Protecting axonal mitochondria prevents chemotherapy-driven neuropathy
Protecting axonal mitochondria prevents chemotherapy-driven neuropathy
Peripheral neuropathy is a poorly understood yet extraordinarily relevant obstacle to the effective implementation of cytotoxic chemotherapy in patients with cancer. Recent findings from Heles et al. demonstrate that safe neuroactive molecules that promote mitochondrial fitness in axons effectively prevent peripheral neuropathy in preclinical tumor models, thereby supporting clinical translation.
dlvr.it
October 9, 2026 at 12:22 PM
Protecting axonal mitochondria prevents chemotherapy-driven neuropathy
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #reproducibility #STMpublishing #accelerateopenscience
Rewired Neuroactive Ligand-Receptor Signaling Confers Adaptive Resistance to BCL-2 Inhibition in AML
A major challenge in treating AML with the BCL-2 inhibitor venetoclax is the frequent development of drug resistance, which diminishes therapeutic efficacy and leads to patient death. The fundamental mechanisms underlying this resistance are not fully understood. Here, we established venetocla...
doi.org
October 9, 2026 at 7:04 AM
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #reproducibility #STMpublishing #accelerateopenscience
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug (Brumm et al., 2026). www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of…
www.science.org
October 5, 2026 at 4:45 PM
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug (Brumm et al., 2026). www.science.org/doi/10.1126/...
El análisis biomolecular de los dientes de dos cazadores-recolectores preagrícolas de Sulawesi, Indonesia (el más antiguo de 25-16 ka), sugiere succión habitual y permanencia prolongada de nueces de betel en la boca, lo que libera arecolina, sustancia psicoactiva.
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of…
www.science.org
October 5, 2026 at 4:45 PM
El análisis biomolecular de los dientes de dos cazadores-recolectores preagrícolas de Sulawesi, Indonesia (el más antiguo de 25-16 ka), sugiere succión habitual y permanencia prolongada de nueces de betel en la boca, lo que libera arecolina, sustancia psicoactiva.
I am not going to listen to 'Choosin' Texas' just cause some Roilling Stone dipshit says I should.
#MusicSky
youtu.be/uSpFm_ZBJSo?...
#MusicSky
youtu.be/uSpFm_ZBJSo?...
Shrieks and Sighs
YouTube video by Neuroactive - Topic
youtu.be
September 27, 2026 at 3:20 PM
I am not going to listen to 'Choosin' Texas' just cause some Roilling Stone dipshit says I should.
#MusicSky
youtu.be/uSpFm_ZBJSo?...
#MusicSky
youtu.be/uSpFm_ZBJSo?...
Neurae Harmonie The Eye Contour targets fine lines, puffiness, and dark circles with a cooling metal tip and neuroactive ingredients for stress- and fatigue-related under-eye effects.
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briefly.co
September 15, 2026 at 12:45 PM
Neurae Harmonie The Eye Contour targets fine lines, puffiness, and dark circles with a cooling metal tip and neuroactive ingredients for stress- and fatigue-related under-eye effects.
Neurae Harmonie The Eye Contour targets fine lines, puffiness, and dark circles with a cooling metal tip and neuroactive ingredients for stress- and fatigue-related under-eye effects.
Save What Matters
Curate Feeds | Make Collections | Customize Email Briefs
briefly.co
September 15, 2026 at 12:45 PM
Neurae Harmonie The Eye Contour targets fine lines, puffiness, and dark circles with a cooling metal tip and neuroactive ingredients for stress- and fatigue-related under-eye effects.
Neurae Harmonie The Eye Contour targets fine lines, puffiness, and dark circles with a cooling metal tip and neuroactive ingredients for stress- and fatigue-related under-eye effects.
Save What Matters
Curate Feeds | Make Collections | Customize Email Briefs
briefly.co
September 15, 2026 at 12:43 PM
Neurae Harmonie The Eye Contour targets fine lines, puffiness, and dark circles with a cooling metal tip and neuroactive ingredients for stress- and fatigue-related under-eye effects.
#考古学のおやつ 2/2
▶ Adam Brumm 𝑒𝑡 𝑎𝑙. (2026) Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug. 𝑆𝑐𝑖𝑒𝑛𝑐𝑒 𝐴𝑑𝑣𝑎𝑛𝑐𝑒𝑠, Vol 12, Issue 37. doi.org/10.1126/scia...
