Ye et al. describe a synthetic-lethality-analogous killing model. Shared peptide-MHC-II co-activation enables Treg perforin-granzyme B cytotoxicity; responder Bim confers susceptibility in vitro and in mouse airway inflammation.

For decades, scientists have known that a protein made by T cells and natural killer (NK) cells in the immune system, called perforin, can kill tumor cells by punching a hole in the cell wall and injecting proteases called granzymes, which kill the cell.

Ye et al. describe a synthetic-lethality-analogous killing model. Shared peptide-MHC-II co-activation enables Treg perforin-granzyme B cytotoxicity; responder Bim confers susceptibility in vitro and i...

For decades, scientists have known that a protein made by T cells and natural killer (NK) cells in the immune system, called perforin, can kill tumor cells by punching a hole in the cell wall and injecting proteases called granzymes, which kill the cell.

Perforin is best known for delivering granzymes into tumor cells, but this study shows it has a second, independent killing function: it drives iron uptake and mitochondrial iron overload that trigger...

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Perforin is best known for delivering granzymes into tumor cells, but this study shows it has a second, independent killing function: it drives iron uptake and mitochondrial iron overload that trigger ferroptosis. This granzyme-independent pathway links cytotoxic immunity to iron metabolism, predicts patient response to checkpoint blockade, and points to iron supplementation as a possible lever for boosting anti-tumor immunity.

For decades, scientists have known that a protein made by T cells and natural killer (NK) cells in the immune system, called perforin, can kill tumor cells by punching a hole in the cell wall and injecting proteases called granzymes, which kill the cell. Now, new work led by researchers at the University of Michigan Health Rogel Cancer Center found that tumor cells could be killed even when major granzymes were missing.

Read the full paper: Perforin triggers iron-induced mitochondrial damage to drive ferroptosis and anti-tumor immunity

Submergence and flooding impose severe crop losses through hypoxic stress. The Membrane Attack Complex/Perforin (MACPF) superfamily proteins function …

Perforin-2 is a pore-forming protein localised to the endocytic compartments of dendritic cells and macrophages. It is reported to perform two distinct functions during immune responses: attacking int...

Macrophage Expressed Gene-1 (MPEG-1; also termed Perforin...