Oligodendrocyte ER-phagy Restricts Excessive Myelination by Degrading Sphingolipid Synthases https://www.biorxiv.org/content/10.64898/2026.10.04.756522v1
October 11, 2026 at 10:15 PM
Oligodendrocyte ER-phagy Restricts Excessive Myelination by Degrading Sphingolipid Synthases https://www.biorxiv.org/content/10.64898/2026.10.04.756522v1
Oligodendrocyte ER-phagy Restricts Excessive Myelination by Degrading Sphingolipid Synthases https://www.biorxiv.org/content/10.64898/2026.10.04.756522v1
October 11, 2026 at 10:15 PM
Oligodendrocyte ER-phagy Restricts Excessive Myelination by Degrading Sphingolipid Synthases https://www.biorxiv.org/content/10.64898/2026.10.04.756522v1
From MBoC: Could a cellular cleanup process contribute to the spread of α-synuclein?
New research links RTN3L-mediated ER-phagy to α-synuclein secretion, offering insight into a pathway relevant to Parkinson’s disease.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138
New research links RTN3L-mediated ER-phagy to α-synuclein secretion, offering insight into a pathway relevant to Parkinson’s disease.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138
October 5, 2026 at 1:05 PM
From MBoC: Could a cellular cleanup process contribute to the spread of α-synuclein?
New research links RTN3L-mediated ER-phagy to α-synuclein secretion, offering insight into a pathway relevant to Parkinson’s disease.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138
New research links RTN3L-mediated ER-phagy to α-synuclein secretion, offering insight into a pathway relevant to Parkinson’s disease.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138
Atg39-dependent nucleophagy and Atg40-dependent ER-phagy require the Apq12/Brr6/Brl1 complex | PNAS www.pnas.org/doi/10.1073/...
Atg39-dependent nucleophagy and Atg40-dependent ER-phagy require the Apq12/Brr6/Brl1 complex | PNAS
Autophagic degradation of parts of the nucleus (nucleophagy) and endoplasmic reticulum
(ER-phagy) utilizes the selective autophagy receptors, Atg39...
www.pnas.org
October 1, 2026 at 3:42 PM
Atg39-dependent nucleophagy and Atg40-dependent ER-phagy require the Apq12/Brr6/Brl1 complex | PNAS www.pnas.org/doi/10.1073/...
🎓 Postdoc: Molecular Cell Biology 🇳🇴 · University of Oslo · Oslo, Norway
⏳ 13 Oct 2026
Study ER-phagy regulators in cancer progression using image-based siRNA screens.
📲 Laplace Apply — WhatsApp: https://wa.me/447762266914
🌐 https://laplace.expert/
#Postdoc #AcademicCareers
⏳ 13 Oct 2026
Study ER-phagy regulators in cancer progression using image-based siRNA screens.
📲 Laplace Apply — WhatsApp: https://wa.me/447762266914
🌐 https://laplace.expert/
#Postdoc #AcademicCareers
September 24, 2026 at 5:11 PM
🎓 Postdoc: Molecular Cell Biology 🇳🇴 · University of Oslo · Oslo, Norway
⏳ 13 Oct 2026
Study ER-phagy regulators in cancer progression using image-based siRNA screens.
📲 Laplace Apply — WhatsApp: https://wa.me/447762266914
🌐 https://laplace.expert/
#Postdoc #AcademicCareers
⏳ 13 Oct 2026
Study ER-phagy regulators in cancer progression using image-based siRNA screens.
📲 Laplace Apply — WhatsApp: https://wa.me/447762266914
🌐 https://laplace.expert/
#Postdoc #AcademicCareers
Extract: A postdoctoral position is available in the Autophagy group at the Department of Molecular Cell Biology, Oslo University Hospital. The project focuses on ER-phagy in cancer, requiring a PhD in cell or molecular biology.
September 23, 2026 at 5:36 PM
Extract: A postdoctoral position is available in the Autophagy group at the Department of Molecular Cell Biology, Oslo University Hospital. The project focuses on ER-phagy in cancer, requiring a PhD in cell or molecular biology.
causing ER stress, activation of UPR, and increased ER-phagy/nucleophagy.
The authors propose CLCC! acts as a host restriction factor, while ORF3a "hijacks" it to aid viral pathogenesis. Overexpressing CLCC1 reduced viral replication in their models.
2/6
The authors propose CLCC! acts as a host restriction factor, while ORF3a "hijacks" it to aid viral pathogenesis. Overexpressing CLCC1 reduced viral replication in their models.
2/6
September 21, 2026 at 1:42 PM
causing ER stress, activation of UPR, and increased ER-phagy/nucleophagy.
The authors propose CLCC! acts as a host restriction factor, while ORF3a "hijacks" it to aid viral pathogenesis. Overexpressing CLCC1 reduced viral replication in their models.
2/6
The authors propose CLCC! acts as a host restriction factor, while ORF3a "hijacks" it to aid viral pathogenesis. Overexpressing CLCC1 reduced viral replication in their models.
2/6
📣 Shoutout to Nikol Gelman (Technion), winner of a FEBS Letters Poster Prize at the EMBO Workshop: Autophagy: Foundations, Functions and Physiology.
