Having seen a patient yesterday who has been ravaged by COVID19 with multiple complications - just a friendly reminder that we know an awful lot about the pathophysiology. Superb review here;
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Long COVID: pathophysiological factors and abnormalities of coagulation
Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten cases: known as Long COVID. The disease affects ~65 million individuals worldwide. Many pathophysiological proces...
pmc.ncbi.nlm.nih.gov
December 8, 2024 at 11:00 AM
Having seen a patient yesterday who has been ravaged by COVID19 with multiple complications - just a friendly reminder that we know an awful lot about the pathophysiology. Superb review here;
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Our new paper is here:
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID - Communications Medicine
Faghy et al., review the current literature on Long COVID pathophysiology, linking immune dysregulation, viral persistence, and vascular injury to enduring symptoms. They highlight evidence to guide f...
www.nature.com
April 29, 2026 at 11:55 AM
Our new paper is here:
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID
www.nature.com/articles/s43...
How do you get to the nitty-gritty of Parkinson's disease?
Do high-throughput proteomics.
www.nature.com/articles/s43...
Do high-throughput proteomics.
www.nature.com/articles/s43...
Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological insights and potential biomarkers - Nature Aging
The early pathophysiology of Parkinson’s disease is not well understood. Here the authors perform large-scale proteomic analyses of incident Parkinson’s disease to reveal pathophysiological insights a...
www.nature.com
February 20, 2025 at 7:36 PM
How do you get to the nitty-gritty of Parkinson's disease?
Do high-throughput proteomics.
www.nature.com/articles/s43...
Do high-throughput proteomics.
www.nature.com/articles/s43...
I'm fascinated by the implication that the "chief of islet transplantation surgery at Johns Hopkins" doesn't know that T1D and T2D reflect distinct pathophysiological mechanisms
May 26, 2025 at 8:05 AM
I'm fascinated by the implication that the "chief of islet transplantation surgery at Johns Hopkins" doesn't know that T1D and T2D reflect distinct pathophysiological mechanisms
Long Covid isn’t FND. Pass it on. www.mdpi.com/2075-4426/14...
Long COVID Is Not a Functional Neurologic Disorder
Long COVID is a common sequela of SARS-CoV-2 infection. Data from numerous scientific studies indicate that long COVID involves a complex interaction between pathophysiological processes. Long COVID m...
www.mdpi.com
November 26, 2024 at 3:38 AM
Long Covid isn’t FND. Pass it on. www.mdpi.com/2075-4426/14...
Our new paper out today in Nature Comms, led by the amazing @profmarkfaghy.bsky.social
Current status and future perspectives on the mechanistic And pathophysiological understanding of Long Covid
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic And pathophysiological understanding of Long Covid
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID - Communications Medicine
Faghy et al., review the current literature on Long COVID pathophysiology, linking immune dysregulation, viral persistence, and vascular injury to enduring symptoms. They highlight evidence to guide f...
www.nature.com
April 29, 2026 at 8:48 PM
Our new paper out today in Nature Comms, led by the amazing @profmarkfaghy.bsky.social
Current status and future perspectives on the mechanistic And pathophysiological understanding of Long Covid
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic And pathophysiological understanding of Long Covid
www.nature.com/articles/s43...
Horizon-Förderung für 4 Jahre Forschung zu den "core pathophysiological mechanisms of #ME/CFS - immune dysregulation, neurological involvement, autonomic dysfunction, and metabolic abnormalities" - klasse!! 👏
EMERG announces EU Horizon funding for 𝗗𝗜𝗦𝗖𝗢𝗩𝗘𝗥-𝗠𝗘 - the first major pan-European biomedical research programme dedicated to #MECFS
Ten years of building European ME research. Now the work begins at a scale ME deserves
emerg.eu/emergnews260...
#MEresearch #DISCOVER-ME #research #HorizonEurope
Ten years of building European ME research. Now the work begins at a scale ME deserves
emerg.eu/emergnews260...
