Redefining obesity, report of a new commission, to override current BMI categories and better define features and pathophysiologic consequences of pre-clinical and clinical obesity
www.thelancet.com/journals/lan... open-access
www.thelancet.com/journals/lan... open-access
January 14, 2025 at 11:38 PM
Redefining obesity, report of a new commission, to override current BMI categories and better define features and pathophysiologic consequences of pre-clinical and clinical obesity
www.thelancet.com/journals/lan... open-access
www.thelancet.com/journals/lan... open-access
November 12, 2024 at 5:45 PM
- The authors called for long COVID to be recognized as a chronic condition requiring long-term clinical and social support, as well as for further research to clarify pathophysiologic factors and identify diagnostic markers and effective treatment.
CIDRAP: “Up to 60% of health care workers may have long COVID 4 years after infection”
www.cidrap.umn.edu/covid-19/60-...
www.cidrap.umn.edu/covid-19/60-...
Up to 60% of health care workers may have long COVID 4 years after infection
www.cidrap.umn.edu
March 21, 2026 at 10:12 AM
- The authors called for long COVID to be recognized as a chronic condition requiring long-term clinical and social support, as well as for further research to clarify pathophysiologic factors and identify diagnostic markers and effective treatment.
Inflammation-inducible IL-1-targeted therapy using an rAAV vector as a long-lasting, pathophysiologic treatment for chronic inflammatory diseases @moltherapy.bsky.social @umasschan.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
September 20, 2025 at 4:45 PM
Inflammation-inducible IL-1-targeted therapy using an rAAV vector as a long-lasting, pathophysiologic treatment for chronic inflammatory diseases @moltherapy.bsky.social @umasschan.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
In this Core Curriculum, @rwbonner.bsky.social and Gerald Hladik describe the etiologies and pathophysiologic disturbances leading to renal tubular acidoses:
https://bit.ly/4aSiXOg (FREE)
@UNCKidney
https://bit.ly/4aSiXOg (FREE)
@UNCKidney
February 19, 2025 at 2:03 PM
In this Core Curriculum, @rwbonner.bsky.social and Gerald Hladik describe the etiologies and pathophysiologic disturbances leading to renal tubular acidoses:
https://bit.ly/4aSiXOg (FREE)
@UNCKidney
https://bit.ly/4aSiXOg (FREE)
@UNCKidney
One unambiguous result of the #InternationalMECFSConference2025:
The evidence for pathophysiologic disease mechanisms in #MECFS is - once again - so overwhelming that no serious doctor or researcher can still claim otherwise.
The evidence for pathophysiologic disease mechanisms in #MECFS is - once again - so overwhelming that no serious doctor or researcher can still claim otherwise.
May 13, 2025 at 1:42 PM
One unambiguous result of the #InternationalMECFSConference2025:
The evidence for pathophysiologic disease mechanisms in #MECFS is - once again - so overwhelming that no serious doctor or researcher can still claim otherwise.
The evidence for pathophysiologic disease mechanisms in #MECFS is - once again - so overwhelming that no serious doctor or researcher can still claim otherwise.
5/
The proposed pathophysiologic mechanisms for UP seem to break down along two broad categories: cutaneous/peripheral and systemic.
Let's start with cutaneous/peripheral.
https://buff.ly/3Pf0OA6
The proposed pathophysiologic mechanisms for UP seem to break down along two broad categories: cutaneous/peripheral and systemic.
Let's start with cutaneous/peripheral.
https://buff.ly/3Pf0OA6
December 30, 2024 at 6:49 PM
5/
The proposed pathophysiologic mechanisms for UP seem to break down along two broad categories: cutaneous/peripheral and systemic.
Let's start with cutaneous/peripheral.
https://buff.ly/3Pf0OA6
The proposed pathophysiologic mechanisms for UP seem to break down along two broad categories: cutaneous/peripheral and systemic.
Let's start with cutaneous/peripheral.
https://buff.ly/3Pf0OA6
UT Austin and Greater Austin Allergy studied 16 people with Long COVID.
Immunoglobulin replacement did not significantly improve overall symptoms, but insomnia, muscle pain, joint pain, GI discomfort, and general unwellness improved.
www.jacionline.org/article/S009...
Immunoglobulin replacement did not significantly improve overall symptoms, but insomnia, muscle pain, joint pain, GI discomfort, and general unwellness improved.
www.jacionline.org/article/S009...
Immunoglobulin Replacement Does Not Correlate With Overall Improvement in Post-Acute Sequelae of COVID-19 Symptoms
Immunoglobulin (Ig) replacement therapy is a current treatment for patients with certain
immune deficiencies. Multiple pathophysiologic mechanisms have indicated the potential
benefit of Ig replacemen...
www.jacionline.org
September 25, 2026 at 3:37 PM
UT Austin and Greater Austin Allergy studied 16 people with Long COVID.
