@biorxivpreprint.bsky.social Multi-scale gene regulatory networks for resolving transcription factor and autoimmune variant impacts on human B cell fate dynamics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 28, 2026 at 1:12 AM
@biorxivpreprint.bsky.social Multi-scale gene regulatory networks for resolving transcription factor and autoimmune variant impacts on human B cell fate dynamics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A single-nucleus multi-omic atlas of gene regulation across 21 adult human tissues https://www.biorxiv.org/content/10.64898/2026.09.25.754561v1
September 27, 2026 at 7:30 AM
A single-nucleus multi-omic atlas of gene regulation across 21 adult human tissues https://www.biorxiv.org/content/10.64898/2026.09.25.754561v1
A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping - Nature Communications
Brain gene regulation is key for neuropsychiatric disorders. Here, the authors show that profiling gene expression and chromatin states in 25 brain regions enables enhancer-promoter mapping at isoform...
www.nature.com
November 23, 2024 at 12:09 PM
A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A single-nucleus multi-omic atlas of gene regulation across 21 adult human tissues https://www.biorxiv.org/content/10.64898/2026.09.25.754561v1
September 27, 2026 at 7:30 AM
A single-nucleus multi-omic atlas of gene regulation across 21 adult human tissues https://www.biorxiv.org/content/10.64898/2026.09.25.754561v1
Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...
May 13, 2025 at 9:41 AM
Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
What kind of Game of Thrones-level multi-front war was going on between The Comics Code Authority, Marvel's production department, and Bill Everett's penchant for delineating Natasha Romanoff's nipples?
March 4, 2026 at 4:16 PM
What kind of Game of Thrones-level multi-front war was going on between The Comics Code Authority, Marvel's production department, and Bill Everett's penchant for delineating Natasha Romanoff's nipples?
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
doi.org
January 3, 2025 at 7:18 PM
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
#GenePitney #60sMusic
My Auntie adores Gene Pitney.
He also wrote He's A Rebel for The Crystals. Plus heaps more.
Lots of multi-tracked vocals & harmonies on this. 😍
Source: GENE PITNEY 📀 It Hurts To Be In Love {DES Stereo} 1964 by Smurfstools Oldies Music Time Machine
youtu.be/zJ02K5ZGs-8?...
My Auntie adores Gene Pitney.
He also wrote He's A Rebel for The Crystals. Plus heaps more.
Lots of multi-tracked vocals & harmonies on this. 😍
Source: GENE PITNEY 📀 It Hurts To Be In Love {DES Stereo} 1964 by Smurfstools Oldies Music Time Machine
youtu.be/zJ02K5ZGs-8?...
September 25, 2026 at 6:33 AM
#GenePitney #60sMusic
My Auntie adores Gene Pitney.
He also wrote He's A Rebel for The Crystals. Plus heaps more.
Lots of multi-tracked vocals & harmonies on this. 😍
Source: GENE PITNEY 📀 It Hurts To Be In Love {DES Stereo} 1964 by Smurfstools Oldies Music Time Machine
youtu.be/zJ02K5ZGs-8?...
My Auntie adores Gene Pitney.
He also wrote He's A Rebel for The Crystals. Plus heaps more.
Lots of multi-tracked vocals & harmonies on this. 😍
Source: GENE PITNEY 📀 It Hurts To Be In Love {DES Stereo} 1964 by Smurfstools Oldies Music Time Machine
youtu.be/zJ02K5ZGs-8?...
NEW publication from our lab: One of the first methodologies (FUGAsseM) for gene function prediction from microbial community multi-omics data!
www.nature.com/articles/s41...
🧵⬇️
1/8
www.nature.com/articles/s41...
🧵⬇️
1/8
Predicting functions of uncharacterized gene products from microbial communities - Nature Biotechnology
FUGAsseM predicts protein function in microbiomes using coexpression patterns from metatranscriptomes and diverse community-wide data.
www.nature.com
October 23, 2025 at 6:53 PM
NEW publication from our lab: One of the first methodologies (FUGAsseM) for gene function prediction from microbial community multi-omics data!
www.nature.com/articles/s41...
🧵⬇️
1/8
www.nature.com/articles/s41...
🧵⬇️
1/8
On pourrait dire une grosse m.rde ,mais du pied gauche, il ne porterait même pas bonheur
Laurent Wauquiez n’aurait aucun problème à soutenir Eric Zemmour à la présidentielle
L’ex-président de LR ne serait absolument pas gêné de rallier le polémiste multi-condamné s’il gagnait une primaire à laquelle LR participerait.
www.liberation.fr
November 17, 2025 at 3:48 PM
On pourrait dire une grosse m.rde ,mais du pied gauche, il ne porterait même pas bonheur
GeneChat: A Multi-Modal Large Language Model for Gene Function Prediction www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/Shashi-Sekar...
June 7, 2025 at 11:04 AM
GeneChat: A Multi-Modal Large Language Model for Gene Function Prediction www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/Shashi-Sekar...
Many areas of science, such as genetics, have found that causation is often multi-factorial: there’s no single gene for intelligence for example, but many different genes have an influence.
We are yet to learn this lesson in politics, still looking for the one weird trick other parties don’t know.
We are yet to learn this lesson in politics, still looking for the one weird trick other parties don’t know.
