#multi-gene
Our final 2026 BME UNITE Future Faculty Seminar will be on Monday, October 5th, at 1 pm EST. Come hear from Drs. Shaniel Bowen, Kelsey Watts, and Angelea Maestas-Olguin to learn more about their ongoing work and future research programs! Register here: tinyurl.com/bmeunite2026
September 29, 2026 at 6:27 PM
Prognostic value, signal interaction network, and immune infiltration characteristics of MET gene expression in gastric cancer analyzed by multi-database bioinformatics #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.23.753715v1
September 29, 2026 at 7:00 AM
Prognostic value, signal interaction network, and immune infiltration characteristics of MET gene expression in gastric cancer analyzed by multi-database bioinformatics https://www.biorxiv.org/content/10.64898/2026.09.23.753715v1
September 29, 2026 at 4:46 AM
Prognostic value, signal interaction network, and immune infiltration characteristics of MET gene expression in gastric cancer analyzed by multi-database bioinformatics https://www.biorxiv.org/content/10.64898/2026.09.23.753715v1
September 29, 2026 at 4:46 AM
🍐🧬 RESEARCH 🧬🍐

A cross-species protoplast isolation system for woody plants is developed alongside a DNA-free CRISPR/Cas9 multiplex editing platform for Pyrus, enabling rapid trait analysis and transgene-free precision breeding - Shao et al.

🔗 doi.org/10.1093/jxb/...

#PlantScience 🧪
September 28, 2026 at 5:00 PM
🩸 How can a lipid–endothelial #signature stratify patients with #HCC?
Luxi Yang et al. explore this through an integrated multi-omics approach, linking a six-gene signature with prognosis and immune-excluded features in HCC.
🔗 buff.ly/YnGZpEo
September 28, 2026 at 4:01 PM
@biorxivpreprint.bsky.social Multi-scale gene regulatory networks for resolving transcription factor and autoimmune variant impacts on human B cell fate dynamics
www.biorxiv.org/content/10.1...
September 28, 2026 at 1:12 AM
Integrated Multi-Omics Network by Physical Exercise Across Aging: Molecular Adaptation Beyond Single Signaling Pathways
journals.physiology.org/doi/abs/10.1...
Integrated Multi-Omics Network by Physical Exercise Across Aging: Molecular Adaptation Beyond Single Signaling Pathways | Physiological Genomics | American Physiological Society
Aging is characterized by progressive molecular dysregulation across interconnected biological systems, involving alterations in epigenetic regulation, gene expression, protein homeostasis, and metabo...
journals.physiology.org
September 27, 2026 at 6:12 PM
A single-nucleus multi-omic atlas of gene regulation across 21 adult human tissues https://www.biorxiv.org/content/10.64898/2026.09.25.754561v1
September 27, 2026 at 7:30 AM
A single-nucleus multi-omic atlas of gene regulation across 21 adult human tissues https://www.biorxiv.org/content/10.64898/2026.09.25.754561v1
September 27, 2026 at 7:30 AM
Generation MLM Software Kharadi: A Practical Look at Managing Multi-Level Growth mlmengine.blogspot.com/2026/09/gene...
September 26, 2026 at 12:58 PM
“Every person in California should be able to access the most promising medical advances, including cell and gene therapies that are changing what is possible for serious and life-threatening diseases.” - Shyam Patel, Associate Vice President of Patient Access. Press release: https://bit.ly/46Feeyb
September 25, 2026 at 3:30 PM
#GenePitney #60sMusic

My Auntie adores Gene Pitney.

He also wrote He's A Rebel for The Crystals. Plus heaps more.

Lots of multi-tracked vocals & harmonies on this. 😍

Source: GENE PITNEY 📀 It Hurts To Be In Love {DES Stereo} 1964 by Smurfstools Oldies Music Time Machine

youtu.be/zJ02K5ZGs-8?...
September 25, 2026 at 6:33 AM
ISP Platform powered by Geneformer: Framework for Cross-Species, Sequential, and Multi-Gene In Silico Perturbation Screens with Application to iPS Cell State Transitions #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.17.752497v1
September 25, 2026 at 1:01 AM
ISP Platform powered by Geneformer: Framework for Cross-Species, Sequential, and Multi-Gene In Silico Perturbation Screens with Application to iPS Cell State Transitions https://www.biorxiv.org/content/10.64898/2026.09.17.752497v1
September 24, 2026 at 10:46 PM
ISP Platform powered by Geneformer: Framework for Cross-Species, Sequential, and Multi-Gene In Silico Perturbation Screens with Application to iPS Cell State Transitions https://www.biorxiv.org/content/10.64898/2026.09.17.752497v1
September 24, 2026 at 10:46 PM
Microsoft shuts down EvilTokens AI hacking service 12k email accounts compromised! Vigilance needed. #Microsoft #EvilTokens #AI #Cybersecurity #DataBreach #MFA #Hackers
Video
On September 24, 2026, Microsoft shut down EvilTokens, an AI-powered hacking service that compromised over 12,000 email accounts across 10,000 organizations. The platform used an AI chatbot to guide criminals through credential theft, stealing session tokens and bypassing multi-factor authentication entirely. While cleanup continues for affected organizations, experts warn another EvilTokens version is already in development. Stay vigilant—this was a massive cybercrime bust. Tools used for generation Text Gemini Narator Azure TTS Clips Pexel Rendering Remotion
www.youtube.com
September 24, 2026 at 7:37 PM
Some of those against diversity equality & inclusion appear to favor incest. Making babies but only among their own kind..!? They wouldn't call that inbreeding tho. Perish the thought! Personally I feel we need more multi-racial babies cuz it improves the gene pool! youtu.be/Nm6J_5xwJW0?...
Paul McCartney & Stevie Wonder - Ebony and Ivory (1982/HD)
YouTube video by rokum71
youtu.be
September 24, 2026 at 6:03 PM
Shredtools is making it easier to explore regions across a pangenome by quickly finding matching genomic regions across hundreds of genomes.

The tool can identify a gene region across 476 human genomes in approximately half a second. 

Read more: www.biorxiv.org/content/10.6...
Navigating the pangenome coordinate system with Shredtools
Existing notions of pangenome coordinates rely on hard-to-compute multiple sequence alignments. On the other hand, pangenome-wide exact unique matches (multi-MUMs) can be computed efficiently, and rep...
www.biorxiv.org
September 24, 2026 at 4:34 PM
Changes in metabolic pathways are frequently seen in cancer cells, and mutations in certain metabolic genes may even play a direct role in cancer development and progression. One gene for which this is true is the multi-localizing gene FH.

