3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets: Cell Reports www.cell.com/cell-reports...
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets
Vijayakumaran et al. present a three-dimensional nanoscale reconstruction of human
airway multiciliogenesis, revealing extensive organelle and architectural remodeling.
They show that rootlets form ev...
www.cell.com
July 29, 2026 at 11:57 AM
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets: Cell Reports www.cell.com/cell-reports...
Our 52nd BSCB GenSoc UK Cilia and Centrosome e-symposium kicks off with a spectacular #super-resolution showcase on how RPGR variants affect #multiciliogenesis & cilia motility to cause #PCD or #IRDs via #actin dynamics! Zhen Liu wows- ICYMI: www.biorxiv.org/content/10.1... #UKCilia2025 /1
August 19, 2025 at 5:11 PM
Our 52nd BSCB GenSoc UK Cilia and Centrosome e-symposium kicks off with a spectacular #super-resolution showcase on how RPGR variants affect #multiciliogenesis & cilia motility to cause #PCD or #IRDs via #actin dynamics! Zhen Liu wows- ICYMI: www.biorxiv.org/content/10.1... #UKCilia2025 /1
Cool paper about special cell cycle regulation for multiciliogenesis! #cilia #cellbio #cellcycle www.sciencedirect.com/science/arti...
Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis
Meiosis, endoreplication, and asynthetic fissions are variations of the canonical cell cycle where either replication or mitotic divisions are muted. …
www.sciencedirect.com
January 10, 2025 at 7:48 PM
Cool paper about special cell cycle regulation for multiciliogenesis! #cilia #cellbio #cellcycle www.sciencedirect.com/science/arti...
New from CiRA in Stem Cell Reports! Deuterosomal cells are the responsible lineage for multiciliogenesis in human airway differentiation. An iPSC-based platform for investigating mechanisms underlying airway multiciliogenesis and modeling primary ciliary dyskinesia. https://ow.ly/8afr50YwSbK
March 25, 2026 at 5:30 PM
New from CiRA in Stem Cell Reports! Deuterosomal cells are the responsible lineage for multiciliogenesis in human airway differentiation. An iPSC-based platform for investigating mechanisms underlying airway multiciliogenesis and modeling primary ciliary dyskinesia. https://ow.ly/8afr50YwSbK
@natmosqueda.bsky.social, @psutton54.bsky.social and @brownlee.bsky.social @stonybrooku.bsky.social discover that importin α plays a regulatory role in ciliogenesis and cilia length with implications for Xenopus nephrogenesis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 4, 2025 at 10:07 AM
@natmosqueda.bsky.social, @psutton54.bsky.social and @brownlee.bsky.social @stonybrooku.bsky.social discover that importin α plays a regulatory role in ciliogenesis and cilia length with implications for Xenopus nephrogenesis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Cool new story which discovers a novel role for the multiciliogenesis-linked transcription factor McIdas (aka Multicilin) in centriole duplication.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation - EMBO Reports
The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle. Aberrations in centriole biogenesis can cause developmental disorders, ciliopathies and cancer, ye...
link.springer.com
February 14, 2026 at 8:53 PM
Cool new story which discovers a novel role for the multiciliogenesis-linked transcription factor McIdas (aka Multicilin) in centriole duplication.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The MYB family is of particular interest due to its role in regulating ciliogenesis and centriole biogenesis
pubmed.ncbi.nlm.nih.gov/24048590/
both of which are important for regeneration in Stentor.
pubmed.ncbi.nlm.nih.gov/24048590/
both of which are important for regeneration in Stentor.
Myb promotes centriole amplification and later steps of the multiciliogenesis program - PubMed
The transcriptional control of primary cilium formation and ciliary motility are beginning to be understood, but little is known about the transcriptional programs that control cilium number and other...
pubmed.ncbi.nlm.nih.gov
December 2, 2024 at 9:42 PM
The MYB family is of particular interest due to its role in regulating ciliogenesis and centriole biogenesis
pubmed.ncbi.nlm.nih.gov/24048590/
both of which are important for regeneration in Stentor.
pubmed.ncbi.nlm.nih.gov/24048590/
both of which are important for regeneration in Stentor.
