*stares in RSV vaccine*
*stares in recombinant flu vaccine*
*stares in monovalent acellular pertussis vaccine*
*stares in recombinant flu vaccine*
*stares in monovalent acellular pertussis vaccine*
Why has FDA delayed approval of Novavax's COVID-19 vaccine?
Secy Kennedy told Dr Lapook:
"it is a single antigen vaccine. And, for respiratory illnesses, the single antigen vaccines have never worked"
tinalexander.github.io/notes/2025/0...
Secy Kennedy told Dr Lapook:
"it is a single antigen vaccine. And, for respiratory illnesses, the single antigen vaccines have never worked"
tinalexander.github.io/notes/2025/0...
![Question [00:14:29] For example, the Novavax vaccine, and that’s not an mRNA vaccine, was expected to be approved by the FDA, but there’s a delay. Why is there a delay? Is it just personnel being shuffled? Why is that? Robert F Kennedy Jr [00:14:40] No, we’re looking at that vaccine and it is a single antigen vaccine. And, for respiratory illnesses, the single antigen vaccines have never worked. Question [00:14:52] So it’s not because of lack of personnel or lack of– Robert F Kennedy Jr [00:14:56] No, we are actually shifting our priorities to multiple antigen vaccines. And NIH is already working on a number of those.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:uxvc5nwyutzf5gtu4x7jqyk3/bafkreifiygjijj7bxfyx4prz5cfkh3scewg3vmtw5whsry7xzawdtwtnge)
April 10, 2025 at 4:21 AM
*stares in RSV vaccine*
*stares in recombinant flu vaccine*
*stares in monovalent acellular pertussis vaccine*
*stares in recombinant flu vaccine*
*stares in monovalent acellular pertussis vaccine*
Single Immunization With a Monovalent Vesicular Stomatitis Virus–Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus academic.oup.com/jid/article-...
Single Immunization With a Monovalent Vesicular Stomatitis Virus–Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus
Abstract. The recombinant vesicular stomatitis virus (rVSV) vector-based monovalent vaccine platform expressing a filovirus glycoprotein has been demonstra
academic.oup.com
May 18, 2026 at 9:50 PM
Single Immunization With a Monovalent Vesicular Stomatitis Virus–Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus academic.oup.com/jid/article-...
I'd normally revel in this pettiness, except this IS actually about vaccines.
MMR has a tiny risk of febrile seizures.
Risk can't be reduced because Tylenol causes autism*
ACIP recommends monovalent M,M,R instead
There are no monovalent M,M,R vaccines
*No it doesn't
MMR has a tiny risk of febrile seizures.
Risk can't be reduced because Tylenol causes autism*
ACIP recommends monovalent M,M,R instead
There are no monovalent M,M,R vaccines
*No it doesn't
The MAHA anti-vax contingent is upset about the now infamous Tylenol announcement. Apparently the wrong kind of unhinged pseudoscience. They have standards!
We’re gonna take a petty moment to enjoy this infighting. 🍿
We’re gonna take a petty moment to enjoy this infighting. 🍿
Anti-vaccine groups melt down over RFK Jr. linking autism to Tylenol
“THIS WAS NOT CAUSED BY TYLENOL” Kennedy’s anti-vaccine group retweeted.
arstechnica.com
September 24, 2025 at 7:07 PM
I'd normally revel in this pettiness, except this IS actually about vaccines.
MMR has a tiny risk of febrile seizures.
Risk can't be reduced because Tylenol causes autism*
ACIP recommends monovalent M,M,R instead
There are no monovalent M,M,R vaccines
*No it doesn't
MMR has a tiny risk of febrile seizures.
Risk can't be reduced because Tylenol causes autism*
ACIP recommends monovalent M,M,R instead
There are no monovalent M,M,R vaccines
*No it doesn't
We literally give this vaccine to people with end-stage renal disease with no issues.
Also this slide is really bizarre. The birth dose of HBV vaccine is exclusively monovalent.
Also this slide is really bizarre. The birth dose of HBV vaccine is exclusively monovalent.
December 4, 2025 at 5:26 PM
We literally give this vaccine to people with end-stage renal disease with no issues.
Also this slide is really bizarre. The birth dose of HBV vaccine is exclusively monovalent.
Also this slide is really bizarre. The birth dose of HBV vaccine is exclusively monovalent.
If Kennedy is going to front like he is enough of a vaccinologist to weigh in on antigenicity, perhaps he should learn the term “monovalent” while he’s at it.
