Huge Panzer Dragoon Saga Fan Excited to Finish Disk One for the First Time
November 29, 2025 at 10:54 PM
Huge Panzer Dragoon Saga Fan Excited to Finish Disk One for the First Time
A new proximity labeling and biophysical analysis shows that the protein Girdin-L is an unexpected ligand of the PDZ domain of the Dishevelled protein and plays an important role in promoting the breakdown of primary cilia on cells. #ScienceSignaling https://scim.ag/47koCeN
Dishevelled drives disassembly of primary cilia through an unusual PDZ domain–mediated binding mode with Girdin-L
Girdin binds to the PDZ domain of Dishevelled to promote cilium disassembly.
scim.ag
September 23, 2026 at 3:00 PM
A new proximity labeling and biophysical analysis shows that the protein Girdin-L is an unexpected ligand of the PDZ domain of the Dishevelled protein and plays an important role in promoting the breakdown of primary cilia on cells. #ScienceSignaling https://scim.ag/47koCeN
PDZ on PC soon hopefully
June 8, 2025 at 12:51 PM
PDZ on PC soon hopefully
sometimes I wish the only pre-transition photo I hung onto wasn't me badly crossplaying PDZ joanna dark posing with the guy who made 4chan but like, I love how much and how little I've changed over the past 20 years
NoHRT manhon Perfect Dark Zero crossplayer who doesn’t eat to a cowmaxing Perfect Dark PC port modder
September 24, 2026 at 4:51 AM
sometimes I wish the only pre-transition photo I hung onto wasn't me badly crossplaying PDZ joanna dark posing with the guy who made 4chan but like, I love how much and how little I've changed over the past 20 years
PDZ Stevanović ima resen problem! Kdaj bo razumel, da je nesprejem dnevnega reda, huda degradacija DZ in njega osebno?
Če za zahtevo stoji 30 poslancev preiskava mora biti odrejena, ne glede, kaj si PDZ misli o njej!
Če za zahtevo stoji 30 poslancev preiskava mora biti odrejena, ne glede, kaj si PDZ misli o njej!
July 13, 2026 at 5:07 PM
PDZ Stevanović ima resen problem! Kdaj bo razumel, da je nesprejem dnevnega reda, huda degradacija DZ in njega osebno?
Če za zahtevo stoji 30 poslancev preiskava mora biti odrejena, ne glede, kaj si PDZ misli o njej!
Če za zahtevo stoji 30 poslancev preiskava mora biti odrejena, ne glede, kaj si PDZ misli o njej!
Zelda CDI all Cutscenes (Full Screen)
YouTube video by AnimeReUploader
youtu.be
May 13, 2025 at 4:37 PM
New preprint! 🎉
We discovered an unexpected way that the postsynaptic scaffold protein Densin-180 binds SHANK proteins.
Instead of using a conventional C-terminal PDZ-binding motif, Densin-180 uses an internal PDZ-binding motif that engages the canonical SHANK3 PDZ domain. 🧵1/8
We discovered an unexpected way that the postsynaptic scaffold protein Densin-180 binds SHANK proteins.
Instead of using a conventional C-terminal PDZ-binding motif, Densin-180 uses an internal PDZ-binding motif that engages the canonical SHANK3 PDZ domain. 🧵1/8
July 10, 2026 at 2:58 PM
New preprint! 🎉
We discovered an unexpected way that the postsynaptic scaffold protein Densin-180 binds SHANK proteins.
Instead of using a conventional C-terminal PDZ-binding motif, Densin-180 uses an internal PDZ-binding motif that engages the canonical SHANK3 PDZ domain. 🧵1/8
We discovered an unexpected way that the postsynaptic scaffold protein Densin-180 binds SHANK proteins.
Instead of using a conventional C-terminal PDZ-binding motif, Densin-180 uses an internal PDZ-binding motif that engages the canonical SHANK3 PDZ domain. 🧵1/8
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
August 28, 2025 at 10:25 AM
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
interactome_pdz: PDZ-domain interactome (2005).
A network of PDZ-domain-mediated protein–protein binding interactions, extracted from the PDZBase database.
212 nodes, 244 edges.
https://networks.skewed.de/net/interactome_pdz
Ridiculogram:
A network of PDZ-domain-mediated protein–protein binding interactions, extracted from the PDZBase database.
212 nodes, 244 edges.
https://networks.skewed.de/net/interactome_pdz
Ridiculogram:
September 26, 2026 at 2:00 PM
interactome_pdz: PDZ-domain interactome (2005).
A network of PDZ-domain-mediated protein–protein binding interactions, extracted from the PDZBase database.
