Neuroinflammation is a known pathophysiologic mechanism in multiple sclerosis and a proposed mechanism in fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Positron Emissio...

Swiss J. Radiol. Nucl. Med. · Vol. 24 No. 1 · 2025-10-31 · DOI doi.org/10.59667/sjoranm.v24i1.16 · LG1 encephalitis is an immune mediated neurological disorder effecting temporal lobe and basal ganglia. The classic clinical syndrome comprises of myoclonic jerks of the ipsilateral upper arms…

Abstract. Chronic kidney disease (CKD) is one of the most prevalent diseases in feline medicine. Mass spectrometry-based urinary proteomics offers powerful

AbstractChronic kidney disease (CKD) is one of the most prevalent diseases in feline medicine. Mass spectrometry-based urinary proteomics offers powerful insight into biomarker candidates and disease subtyping in CKD by measuring protein profiles rather than individual proteins. This study aims to measure the urinary proteome to identify protein profiles in cats with and without CKD to gain pathophysiological insights into the disease and more precisely diagnose CKD. Here, we identify 2,219 urinary proteins in the feline urinary proteome. Using univariate biomarker analysis, we show that MMP-7 may be a promising biomarker of CKD in cats. We then demonstrate the power of using protein profiles rather than individual proteins by grouping proteins based on how they trend across disease states. The changes to the global urinary proteomes of individual cats showed three distinct groups of CKD cats with unique protein profiles, suggesting that different pathophysiological mechanisms mediate disease subtypes. We demonstrate that large-scale urinary proteomics may provide a powerful framework for discovering candidate biomarkers that advance the subtyping and mechanistic understanding of feline CKD.

Stuart T. Haines/Thomas D. Nolin/Vicki Ellingrod

Immunoglobulin (Ig) replacement therapy is a current treatment for patients with certain immune deficiencies. Multiple pathophysiologic mechanisms have indicated the potential benefit of Ig replacemen...

Iridocorneal endothelial (ICE) syndrome is a rare acquired anterior segment disorder characterized by abnormal proliferation and migration of corneal endothelial cells, leading to progressive angle closure, iris abnormalities, secondary glaucoma, and corneal decompensation. Historically divided into Chandler syndrome, progressive iris atrophy, and Cogan–Reese syndrome, ICE is now recognized as a disease spectrum with a shared pathophysiologic basis. Diagnosis and management remain challenging because of variable clinical manifestations and progressive vision-threatening complications.

In a series of studies on histaminergic functions in the hypothalamus, probes to manipulate activities of histaminergic neuron systems were applied to assess its physiologic and pathophysiologic implications using non-obese normal and Zucker obese rats, an animal model of genetic obesity. Food intak …

ng, but suboptimal. Maximal benefit from CPCR will be achievable: a) by minimizing response times; and b) by extending reversible arrest times—the topic of this symposium. For reperfusion, closed ches...

BACKGROUND: Evidence suggests that the intrauterine environment shapes offspring cardiovascular disease risk. Although placental dysfunction may be an important pathophysiologic pathway, numerous pare...

To complete this exercise, carefully read each clinical condition listed and match it to the correct underlying cause of disorientation. This activity helps you strengthen your understanding of neurological disorders and their pathophysiologic basis. For example, Wernicke encephalopathy is linked to thiamine deficiency, while hypoxia results from respiratory failure. Identify the key features of each condition, and align them logically with the cause that explains the patient’s altered mental state.

Purpose of Review This review explores the evidence for using a ketogenic diet as a transdiagnostic treatment for mental health disorders. We examine the biological pathophysiologic mechanisms that un...

Purpose of Review This review explores the evidence for using a ketogenic diet as a transdiagnostic treatment for mental health disorders. We examine the biological pathophysiologic mechanisms that un...

Introduction The differentiation between Alzheimer’s disease (AD) and behavioral-variant frontotemporal dementia (bvFTD) can be complicated in the initial phase by shared symptoms and pathophysiologic...

Read DiPiro’s Pharmacotherapy: A Pathophysiologic Approach, 12th Edition online now, exclusively on AccessPharmacy. AccessPharmacy is a subscription-based resource from McGraw Hill that features trust...

A NEW paradigm for medical practice is emerging. Evidence-based medicine de-emphasizes intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient grounds for clinical de...