Why has FDA delayed approval of Novavax's COVID-19 vaccine?
Secy Kennedy told Dr Lapook:
"it is a single antigen vaccine. And, for respiratory illnesses, the single antigen vaccines have never worked"
tinalexander.github.io/notes/2025/0...
Secy Kennedy told Dr Lapook:
"it is a single antigen vaccine. And, for respiratory illnesses, the single antigen vaccines have never worked"
tinalexander.github.io/notes/2025/0...
April 10, 2025 at 4:19 AM
If Kennedy is going to front like he is enough of a vaccinologist to weigh in on antigenicity, perhaps he should learn the term “monovalent” while he’s at it.
'The unexpected finding that vaccination-only participants showed superior cross-neutralization compared to individuals with hybrid immunity challenges conventional assumptions about hybrid immunity advantages'.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Antibody responses to SARS-CoV-2 variants LP.8.1, LF.7.1, NB.1.8.1, XFG and BA.3.2 following KP.2 monovalent mRNA vaccination
The evolution of SARS-CoV-2 has resulted in antigenically distinct variants that challenge vaccine-induced immunity. The KP.2 monovalent mRNA vaccine was deployed in 2024 to address immune escape by e...
www.medrxiv.org
August 30, 2025 at 5:15 PM
'The unexpected finding that vaccination-only participants showed superior cross-neutralization compared to individuals with hybrid immunity challenges conventional assumptions about hybrid immunity advantages'.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
vesicular stomatitis virus (VSV), a virus that infects mainly horse and cattle, but altered it to remove glycoproteins from the virus particle’s surface- a step that makes the virus incapable of replicating or becoming virulent. Then the researchers added to the surface the spike protein found on
March 13, 2025 at 4:06 PM
vesicular stomatitis virus (VSV), a virus that infects mainly horse and cattle, but altered it to remove glycoproteins from the virus particle’s surface- a step that makes the virus incapable of replicating or becoming virulent. Then the researchers added to the surface the spike protein found on
Every single barrier to vaccination leaves more and more people unprotected.
Furthermore, the U.S. presently doesn’t have monovalent vaccines for MMR.
Finally, if anti-vaxxers want kids to get fewer shots because of unnecessary fears of aluminum, why do they want to expose them 3x as much?
Furthermore, the U.S. presently doesn’t have monovalent vaccines for MMR.
Finally, if anti-vaxxers want kids to get fewer shots because of unnecessary fears of aluminum, why do they want to expose them 3x as much?
November 4, 2025 at 12:34 AM
Every single barrier to vaccination leaves more and more people unprotected.
Furthermore, the U.S. presently doesn’t have monovalent vaccines for MMR.
Finally, if anti-vaxxers want kids to get fewer shots because of unnecessary fears of aluminum, why do they want to expose them 3x as much?
Furthermore, the U.S. presently doesn’t have monovalent vaccines for MMR.
Finally, if anti-vaxxers want kids to get fewer shots because of unnecessary fears of aluminum, why do they want to expose them 3x as much?
A new #ScienceReview looks at the contrast between monovalent and multivalent metal battery anodes. https://scim.ag/41WONGs
The contrast between monovalent and multivalent metal battery anodes
Monovalent (lithium, sodium, potassium) and multivalent (magnesium, calcium, aluminum) metal anodes are promising alternatives to graphite anodes for overcoming the performance limitations of lithium-...
scim.ag
September 23, 2025 at 1:23 PM
A new #ScienceReview looks at the contrast between monovalent and multivalent metal battery anodes. https://scim.ag/41WONGs
I actually don't disagree that there's nothing wrong with noting the tackiness-- it speaks to the way commodifies and grifts off the office, in a way that mocks the notion of respect for folks living under his regime.
*And.* These symbols of republic are not monovalent.
*And.* These symbols of republic are not monovalent.
The institutions of the republic should be regarded with some solemnity if they are to be anything but hollow forms. These are symbols of the righteous and sacred cause of human freedom, and our treatment of them should reflect the earnestness of our commitment to this cause.
My problem with the White House thunderdome isn’t that it’s “vulgar,” or “tacky,” qualities I often enjoy & terms which are often crudely classist when used pejoratively. My problem, as always, is the fascism. Don’t get distracted by taste, which is deeply subjective; it’s the fascism.
June 15, 2026 at 1:02 AM
I actually don't disagree that there's nothing wrong with noting the tackiness-- it speaks to the way commodifies and grifts off the office, in a way that mocks the notion of respect for folks living under his regime.
