Base-modified nucleotides mediate immune signaling in bacteria | Science www.science.org/doi/10.1126/...
Base-modified nucleotides mediate immune signaling in bacteria
Signaling from pathogen sensing to effector activation is a fundamental principle of cellular immunity. Whereas cyclic (oligo)nucleotides have emerged as key signaling molecules, the existence of othe...
www.science.org
April 25, 2025 at 7:48 AM
Nature research paper: Construction of complex and diverse DNA sequences using DNA three-way junctions
go.nature.com/4qu2ExZ
go.nature.com/4qu2ExZ
Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature
Sidewinder enables high-fidelity DNA assembly by separating the information that guides assembly from the final assembled sequence.
go.nature.com
January 22, 2026 at 5:45 AM
#PhageSky
wow, what a sneaky mechanism
wow, what a sneaky mechanism
Another newly discovered mechanism of bacteria inhibiting competitors - increasing their sensitivity to phages - fascinating
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology
A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.
www.nature.com
January 15, 2025 at 9:18 PM
#PhageSky
wow, what a sneaky mechanism
wow, what a sneaky mechanism
Honouring Esther Lederberg’s outstanding work on bacterial gene regulation, recombination and exchange, DSMZ researchers named the strain Streptomyces lederbergiae (DSM 44399) after her.
#herstory #WomenInScience #microbiology #genetics
#herstory #WomenInScience #microbiology #genetics
December 9, 2024 at 1:04 PM
Now online! Structure and infection dynamics of mycobacteriophage Bxb1
Structure and infection dynamics of mycobacteriophage Bxb1
Cryo-EM and cryo-ET reveal the structural details and conformational dynamics of mycobacteriophage Bxb1 as it infects its Mycobacterium smegmatis host.
dlvr.it
April 26, 2025 at 10:05 PM
April 29, 2026 at 6:15 PM
🚨 ‼️ NEW PUBLICATION ‼️
While we start to know a lot about how bacterial genomes are organized in 3D, almost nothing is known about phage genome once it enters a bacterial cell.
read the paper here:
www.science.org/doi/10.1126/...
While we start to know a lot about how bacterial genomes are organized in 3D, almost nothing is known about phage genome once it enters a bacterial cell.
read the paper here:
www.science.org/doi/10.1126/...
Bacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interaction patterns
While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...
www.science.org
August 30, 2026 at 5:45 PM
Yet another awesome single-phage paper from Ido Golding's lab #phagesky
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 24, 2026 at 11:19 PM
Yet another awesome single-phage paper from Ido Golding's lab #phagesky
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
New paper alert: Our 20-year study of viral ecology and evolution reveals viral roles in microbial dynamics, phage genome evolution over time, and key interactions with hosts. A big thank you to our awesome collaborators @quendi.bsky.social @archaeal.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unravelling viral ecology and evolution over 20 years in a freshwater lake - Nature Microbiology
A long-term metagenomic time series reveals how viruses impact diversity, ecological dynamics and evolution of freshwater microbiomes.
www.nature.com
January 3, 2025 at 2:16 PM
A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli
#PLoSPathogen from @prsecor.bsky.social
journals.plos.org/plospathogen...
#PLoSPathogen from @prsecor.bsky.social
journals.plos.org/plospathogen...
A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli
Author summary Prophages—viral genomes integrated into bacterial chromosomes—are common in enteric bacteria and can profoundly influence bacterial physiology and ecological fitness. Here we show that ...
journals.plos.org
January 3, 2026 at 12:07 PM
Catch a Virus by Its Tail
#Viruses #Microorganisms #MolecularBiology #CellBiology #Immunology #Evolution #Development
#Viruses #Microorganisms #MolecularBiology #CellBiology #Immunology #Evolution #Development
Catch a Virus by Its Tail - Weizmann Wonder Wander - News, Features and Discoveries
A bacterial immune system that alters the tails of phages might help clarify an immunity mechanism in humans
wis-wander.weizmann.ac.il
September 27, 2026 at 2:31 PM
Contractile-tailed phages use baseplates to attach to 🦠 and initiate infection. How phages target and penetrate Gram+ 🦠 is poorly understood.
Meet phage phi812, a #PhageTherapy contender infecting #AntibioticResistant S. aureus.
2/11
Meet phage phi812, a #PhageTherapy contender infecting #AntibioticResistant S. aureus.
2/11
October 15, 2024 at 11:23 AM
September 29, 2026 at 11:30 PM
20 years of research on giant viruses www.nature.com/articles/s44...
June 5, 2025 at 2:13 PM
Excited🚨to share our first work on the human gut phageome doi.org/10.1101/2025...
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social+@pasteur.fr+@inserm.fr! Many thanks for this great journey!🙌
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social+@pasteur.fr+@inserm.fr! Many thanks for this great journey!🙌
Third-generation cephalosporin antibiotics induce phage bursts in the human gut microbiome.
The use of antibiotics disrupts the gut microbiota, potentially leading to long-term health issues and the spread of resistance. To investigate the impact of antibiotics on phage populations, we follo...
doi.org
February 10, 2025 at 6:08 PM
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates
-in @natcomms.nature.com
www.nature.com/articles/s41...
-in @natcomms.nature.com
www.nature.com/articles/s41...
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates - Nature Communications
Ghatbale et al. adapted a co-evolutionary technique to develop Klebsiella pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates, including drug resistant isolate...
www.nature.com
November 20, 2025 at 12:30 PM
Phage-based microbiome manipulation reveals ecological interactions within gut communities https://www.biorxiv.org/content/10.64898/2026.05.13.724931v1
May 19, 2026 at 1:47 PM
Nature research paper: Prophages block cell surface receptors to preserve their viral progeny
go.nature.com/3IwINxb
go.nature.com/3IwINxb
Prophages block cell surface receptors to preserve their viral progeny - Nature
Zip promotes the accumulation of free phages in bacterial lysogen communities, safeguarding phage progeny.
go.nature.com
August 28, 2025 at 5:57 AM
New online! Genetics, ecology and evolution of phage satellites
Genetics, ecology and evolution of phage satellites
Nature Reviews Microbiology, Published online: 27 March 2025; doi:10.1038/s41579-025-01156-zIn this Review, Penadés et al. explore the genetics, potential origins and life cycle of phage satellites, and they discuss the impact of these elements on the evolution of other mobile genetic elements and their host bacteria.
www.nature.com
March 27, 2025 at 11:30 AM
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 21, 2025 at 5:19 PM
Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...
July 23, 2025 at 12:55 PM
Excited to share our new paper out today in @science.org 🎉
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
www.science.org
April 10, 2026 at 10:46 AM
Excited to share our new paper out today in @science.org 🎉
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
Rapid resistance evolution against phage cocktails
#ISMEJournal by Baltus van der Steen, Matti Gralka, and @yuvalmulla.bsky.social
academic.oup.com/ismej/advanc...
#ISMEJournal by Baltus van der Steen, Matti Gralka, and @yuvalmulla.bsky.social
academic.oup.com/ismej/advanc...
Rapid resistance evolution against phage cocktails
Abstract. When bacteria are treated with multiple antibiotics simultaneously, resistance is highly unlikely to evolve. In contrast, resistance against mult
academic.oup.com
March 29, 2026 at 3:12 PM