1, 2024 at 12:30 PM
Mechanical Centrosome Fracturing during Cell Navigation https://www.biorxiv.org/content/10.1101/2024.10.01.615992v1
📜 Plant microtubule nucleating apparatus and its potential signaling pathway
🧑🔬 Noriyoshi Yagi, Satoshi Fujita, Masayoshi Nakamura
📔 Current Opinion in Plant Biology
🔗 www.sciencedirect.com/science/arti...
#️⃣ #PlantScience #PlantMicrotubules #PlantCytoskeleton #PlantCellBiology #PlantCellWalls
🧑🔬 Noriyoshi Yagi, Satoshi Fujita, Masayoshi Nakamura
📔 Current Opinion in Plant Biology
🔗 www.sciencedirect.com/science/arti...
#️⃣ #PlantScience #PlantMicrotubules #PlantCytoskeleton #PlantCellBiology #PlantCellWalls
Plant microtubule nucleating apparatus and its potential signaling pathway
Plant cell cortical microtubules are located beneath the plasma membrane and direct the location of cellulose synthases during interphase, influencing…
www.sciencedirect.com
September 5, 2024 at 6:21 AM
📜 Plant microtubule nucleating apparatus and its potential signaling pathway
🧑🔬 Noriyoshi Yagi, Satoshi Fujita, Masayoshi Nakamura
📔 Current Opinion in Plant Biology
🔗 www.sciencedirect.com/science/arti...
#️⃣ #PlantScience #PlantMicrotubules #PlantCytoskeleton #PlantCellBiology #PlantCellWalls
🧑🔬 Noriyoshi Yagi, Satoshi Fujita, Masayoshi Nakamura
📔 Current Opinion in Plant Biology
🔗 www.sciencedirect.com/science/arti...
#️⃣ #PlantScience #PlantMicrotubules #PlantCytoskeleton #PlantCellBiology #PlantCellWalls