*And.* These symbols of republic are not monovalent.
*And.* These symbols of republic are not monovalent.
SARS-CoV-2, Ende des Hybrid Immunitäts Mythos:
"Teilnehmer, die nur geimpft waren, hatten eine bessere Kreuzneutralisierung als Personen mit hybrider Immunität."
Ihr habt Kinder & alle anderen für ideologischen Schwachsinn unter den Bus geworfen & tut es weiterhin
www.medrxiv.org/content/10.1...
"Teilnehmer, die nur geimpft waren, hatten eine bessere Kreuzneutralisierung als Personen mit hybrider Immunität."
Ihr habt Kinder & alle anderen für ideologischen Schwachsinn unter den Bus geworfen & tut es weiterhin
www.medrxiv.org/content/10.1...
Antibody responses to SARS-CoV-2 variants LP.8.1, LF.7.1, NB.1.8.1, XFG and BA.3.2 following KP.2 monovalent mRNA vaccination
The evolution of SARS-CoV-2 has resulted in antigenically distinct variants that challenge vaccine-induced immunity. The KP.2 monovalent mRNA vaccine was deployed in 2024 to address immune escape by e...
www.medrxiv.org
August 30, 2025 at 6:31 PM
SARS-CoV-2, Ende des Hybrid Immunitäts Mythos:
"Teilnehmer, die nur geimpft waren, hatten eine bessere Kreuzneutralisierung als Personen mit hybrider Immunität."
Ihr habt Kinder & alle anderen für ideologischen Schwachsinn unter den Bus geworfen & tut es weiterhin
www.medrxiv.org/content/10.1...
"Teilnehmer, die nur geimpft waren, hatten eine bessere Kreuzneutralisierung als Personen mit hybrider Immunität."
Ihr habt Kinder & alle anderen für ideologischen Schwachsinn unter den Bus geworfen & tut es weiterhin
www.medrxiv.org/content/10.1...
I spoke to @melodyschreiber.com @theguardian.com along with @pauloffit.bsky.social & @jasonlschwartz.bsky.social about the MMR going monovalent.
We all agree: following Andrew Wakefield's advice to "break up the vaccines" is unnecessary, pointless, & will only prevent kids from getting vaccinated
We all agree: following Andrew Wakefield's advice to "break up the vaccines" is unnecessary, pointless, & will only prevent kids from getting vaccinated
"If a vaccine is sitting on a shelf and not going into somebody’s arm, then it’s worthless, essentially," @angierasmussen.bsky.social said.
"I think anti-vaxxers love vaccines that sit on shelves.” www.theguardian.com/us-news/2025...
"I think anti-vaxxers love vaccines that sit on shelves.” www.theguardian.com/us-news/2025...
Alarm as CDC calls for separate MMR vaccines despite measles outbreak
Concerns that three separate shots would be more costly and time-consuming, and keep kids from being vaccinated
www.theguardian.com
October 9, 2025 at 11:08 PM
I spoke to @melodyschreiber.com @theguardian.com along with @pauloffit.bsky.social & @jasonlschwartz.bsky.social about the MMR going monovalent.
We all agree: following Andrew Wakefield's advice to "break up the vaccines" is unnecessary, pointless, & will only prevent kids from getting vaccinated
We all agree: following Andrew Wakefield's advice to "break up the vaccines" is unnecessary, pointless, & will only prevent kids from getting vaccinated
USA: "FDA Panel Backs New COVID Vaccines Aimed at Dominant Strain."
"The FDA's vaccine advisors voted 8 to 0, with one abstention, in favor of a monovalent XFG vaccine for COVID-19 shots for the 2026-2027 season."
Source: archive.md/wTWaw
"The FDA's vaccine advisors voted 8 to 0, with one abstention, in favor of a monovalent XFG vaccine for COVID-19 shots for the 2026-2027 season."
Source: archive.md/wTWaw
May 29, 2026 at 2:33 AM
USA: "FDA Panel Backs New COVID Vaccines Aimed at Dominant Strain."
"The FDA's vaccine advisors voted 8 to 0, with one abstention, in favor of a monovalent XFG vaccine for COVID-19 shots for the 2026-2027 season."
Source: archive.md/wTWaw
"The FDA's vaccine advisors voted 8 to 0, with one abstention, in favor of a monovalent XFG vaccine for COVID-19 shots for the 2026-2027 season."