Poster Title: Phase Separation of ER-Phagy Receptors as a Signal-Integrating Mechanism in Cellular Quality Control and Disease
@events.embl.org
Poster Title: Phase Separation of ER-Phagy Receptors as a Signal-Integrating Mechanism in Cellular Quality Control and Disease
@events.embl.org
September 15, 2026 at 8:45 AM
📣 Shoutout to Nikol Gelman (Technion), winner of a FEBS Letters Poster Prize at the EMBO Workshop: Autophagy: Foundations, Functions and Physiology.
Poster Title: Phase Separation of ER-Phagy Receptors as a Signal-Integrating Mechanism in Cellular Quality Control and Disease
@events.embl.org
Poster Title: Phase Separation of ER-Phagy Receptors as a Signal-Integrating Mechanism in Cellular Quality Control and Disease
@events.embl.org
(Note: -phagy = "eating"
Phage endings mean we're talking about something that consumes/breaks down something else.)
Phage endings mean we're talking about something that consumes/breaks down something else.)
September 11, 2026 at 6:41 PM
(Note: -phagy = "eating"
Phage endings mean we're talking about something that consumes/breaks down something else.)
Phage endings mean we're talking about something that consumes/breaks down something else.)
The ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plants: Developmental Cell www.cell.com/developmenta...
The ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plants
Yang et al. reveal that the ARLA1A-NAC089 module couples ER phagy with the UPR in plants. This dual regulatory axis fine-tunes cell survival versus death under stress, providing a mechanistic framework for maintaining ER homeostasis and enhancing environmental resilience.
www.cell.com
September 10, 2026 at 3:30 PM
The ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plants: Developmental Cell www.cell.com/developmenta...
ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology
ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology
Jimenez-Moreno et al. reveal that ER-phagy receptors directly control cytosolic signaling events. Upon stimulation, cytoplasmic PRKAR1A condensates interact with FAM134B/C, forming inter-organellar contacts that bridge the ER and lysosomes into a localized hydrolytic hub. This hub drives the degradation of RhoA, coordinating morphology transitions during cancer cell invasion.
dlvr.it
September 6, 2026 at 3:19 PM
ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology
The plant RABC1 GTPase coordinates with exocyst component SEC5A in regulating ER-phagy under endoplasmic reticulum stress (Shuai Hu , Dongmei Zhu , Xiaohui Ma , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
The plant RABC1 GTPase coordinates with exocyst component SEC5A in regulating ER-phagy under endoplasmic reticulum stress
Autophagy maintains cellular homeostasis under stress, but how membrane-trafficking regulators coordinate selective ER turnover in plants is unclear. Here,
doi.org
September 3, 2026 at 3:44 PM
The plant RABC1 GTPase coordinates with exocyst component SEC5A in regulating ER-phagy under endoplasmic reticulum stress (Shuai Hu , Dongmei Zhu , Xiaohui Ma , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
Can dual-targeting #UFMylation inhibitors defeat #Glioblastoma?
Targeting the DDRGK1–UFL1 pathway with osimertinib or CP-24 suppresses UFMylation and ER-phagy, induces #ERstress and promotes antitumor M1 macrophage polarization. @tsinghuauniversity.bsky.social
#OpenAccess: doi.org/10.1038/s413...
Targeting the DDRGK1–UFL1 pathway with osimertinib or CP-24 suppresses UFMylation and ER-phagy, induces #ERstress and promotes antitumor M1 macrophage polarization. @tsinghuauniversity.bsky.social
#OpenAccess: doi.org/10.1038/s413...
August 30, 2026 at 1:01 PM
Can dual-targeting #UFMylation inhibitors defeat #Glioblastoma?
Targeting the DDRGK1–UFL1 pathway with osimertinib or CP-24 suppresses UFMylation and ER-phagy, induces #ERstress and promotes antitumor M1 macrophage polarization. @tsinghuauniversity.bsky.social
#OpenAccess: doi.org/10.1038/s413...
Targeting the DDRGK1–UFL1 pathway with osimertinib or CP-24 suppresses UFMylation and ER-phagy, induces #ERstress and promotes antitumor M1 macrophage polarization. @tsinghuauniversity.bsky.social
#OpenAccess: doi.org/10.1038/s413...
It's vegan if it's human and you have consent under the same loophole that allows consensual cannibalism.
It's also vegan if if your own under the same loophole that allows auto phagy
It's also vegan if if your own under the same loophole that allows auto phagy
August 27, 2026 at 1:16 PM
It's vegan if it's human and you have consent under the same loophole that allows consensual cannibalism.
It's also vegan if if your own under the same loophole that allows auto phagy
It's also vegan if if your own under the same loophole that allows auto phagy
#ER_literature ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology: Molecular Cell www.cell.com/molecular-ce...
ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology
Jimenez-Moreno et al. reveal that ER-phagy receptors directly control cytosolic signaling
events. Upon stimulation, cytoplasmic PRKAR1A condensates interact with FAM134B/C,
forming inter-organellar co...
www.cell.com
August 19, 2026 at 12:48 PM
#ER_literature ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology: Molecular Cell www.cell.com/molecular-ce...