Immunoglobulin replacement did not significantly improve overall symptoms, but insomnia, muscle pain, joint pain, GI discomfort, and general unwellness improved.
www.jacionline.org/article/S009...
Immunoglobulin replacement did not significantly improve overall symptoms, but insomnia, muscle pain, joint pain, GI discomfort, and general unwellness improved.
www.jacionline.org/article/S009...
#LongCovid symptoms (blue boxes) and possible pathophysiologic mechanisms (red boxes)
December 22, 2024 at 9:22 PM
#LongCovid symptoms (blue boxes) and possible pathophysiologic mechanisms (red boxes)
There are studies suggesting that Long COVID, ME/CFS and Fibromyalgia have similar pathophysiologic pathways. Hopefully these studies will lead to more interest in, and funding for post-viral illness research and education.
New Study: Link Between Long COVID and ME/CFS
NIH’s RECOVER Initiative found that 4.5% of post-COVID participants met ME/CFS criteria — 15x higher than pre-pandemic rates. The study highlights how SARS-CoV-2 infection may trigger chronic conditions like ME/CFS. #LongCOVID
NIH’s RECOVER Initiative found that 4.5% of post-COVID participants met ME/CFS criteria — 15x higher than pre-pandemic rates. The study highlights how SARS-CoV-2 infection may trigger chronic conditions like ME/CFS. #LongCOVID
NIH-funded study finds cases of ME/CFS increase following SARS-CoV-2
ME/CFS is a complex, serious, and chronic condition that often occurs following an infection
www.ninds.nih.gov
January 15, 2025 at 7:56 PM
There are studies suggesting that Long COVID, ME/CFS and Fibromyalgia have similar pathophysiologic pathways. Hopefully these studies will lead to more interest in, and funding for post-viral illness research and education.
8 ) Link to the (open-access) paper:
Jothi et al. Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation.
Jothi et al. Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation.
Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation
Post-acute sequelae of SARS-CoV-2 (PASC or “long COVID”) and chronic fatigue syndrome/myalgic encephalitis (CFS/ME) share symptoms such as exertional dyspnea. We used exercise oxygen pathway analysis...
physoc.onlinelibrary.wiley.com
September 3, 2025 at 3:48 PM
8 ) Link to the (open-access) paper:
Jothi et al. Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation.
Jothi et al. Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation.
Most viewed this week from JAMA: This Review discusses the diagnosis, treatment, and prognosis of adults with type 2 diabetes.
https://ja.ma/3ThpXMF
https://ja.ma/3ThpXMF
June 30, 2025 at 11:00 AM
Most viewed this week from JAMA: This Review discusses the diagnosis, treatment, and prognosis of adults with type 2 diabetes.
https://ja.ma/3ThpXMF
https://ja.ma/3ThpXMF
Type 2 diabetes affects up to 14% of the global population. This Review discusses the diagnosis, treatment, and prognosis of adults with type 2 diabetes.
#ADASciSessions @amdiabetesassn.bsky.social
https://ja.ma/3HK0lFM
#ADASciSessions @amdiabetesassn.bsky.social
https://ja.ma/3HK0lFM
June 23, 2025 at 4:00 PM
Type 2 diabetes affects up to 14% of the global population. This Review discusses the diagnosis, treatment, and prognosis of adults with type 2 diabetes.
#ADASciSessions @amdiabetesassn.bsky.social
https://ja.ma/3HK0lFM
#ADASciSessions @amdiabetesassn.bsky.social
https://ja.ma/3HK0lFM
4/
Uremic pruritis (UP) seems to be a Hickam's dictum-type situation, with more than one pathophysiologic cause.
The overall problem, not surprisingly, seems to relate to metabolic derangement from renal failure.
But why would that make someone itch so severely?
Uremic pruritis (UP) seems to be a Hickam's dictum-type situation, with more than one pathophysiologic cause.
The overall problem, not surprisingly, seems to relate to metabolic derangement from renal failure.
But why would that make someone itch so severely?
December 30, 2024 at 6:49 PM
4/
Uremic pruritis (UP) seems to be a Hickam's dictum-type situation, with more than one pathophysiologic cause.
The overall problem, not surprisingly, seems to relate to metabolic derangement from renal failure.
But why would that make someone itch so severely?
Uremic pruritis (UP) seems to be a Hickam's dictum-type situation, with more than one pathophysiologic cause.
The overall problem, not surprisingly, seems to relate to metabolic derangement from renal failure.
But why would that make someone itch so severely?