Source: archive.md/wTWaw
…da so viele eine #Covid Impfgelegenheit suchen:
⬇️
Berlin, Dresden, Wiesbaden, HH, Köln, München, Stuttgart, Düsseldorf, Frankfurt => tel. Terminvereinbarung, Kosten 20€, ab 5 Jahren
bin zuletzt im Mai 2024 in Berlin geimpft worden (XXB monovalent)
⬇️
Berlin, Dresden, Wiesbaden, HH, Köln, München, Stuttgart, Düsseldorf, Frankfurt => tel. Terminvereinbarung, Kosten 20€, ab 5 Jahren
bin zuletzt im Mai 2024 in Berlin geimpft worden (XXB monovalent)
Startseite | BCRT
bcrt.de
June 23, 2024 at 8:13 PM
…da so viele eine #Covid Impfgelegenheit suchen:
⬇️
Berlin, Dresden, Wiesbaden, HH, Köln, München, Stuttgart, Düsseldorf, Frankfurt => tel. Terminvereinbarung, Kosten 20€, ab 5 Jahren
bin zuletzt im Mai 2024 in Berlin geimpft worden (XXB monovalent)
⬇️
Berlin, Dresden, Wiesbaden, HH, Köln, München, Stuttgart, Düsseldorf, Frankfurt => tel. Terminvereinbarung, Kosten 20€, ab 5 Jahren
bin zuletzt im Mai 2024 in Berlin geimpft worden (XXB monovalent)
The Monovalent Mirage: individual vaccines are not available for MMR, and it's a bad idea anyway, by @angierasmussen.bsky.social open.substack.com/pub/rasmusse...
The Monovalent Mirage
A pretend alternative to the MMR exists, just ask Andrew Wakefield
open.substack.com
October 8, 2025 at 8:30 PM
The Monovalent Mirage: individual vaccines are not available for MMR, and it's a bad idea anyway, by @angierasmussen.bsky.social open.substack.com/pub/rasmusse...
The immune response from the Covid boosters introduced last September is holding up very well against current circulating variants 👍https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00058-1/fulltext
KP.2-based monovalent mRNA vaccines robustly boost antibody responses to SARS-CoV-2
In response to the ongoing evolution of SARS-CoV-2, vaccine manufacturers have released
updated COVID-19 vaccines annually since 2022. For much of 2024, the global spread
was dominated by the JN.1 lin...
www.thelancet.com
February 6, 2025 at 3:00 PM
The immune response from the Covid boosters introduced last September is holding up very well against current circulating variants 👍https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00058-1/fulltext
I wrote a thing about how this split the MMR up into monovalents is bullshit that Andrew Wakefield cooked up. It will be used to strip access to the MMR.
The MAHA movement continues to destroy public health.
open.substack.com/pub/rasmusse...
The MAHA movement continues to destroy public health.
open.substack.com/pub/rasmusse...
The Monovalent Mirage
A pretend alternative to the MMR exists, just ask Andrew Wakefield
open.substack.com
October 7, 2025 at 12:48 PM
I wrote a thing about how this split the MMR up into monovalents is bullshit that Andrew Wakefield cooked up. It will be used to strip access to the MMR.
The MAHA movement continues to destroy public health.
open.substack.com/pub/rasmusse...
The MAHA movement continues to destroy public health.
open.substack.com/pub/rasmusse...
EMA UND WHO EMPFEHLEN ANPASSUNG DER CORONA-IMPFSTOFFE
Ab Herbst wird monovalent gegen JN.1 geimpft.
#CovidIsNotOver #MaskUp #TeamVorsicht #LongCovid
Ab Herbst wird monovalent gegen JN.1 geimpft.
#CovidIsNotOver #MaskUp #TeamVorsicht #LongCovid
COVID-19: Ab Herbst wird monovalent gegen JN.1 geimpft
Die Weltgesundheitsorganisation und die europäische Arzneimittelbehörde haben kürzlich bekannt gegeben, wie COVID-19-Impfstoffe im kommenden Herbst und Winter zusammengesetzt sein sollten. Das hat auc...
www.deutsche-apotheker-zeitung.de
May 9, 2024 at 5:13 PM
EMA UND WHO EMPFEHLEN ANPASSUNG DER CORONA-IMPFSTOFFE
Ab Herbst wird monovalent gegen JN.1 geimpft.
#CovidIsNotOver #MaskUp #TeamVorsicht #LongCovid
Ab Herbst wird monovalent gegen JN.1 geimpft.
