the temporarily embarrassed immortal lich queen would like to complain about the indignities of the alive body and its so-called "nociception"
September 27, 2026 at 1:21 PM
the temporarily embarrassed immortal lich queen would like to complain about the indignities of the alive body and its so-called "nociception"
Everyone trying to give AI this decision making power simply needs to discover the physiological limits of their nociception
“For more than a decade, researchers have wondered whether artificial intelligence could help predict what incapacitated patients might want when doctors must make life-or-death decisions on their behalf.”
Should an AI copy of you help decide if you live or die?
Doctors share top concerns of AI surrogates aiding life-or-death decisions.
arstechnica.com
October 20, 2025 at 2:30 PM
Everyone trying to give AI this decision making power simply needs to discover the physiological limits of their nociception
3/7
Pour autant qu'on le sache, chaque animal est capable de nociception, des réactions réflexes à des stimuli potentiellement nocifs, via des cellules nerveuses.
Mais cette nociception reste différent d’une sensation subjective de douleur, qui est le sujet ici.
Pour autant qu'on le sache, chaque animal est capable de nociception, des réactions réflexes à des stimuli potentiellement nocifs, via des cellules nerveuses.
Mais cette nociception reste différent d’une sensation subjective de douleur, qui est le sujet ici.
February 2, 2025 at 10:08 AM
3/7
Pour autant qu'on le sache, chaque animal est capable de nociception, des réactions réflexes à des stimuli potentiellement nocifs, via des cellules nerveuses.
Mais cette nociception reste différent d’une sensation subjective de douleur, qui est le sujet ici.
Pour autant qu'on le sache, chaque animal est capable de nociception, des réactions réflexes à des stimuli potentiellement nocifs, via des cellules nerveuses.
Mais cette nociception reste différent d’une sensation subjective de douleur, qui est le sujet ici.
If evolution, comparative #neuroskyence & #PainResearch are your thing, here's a great review from Terry Walters: journals.biologists.com/jeb/article/...
From nociception in aneural animals to human suffering: toward a comparative biology of pain
Summary: The biology of widely shared and unusual features of human pain is informed by functional and mechanistic comparisons of nociception and pain-like aversive states across vertebrate and invert...
journals.biologists.com
October 14, 2025 at 7:06 AM
If evolution, comparative #neuroskyence & #PainResearch are your thing, here's a great review from Terry Walters: journals.biologists.com/jeb/article/...
I'm SUPER late, but tis done 🥹
#pride🌈 #Everhood #smrpg #puppetmon #pinocchimon #showdownbandit #aleron #nociception #everhood2 #oc #scavengersreign #larryandlawriebrawlstars #larryandlawrie #robofortune #skullgirlsrobofortune #meeple #meeplebrawlstars #ena #enedreambbq
#pride🌈 #Everhood #smrpg #puppetmon #pinocchimon #showdownbandit #aleron #nociception #everhood2 #oc #scavengersreign #larryandlawriebrawlstars #larryandlawrie #robofortune #skullgirlsrobofortune #meeple #meeplebrawlstars #ena #enedreambbq
July 31, 2025 at 11:40 PM
Painful stings like the velvet ants' venom actually evolved to defend them from insect predators, so it's surprising how well they target mammalian nociception ('pain-sensing') pathways.
There's a nice paper on this where they found velvet ant venom caused aversion in fruit flies, mice, and mantis.
There's a nice paper on this where they found velvet ant venom caused aversion in fruit flies, mice, and mantis.
Arizona velvet ants are colorful little insects that will DESTROY you. Their sting is described as 'hot oil from the deep fryer'. As wingless wasps, they will drop you to your knees. They will make you call to god. They are the reason countless children are afraid of cute insects.
they are perfect
they are perfect
January 21, 2025 at 5:22 PM
Painful stings like the velvet ants' venom actually evolved to defend them from insect predators, so it's surprising how well they target mammalian nociception ('pain-sensing') pathways.
There's a nice paper on this where they found velvet ant venom caused aversion in fruit flies, mice, and mantis.
There's a nice paper on this where they found velvet ant venom caused aversion in fruit flies, mice, and mantis.
Even just looking at images of nature changes our brain and can reduce physical pain, a new study by @maxsteininger.bsky.social and colleagues finds!
Nature exposure induces analgesic effects by acting on nociception-related neural processing - Nature Communications
Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mecha...
www.nature.com
March 17, 2025 at 1:02 PM
Even just looking at images of nature changes our brain and can reduce physical pain, a new study by @maxsteininger.bsky.social and colleagues finds!
Our book chapter on the role of CCK in nociception & pain is now online! @docnessmonster.bsky.social #PainResearch www.sciencedirect.com/science/arti...
Cholecystokinin in nociception and pain
The neuropeptide, cholecystokinin (CCK), and its receptors, CCK1R and CCK2R, are involved in nociception and pain. CCK1R and CCK2R are Gq-coupled GPCR…
www.sciencedirect.com
April 3, 2025 at 9:42 AM
Our book chapter on the role of CCK in nociception & pain is now online! @docnessmonster.bsky.social #PainResearch www.sciencedirect.com/science/arti...
Word of the Day: nociception
January 21, 2025 at 5:29 PM
Word of the Day: nociception
Traditional pharma therapies, non-steroidal anti-inflammatories, gabapentinoids & opioids yield suboptimal results & carry risks—adverse side effects & dependence. Evidence suggests cannabinoids interact with the ECS to modulate nociception & inflammation. surgicoll.scholasticahq.com/article/1385...
January 19, 2026 at 1:18 AM
Traditional pharma therapies, non-steroidal anti-inflammatories, gabapentinoids & opioids yield suboptimal results & carry risks—adverse side effects & dependence. Evidence suggests cannabinoids interact with the ECS to modulate nociception & inflammation. surgicoll.scholasticahq.com/article/1385...
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
September 5, 2025 at 6:53 PM
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
Ultimately, pain/nociception/adverse reactions to noxious stimuli should be seen as universal until proven otherwise.
January 9, 2025 at 5:16 PM
Ultimately, pain/nociception/adverse reactions to noxious stimuli should be seen as universal until proven otherwise.
I love this work! And Im now convinced that flies feel pain, not just nociception.
Do flies feel pain?
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
October 29, 2025 at 10:57 PM
I love this work! And Im now convinced that flies feel pain, not just nociception.
now out in Cerebral Cortex! my newest opinion piece,
"Introspective psychophysics for the study of subjective experience"
#neuroskyence #neuroAI #consciousness #introspection #psychology
academic.oup.com/cercor/advan...
"Introspective psychophysics for the study of subjective experience"
#neuroskyence #neuroAI #consciousness #introspection #psychology
academic.oup.com/cercor/advan...
Introspective psychophysics for the study of subjective experience
Abstract. Studying subjective experience is hard. We believe that pain is not identical to nociception, nor pleasure a computational reward signal, nor fea
academic.oup.com
November 22, 2024 at 9:49 PM
now out in Cerebral Cortex! my newest opinion piece,
"Introspective psychophysics for the study of subjective experience"
#neuroskyence #neuroAI #consciousness #introspection #psychology
academic.oup.com/cercor/advan...
"Introspective psychophysics for the study of subjective experience"
#neuroskyence #neuroAI #consciousness #introspection #psychology
academic.oup.com/cercor/advan...
Meningeal regulatory T cells inhibit nociception in female mice @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 3, 2025 at 8:50 PM
Meningeal regulatory T cells inhibit nociception in female mice @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#MBBS2026 continues with @ulrikebingel.bsky.social @sfb-trr-289.bsky.social on how #expectation modulates treatment outcome & #pain relief, stressing the synergetic potential of pharmacology and expectancy! ✨
#MindBrainBody #placebo #neuroskyence #nociception
treatment-expectation.de
#MindBrainBody #placebo #neuroskyence #nociception
treatment-expectation.de
March 10, 2026 at 2:02 PM
#MBBS2026 continues with @ulrikebingel.bsky.social @sfb-trr-289.bsky.social on how #expectation modulates treatment outcome & #pain relief, stressing the synergetic potential of pharmacology and expectancy! ✨
#MindBrainBody #placebo #neuroskyence #nociception
treatment-expectation.de
#MindBrainBody #placebo #neuroskyence #nociception
treatment-expectation.de
Every single Christmas song played endlessly in retail jobs. The people who chose to play that music nonstop are the ones who deserve to explore the limits of human nociception though
Name a song you hate
"Bad Day" by Daniel Powter
"Bad Day" makes a good day bad. "Bad Day" makes a bad day nuclear.
"Bad Day" by Daniel Powter
"Bad Day" makes a good day bad. "Bad Day" makes a bad day nuclear.
Name a song you hate
"Scenes from an Italian Restaurant", Billy Joel
"Scenes from an Italian Restaurant", Billy Joel
June 17, 2024 at 3:12 PM
Every single Christmas song played endlessly in retail jobs. The people who chose to play that music nonstop are the ones who deserve to explore the limits of human nociception though
nociception moment
November 24, 2024 at 1:56 AM
nociception moment
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception #PainResearch
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
September 9, 2025 at 3:20 PM
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception #PainResearch
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#Podcast Nociception : le cerveau en voit de toutes les douleurs tinyurl.com/26hdwyd5 à (ré)écouter via @franceculture.fr ! #ScienceCQFD
September 23, 2025 at 2:58 PM
#Podcast Nociception : le cerveau en voit de toutes les douleurs tinyurl.com/26hdwyd5 à (ré)écouter via @franceculture.fr ! #ScienceCQFD
2025. From nociception in aneural animals to human suffering: toward a comparative biology of pain url: journals.biologists.com/jeb/article-...
From nociception in aneural animals to human suffering: toward a comparative biology of pain
Summary: The biology of widely shared and unusual features of human pain is informed by functional and mechanistic comparisons of nociception and pain-like aversive states across vertebrate and invert...
journals.biologists.com
October 15, 2025 at 10:40 PM
2025. From nociception in aneural animals to human suffering: toward a comparative biology of pain url: journals.biologists.com/jeb/article-...
FULL FORCE FRIDAY:🆕Apr 10th ENCORE! 🎧
NOCICEPTION - Cognitive Dismemberment 🇺🇸⚛️
3rd album from Grand Rapids, Michigan, American Death Metal outfit⚛️
BC➡️nociception.bandcamp.com/album/cognit...⚛️
#Nociception #CognitiveDismemberment #DeathMetal #FFFApr10 #KMäN
NOCICEPTION - Cognitive Dismemberment 🇺🇸⚛️
3rd album from Grand Rapids, Michigan, American Death Metal outfit⚛️
BC➡️nociception.bandcamp.com/album/cognit...⚛️
#Nociception #CognitiveDismemberment #DeathMetal #FFFApr10 #KMäN
April 10, 2026 at 10:29 PM
FULL FORCE FRIDAY:🆕Apr 10th ENCORE! 🎧
NOCICEPTION - Cognitive Dismemberment 🇺🇸⚛️
3rd album from Grand Rapids, Michigan, American Death Metal outfit⚛️
BC➡️nociception.bandcamp.com/album/cognit...⚛️
#Nociception #CognitiveDismemberment #DeathMetal #FFFApr10 #KMäN
NOCICEPTION - Cognitive Dismemberment 🇺🇸⚛️
3rd album from Grand Rapids, Michigan, American Death Metal outfit⚛️
BC➡️nociception.bandcamp.com/album/cognit...⚛️
#Nociception #CognitiveDismemberment #DeathMetal #FFFApr10 #KMäN
very cool. this nucleus has a role in nociception and pain
1/ A deep brain region known as the A13 plays a central role across a diverse range of behavioural functions (in rodents).
To our knowledge, no human homologue has been identified to date.
In this #preprint, we map the human A13!🎯
🔗 www.biorxiv.org/content/10.6...
To our knowledge, no human homologue has been identified to date.
In this #preprint, we map the human A13!🎯
🔗 www.biorxiv.org/content/10.6...
June 16, 2026 at 3:05 PM
very cool. this nucleus has a role in nociception and pain
Ignored Sense 4:
Nociception.
Nociception is the perception of pain. This part might be confronting to read.
Some of us seek pain actively. MANY of us do it subconsciously as a stim. The very traumatised amongst us use it to regulate and it works. This is confronting.
5/7
Nociception.
Nociception is the perception of pain. This part might be confronting to read.
Some of us seek pain actively. MANY of us do it subconsciously as a stim. The very traumatised amongst us use it to regulate and it works. This is confronting.
5/7
May 25, 2025 at 10:24 PM
Ignored Sense 4:
Nociception.
Nociception is the perception of pain. This part might be confronting to read.
Some of us seek pain actively. MANY of us do it subconsciously as a stim. The very traumatised amongst us use it to regulate and it works. This is confronting.
5/7
Nociception.
Nociception is the perception of pain. This part might be confronting to read.
Some of us seek pain actively. MANY of us do it subconsciously as a stim. The very traumatised amongst us use it to regulate and it works. This is confronting.
5/7
Mmm…how about…NO? This is a blatant conflation of pain and #nociception
#painscience
#painresearch
#physiotherapy
Open access: www.dovepress.com/on-including...
#painscience
#painresearch
#physiotherapy
Open access: www.dovepress.com/on-including...
November 17, 2024 at 1:56 PM
Mmm…how about…NO? This is a blatant conflation of pain and #nociception
#painscience
#painresearch
#physiotherapy
Open access: www.dovepress.com/on-including...
#painscience
#painresearch
#physiotherapy
Open access: www.dovepress.com/on-including...