#MEresearch #DISCOVER-ME #research #HorizonEurope
June 30, 2026 at 6:00 PM
Horizon-Förderung für 4 Jahre Forschung zu den "core pathophysiological mechanisms of #ME/CFS - immune dysregulation, neurological involvement, autonomic dysfunction, and metabolic abnormalities" - klasse!! 👏
"nicht über den Placebo-Effekt hinaus".
Herzlich grüßt die Evidenz...:-)
pmc.ncbi.nlm.nih.gov/articles/PMC...
Herzlich grüßt die Evidenz...:-)
pmc.ncbi.nlm.nih.gov/articles/PMC...
June 12, 2026 at 8:26 AM
"nicht über den Placebo-Effekt hinaus".
Herzlich grüßt die Evidenz...:-)
pmc.ncbi.nlm.nih.gov/articles/PMC...
Herzlich grüßt die Evidenz...:-)
pmc.ncbi.nlm.nih.gov/articles/PMC...
2/2
L'article "Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID" :
www.nature.com/articles/s43...
L'article "Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID" :
www.nature.com/articles/s43...
May 29, 2026 at 12:28 PM
2/2
L'article "Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID" :
www.nature.com/articles/s43...
L'article "Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID" :
www.nature.com/articles/s43...
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
onlinelibrary.wiley.com/doi/10.1002/...
#LongCovid #MEcfs @scheibenbogen.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
#LongCovid #MEcfs @scheibenbogen.bsky.social
December 27, 2024 at 1:10 PM
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
onlinelibrary.wiley.com/doi/10.1002/...
#LongCovid #MEcfs @scheibenbogen.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
#LongCovid #MEcfs @scheibenbogen.bsky.social
Advances in Understanding Long COVID: Pathophysiological Mechanisms and the Role of Omics Technologies in Biomarker Identification
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Advances in Understanding Long COVID: Pathophysiological Mechanisms and the Role of Omics Technologies in Biomarker Identification - Molecular Diagnosis & Therapy
Long coronavirus disease (COVID) is a multisystem condition that affects a significant proportion of individuals following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with ...
link.springer.com
June 30, 2025 at 5:15 AM
Advances in Understanding Long COVID: Pathophysiological Mechanisms and the Role of Omics Technologies in Biomarker Identification
link.springer.com/article/10.1...
link.springer.com/article/10.1...
1) A new article in The Lancet Infectious Diseases calls for "routine patient review of all manuscripts on long COVID, including but not limited to clinical trial protocols and results, pathophysiological research, and opinion pieces"
April 4, 2026 at 8:11 AM
1) A new article in The Lancet Infectious Diseases calls for "routine patient review of all manuscripts on long COVID, including but not limited to clinical trial protocols and results, pathophysiological research, and opinion pieces"
They are excluding all other conditions with a known diagnosis that happens after infection, which is good in some ways, but interesting in other ways... because eventually we will probably find pathophysiological mechanisms for most of it.
June 3, 2025 at 4:04 AM
They are excluding all other conditions with a known diagnosis that happens after infection, which is good in some ways, but interesting in other ways... because eventually we will probably find pathophysiological mechanisms for most of it.
Published today!
Carmen Scheibenbogen, Klaus J. Wirth: Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
doi.org/10.1002/jcsm...
Carmen Scheibenbogen, Klaus J. Wirth: Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
doi.org/10.1002/jcsm...
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pa...
doi.org
December 27, 2024 at 12:07 PM
Published today!
Carmen Scheibenbogen, Klaus J. Wirth: Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
doi.org/10.1002/jcsm...
Carmen Scheibenbogen, Klaus J. Wirth: Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
doi.org/10.1002/jcsm...
It takes humility to admit "I don't know". What we DO know is that LC and ME are real pathophysiological multiorgan diseases, typically very debilitating. No amount of brain retraining will change that (except maybe making sympotoms worse as you 'push through')
September 28, 2026 at 5:18 AM
It takes humility to admit "I don't know". What we DO know is that LC and ME are real pathophysiological multiorgan diseases, typically very debilitating. No amount of brain retraining will change that (except maybe making sympotoms worse as you 'push through')
I’m just really glad adrenal fatigue isn’t a real pathophysiological entity
May 8, 2026 at 2:09 AM
I’m just really glad adrenal fatigue isn’t a real pathophysiological entity
EXCELLENT article published today, April 29, 2026 👇
“Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID”
www.nature.com/articles/s43...
“Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID”
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID - Communications Medicine
Faghy et al., review the current literature on Long COVID pathophysiology, linking immune dysregulation, viral persistence, and vascular injury to enduring symptoms. They highlight evidence to guide f...
www.nature.com
April 29, 2026 at 2:14 PM
EXCELLENT article published today, April 29, 2026 👇
“Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID”
www.nature.com/articles/s43...
“Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID”
www.nature.com/articles/s43...
Long Covid is complex... Very complex and not your friend.
#Leornardi_Effect
www.sciencedirect.com/science/arti...
#Leornardi_Effect
www.sciencedirect.com/science/arti...
Comprehensive molecular characterization of post-COVID condition: Immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
Post-COVID condition (PCC), or long COVID, affects a significant proportion of individuals following SARS-CoV-2 infection, yet its molecular framework…
www.sciencedirect.com
July 7, 2025 at 9:59 AM
Long Covid is complex... Very complex and not your friend.
#Leornardi_Effect
www.sciencedirect.com/science/arti...
#Leornardi_Effect
www.sciencedirect.com/science/arti...
Managing insulin resistance: the forgotten pathophysiological component of type 2 #diabetes thelancet.com/journals/lan... #T2D
#MedSky #EndoSky
#MedSky #EndoSky
March 15, 2025 at 4:10 PM
Managing insulin resistance: the forgotten pathophysiological component of type 2 #diabetes thelancet.com/journals/lan... #T2D
#MedSky #EndoSky
#MedSky #EndoSky
10) Link to the review:
Faghy et al. 2026. Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID.
Faghy et al. 2026. Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID.
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID
Communications Medicine - Faghy et al., review the current literature on Long COVID pathophysiology, linking immune dysregulation, viral persistence, and vascular injury to enduring symptoms. They...
www.nature.com
May 2, 2026 at 7:38 AM
10) Link to the review:
Faghy et al. 2026. Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID.
Faghy et al. 2026. Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID.
An Opus from my Long C-19 Colleagues from across the world.
Lead author, @profmarkfaghy.bsky.social ... Total CHAMPION‼️
My contribution... Sleep Medicine🙏🏻
www.nature.com/articles/s43...
Lead author, @profmarkfaghy.bsky.social ... Total CHAMPION‼️
My contribution... Sleep Medicine🙏🏻
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID - Communications Medicine
Faghy et al., review the current literature on Long COVID pathophysiology, linking immune dysregulation, viral persistence, and vascular injury to enduring symptoms. They highlight evidence to guide f...
www.nature.com
April 29, 2026 at 11:08 AM
An Opus from my Long C-19 Colleagues from across the world.
Lead author, @profmarkfaghy.bsky.social ... Total CHAMPION‼️
My contribution... Sleep Medicine🙏🏻
www.nature.com/articles/s43...
Lead author, @profmarkfaghy.bsky.social ... Total CHAMPION‼️
My contribution... Sleep Medicine🙏🏻
www.nature.com/articles/s43...
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
pmc.ncbi.nlm.nih.gov/articles/PMC...
Image is from April 2025 AMMES Newsletter
#MEcfs #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
Image is from April 2025 AMMES Newsletter
#MEcfs #LongCovid
April 13, 2025 at 12:14 AM
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
pmc.ncbi.nlm.nih.gov/articles/PMC...
Image is from April 2025 AMMES Newsletter
#MEcfs #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
Image is from April 2025 AMMES Newsletter
#MEcfs #LongCovid
The pathophysiology of that disease they are trying to treat with positive vibes.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID - Communications Medicine
Faghy et al., review the current literature on Long COVID pathophysiology, linking immune dysregulation, viral persistence, and vascular injury to enduring symptoms. They highlight evidence to guide f...
www.nature.com
April 30, 2026 at 10:01 AM
The pathophysiology of that disease they are trying to treat with positive vibes.
www.nature.com/articles/s43...
www.nature.com/articles/s43...