Most viewed this week from JAMA: This Review discusses the diagnosis, treatment, and prognosis of adults with type 2 diabetes.
https://ja.ma/4ntmQiE
https://ja.ma/4ntmQiE
June 28, 2025 at 11:00 AM
Most viewed this week from JAMA: This Review discusses the diagnosis, treatment, and prognosis of adults with type 2 diabetes.
https://ja.ma/4ntmQiE
https://ja.ma/4ntmQiE
Normally hard science & objective findings like these would bring all hands on deck and serious research fundings, but when it’s in #pwME, it’s just a meh & barely get noticed
#ME/CFS = medicine pariah
• Oxygen extraction issues
• Preload failure
• Reduced V̇O2peak
• Skeletal muscle O2 diffusion
#ME/CFS = medicine pariah
• Oxygen extraction issues
• Preload failure
• Reduced V̇O2peak
• Skeletal muscle O2 diffusion
Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation
Post-acute sequelae of SARS-CoV-2 (PASC or “long COVID”) and chronic fatigue syndrome/myalgic encephalitis (CFS/ME) share symptoms such as exertional dyspnea. We used exercise oxygen pathway analysis...
physoc.onlinelibrary.wiley.com
September 3, 2025 at 2:02 AM
In this Core Curriculum, Ryan Bonner and Gerald Hladik describe the etiologies and pathophysiologic disturbances leading to renal tubular acidoses:
bit.ly/3EIS8jl (FREE)
@UNCKidney
bit.ly/3EIS8jl (FREE)
@UNCKidney
June 17, 2025 at 10:02 PM
In this Core Curriculum, Ryan Bonner and Gerald Hladik describe the etiologies and pathophysiologic disturbances leading to renal tubular acidoses:
bit.ly/3EIS8jl (FREE)
@UNCKidney
bit.ly/3EIS8jl (FREE)
@UNCKidney
2/
"We conclude that considering #LongCOVID as #FND is inappropriate based on differentiating pathophysiologic mechanisms and distinguishing clinical findings":
@sunsopeningband.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
"We conclude that considering #LongCOVID as #FND is inappropriate based on differentiating pathophysiologic mechanisms and distinguishing clinical findings":
@sunsopeningband.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
Checking your browser - reCAPTCHA
pmc.ncbi.nlm.nih.gov
May 1, 2026 at 1:46 PM
2/
"We conclude that considering #LongCOVID as #FND is inappropriate based on differentiating pathophysiologic mechanisms and distinguishing clinical findings":
@sunsopeningband.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
"We conclude that considering #LongCOVID as #FND is inappropriate based on differentiating pathophysiologic mechanisms and distinguishing clinical findings":
@sunsopeningband.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
From South Korea:
Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19
www.nature.com/articles/s41...
Screenshot from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC
Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19
www.nature.com/articles/s41...
Screenshot from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC
December 2, 2025 at 2:09 AM
From South Korea:
Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19
www.nature.com/articles/s41...
Screenshot from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC
Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19
www.nature.com/articles/s41...
Screenshot from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC
I think one thing people in medicine choose to ignore is that while cannabinoid hyperemesis is definitely real it’s not only incredibly rare, but is pretty easily treatable. More importantly than any of that, there is no pathophysiologic basis for CHS so the people fixating on it should do some work
November 5, 2023 at 1:01 AM
I think one thing people in medicine choose to ignore is that while cannabinoid hyperemesis is definitely real it’s not only incredibly rare, but is pretty easily treatable. More importantly than any of that, there is no pathophysiologic basis for CHS so the people fixating on it should do some work
"For many patients, the clinical presentation of Long COVID is indistinguishable from ME/CFS, with researchers increasingly identifying shared pathophysiologic features between these two illnesses and other post-infectious fatiguing syndromes."
🤷🏼♀️
2/2
🤷🏼♀️
2/2
September 21, 2024 at 9:00 AM
"For many patients, the clinical presentation of Long COVID is indistinguishable from ME/CFS, with researchers increasingly identifying shared pathophysiologic features between these two illnesses and other post-infectious fatiguing syndromes."
🤷🏼♀️
2/2
🤷🏼♀️
2/2
Our MRSA rate came down from 20% and more in 2010 to now <10%. Likely due to <insert your favorite pathophysiologic take here>
April 29, 2026 at 5:20 PM
Our MRSA rate came down from 20% and more in 2010 to now <10%. Likely due to <insert your favorite pathophysiologic take here>
Although long COVID may manifest in various phenotypes, it typically presents with symptom clusters that suggest interconnected pathophysiologic mechanisms, characterized by chronic inflammation, immune dysregulation, and neurovascular dysfunction.
Although health system has evidence-based treatments for first 2 categories, long COVID remains vexing. The most common persisting symptoms after acute COVID-19 are nonspecific: postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, and palpitations.
and 3) long COVID itself, characterized by a spectrum of persistent symptoms that significantly impair functionality without detectable tissue damage using currently available diagnostic methods.
May 22, 2024 at 7:15 PM
Although long COVID may manifest in various phenotypes, it typically presents with symptom clusters that suggest interconnected pathophysiologic mechanisms, characterized by chronic inflammation, immune dysregulation, and neurovascular dysfunction.