212 nodes, 244 edges.
https://networks.skewed.de/net/interactome_pdz
Ridiculogram:
A network of PDZ-domain-mediated protein–protein binding interactions, extracted from the PDZBase database.
212 nodes, 244 edges.
https://networks.skewed.de/net/interactome_pdz
Ridiculogram:
Palestyńskiego Islamskiego Dżihadu została przywrócona do tego stopnia, że Hamas ma ponad 25 000, a PDż ponad 5000 uzbrojonych terrorystów” to w sumie ciekawe, bo tym razem to już samobójstwo z ich strony.
March 17, 2025 at 8:06 PM
Palestyńskiego Islamskiego Dżihadu została przywrócona do tego stopnia, że Hamas ma ponad 25 000, a PDż ponad 5000 uzbrojonych terrorystów” to w sumie ciekawe, bo tym razem to już samobójstwo z ich strony.
interactome_pdz: PDZ-domain interactome (2005).
A network of PDZ-domain-mediated protein–protein binding interactions, extracted from the PDZBase database.
212 nodes, 244 edges.
https://networks.skewed.de/net/interactome_pdz
Ridiculogram:
A network of PDZ-domain-mediated protein–protein binding interactions, extracted from the PDZBase database.
212 nodes, 244 edges.
https://networks.skewed.de/net/interactome_pdz
Ridiculogram:
September 25, 2026 at 9:00 AM
interactome_pdz: PDZ-domain interactome (2005).
A network of PDZ-domain-mediated protein–protein binding interactions, extracted from the PDZBase database.
212 nodes, 244 edges.
https://networks.skewed.de/net/interactome_pdz
Ridiculogram:
A network of PDZ-domain-mediated protein–protein binding interactions, extracted from the PDZBase database.
212 nodes, 244 edges.
https://networks.skewed.de/net/interactome_pdz
Ridiculogram:
That said though, I did play PDZ in 2023 and ended up enjoying it.
January 4, 2025 at 8:53 PM
That said though, I did play PDZ in 2023 and ended up enjoying it.
あ、ふふふのおじさん……
おじさん……ですか……
……………………………………
終
制作・著作
━━━━━
PDZ
おじさん……ですか……
……………………………………
終
制作・著作
━━━━━
PDZ
November 3, 2025 at 11:21 AM
あ、ふふふのおじさん……
おじさん……ですか……
……………………………………
終
制作・著作
━━━━━
PDZ
おじさん……ですか……
……………………………………
終
制作・著作
━━━━━
PDZ
For everyone who missed it: @rude1.blacksky.team's keynote speech at @publicspaces.net conference 2026 in @pakhuisdezwijger.bsky.social is online for viewing now.
highly recommended
highly recommended
Public Spaces x PdZ PublicSpaces conferentie 2026: Technology for democracy
Tijdens de zesde editie van de PublicSpaces Conferentie op 4, 5 en 6 juni 2026 buigen we ons over de impact van technologie op onze democratie. Op 5 juni vindt het conferentieprogramma plaats in Pakhu...
dezwijger.nl
June 9, 2026 at 7:40 AM
For everyone who missed it: @rude1.blacksky.team's keynote speech at @publicspaces.net conference 2026 in @pakhuisdezwijger.bsky.social is online for viewing now.
highly recommended
highly recommended
Res ne razumem, zakaj novinarji govorijo o manjšinski vladi? Samo zato, ker Resni.ca ni podpisala koalicijske pogodbe in nima ministra, ima pa PDZ, ki šteje vsaj za za dva!
Stranka Resni.ca
Resni.ca
June 4, 2026 at 6:10 PM
Res ne razumem, zakaj novinarji govorijo o manjšinski vladi? Samo zato, ker Resni.ca ni podpisala koalicijske pogodbe in nima ministra, ima pa PDZ, ki šteje vsaj za za dva!
Panzer Dragoon Zwei is on a short list of games I'd consider an actual Masterpiece™️. I can't help but sound hyperbolic, it's a virtuosic work of brilliance and one of the most ambitious AND finely honed arcade games ever. @partyinthefront.bsky.social's art is the centerpiece of our living room wall.
August 14, 2026 at 2:30 AM
Panzer Dragoon Zwei is on a short list of games I'd consider an actual Masterpiece™️. I can't help but sound hyperbolic, it's a virtuosic work of brilliance and one of the most ambitious AND finely honed arcade games ever. @partyinthefront.bsky.social's art is the centerpiece of our living room wall.