I'm thrilled to share that my postdoc research is published in Mol Cell. Congratulations to everyone involved!
We discovered a new role of ER-phagy via interorganellar communication. Join me at the WIA Journal Club on Sep 16th at 10am CET to discuss @uoe-igc.bsky.social @womeninautophagy.bsky.social
We discovered a new role of ER-phagy via interorganellar communication. Join me at the WIA Journal Club on Sep 16th at 10am CET to discuss @uoe-igc.bsky.social @womeninautophagy.bsky.social
ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology
Jimenez-Moreno et al. reveal that ER-phagy receptors directly control cytosolic signaling
events. Upon stimulation, cytoplasmic PRKAR1A condensates interact with FAM134B/C,
forming inter-organellar co...
www.cell.com
August 18, 2026 at 1:11 PM
I'm thrilled to share that my postdoc research is published in Mol Cell. Congratulations to everyone involved!
We discovered a new role of ER-phagy via interorganellar communication. Join me at the WIA Journal Club on Sep 16th at 10am CET to discuss @uoe-igc.bsky.social @womeninautophagy.bsky.social
We discovered a new role of ER-phagy via interorganellar communication. Join me at the WIA Journal Club on Sep 16th at 10am CET to discuss @uoe-igc.bsky.social @womeninautophagy.bsky.social
Online Now: ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology Online now:
ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology
Jimenez-Moreno et al. reveal that ER-phagy receptors directly control cytosolic signaling events. Upon stimulation, cytoplasmic PRKAR1A condensates interact with FAM134B/C, forming inter-organellar contacts that bridge the ER and lysosomes into a localized hydrolytic hub. This hub drives the degradation of RhoA, coordinating morphology transitions during cancer cell invasion.
dlvr.it
August 17, 2026 at 10:57 PM
Online Now: ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology Online now:
New publication: #Generalism in nature: a community ecology perspective, by @Jeffrey75327765 #phagy #speciesidentity #communityecology
https://doi.org/10.1007/s42974-022-00130-6
https://doi.org/10.1007/s42974-022-00130-6
December 3, 2024 at 4:08 AM
New publication: #Generalism in nature: a community ecology perspective, by @Jeffrey75327765 #phagy #speciesidentity #communityecology
https://doi.org/10.1007/s42974-022-00130-6
https://doi.org/10.1007/s42974-022-00130-6
Más investigación de calidad de científicos españoles intentando entender los mecanismos de reciclado de proteínas y de autofagia y su importancia en la salud. Enhorabuena.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
www.science.org
November 15, 2024 at 9:10 AM
Más investigación de calidad de científicos españoles intentando entender los mecanismos de reciclado de proteínas y de autofagia y su importancia en la salud. Enhorabuena.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications - Acta Pharmacologica Sinica
Acta Pharmacologica Sinica - ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications
www.nature.com
January 27, 2026 at 1:42 PM
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The role of ER-associated degradation and ER-phagy in health and disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The role of ER-associated degradation and ER-phagy in health and disease - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - The role of ER-associated degradation and ER-phagy in health and disease
www.nature.com
January 5, 2026 at 1:40 PM
The role of ER-associated degradation and ER-phagy in health and disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity - Nature Communications
Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles, but the role of ER-phagy in viral replication process remains poorly understood. Here, the authors show Z...
www.nature.com
November 7, 2024 at 3:53 PM
AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PRRSV non-structural protein 5 inhibits antiviral innate immunity by degrading multiple proteins of RLR signaling pathway through FAM134B-mediated ER-phagy journals.asm.org/doi/10.1128/...
PRRSV non-structural protein 5 inhibits antiviral innate immunity by degrading multiple proteins of RLR signaling pathway through FAM134B-mediated ER-phagy | Journal of Virology
Innate immunity is the first line of host defense against viral infections. Therefore,
viruses developed numerous mechanisms to evade the host innate immune responses for
their own benefit. PRRSV, one...
journals.asm.org
September 12, 2024 at 9:37 PM
PRRSV non-structural protein 5 inhibits antiviral innate immunity by degrading multiple proteins of RLR signaling pathway through FAM134B-mediated ER-phagy journals.asm.org/doi/10.1128/...
UVRAG cooperates with cargo receptors to assemble the ER‐phagy site www.embopress.org/doi/abs/10.1...
UVRAG cooperates with cargo receptors to assemble the ER‐phagy site
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
December 2, 2023 at 6:41 PM
UVRAG cooperates with cargo receptors to assemble the ER‐phagy site www.embopress.org/doi/abs/10.1...
Sec62 restricts ER-replicating positive-strand RNA virus infections via UPR-dependent ER-phagy (Ruiqi Wang , Qianshen Zhang , Lifan Zhou , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
Validate User
doi.org
March 23, 2026 at 4:03 PM
Sec62 restricts ER-replicating positive-strand RNA virus infections via UPR-dependent ER-phagy (Ruiqi Wang , Qianshen Zhang , Lifan Zhou , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial