Ruhr University Bochum scientists show that JNK kinase activates during coronavirus infection and phosphorylates the nucleocapsid protein.
Blocking JNK cut replication of both HCoV-229E and SARS-CoV-2, suggesting a new antiviral target.
www.nature.com/articles/s44...
Blocking JNK cut replication of both HCoV-229E and SARS-CoV-2, suggesting a new antiviral target.
www.nature.com/articles/s44...
JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein - npj Viruses
npj Viruses - JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein
www.nature.com
September 21, 2025 at 12:23 AM
Ruhr University Bochum scientists show that JNK kinase activates during coronavirus infection and phosphorylates the nucleocapsid protein.
Blocking JNK cut replication of both HCoV-229E and SARS-CoV-2, suggesting a new antiviral target.
www.nature.com/articles/s44...
Blocking JNK cut replication of both HCoV-229E and SARS-CoV-2, suggesting a new antiviral target.
www.nature.com/articles/s44...
Study: Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
Using a cell-culture model, Fahoum et al. demonstrate SARS-CoV-2 nucleocapsid protein
(NP) spread from infected to neighboring non-susceptible cells. This elicits NP-driven,
antibody-dependent activat...
www.cell.com
June 11, 2025 at 5:03 AM
Study: Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
www.cell.com/cell-reports...
www.cell.com/cell-reports...
My immunologist friend just sent this to me and oh my damn, this is good news.
Not only does it suggest heparin is a good treatment for LC patients, it seems it may be good during acute protection to prevent damage that can lead to long COVID in the first place.
pubmed.ncbi.nlm.nih.gov/40343796/
Not only does it suggest heparin is a good treatment for LC patients, it seems it may be good during acute protection to prevent damage that can lead to long COVID in the first place.
pubmed.ncbi.nlm.nih.gov/40343796/
Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition - PubMed
SARS-CoV-2 infection triggers a strong antibody response toward nucleocapsid protein (NP), suggesting its extracellular presence beyond intravirion RNA binding. Our co-culture experiments show NP deco...
pubmed.ncbi.nlm.nih.gov
June 30, 2025 at 12:10 AM
My immunologist friend just sent this to me and oh my damn, this is good news.
Not only does it suggest heparin is a good treatment for LC patients, it seems it may be good during acute protection to prevent damage that can lead to long COVID in the first place.
pubmed.ncbi.nlm.nih.gov/40343796/
Not only does it suggest heparin is a good treatment for LC patients, it seems it may be good during acute protection to prevent damage that can lead to long COVID in the first place.
pubmed.ncbi.nlm.nih.gov/40343796/
Researchers studied 99 COVID-19 patients and found that SARS-CoV-2’s nucleocapsid protein can trigger complement activation even without matching antibodies.
This suggests the N protein may play a larger role than spike in severe immune overreactions.
www.nature.com/articles/s41...
This suggests the N protein may play a larger role than spike in severe immune overreactions.
www.nature.com/articles/s41...
In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients - Scientific Reports
Scientific Reports - In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients
www.nature.com
October 22, 2025 at 12:53 PM
Researchers studied 99 COVID-19 patients and found that SARS-CoV-2’s nucleocapsid protein can trigger complement activation even without matching antibodies.
This suggests the N protein may play a larger role than spike in severe immune overreactions.
www.nature.com/articles/s41...
This suggests the N protein may play a larger role than spike in severe immune overreactions.
www.nature.com/articles/s41...
Spike and nucleocapsid proteins persisted months after infection despite antibodies. A high-nucleocapsid subgroup showed vascular inflammation.
In mice, remnant viral proteins drove organ inflammation after virus cleared; steroids reduced it. #LongCovid
In mice, remnant viral proteins drove organ inflammation after virus cleared; steroids reduced it. #LongCovid
https://pubmed.ncbi.nlm.nih.gov/42781857/
pubmed.ncbi.nlm.nih.gov
September 25, 2026 at 9:09 PM
Spike and nucleocapsid proteins persisted months after infection despite antibodies. A high-nucleocapsid subgroup showed vascular inflammation.
In mice, remnant viral proteins drove organ inflammation after virus cleared; steroids reduced it. #LongCovid
In mice, remnant viral proteins drove organ inflammation after virus cleared; steroids reduced it. #LongCovid
We are very excited that our in-situ structural analysis of the Ebola virus nucleocapsid assembly cascade is now published in @cellpress.bsky.social!
January 7, 2025 at 10:13 AM
We are very excited that our in-situ structural analysis of the Ebola virus nucleocapsid assembly cascade is now published in @cellpress.bsky.social!
Study: Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
Using a cell-culture model, Fahoum et al. demonstrate SARS-CoV-2 nucleocapsid protein
(NP) spread from infected to neighboring non-susceptible cells. This elicits NP-driven,
antibody-dependent activat...
www.cell.com
June 24, 2025 at 11:56 PM
Study: Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Structural basis for Ebola virus nucleocapsid assembly and function regulated by VP24
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis for Ebola virus nucleocapsid assembly and function regulated by VP24 - Nature Communications
Here, the authors use cryo-electron microscopy to structurally characterise the Ebola virus nucleocapsid within virus-like particles, uncovering how specific interactions regulate viral genome synthes...
www.nature.com
March 10, 2025 at 12:59 PM
Structural basis for Ebola virus nucleocapsid assembly and function regulated by VP24
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Day 19 of making proteins for #ArtAdventCalendar
This is the measles virus nucleocapsid, which is a helical complex formed around its RNA genome to protect it from cellular enzymes
More projects: e-nox.net/portfolio/
#SciArt
This is the measles virus nucleocapsid, which is a helical complex formed around its RNA genome to protect it from cellular enzymes
More projects: e-nox.net/portfolio/
#SciArt
December 19, 2025 at 11:31 PM
Day 19 of making proteins for #ArtAdventCalendar
This is the measles virus nucleocapsid, which is a helical complex formed around its RNA genome to protect it from cellular enzymes
More projects: e-nox.net/portfolio/
#SciArt
This is the measles virus nucleocapsid, which is a helical complex formed around its RNA genome to protect it from cellular enzymes
More projects: e-nox.net/portfolio/
#SciArt
Congratulations to our PhD student David @rnadavid.bsky.social for his successful defense of his PhD thesis! @mpi-cbg.de imprs.mpi-cbg.de
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!
October 29, 2025 at 2:07 PM
Congratulations to our PhD student David @rnadavid.bsky.social for his successful defense of his PhD thesis! @mpi-cbg.de imprs.mpi-cbg.de
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!
SARS-CoV-2 Nucleocapsid Protein Increases RANTES Levels in Glioblastoma Cells
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
SARS-CoV-2 Nucleocapsid Protein Increases RANTES Levels in Glioblastoma Cells - Thailand Medical News
www.thailandmedical.news
March 12, 2025 at 10:31 AM
SARS-CoV-2 Nucleocapsid Protein Increases RANTES Levels in Glioblastoma Cells
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
Dieser faszinierende neue Preprint liefert nicht nur weitere Hinweise auf eine persistierende Infektion bei Long COVID, sondern weist auch darauf hin, dass kryptische Virusreservoirs in der tiefen Lunge an Long COVID beteiligt sein könnten. Ein exzellenter 🧵 von Ryan Hisner @ryanhisner.bsky.social.
September 2, 2025 at 9:53 PM
Dieser faszinierende neue Preprint liefert nicht nur weitere Hinweise auf eine persistierende Infektion bei Long COVID, sondern weist auch darauf hin, dass kryptische Virusreservoirs in der tiefen Lunge an Long COVID beteiligt sein könnten. Ein exzellenter 🧵 von Ryan Hisner @ryanhisner.bsky.social.
Researchers found that in mice, the SARS-CoV-2 nucleocapsid protein triggers microglial senescence and cognitive impairment by disrupting mitochondria and shifting energy use toward glycolysis.
Blocking glycolysis reversed the damage.
www.researchsquare.com/article/rs-6...
