Engagement in nonsuicidal self-injury (NSSI) often begins in adolescence, and commonly occurs when a person is emotionally dysregulated. Parental emotion socialization (ES) plays a key role in shaping...

This study attempts to provide a meta-analytic synthesis of research investigating the prevalence of suicidal ideation, suicide attempts, and nonsuicidal self-injury in transgender and gender diverse ...

This randomized clinical trial evaluates the efficacy of dialectical behavior therapy compared with individual and group supportive therapy for reducing suicide attempts, nonsuicidal self-injury, and overall self-harm among high-risk youths.

Background: Autistic people are at significant risk for suicidal thoughts and behaviors (STBs) and nonsuicidal self-injury (NSSI). We examined STB and NSSI in different age-groups, considering sex- an...

This study attempts to provide a meta-analytic synthesis of research investigating the prevalence of suicidal ideation, suicide attempts, and nonsuicidal self-injury in transgender and gender diverse ...

Background: Autistic people are at significant risk for suicidal thoughts and behaviors (STBs) and nonsuicidal self-injury (NSSI). We examined STB and NSSI in different age-groups, considering sex- an...

This study attempts to provide a meta-analytic synthesis of research investigating the prevalence of suicidal ideation, suicide attempts, and nonsuicidal self-injury in transgender and gender diverse ...

Background: Nonsuicidal self-injury (NSSI) is common in adolescents and young adults, and few evidence-based treatments are available for this significant problem. N-acetylcysteine (NAC) is a widely a...

Neuropsychopharmacology - A biological phenotype of suicide attempt in adolescents with nonsuicidal self-injury: a machine-based learning approach

Research examining non-suicidal self-injury (NSSI) in daily life has grown substantially; thus, it is essential in conducting ecological momentary assessment (EMA) research with individuals who sel...

Nonsuicidal self-injury (NSSI) is common in trauma-exposed adolescents and has been linked to dysregulation of stress-response systems, including the …

This cohort study examines the joint development of substance use and nonsuicidal self-injury (NSSI) behavior to explore whether shifting from NSSI to substance use is associated with emerging or pers...

Background Adolescents who engage in nonsuicidal self-injury (NSSI) show a high sensitivity to ostracism, and its effects may be amplified by dysregulated stress-system function. However, ecologically grounded experimental studies examining multilevel stress responses in adolescent mental health remain scarce. We used a novel, ecologically valid in-person ostracism paradigm to assess subjective, autonomic, and endocrine responses in adolescents with recent NSSI and to characterize stress trajectories. Methods Fifty adolescents with recent NSSI (mean age = 16.40 years, 76% female) were randomized (1:1) to live social inclusion or exclusion in a face-to-face ball-toss task based on the Cyberball paradigm. Salivary cortisol was sampled at five points from pre-task to 40 min post-task. Heart rate (HR) and heart rate variability (HRV) were recorded at baseline and during the interaction. Subjective stress, tension, and NSSI urges were assessed before and after the task. Perceived exclusion and psychological need threat were also assessed. Results We found clear ostracism effects on perceived exclusion and basic psychological need threat. Cortisol declined across the paradigm in both conditions (inclusion/exclusion), but the decline was flatter after exclusion, indicating attenuated hypothalamic-pituitary-adrenal axis downregulation. HR decreased modestly over time across conditions, and HRV diverged by condition: it decreased during exclusion and increased during inclusion. There were no condition-related changes in self-reported stress, tension, or NSSI urges. Conclusions These findings suggest a decoupling between subjective and psychobiological stress systems in adolescents with NSSI in response to ostracism, characterized by rapid parasympathetic withdrawal and a blunted HPA axis downregulation. This pattern may reflect heightened physiological sensitivity to social threat despite limited conscious distress. Trial registration: This study has been registered at the German Clinical Trials Register (ID: DRKS00025905, https://drks.de/search/en/trial/DRKS00025905).

Background: Autistic people are at significant risk for suicidal thoughts and behaviors (STBs) and nonsuicidal self-injury (NSSI). We examined STB and NSSI in different age-groups, considering sex- an...

What are the primary functions of non-suicidal self-injury in coping with emotional distress and social influences? Dr. Nicholas Westers explains by discussing the triggers, four-factor model categorizing…