An ancient transcription activator is required for the multiciliogenesis program https://www.biorxiv.org/content/10.1101/2023.12.16.571971v1
An ancient transcription activator is required for the multiciliogenesis program https://www.biorxiv.org/content/10.1101/2023.12.16.571971v1
Multiciliogenesis is an evolutionarily conserved process required a unique transcriptional program.
www.biorxiv.org
December 17, 2023 at 1:30 PM
An ancient transcription activator is required for the multiciliogenesis program https://www.biorxiv.org/content/10.1101/2023.12.16.571971v1
The Joubert syndrome protein CSPP1 is a conserved regulator of vertebrate multiciliogenesis and motile cilia function https://www.biorxiv.org/content/10.64898/2026.03.20.713242v1
March 23, 2026 at 6:30 PM
The Joubert syndrome protein CSPP1 is a conserved regulator of vertebrate multiciliogenesis and motile cilia function https://www.biorxiv.org/content/10.64898/2026.03.20.713242v1
RRIDs were included in this in The EMBO Reports paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #reproducibility #ReproducibleResearch
Male infertility‐associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery
Read the full paper: Male infertility‐associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery
doi.org
September 20, 2026 at 7:00 AM
RRIDs were included in this in The EMBO Reports paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #reproducibility #ReproducibleResearch
RRID:AB_2223041 was used by the authors of the Cell Reports paper "Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis".RRIDs like this improve reproducibility in scientific research. #methodsmatter #accelerateopenscience
doi.org
January 5, 2025 at 12:34 PM
RRID:AB_2223041 was used by the authors of the Cell Reports paper "Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis".RRIDs like this improve reproducibility in scientific research. #methodsmatter #accelerateopenscience
I am delighted to see this amazing collaborative paper out in press. Using gene edited human ES cells differentiated into airway epithelium to uncover a novel role for MCIDAS in multiciliogenesis.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Nuclear-cytoplasmic translocation of MCIDAS couples transcription with massive de novo centriole biogenesis in multiciliated cells
How multiciliated cells (MCCs) generate hundreds of centrioles for multiciliation
has remained an unresolved problem in cell biology. Lu et al. show that the MCC “master”
transcriptional regulator, MC...
www.cell.com
September 22, 2025 at 3:20 PM
I am delighted to see this amazing collaborative paper out in press. Using gene edited human ES cells differentiated into airway epithelium to uncover a novel role for MCIDAS in multiciliogenesis.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
🥁Back to back on @cp-cellreports.bsky.social
👉Cyclin switch tailors a cell cycle variant to
orchestrate multiciliogenesis
🔗https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01454-2
👏Congratulations to Jacques Serizay, @michellakd.bsky.social, Alice Meunier and all authors and collaborators!
👉Cyclin switch tailors a cell cycle variant to
orchestrate multiciliogenesis
🔗https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01454-2
👏Congratulations to Jacques Serizay, @michellakd.bsky.social, Alice Meunier and all authors and collaborators!
February 17, 2025 at 4:30 PM
🥁Back to back on @cp-cellreports.bsky.social
👉Cyclin switch tailors a cell cycle variant to
orchestrate multiciliogenesis
🔗https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01454-2
👏Congratulations to Jacques Serizay, @michellakd.bsky.social, Alice Meunier and all authors and collaborators!
👉Cyclin switch tailors a cell cycle variant to
orchestrate multiciliogenesis
🔗https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01454-2
👏Congratulations to Jacques Serizay, @michellakd.bsky.social, Alice Meunier and all authors and collaborators!
Check out their papers on this work here:
www.researchsquare.com/article/rs-5...
www.science.org/doi/10.1126/...
www.researchsquare.com/article/rs-5...
www.science.org/doi/10.1126/...
Molecular basis for the activation of outer dynein arms in cilia
Multiciliogenesis requires large-scale biosynthesis of motility-powering axonemal inner and outer dynein arm motors (IDA and ODA) prior to their intraflagellar transport (IFT) into cilia. ODAs are inh...
www.researchsquare.com
July 31, 2025 at 3:54 PM
Check out their papers on this work here:
www.researchsquare.com/article/rs-5...
www.science.org/doi/10.1126/...
www.researchsquare.com/article/rs-5...
www.science.org/doi/10.1126/...