Blocking glycolysis reversed the damage.
www.researchsquare.com/article/rs-6...
The SARS-CoV-2 nucleocapsid protein induces microglia senescence- mediated cognitive impairment via glycolysis
COVID-19-associated cognitive dysfunction has emerged as a significant public health challenge, creating substantial socioeconomic burdens for affected individuals, their families, and healthcare syst...
www.researchsquare.com
June 21, 2025 at 12:33 AM
Researchers found that in mice, the SARS-CoV-2 nucleocapsid protein triggers microglial senescence and cognitive impairment by disrupting mitochondria and shifting energy use toward glycolysis.
Blocking glycolysis reversed the damage.
www.researchsquare.com/article/rs-6...
Blocking glycolysis reversed the damage.
www.researchsquare.com/article/rs-6...
I asked my aunt, the doctor,
to help me understand
a study that found
“Transfer of SARS-CoV-2
nucleocapsid protein
to uninfected epithelial cells
induces antibody-mediated
complement disposition,”
and my aunt, the doctor,
replied: “it means
don’t catch this virus.”
to help me understand
a study that found
“Transfer of SARS-CoV-2
nucleocapsid protein
to uninfected epithelial cells
induces antibody-mediated
complement disposition,”
and my aunt, the doctor,
replied: “it means
don’t catch this virus.”
May 14, 2025 at 7:11 PM
I asked my aunt, the doctor,
to help me understand
a study that found
“Transfer of SARS-CoV-2
nucleocapsid protein
to uninfected epithelial cells
induces antibody-mediated
complement disposition,”
and my aunt, the doctor,
replied: “it means
don’t catch this virus.”
to help me understand
a study that found
“Transfer of SARS-CoV-2
nucleocapsid protein
to uninfected epithelial cells
induces antibody-mediated
complement disposition,”
and my aunt, the doctor,
replied: “it means
don’t catch this virus.”
Ea ist sehr unwahrscheinlich bis ausgeschlossen, dass du noch keine Infektion hattest. Wahrscheinlich inapparent. Die virologischen Institute in D und weltweit finden kaum noch Stichproben ohne Nucleocapsid-Antikörper. Außer einsame Insel. Ja, hybride Immunität schützt. Uns alle.
September 10, 2026 at 6:50 PM
Ea ist sehr unwahrscheinlich bis ausgeschlossen, dass du noch keine Infektion hattest. Wahrscheinlich inapparent. Die virologischen Institute in D und weltweit finden kaum noch Stichproben ohne Nucleocapsid-Antikörper. Außer einsame Insel. Ja, hybride Immunität schützt. Uns alle.
Study Shockingly Finds That the Nucleocapsid Protein of the COVID-19 Virus Triggers Brain Cell Aging!
www.thailandmedical.news/news/study-s...
www.thailandmedical.news/news/study-s...
Study Shockingly Finds That the Nucleocapsid Protein of the COVID-19 Virus Triggers Brain Cell Aging! - Thailand Medical News
www.thailandmedical.news
June 21, 2025 at 12:09 PM
Study Shockingly Finds That the Nucleocapsid Protein of the COVID-19 Virus Triggers Brain Cell Aging!
www.thailandmedical.news/news/study-s...
www.thailandmedical.news/news/study-s...
Phosphorylation toggles the SARS-CoV-2 nucleocapsid protein between two membrane-associated condensate states
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phosphorylation toggles the SARS-CoV-2 nucleocapsid protein between two membrane-associated condensate states - Nature Communications
The SARS-CoV-2 Nucleocapsid (N) protein serves multiple roles in the viral lifecycle. Phosphorylation toggles N between these roles by altering N’s conformation, its material properties when phase sep...
www.nature.com
August 28, 2025 at 1:49 PM
Phosphorylation toggles the SARS-CoV-2 nucleocapsid protein between two membrane-associated condensate states
www.nature.com/articles/s41...
www.nature.com/articles/s41...
boosters give spike protein in your muscle. covid tests look for nucleocapsid antigen in your nose. No risk of crossover.
