A reagentless, wireless, wearable aptamer nanobiosensor interfaced with a gold nanoparticle-MXene-based electrode enables the selective, automatic and non-invasive analysis of the female hormone oestr...

Toxin in baby food? Study’s nanobiosensor detects AFB1 at 0.09 μg/kg—ensures safety. #FoodSafety #Nanobiosensor

Since the term nanobiosensor first emerged over three decades ago, the field has witnessed an explosion of groundbreaking research. Thanks to the development of advanced nanomaterials and nanotechnolo...

Nature Nanotechnology, Published online: 15 October 2025; doi:10.1038/s41565-025-02038-4Since the term nanobiosensor first emerged over three decades ago, the field has witnessed an explosion of groundbreaking research. Thanks to the development of advanced nanomaterials and nanotechnologies, combined with decades of expertise in biosensing, a wide range of innovative and improved nanobiosensors have been reported, but many challenges remain. For this technology to truly meet real-world needs — particularly in global health and related applications — further efforts are needed to improve performance, useability, scalability and cost-effectiveness.

Journal of Medical Internet Research 21, https://doi.org/10.2196/13404 (2019). Ye, C. et al. A wearable aptamer nanobiosensor for non-invasive ...

Explore current imaging, serological, and immunological techniques for identifying hydatid cysts in cystic echinococcosis as well as the recent breakthroughs in recombinant antigen-based assays and…

Diagnostic sensor technologies lie at the core of the healthcare system and encompass disease screening, detection, and therapy monitoring. In past decades, many nanobiosensor technologies have emerged which rely on diverse principles using electrical, magnetic, mass-based, or photonic signal transduction methods. We provide an overview of recent and emerging nanobiosensing transduction technologies and illustrate the reported quantification capabilities for nucleic acids, proteins, and small molecules. The review assesses and compares their performance, multimodality, and multiplexing capabilities as well as their portability and throughput, among other criteria. In addition, we elaborate on demonstrated as well as envisaged medical applications of nanobiosensors. Finally, fundamental limitations such as the diffusion limit are discussed and opportunities for future research are outlined.