▶ Adam Brumm 𝑒𝑡 𝑎𝑙. (2026) Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug. 𝑆𝑐𝑖𝑒𝑛𝑐𝑒 𝐴𝑑𝑣𝑎𝑛𝑐𝑒𝑠, Vol 12, Issue 37. doi.org/10.1126/scia...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of t...
doi.org
September 14, 2026 at 12:43 PM
#考古学のおやつ 2/2
▶ Adam Brumm 𝑒𝑡 𝑎𝑙. (2026) Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug. 𝑆𝑐𝑖𝑒𝑛𝑐𝑒 𝐴𝑑𝑣𝑎𝑛𝑐𝑒𝑠, Vol 12, Issue 37. doi.org/10.1126/scia...
▶ Adam Brumm 𝑒𝑡 𝑎𝑙. (2026) Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug. 𝑆𝑐𝑖𝑒𝑛𝑐𝑒 𝐴𝑑𝑣𝑎𝑛𝑐𝑒𝑠, Vol 12, Issue 37. doi.org/10.1126/scia...
#Gut #bacteria linked to #key #brain #chemicals in 1st-of-its-kind human study
The #neuroactive potential of bacteria living in the human gut is associated with levels of key chemicals in the brain, according to a new study in Molecular Psychiatry>> scitechupdates.com/g...
The #neuroactive potential of bacteria living in the human gut is associated with levels of key chemicals in the brain, according to a new study in Molecular Psychiatry>> scitechupdates.com/g...
September 14, 2026 at 6:32 AM
#Gut #bacteria linked to #key #brain #chemicals in 1st-of-its-kind human study
The #neuroactive potential of bacteria living in the human gut is associated with levels of key chemicals in the brain, according to a new study in Molecular Psychiatry>> scitechupdates.com/g...
The #neuroactive potential of bacteria living in the human gut is associated with levels of key chemicals in the brain, according to a new study in Molecular Psychiatry>> scitechupdates.com/g...
25,000-Year-Old Teeth Reveal the World’s Oldest Drug Habit
Deep grooves in the teeth of two ice age hunter-gatherers from Sulawesi, Indonesia, reveal that people were habitually sucking on betel nuts for pain relief as far back as 25,000 years ago, the oldest known evidence of habitual neuroactive…
Deep grooves in the teeth of two ice age hunter-gatherers from Sulawesi, Indonesia, reveal that people were habitually sucking on betel nuts for pain relief as far back as 25,000 years ago, the oldest known evidence of habitual neuroactive…
25,000-Year-Old Teeth Reveal the World’s Oldest Drug Habit
Deep grooves in the teeth of two ice age hunter-gatherers from Sulawesi, Indonesia, reveal that people were habitually sucking on betel nuts for pain relief as far back as 25,000 years ago, the oldest known evidence of habitual neuroactive plant use, predating farming by tens of thousands of years.
livequrious.com
September 12, 2026 at 5:46 PM
25,000-Year-Old Teeth Reveal the World’s Oldest Drug Habit
Deep grooves in the teeth of two ice age hunter-gatherers from Sulawesi, Indonesia, reveal that people were habitually sucking on betel nuts for pain relief as far back as 25,000 years ago, the oldest known evidence of habitual neuroactive…
Deep grooves in the teeth of two ice age hunter-gatherers from Sulawesi, Indonesia, reveal that people were habitually sucking on betel nuts for pain relief as far back as 25,000 years ago, the oldest known evidence of habitual neuroactive…
Preagricultural foragers who sucked on whole betel nuts may be the earliest examples of human drug use, a new #ScienceAdvances study finds. scim.ag/4gOrRkp
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of t...
scim.ag
September 12, 2026 at 12:43 PM
Preagricultural foragers who sucked on whole betel nuts may be the earliest examples of human drug use, a new #ScienceAdvances study finds. scim.ag/4gOrRkp
Preagricultural foragers who sucked on whole betel nuts may be the earliest examples of human drug use, a new #ScienceAdvances study finds. https://scim.ag/4xl4LHe
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of two preagricultural foragers from Sulawesi (Indonesia)...
scim.ag
September 11, 2026 at 6:29 PM
Preagricultural foragers who sucked on whole betel nuts may be the earliest examples of human drug use, a new #ScienceAdvances study finds. https://scim.ag/4xl4LHe
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug | Science Advances www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of t...
www.science.org
September 11, 2026 at 10:38 PM
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug | Science Advances www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of t...
www.science.org
September 11, 2026 at 7:07 AM
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug www.science.org/doi/10.1126/...
World's oldest evidence of habitual drug use from 25,000 y ago. Hunter-gatherers sucked on betel nuts that contain a neuroactive substance. Prehistoric plant-based drugs include 10,000 yo psychedelic cactus pollen in Peru and 13,000 yo beer in Israel.
buff.ly/Z5me9ZU
buff.ly/Z5me9ZU
World's oldest evidence of habitual drug use traced back 25,000 years to Indonesia
Hunter-gatherers from the last ice age sucked on betel nuts to soothe their toothaches, a new study reveals.
www.livescience.com
September 11, 2026 at 4:30 PM
World's oldest evidence of habitual drug use from 25,000 y ago. Hunter-gatherers sucked on betel nuts that contain a neuroactive substance. Prehistoric plant-based drugs include 10,000 yo psychedelic cactus pollen in Peru and 13,000 yo beer in Israel.
buff.ly/Z5me9ZU
buff.ly/Z5me9ZU
Betel nuts are the oldest known habitual-use neuroactive plant drug. Recently discovered skeletal remains suggest that ancient foragers likely used this stimulant long before farming began (16-25k years ago)! 🧪
www.science.org/doi/full/10....
www.science.org/doi/full/10....
September 10, 2026 at 8:51 PM
Betel nuts are the oldest known habitual-use neuroactive plant drug. Recently discovered skeletal remains suggest that ancient foragers likely used this stimulant long before farming began (16-25k years ago)! 🧪
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug | Science Advances www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of t...
www.science.org
September 10, 2026 at 1:20 PM
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug | Science Advances www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug | Science Advances www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of t...
www.science.org
September 10, 2026 at 10:00 PM
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug | Science Advances www.science.org/doi/10.1126/...
The title of this cool new paper is accurate (dental evidence c. 25-16k BP). However, routine consumption of ethanol is likely ancient: 1) Wild chimpanzees consume perhaps the equivalent of 1.4 drinks/day from naturally fermenting fruit; 2) ADH genes are widespread🧪🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of t...
www.science.org
September 10, 2026 at 4:29 PM
The title of this cool new paper is accurate (dental evidence c. 25-16k BP). However, routine consumption of ethanol is likely ancient: 1) Wild chimpanzees consume perhaps the equivalent of 1.4 drinks/day from naturally fermenting fruit; 2) ADH genes are widespread🧪🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Oldest evidence of habitual drug use traced back 25,000 years to Indonesia
Hunter-gatherers from last ice age may have sucked on betel nuts to soothe toothaches
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug🏺🧪
www.science.org/doi/10.1126/...
Hunter-gatherers from last ice age may have sucked on betel nuts to soothe toothaches
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug🏺🧪
www.science.org/doi/10.1126/...
![Drug use-related dental wear in early Sulawesi foragers.
(A and B) Right maxilla fragment with three molars (M1 to M3) from a Late Pleistocene individual (Maros-LBB-1a); (A) right lateral view; (B) left lateral view. (C to H) Maxillary [(C) to (F)] and mandibular [(G) to (H)] dentition of a Middle Holocene individual (CPL-R2a). Both are middle to old adults. Circumferential wear facets are indicated by arrows and dotted half circles. Scale bars, 10 mm.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:rygp62vxjwmuyb4xin4uyt7z/bafkreib2lituvaa7i6syl4cdprjlo4uy37pfnig3b4tixr2fpumvvh4wk4)
September 10, 2026 at 3:02 PM
Oldest evidence of habitual drug use traced back 25,000 years to Indonesia
Hunter-gatherers from last ice age may have sucked on betel nuts to soothe toothaches
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug🏺🧪
www.science.org/doi/10.1126/...
Hunter-gatherers from last ice age may have sucked on betel nuts to soothe toothaches
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug🏺🧪
www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown. We report rare skeletal remains of t...
www.science.org
September 10, 2026 at 5:30 AM
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...