Speaking of PDZ. 👀
January 4, 2025 at 10:47 PM
Speaking of PDZ. 👀
Visited the cherry blossoms at the waterfront with my friends Kira and Amy 🌸
#cherryblossoms #pdz #portland #emo #femboy
#cherryblossoms #pdz #portland #emo #femboy
March 21, 2024 at 2:22 PM
Visited the cherry blossoms at the waterfront with my friends Kira and Amy 🌸
#cherryblossoms #pdz #portland #emo #femboy
#cherryblossoms #pdz #portland #emo #femboy
Hoe wapenen we ons tegen de beïnvloedingstechnieken van Big Tech als zij het grootste gedeelte van de wereldwijde communicatie-infrastructuren in handen hebben?
We bespreken het op 30 september tijdens Attention under Attack in Pakhuis de Zwijger. Zien we je daar? dezwijger.nl/programma/at...
We bespreken het op 30 september tijdens Attention under Attack in Pakhuis de Zwijger. Zien we je daar? dezwijger.nl/programma/at...
Bits of Freedom x PdZ #1: Attention under attack
Hoe Big Tech onze aandacht kaapt en hoe je daar tegen te wapenen.
dezwijger.nl
September 16, 2026 at 6:00 AM
Hoe wapenen we ons tegen de beïnvloedingstechnieken van Big Tech als zij het grootste gedeelte van de wereldwijde communicatie-infrastructuren in handen hebben?
We bespreken het op 30 september tijdens Attention under Attack in Pakhuis de Zwijger. Zien we je daar? dezwijger.nl/programma/at...
We bespreken het op 30 september tijdens Attention under Attack in Pakhuis de Zwijger. Zien we je daar? dezwijger.nl/programma/at...
Hidden away in at the back of the wardrobe we have two more PDZ entries: a sampler of the Perfect Dark comic, and a 2006 'glamour' calendar which... speaks for itself, really.
2006 sure was a year, eh?
2006 sure was a year, eh?
November 22, 2025 at 6:31 PM
Hidden away in at the back of the wardrobe we have two more PDZ entries: a sampler of the Perfect Dark comic, and a 2006 'glamour' calendar which... speaks for itself, really.
2006 sure was a year, eh?
2006 sure was a year, eh?
Happy International Polar Bear Day .. here’s to Laerke & the Staff at the PDZ&A who care for this sweet girl! 🐼🤍
Meet our polar bear Laerke for #InternationalPolarBearDay! 🐻❄️
Laerke’s start in life was difficult, requiring intensive care after birth. Ongoing health issues meant she was hand-reared. Though she’s made progress, she still has specific needs and receives personalized care.
Laerke’s start in life was difficult, requiring intensive care after birth. Ongoing health issues meant she was hand-reared. Though she’s made progress, she still has specific needs and receives personalized care.
February 27, 2026 at 9:22 PM
Happy International Polar Bear Day .. here’s to Laerke & the Staff at the PDZ&A who care for this sweet girl! 🐼🤍
For reference:
youtu.be/TN8-Pdz-ns8
youtu.be/TN8-Pdz-ns8
Zelda CDI all Cutscenes (Full Screen)
YouTube video by AnimeReUploader
www.youtube.com
January 28, 2025 at 7:56 PM
For reference:
youtu.be/TN8-Pdz-ns8
youtu.be/TN8-Pdz-ns8
Do you think Joanna Dark fucks as good as she kills? #joannadark #perfectdark #n64 #perfectdarkzero #pdz #pd #pd64 #agentdark
July 17, 2024 at 4:26 AM
Do you think Joanna Dark fucks as good as she kills? #joannadark #perfectdark #n64 #perfectdarkzero #pdz #pd #pd64 #agentdark
building a skin-tone matcher for perfect dark.
@foslerfer.bsky.social, Willow Dark, and myself are the immediate beneficiaries of this bc we're all paler than N64 Jo but long term I want to add foj with darker skin tones
next: freckles (for me lmao) and decal support (pdz jo's tattoos + scars)
@foslerfer.bsky.social, Willow Dark, and myself are the immediate beneficiaries of this bc we're all paler than N64 Jo but long term I want to add foj with darker skin tones
next: freckles (for me lmao) and decal support (pdz jo's tattoos + scars)
September 20, 2026 at 6:23 PM
building a skin-tone matcher for perfect dark.
@foslerfer.bsky.social, Willow Dark, and myself are the immediate beneficiaries of this bc we're all paler than N64 Jo but long term I want to add foj with darker skin tones
next: freckles (for me lmao) and decal support (pdz jo's tattoos + scars)
@foslerfer.bsky.social, Willow Dark, and myself are the immediate beneficiaries of this bc we're all paler than N64 Jo but long term I want to add foj with darker skin tones
next: freckles (for me lmao) and decal support (pdz jo's tattoos + scars)