www.proteinatlas.org/news/2026-09...
September 24, 2026 at 8:28 AM
Software engineering is now just manager AIs bossing around budget sub-agents while visual models manually click buttons on your desktop. Dictate another micro-app into your mic, why don't you.
Great now GPT-6 Soul has a perfect test pass rate
The 30-Second Rundown * **Multi-agent software architectures are shifting heavy execution workloads from expensive primary models to ultra-cheap specialized worker models.** — Reduces LLM operational costs by up to 90% while maintaining complex reasoning capabilities. * **Universal screen-based computer use has reached operational speed and visual fluency thresholds.** — Bypasses expensive custom API development and connector maintenance for legacy enterprise software. * **Dynamic AI-generated web micro-applications are actively replacing static spreadsheets and slide decks across enterprise teams.** — Empowers non-technical staff to deploy interactive internal micro-apps directly from voice and text prompts. * **Automated repository auditing pipelines running specialized low-cost worker models can fix software bugs with 100% test pass rates.** — Maximizes CI/CD security coverage without spending top-tier model tokens on routine codebase maintenance. ## Guru Chatter ### Hub and Spoke Multi Agent Orchestration Architectures **TL;DR:** High-level AI models now act as lead architects that plan complex software projects and delegate repetitive coding tasks to smaller, highly affordable worker models. High-cost reasoning models (e.g., Claude Opus 5.5, OpenAI Luna) act as strategic orchestrators, maintaining system planning and execution state without context-window inflation, while delegating discrete coding sub-tasks to high-throughput, low-cost sub-agents (e.g., GPT-6 Soul, OpenAI Astra in Code Mode). **Market impact:** Compute spending will consolidate around reserving top-tier, floating-point dense inference for spatial and logical planning while offloading deterministic execution to low-cost API endpoints. Capital allocation should favor orchestration middleware and multi-tier agent frameworks over monolithic model deployments. **Sources:** AI News & Strategy Daily | Nate B Jones · Nate Herk | AI Automation * * * ### Universal GUI Computer Use Over Native Integration APIs **TL;DR:** AI models can now visually navigate desktop applications and web pages just like human operators, bypassing the need for custom programming connectors. Rapid improvements in visual token processing latency allow computer use models to interact with legacy software, unstructured form inputs, and desktop interfaces directly via visual screen capture and mouse emulation, eliminating reliance on native APIs or Model Context Protocol (MCP) software bridges. **Market impact:** Value shifts away from intermediate SaaS connector middleware toward low-latency, execution-focused client platforms with visual control capabilities. Portfolios should overweight compute infrastructure optimized for high-frame-rate visual token streaming. **Sources:** AI News & Strategy Daily | Nate B Jones * * * ### Dynamic AI Generated Web Artifacts Replacing Static Productivity Suites **TL;DR:** Knowledge workers are replacing static documents and spreadsheets with dynamic, interactive web micro-apps generated on the fly by AI. Knowledge work is transitioning from static documents, slide decks, and spreadsheets toward dynamic AI-generated web artifacts and micro-applications ('Sites'). Non-technical domain experts across enterprise functions are generating interactive tools to capture operational logic and deploying them directly. **Market impact:** Disrupts legacy enterprise productivity suites. Software strategy must pivot toward platforms enabling real-time user interface synthesis, automated dynamic app deployment, and client-side sandboxed execution runtimes designed for dynamic AI generation. **Sources:** AI News & Strategy Daily | Nate B Jones * * * ### Model Capability Bifurcation for Creative Design versus Low Cost Maintenance **TL;DR:** Top-tier models excel at complex visual and 3D web design, while cheaper mid-tier models actually perform better on routine bug fixes. Top-tier models demonstrate massive superiority in multi-modal visual synthesis, scroll-driven website design, and complex spatial generation, whereas mid-tier specialized models outperform in structured, repetitive codebase reviews, vulnerability testing, and deterministic bug fixing at a fraction of the cost. **Market impact:** Directs tech portfolio allocation away from high-tier models in CI/CD (Continuous Integration / Continuous Delivery) and DevOps maintenance pipelines. Compute hardware infrastructure will bifurcate into high-throughput edge/server nodes for code execution and heavy compute clusters for multi-modal spatial generation. **Sources:** Nate Herk | AI Automation * * * ### Enterprise Autonomous Agents Deeply Embedded in Proprietary Data Ecosystems **TL;DR:** AI agents are evolving from passive chatbots into active digital workers embedded directly within enterprise management platforms. The enterprise landscape is shifting from passive generative assistants to proactive autonomous agents deeply embedded in CRM (Customer Relationship Management) and messaging ecosystems (e.g., Salesforce Agentforce, Slack). These agents pull context directly from enterprise data lakes to execute backend operational tasks autonomously. **Market impact:** Accelerates capital allocation toward enterprise agent orchestration platforms and API-first software architectures. Long-term investment strategies must favor platforms with deep proprietary context over standalone model wrappers. **Sources:** AI News & Strategy Daily | Nate B Jones ## Master Workflows Today's Top Pick ### Automated Low Cost Codebase Audit and Vulnerability Repair Pipeline Intermediate~15 min **Why it's worth it:** Cuts vulnerability repair costs by 95% while achieving a 100% test pass rate on structural codebase fixes. Runs automated full-repository scans, unit test checks, and bug remediation using a low-cost specialized model (GPT-6 Soul) inside a headless CLI environment, enforcing security overrides and compliance checks. Codex Desktop CLIGPT-6 SoulPythonBash 1. Navigate to your target project directory on your server or desktop workstation. cd /path/to/your/target-repository 2. Execute Codex CLI using the low-cost engine to scan the repository code, repair identified bugs, and run unit tests. codex-cli review --repo ./src --fix-bugs --run-tests --model gpt-6-soul 3. Export environment security overrides if automated dependency scans trigger false-positive cybersecurity circuit breakers. export SECURITY_CHECK_OVERRIDE=true 4. Run automated post-repair compliance validation scripts to confirm all unit checks achieve full pass thresholds. python3 test_runner.py --repo ./src --pass-threshold 100 **Sources:** Nate Herk | AI Automation ### Isolated Workspace Setup for Parallel Multi Agent Execution Advanced~30 min **Why it's worth it:** Prevents file corruption and context collision when running multiple AI coding agents concurrently on a single repository. Uses Git worktrees and strict configuration scopes to isolate working environments for concurrent high-reasoning orchestrators and lightweight worker sub-agents on macOS or Linux servers. Claude Code CLIOpus 5.5Codex Desktop CLIGPT-6 SoulGit 1. Create distinct Git worktree branches for each agent to ensure file isolation. git worktree add -b feature-opus ./workspaces/opus-env git worktree add -b feature-soul ./workspaces/soul-env 2. Configure agent boundary parameters in the local settings files to restrict agents to their assigned working directory. { "do_not_overwrite_external_files": true, "isolated_scope": "./workspaces/current" } 3. Launch Claude Code in the dedicated Opus workspace directory. claude --model opus-5.5 --cwd ./workspaces/opus-env 4. Launch Codex CLI concurrently in the Soul workspace directory. codex --model gpt-6-soul --cwd ./workspaces/soul-env 5. Review generated execution logs and merge validated feature branches back into the main repository. git merge feature-opus **Sources:** Nate Herk | AI Automation ### Token Efficient Multi Tier Agent Orchestration Setup Advanced~45 min **Why it's worth it:** Maintains long-horizon project context without token context window inflation, saving cost on complex multi-hour code transformations. Configures a high-reasoning orchestrator model (Luna) to delegate discrete code sub-tasks to fast sub-agents (Astra in Code Mode) using automated context-clearing dispatch scripts. OpenAI LunaOpenAI AstraCode ModeCodex CLIBash 1. Define environment variables for the orchestrator and worker executor models in your terminal session. export ORCHESTRATOR_MODEL="luna-high-agency" export EXECUTOR_MODEL="astra-code-mode" 2. Initialize a long-running orchestrator session in Codex CLI. codex session start --name "enterprise-orchestrator" --model $ORCHESTRATOR_MODEL 3. Create an automated dispatch script to strip global context history before sending sub-tasks to worker agents. cat << 'EOF' > dispatch_subagent.sh #!