May 9, 2026 at 9:25 AM
Many areas of science, such as genetics, have found that causation is often multi-factorial: there’s no single gene for intelligence for example, but many different genes have an influence.
We are yet to learn this lesson in politics, still looking for the one weird trick other parties don’t know.
We are yet to learn this lesson in politics, still looking for the one weird trick other parties don’t know.
Now published in JBac. Absolutely great publishing experience!!! Thank you to editors and reviewers.https://journals.asm.org/doi/10.1128/jb.00286-26 Another great one from @tommclean.bsky.social @johninnescentre.bsky.social @hbio-isp.bsky.social
August 11, 2026 at 3:07 PM
Now published in JBac. Absolutely great publishing experience!!! Thank you to editors and reviewers.https://journals.asm.org/doi/10.1128/jb.00286-26 Another great one from @tommclean.bsky.social @johninnescentre.bsky.social @hbio-isp.bsky.social
A spatially resolved multi-omic single-cell atlas of soybean development: Cell www.cell.com/cell/fulltex...
A spatially resolved multi-omic single-cell atlas of soybean development
By integrating spatial transcriptomics and single-cell genomics technologies, we constructed
a comprehensive single-cell atlas of gene expression and chromatin accessibility of
the crop species Glycin...
www.cell.com
February 1, 2025 at 7:29 AM
A spatially resolved multi-omic single-cell atlas of soybean development: Cell www.cell.com/cell/fulltex...
Starfleet Academy continues Gene Roddenberry's teaching of "Infinite Diversity in Infinite Combinations" (IDIC). It's simply the appreciation of differences in ideas and life forms.
Gene broke barriers with diverse, multi-cultural casts and narratives, including the first interracial kiss.
Gene broke barriers with diverse, multi-cultural casts and narratives, including the first interracial kiss.
February 24, 2026 at 2:02 AM
Starfleet Academy continues Gene Roddenberry's teaching of "Infinite Diversity in Infinite Combinations" (IDIC). It's simply the appreciation of differences in ideas and life forms.
Gene broke barriers with diverse, multi-cultural casts and narratives, including the first interracial kiss.
Gene broke barriers with diverse, multi-cultural casts and narratives, including the first interracial kiss.
Just finished Aliya Whiteley's 381. Exceptionally clever, deep and multi-layered story(/ies), leaving a lot of matter to think about. Reminds me of some of Gene Wolfe's stuff in the best way,
February 14, 2024 at 10:04 PM
Just finished Aliya Whiteley's 381. Exceptionally clever, deep and multi-layered story(/ies), leaving a lot of matter to think about. Reminds me of some of Gene Wolfe's stuff in the best way,
Congratulations Dr. Chandrashekar 💐
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
doi.org/10.1101/2024...
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
doi.org/10.1101/2024...
November 25, 2024 at 11:05 AM
Congratulations Dr. Chandrashekar 💐
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
doi.org/10.1101/2024...
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
doi.org/10.1101/2024...
Today in Nature Genetics:
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41...
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
www.nature.com
January 3, 2025 at 8:19 PM
Today in Nature Genetics:
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41...
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41...
Check out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...
Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination
In human cells, large multi-protein transcription co-activators, such as chromatin remodelers or histone acetyltransferases, play critical roles in gene-expression regulation and are often implicated ...
doi.org
August 12, 2025 at 7:30 AM
Check out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...
A spatially resolved multi-omic single-cell atlas of soybean development www.cell.com/cell/fulltex...
A spatially resolved multi-omic single-cell atlas of soybean development
By integrating spatial transcriptomics and single-cell genomics technologies, we constructed a comprehensive single-cell atlas of gene expression and chromatin accessibility of the crop species Glycine max (soybean).
www.cell.com
January 1, 2025 at 6:01 AM
A spatially resolved multi-omic single-cell atlas of soybean development www.cell.com/cell/fulltex...
LDB1 establishes multi-enhancer networks to regulate gene expression www.cell.com/molecular-c...
January 24, 2025 at 3:15 PM
LDB1 establishes multi-enhancer networks to regulate gene expression www.cell.com/molecular-c...
📢 New publication 'MicroRNA-Induced Gene Silencing ( #MIGS): A Tool for Multi-Gene Silencing and Targeting Viruses in Plants' by Marie-Emilie Gauthier et al. in Plant Biotechnology Journal 🧬🧪
#RNAi #GeneSilencing
doi.org/10.1111/pbi....
#RNAi #GeneSilencing
doi.org/10.1111/pbi....
MicroRNA‐Induced Gene Silencing (MIGS): A Tool for Multi‐Gene Silencing and Targeting Viruses in Plants
Since its discovery, RNA interference (RNAi, also known as gene silencing) has been a key tool to downregulate gene expression in plants for a range of applications, including protection against viru....
doi.org
November 6, 2025 at 12:13 AM
📢 New publication 'MicroRNA-Induced Gene Silencing ( #MIGS): A Tool for Multi-Gene Silencing and Targeting Viruses in Plants' by Marie-Emilie Gauthier et al. in Plant Biotechnology Journal 🧬🧪
#RNAi #GeneSilencing
doi.org/10.1111/pbi....
#RNAi #GeneSilencing
doi.org/10.1111/pbi....