October 5, 2023 at 4:16 PM
boosters give spike protein in your muscle. covid tests look for nucleocapsid antigen in your nose. No risk of crossover.
SARS-CoV-2 Nucleocapsid Protein Blocks Human Cells from Dividing Normally
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
SARS-CoV-2 Nucleocapsid Protein Blocks Human Cells from Dividing Normally - Thailand Medical News
www.thailandmedical.news
September 4, 2025 at 2:02 AM
SARS-CoV-2 Nucleocapsid Protein Blocks Human Cells from Dividing Normally
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
How do baculoviruses protect their genome?
Delighted to present our findings in print!
We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.❄️🔬
www.nature.com/articles/s41...
Delighted to present our findings in print!
We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.❄️🔬
www.nature.com/articles/s41...
Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly - Nature Com...
Baculoviruses are used as insecticides, gene therapy tools, and protein production vectors. Here, the authors report the structure of the Autographa californica MNPV nucleocapsid and its fold conserva...
www.nature.com
January 8, 2024 at 9:44 AM
How do baculoviruses protect their genome?
Delighted to present our findings in print!
We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.❄️🔬
www.nature.com/articles/s41...
Delighted to present our findings in print!
We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.❄️🔬
www.nature.com/articles/s41...
Nucleocapsid assembly drives #Ebola viral factory maturation and dispersion.
Cryo-ET reveals the molecular architecture of Ebola virus replication compartments.
www.cell.com/cell/fulltex... #MicroSky #IDSky
Cryo-ET reveals the molecular architecture of Ebola virus replication compartments.
www.cell.com/cell/fulltex... #MicroSky #IDSky
January 1, 2025 at 10:15 AM
Nucleocapsid assembly drives #Ebola viral factory maturation and dispersion.
Cryo-ET reveals the molecular architecture of Ebola virus replication compartments.
www.cell.com/cell/fulltex... #MicroSky #IDSky
Cryo-ET reveals the molecular architecture of Ebola virus replication compartments.
www.cell.com/cell/fulltex... #MicroSky #IDSky
Troponins. Troponin I ist ein sehr empfindlicher Biomarker für Herzmuskelverletzungen. Bereits leicht erhöhte Werte – auch innerhalb des Normalbereichs – gelten als Hinweis auf eine sogenannte subklinische Myokardschädigung, also eine Herzmuskelbelastung ohne offensichtliche
May 31, 2026 at 3:09 PM
Troponins. Troponin I ist ein sehr empfindlicher Biomarker für Herzmuskelverletzungen. Bereits leicht erhöhte Werte – auch innerhalb des Normalbereichs – gelten als Hinweis auf eine sogenannte subklinische Myokardschädigung, also eine Herzmuskelbelastung ohne offensichtliche
UCLA, 2 blood donors plus cell models.
Delta nucleocapsid bound cGAS, while SARS-CoV-2 nucleocapsid amplified TLR7/8 inflammation in macrophages.
Their secretions cut coronary barrier integrity to 47%.
www.science.org/doi/10.1126/...
Delta nucleocapsid bound cGAS, while SARS-CoV-2 nucleocapsid amplified TLR7/8 inflammation in macrophages.
Their secretions cut coronary barrier integrity to 47%.
www.science.org/doi/10.1126/...
SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages
A coronavirus protein rewires immune signaling, driving inflammation and damaging blood vessels in severe COVID-19.
www.science.org
August 5, 2026 at 7:19 PM
UCLA, 2 blood donors plus cell models.
Delta nucleocapsid bound cGAS, while SARS-CoV-2 nucleocapsid amplified TLR7/8 inflammation in macrophages.
Their secretions cut coronary barrier integrity to 47%.
www.science.org/doi/10.1126/...
Delta nucleocapsid bound cGAS, while SARS-CoV-2 nucleocapsid amplified TLR7/8 inflammation in macrophages.
Their secretions cut coronary barrier integrity to 47%.
www.science.org/doi/10.1126/...