/bin/bash TASK_SPEC="$1" python3 -m codex.subagent --model $EXECUTOR_MODEL --prompt "$TASK_SPEC" --clear-context-on-completion EOF chmod +x dispatch_subagent.sh 4. Execute orchestrator loops by allowing the high-agency model to trigger the dispatch script for sub-task execution. ./dispatch_subagent.sh "Refactor database access layer" **Sources:** AI News & Strategy Daily | Nate B Jones ### Autonomous Computer Use for Legacy Document Parsing and Form Automation Intermediate~20 min **Why it's worth it:** Eliminates manual data entry across legacy enterprise software and unstructured PDFs without building custom APIs. Grants screen recording and system access permissions to visual AI computer use agents to extract data from desktop interfaces and output structured CSV files. OpenAI Codex AppAstra Computer Use ModemacOS System Permissions 1. Grant macOS system accessibility and screen recording permissions to the Codex desktop application. open "x-apple.systempreferences:com.apple.preference.security?Privacy_Accessibility" 2. Open the target desktop application or document file locally on screen. 3. Launch autonomous computer use mode in Codex CLI targeting your document workflow. codex computer-use --target "Legacy Tax Document Scanning" --display-pointer --mode autonomous 4. Enable the data analysis plugin to format extracted visual data into structured tabular output files. codex plugin enable data-analysis-plugin --format csv --output ./tax_report.csv **Sources:** AI News & Strategy Daily | Nate B Jones ### Voice Driven Context Ingestion to Dynamic Web Artifact Generation Intermediate~20 min **Why it's worth it:** Allows non-technical business experts to convert verbal domain logic into deployable interactive web apps in minutes. Captures streaming voice input via Whisper Flow to dictate business requirements into Codex, automatically generating an interactive web micro-application ('Site') running locally. Whisper FlowOpenAI Codex AppChatGPT WorkNode.js 1. Open the OpenAI Codex desktop client on macOS and activate Whisper Flow continuous voice capture mode. 2. Dictate the domain logic, calculation rules, and user interface layout specifications for your interactive reporting tool. 3. Instruct Codex to instantiate an interactive web site artifact project based on the dictated specifications. codex build site --template interactive-dashboard --output ./team-site 4. Launch the local development preview server to inspect and test the interactive web site artifact. cd team-site && npm install && npm run dev **Sources:** AI News & Strategy Daily | Nate B Jones ### Salesforce AI Agentic Task Automation Setup Intermediate~45 min **Why it's worth it:** Automates repetitive backend CRM operations by deploying autonomous agents connected directly to Salesforce Data Cloud and Slack. Binds Salesforce Agentforce agents to real-time Data Cloud objects and Slack workspace triggers for continuous backend enterprise task execution. Salesforce AgentforceSlackSalesforce Data Cloud 1. Log into your Salesforce enterprise console and open the Agent Studio configuration dashboard. 2. Define the operational boundary and primary autonomous objectives for the enterprise agent. 3. Bind the agent to target Salesforce Data Cloud objects to ensure access to real-time business context. 4. Connect the agent to your Slack workspace by configuring custom action triggers and automated notifications. 5. Validate agent execution in a sandbox environment before enabling continuous automated operations in production. **Sources:** AI News & Strategy Daily | Nate B Jones ## Videos Covered Today * AI News & Strategy Daily | Nate B Jones — As you can see ... I had a great time at Dreamforce #AI #Dreamforce #Salesforce #agents * AI News & Strategy Daily | Nate B Jones — Does Your Computer Belong To Codex? I Went To OpenAI To Ask. * Nate Herk | AI Automation — I Tested Opus 5.5 vs. GPT-6 Sol on 10 Real Use Cases Generated and deployed by Hiro Digest Engine v2.3.8
www.headlesshiro.com
September 23, 2026 at 12:02 PM
Interested in our workflows? Request a demo 👉 vugene.com/demo/
DEMO - VUGENE
Schedule a demo review with our team Discover how we can empower your research with advanced data analysis solutions. Featured demo projects: Multi-omics analysis Proteomics analysis Gene expression a...
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September 23, 2026 at 8:56 AM
Meng et al. developed #BPGA, an enzyme-free in vivo Bxb1-ParA recombinase system in standard DH5α E. coli that iteratively stacks #multi-gene plant vectors, demonstrated by assembling a 9-TU, 41.551 kb andrographolide pathway construct. 🌿🤖 #PlantPhysiology #SyntheticBiology #MetabolicEngineering
September 23, 2026 at 7:03 AM