Interesting new paper showing “cell can co-opt the #cellcycle genetic program and regulate only certain elements to qualitatively and quantitatively divert #CDK activity toward differentiation rather than division”
Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis - PubMed
Meiosis, endoreplication, and asynthetic fissions are variations of the canonical cell cycle where either replication or mitotic divisions are muted. Here, we identify a cell cycle variantconserved ac...
pubmed.ncbi.nlm.nih.gov
January 1, 2025 at 10:15 PM
Interesting new paper showing “cell can co-opt the #cellcycle genetic program and regulate only certain elements to qualitatively and quantitatively divert #CDK activity toward differentiation rather than division”
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets
Vijayakumaran et al. present a three-dimensional nanoscale reconstruction of human airway multiciliogenesis, revealing extensive organelle and architectural remodeling. They show that rootlets form evolutionarily distinct arrays, oscillate with motile cilia, and support mitochondrial respiratory capacity. Nanoscale mapping further identifies CROCC2 as an early component of the basal body-rootlet linker.
dlvr.it
August 15, 2026 at 2:38 PM
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets
@thermofishersci.bsky.social's resource, RRID:AB_2541995, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #STMpublishing
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets
Read the full paper: 3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets
doi.org
July 24, 2026 at 7:00 AM
@thermofishersci.bsky.social's resource, RRID:AB_2541995, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #STMpublishing
What do #DNADamageRepair, #CentrioleBiogenesis and #R-loops have in common- required for multiciliogenesis, where DNA damage scales with number of forming #centrioles! Masterclass talk Cayla Jewett (Pearson lab, Anschutz, UColorado). www.biorxiv.org/content/10.1... #UKCilia2025 /5
August 19, 2025 at 5:30 PM
What do #DNADamageRepair, #CentrioleBiogenesis and #R-loops have in common- required for multiciliogenesis, where DNA damage scales with number of forming #centrioles! Masterclass talk Cayla Jewett (Pearson lab, Anschutz, UColorado). www.biorxiv.org/content/10.1... #UKCilia2025 /5
published alongside this great companion paper as well
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis
Does a genuine cell cycle variant control centriole amplification in multiciliated
cells? Serizay et al. tackle this question by performing single-cell RNA-seq during
MCC differentiation. They show th...
www.cell.com
January 13, 2025 at 9:26 PM
published alongside this great companion paper as well
www.cell.com/cell-reports...
www.cell.com/cell-reports...
DNAAF9 (Shulin) and ARL3 regulate the transport and activation of ciliary Outer Dynein Arms https://www.biorxiv.org/content/10.1101/2024.08.15.608058v1
DNAAF9 (Shulin) and ARL3 regulate the transport and activation of ciliary Outer Dynein Arms https://www.biorxiv.org/content/10.1101/2024.08.15.608058v1
Multiciliogenesis requires large-scale biosynthesis of motility-powering axonemal inner and outer dy
www.biorxiv.org
August 16, 2024 at 8:30 AM
DNAAF9 (Shulin) and ARL3 regulate the transport and activation of ciliary Outer Dynein Arms https://www.biorxiv.org/content/10.1101/2024.08.15.608058v1
An ancient transcription activator is required for the multiciliogenesis program https://www.biorxiv.org/content/10.1101/2023.12.16.571971v1
An ancient transcription activator is required for the multiciliogenesis program https://www.biorxiv.org/content/10.1101/2023.12.16.571971v1
Multiciliogenesis is an evolutionarily conserved process required a unique transcriptional program.
www.biorxiv.org
December 17, 2023 at 1:30 PM
An ancient transcription activator is required for the multiciliogenesis program https://www.biorxiv.org/content/10.1101/2023.12.16.571971v1
The Joubert syndrome protein CSPP1 is a conserved regulator of vertebrate multiciliogenesis and motile cilia function https://www.biorxiv.org/content/10.64898/2026.03.20.713242v1
March 23, 2026 at 6:30 PM
The Joubert syndrome protein CSPP1 is a conserved regulator of vertebrate multiciliogenesis and motile cilia function https://www.biorxiv.org/content/10.64898/2026.03.20.713242v1
DNAAF9 (Shulin) and ARL3 regulate the transport and activation of ciliary Outer Dynein Arms https://www.biorxiv.org/content/10.1101/2024.08.15.608058v1
DNAAF9 (Shulin) and ARL3 regulate the transport and activation of ciliary Outer Dynein Arms https://www.biorxiv.org/content/10.1101/2024.08.15.608058v1
Multiciliogenesis requires large-scale biosynthesis of motility-powering axonemal inner and outer dy
www.biorxiv.org
August 16, 2024 at 8:30 AM
DNAAF9 (Shulin) and ARL3 regulate the transport and activation of ciliary Outer Dynein Arms https://www.biorxiv.org/content/10.1101/2024.08.15.608058v1
Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis
Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis
(Cell Reports 44, 115103, January 28, 2024)
dlvr.it
November 5, 2025 at 12:23 AM
Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis