little anti-nonself buzzsaws: en.m.wikipedia.org/wiki/Defensin
Defensin - Wikipedia
en.m.wikipedia.org
August 21, 2025 at 4:08 AM
little anti-nonself buzzsaws: en.m.wikipedia.org/wiki/Defensin
Interestingly, both T cells and B cells rearrange endogenous gene segments to create receptors (TCR and BCR [aka antibody]) that can recognize every potential pathogen you may come in contact with during your lifetime, while simultaneously discriminating self from nonself. 2/2
December 29, 2024 at 3:03 PM
Interestingly, both T cells and B cells rearrange endogenous gene segments to create receptors (TCR and BCR [aka antibody]) that can recognize every potential pathogen you may come in contact with during your lifetime, while simultaneously discriminating self from nonself. 2/2
✨ Recognizing interbeing ✨
🪷 Unifying wisdom from Thich Nhat Hanh (1926–2022) 🪷
💛 Who feels separate from you right now? 💛
🔗 youtube.com/shorts/dopX_...
#Buddhism #Buddha #Dharma #Mahayana #Bodhicitta #Compassion #Interbeing #NonSelf #Zen #Mindfulness #Meditation #Awakening #Spirituality
🪷 Unifying wisdom from Thich Nhat Hanh (1926–2022) 🪷
💛 Who feels separate from you right now? 💛
🔗 youtube.com/shorts/dopX_...
#Buddhism #Buddha #Dharma #Mahayana #Bodhicitta #Compassion #Interbeing #NonSelf #Zen #Mindfulness #Meditation #Awakening #Spirituality
🪷 Buddhistdoor Quote for Today: Thich Nhat Hanh (1926–2022) 🪷
YouTube video by BDG: Buddhistdoor Global
youtube.com
April 10, 2026 at 10:04 AM
✨ Recognizing interbeing ✨
🪷 Unifying wisdom from Thich Nhat Hanh (1926–2022) 🪷
💛 Who feels separate from you right now? 💛
🔗 youtube.com/shorts/dopX_...
#Buddhism #Buddha #Dharma #Mahayana #Bodhicitta #Compassion #Interbeing #NonSelf #Zen #Mindfulness #Meditation #Awakening #Spirituality
🪷 Unifying wisdom from Thich Nhat Hanh (1926–2022) 🪷
💛 Who feels separate from you right now? 💛
🔗 youtube.com/shorts/dopX_...
#Buddhism #Buddha #Dharma #Mahayana #Bodhicitta #Compassion #Interbeing #NonSelf #Zen #Mindfulness #Meditation #Awakening #Spirituality
...and this tarot reading www.youtube.com/watch?v=fQNk...
Nonself - a synthesizer tarot reading
YouTube video by Alfred Valley
www.youtube.com
September 6, 2026 at 6:33 PM
...and this tarot reading www.youtube.com/watch?v=fQNk...
This year’s Nobel Prize in medicine honors scientists who revealed how the immune system maintains balance between defending against pathogens and sparing healthy cells, opening new doors for treating autoimmune diseases and cancer.
buff.ly/PayRUAu
buff.ly/PayRUAu
How does your immune system stay balanced? A Nobel Prize-winning answer
Regulatory T cells help your immune system distinguish between ‘self’ and ‘nonself’ – and can open doors to better treatments for cancer, autoimmune disease and transplant rejection.
theconversation.com
October 6, 2025 at 8:25 PM
This year’s Nobel Prize in medicine honors scientists who revealed how the immune system maintains balance between defending against pathogens and sparing healthy cells, opening new doors for treating autoimmune diseases and cancer.
buff.ly/PayRUAu
buff.ly/PayRUAu
How does your immune system stay balanced? A Nobel Prize-winning answer
theconversation.com/how-does-you...
theconversation.com/how-does-you...
How does your immune system stay balanced? A Nobel Prize-winning answer
Regulatory T cells help your immune system distinguish between ‘self’ and ‘nonself’ – and can open doors to better treatments for cancer, autoimmune disease and transplant rejection.
theconversation.com
October 6, 2025 at 11:33 PM
How does your immune system stay balanced? A Nobel Prize-winning answer
theconversation.com/how-does-you...
theconversation.com/how-does-you...
are you kidding?
check my profile
i am no such thing, same as zen nonself
gotta get outta my own way forever
peak is found before thought
check my profile
i am no such thing, same as zen nonself
gotta get outta my own way forever
peak is found before thought
August 4, 2025 at 6:58 PM
are you kidding?
check my profile
i am no such thing, same as zen nonself
gotta get outta my own way forever
peak is found before thought
check my profile
i am no such thing, same as zen nonself
gotta get outta my own way forever
peak is found before thought
This year’s Nobel Prize in medicine honors scientists who revealed how the immune system maintains balance between defending against pathogens and sparing healthy cells, opening new doors for treating autoimmune diseases and cancer.
buff.ly/PayRUAu
buff.ly/PayRUAu
How does your immune system stay balanced? A Nobel Prize-winning answer
Regulatory T cells help your immune system distinguish between ‘self’ and ‘nonself’ – and can open doors to better treatments for cancer, autoimmune disease and transplant rejection.
buff.ly
October 7, 2025 at 11:13 AM
This year’s Nobel Prize in medicine honors scientists who revealed how the immune system maintains balance between defending against pathogens and sparing healthy cells, opening new doors for treating autoimmune diseases and cancer.
buff.ly/PayRUAu
buff.ly/PayRUAu
This year’s Nobel Prize in medicine honors scientists who revealed how the immune system maintains balance between defending against pathogens and sparing healthy cells, opening new doors for treating autoimmune diseases and cancer.
buff.ly/PayRUAu
buff.ly/PayRUAu
How does your immune system stay balanced? A Nobel Prize-winning answer
Regulatory T cells help your immune system distinguish between ‘self’ and ‘nonself’ – and can open doors to better treatments for cancer, autoimmune disease and transplant rejection.
buff.ly
October 7, 2025 at 2:24 PM
This year’s Nobel Prize in medicine honors scientists who revealed how the immune system maintains balance between defending against pathogens and sparing healthy cells, opening new doors for treating autoimmune diseases and cancer.
buff.ly/PayRUAu
buff.ly/PayRUAu
Reminder to new users here:
99% of T-cells don't survive thymic selection.
But later in life, your thymus involutes into an inert pad of fat, so T-cell tolerance has to also rely on other peripheral signals of self vs nonself
99% of T-cells don't survive thymic selection.
But later in life, your thymus involutes into an inert pad of fat, so T-cell tolerance has to also rely on other peripheral signals of self vs nonself
February 7, 2024 at 2:56 AM
Reminder to new users here:
99% of T-cells don't survive thymic selection.
But later in life, your thymus involutes into an inert pad of fat, so T-cell tolerance has to also rely on other peripheral signals of self vs nonself
99% of T-cells don't survive thymic selection.
But later in life, your thymus involutes into an inert pad of fat, so T-cell tolerance has to also rely on other peripheral signals of self vs nonself
"The core Buddhist teaching of nonself is not so much stating that a self does not exist as it is identifying the self as being as impermanent, inconstant, and unsubstantial as every other conditioned thing." —Andrew Olendzki
What’s in a Word?: Anicca
A Pali scholar discusses its meaning.
tricycle.org
March 20, 2025 at 1:59 PM
"The core Buddhist teaching of nonself is not so much stating that a self does not exist as it is identifying the self as being as impermanent, inconstant, and unsubstantial as every other conditioned thing." —Andrew Olendzki
Cell-internal autocrine receptor inactivation supports maintenance of mating-type identity in yeast | Science Advances www.science.org/doi/10.1126/...
Cell-internal autocrine receptor inactivation supports maintenance of mating-type identity in yeast
Failsafe nonself recognition in yeast premating communication is ensured by cell-internal elimination of self-reactive receptors.
www.science.org
April 26, 2026 at 9:33 AM
Cell-internal autocrine receptor inactivation supports maintenance of mating-type identity in yeast | Science Advances www.science.org/doi/10.1126/...
Buddhist scripture Anatta-lakkhana Sutta teaches that there is no permanent Self. Our body, feelings, perceptions, and Mind are in constant change, like a flowing river. Clinging to a fixed identity only brings suffering. Embrace impermanence and enjoy Freedom. 🙏🙏
#Buddhism #Buddha #NonSelf #Wisdom
#Buddhism #Buddha #NonSelf #Wisdom
February 5, 2025 at 1:47 PM
Buddhistdoor Quote for Today: The Heart Sutra
🔗 Explore BDG on YouTube: youtube.com/shorts/wTkuq...
#Buddhism #Buddha #ThichNhatHanh #Emptiness #Sunyata #NonSelf #Anatman #HeartSutra #Liberation #SpiritualGrowth #Awakening #Spirituality
🔗 Explore BDG on YouTube: youtube.com/shorts/wTkuq...
#Buddhism #Buddha #ThichNhatHanh #Emptiness #Sunyata #NonSelf #Anatman #HeartSutra #Liberation #SpiritualGrowth #Awakening #Spirituality
Buddhistdoor Quote for Today: The Heart Sutra (Translated by Thich Nhat Hanh)
YouTube video by BDG: Buddhistdoor Global
youtube.com
May 6, 2025 at 3:54 AM
Buddhistdoor Quote for Today: The Heart Sutra
🔗 Explore BDG on YouTube: youtube.com/shorts/wTkuq...
#Buddhism #Buddha #ThichNhatHanh #Emptiness #Sunyata #NonSelf #Anatman #HeartSutra #Liberation #SpiritualGrowth #Awakening #Spirituality
🔗 Explore BDG on YouTube: youtube.com/shorts/wTkuq...
#Buddhism #Buddha #ThichNhatHanh #Emptiness #Sunyata #NonSelf #Anatman #HeartSutra #Liberation #SpiritualGrowth #Awakening #Spirituality
We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules
A bacterial sensory protein detects self- and nonself-lipids by similar mechanisms.
www.science.org
March 8, 2025 at 2:39 PM
We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
BDG feature: Maturity on the Path: Guidance from the Buddha
Read here: tinyurl.com/4cfz7d2u
#buddhism #theravada #buddhistmonk #buddhistpractice #buddha #dhamma #dharma #palicanon #meditation #nonself
Read here: tinyurl.com/4cfz7d2u
#buddhism #theravada #buddhistmonk #buddhistpractice #buddha #dhamma #dharma #palicanon #meditation #nonself
Maturity on the Path: Guidance from the Buddha - Buddhistdoor Global
Prof. Dave Holmes presents an episode from the Pali Canon, in which Venerable Meghiya seeks guidance on practice from the Buddha.
tinyurl.com
February 5, 2025 at 6:57 AM
BDG feature: Maturity on the Path: Guidance from the Buddha
Read here: tinyurl.com/4cfz7d2u
#buddhism #theravada #buddhistmonk #buddhistpractice #buddha #dhamma #dharma #palicanon #meditation #nonself
Read here: tinyurl.com/4cfz7d2u
#buddhism #theravada #buddhistmonk #buddhistpractice #buddha #dhamma #dharma #palicanon #meditation #nonself
Contemplating the truth of not-self ~ Ajahn Anan
https://justdharma.org/contemplating-the-truth-of-not-self-ajahn-anan/
#AjahnAnan #breathing #nonself #truth
https://justdharma.org/contemplating-the-truth-of-not-self-ajahn-anan/
#AjahnAnan #breathing #nonself #truth
February 4, 2026 at 2:00 AM
Contemplating the truth of not-self ~ Ajahn Anan
https://justdharma.org/contemplating-the-truth-of-not-self-ajahn-anan/
#AjahnAnan #breathing #nonself #truth
https://justdharma.org/contemplating-the-truth-of-not-self-ajahn-anan/
#AjahnAnan #breathing #nonself #truth
Every now and then I read a paper that opens my eyes to see an aspect of biology in a new way. This paper blew my mind - TLR7/8 have agonist sites to bind viral RNA, and antagonist sites to bind endogenous RNA degrad. products, enabling self/nonself discrimination: www.nature.com/articles/s41...
www.nature.com
February 28, 2026 at 8:48 PM
Every now and then I read a paper that opens my eyes to see an aspect of biology in a new way. This paper blew my mind - TLR7/8 have agonist sites to bind viral RNA, and antagonist sites to bind endogenous RNA degrad. products, enabling self/nonself discrimination: www.nature.com/articles/s41...
Discover how the type III-B CRISPR-Cas in Bacteroides fragilis synthesizes SAM^AMP using SAM and ATP, triggering immune responses. PMID:41272318, Nat Chem Biol 2025, @nchembio @OTSociety @NAR_Open https://doi.org/10.1038/s41589-025-02075-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR–Cas system | Nature Chemical Biology
Upon sensing nonself target RNA, the CorA-associated type III-B CRISPR–Cas system catalyzes S-adenosyl methionine (SAM) and ATP to synthesize SAM-AMP, which activates the effector CorA and triggers immune responses. SAM-AMP can be degraded by NrN and SAM lyase, potentially deactivating the system. Here we find that the type III-B effector complex from Bacteroides fragilis uses a specific mechanism to recognize nonself target RNA and synthesize SAM-AMP. The 3′ anti-tag of nonself target RNA induces conformational changes in the Cmr2 subunit, triggering SAM-AMP synthesis independently of the stalk loop of Cmr3 subunit. SAM-AMP binding induces NrN to transit from an open to a closed conformation, enabling hydrolysis of the 3′–5′ phosphodiester bond. SAM lyase forms a triangular trimer that specifically degrades SAM-AMP into 5′-methylthioadenosine-AMP and homoserine lactone. These findings unveil unique mechanisms for SAM-AMP synthesis and degradation and provide deeper insights into the m
doi.org
December 7, 2025 at 3:10 AM
A 𝐧𝐞𝐨𝐚𝐧𝐭𝐢𝐠𝐞𝐧 is a novel peptide that is derived from a somatic variant in a tumor cell and can be recognized as “nonself” by T cells. Neoantigens are tumor-specific and have not been encountered during thymic T-cell development and are therefore not subject to central tolerance.
January 12, 2026 at 2:05 PM
A 𝐧𝐞𝐨𝐚𝐧𝐭𝐢𝐠𝐞𝐧 is a novel peptide that is derived from a somatic variant in a tumor cell and can be recognized as “nonself” by T cells. Neoantigens are tumor-specific and have not been encountered during thymic T-cell development and are therefore not subject to central tolerance.
Freed from bondage ~ Sengcan
https://justdharma.org/freed-from-bondage-sengcan/
#Sengcan #self #nonself #suchness
https://justdharma.org/freed-from-bondage-sengcan/
#Sengcan #self #nonself #suchness
August 13, 2026 at 7:00 AM
Freed from bondage ~ Sengcan
https://justdharma.org/freed-from-bondage-sengcan/
#Sengcan #self #nonself #suchness
https://justdharma.org/freed-from-bondage-sengcan/
#Sengcan #self #nonself #suchness
I have two moods: self-loathing and self-loathing + nonself-loathing
January 24, 2024 at 4:35 AM
I have two moods: self-loathing and self-loathing + nonself-loathing
This is a comprehensive and fairly recent review of some tools for tumor neoantigen prediction: academic.oup.com/bib/article/...
Computational methods and data resources for predicting tumor neoantigens
Abstract. Neoantigens are tumor-specific antigens presented exclusively by cancer cells. These antigens are recognized as nonself by the host immune system
academic.oup.com
September 25, 2026 at 5:36 PM
This is a comprehensive and fairly recent review of some tools for tumor neoantigen prediction: academic.oup.com/bib/article/...