#CovidIsNotOver #MaskUp #TeamVorsicht #LongCovid
the new vaccines will target a monovalent JN.1-lineage XFG variant, reflecting the viruses currently circulating.Pfizer-BioNTech, Moderna, and Novavax/Sanofi have indicated they can supply updated vaccines for the fall respiratory virus season
June 27, 2026 at 2:53 PM
the new vaccines will target a monovalent JN.1-lineage XFG variant, reflecting the viruses currently circulating.Pfizer-BioNTech, Moderna, and Novavax/Sanofi have indicated they can supply updated vaccines for the fall respiratory virus season
KP.2-based monovalent mRNA vaccines robustly boost antibody responses to SARS-CoV-2
Yes.... vaccines work. Antibody levels are sustained for some time.
www.thelancet.com/jo...
1/4
Yes.... vaccines work. Antibody levels are sustained for some time.
www.thelancet.com/jo...
1/4
February 7, 2025 at 8:01 AM
KP.2-based monovalent mRNA vaccines robustly boost antibody responses to SARS-CoV-2
Yes.... vaccines work. Antibody levels are sustained for some time.
www.thelancet.com/jo...
1/4
Yes.... vaccines work. Antibody levels are sustained for some time.
www.thelancet.com/jo...
1/4
Quick clarification: the article says “new,” but it’s actually referring to the XBB.1.5 monovalent COVID shot that’s already available in many places. The study shows it produces stronger, longer-lasting antibodies than older versions — a good reminder to stay up to date with boosters.
December 3, 2025 at 8:12 AM
Quick clarification: the article says “new,” but it’s actually referring to the XBB.1.5 monovalent COVID shot that’s already available in many places. The study shows it produces stronger, longer-lasting antibodies than older versions — a good reminder to stay up to date with boosters.
According to this Oct 2025 story, mumps- or measles-only (monovalent) vaccines aren't even available in this country. And the process for getting them approved is not an easy one.
So parents are now going to be beseeching their pediatricians for shots that don't exist, thanks to Trump and RFK
So parents are now going to be beseeching their pediatricians for shots that don't exist, thanks to Trump and RFK
August 10, 2026 at 10:53 PM
According to this Oct 2025 story, mumps- or measles-only (monovalent) vaccines aren't even available in this country. And the process for getting them approved is not an easy one.
So parents are now going to be beseeching their pediatricians for shots that don't exist, thanks to Trump and RFK
So parents are now going to be beseeching their pediatricians for shots that don't exist, thanks to Trump and RFK
Japan tried this. They suspended MMR in 1993 and used monovalent vaccines.
Result: coverage plummeted, measles and rubella cases shot up, they had multiple measles outbreaks (one with >100k cases), and they then switched back to MMR.
Result: coverage plummeted, measles and rubella cases shot up, they had multiple measles outbreaks (one with >100k cases), and they then switched back to MMR.
September 26, 2025 at 11:48 PM
Japan tried this. They suspended MMR in 1993 and used monovalent vaccines.
Result: coverage plummeted, measles and rubella cases shot up, they had multiple measles outbreaks (one with >100k cases), and they then switched back to MMR.
Result: coverage plummeted, measles and rubella cases shot up, they had multiple measles outbreaks (one with >100k cases), and they then switched back to MMR.
The XBB.1.5 monovalent vaccine significantly bolstered immunity against COVID-19 strains, enhancing neutralizing activity during the endemic era.
by Kang HM, Kim HJ (...) Ko JH et 17 al. in J Infect Dis #MedSky
📖 read the article:
by Kang HM, Kim HJ (...) Ko JH et 17 al. in J Infect Dis #MedSky
📖 read the article:
Natural Boosting and the Immunogenicity of the XBB.1.5 Monovalent Vaccine in the Coronavirus Disease 2019 Endemic Era: A Longitudinal Observational Study
During the COVID-19 endemic phase, natural boosting cases have increased but remain insufficient to sustain group immunity. The XBB.1.5 monovalent vaccine
academic.oup.com
December 8, 2024 at 10:33 AM
The XBB.1.5 monovalent vaccine significantly bolstered immunity against COVID-19 strains, enhancing neutralizing activity during the endemic era.
by Kang HM, Kim HJ (...) Ko JH et 17 al. in J Infect Dis #MedSky
📖 read the article:
by Kang HM, Kim HJ (...) Ko JH et 17 al. in J Infect Dis #MedSky
📖 read the article: