A reminder: for genotypes to produce phenotypes, they have to go through development
January 8, 2025 at 5:09 PM
A reminder: for genotypes to produce phenotypes, they have to go through development
Are all muppets the same species just with wildly different phenotypes like dogs or are there a lot of different species of muppet
June 3, 2025 at 12:20 AM
Are all muppets the same species just with wildly different phenotypes like dogs or are there a lot of different species of muppet
Not many people realize that SpaghettiO’s have conserved phenotypes and have looked basically the same for 360 million years
January 5, 2025 at 1:31 AM
Not many people realize that SpaghettiO’s have conserved phenotypes and have looked basically the same for 360 million years
the two phenotypes of trans girl are just got her hair done and sleeping
May 2, 2026 at 8:39 AM
the two phenotypes of trans girl are just got her hair done and sleeping
Les trajectoires des phénotypes individuels ("sexe phénotypique" ou biopsychosocial) peuvent s'écarter de la moyenne (intersexuation) ou évoluer (personnes trans). Prétendre que les causes distales *constituent* des catégories (dans lesquelles les phénotypes seraient fixés) est faux.
August 24, 2025 at 5:30 PM
Les trajectoires des phénotypes individuels ("sexe phénotypique" ou biopsychosocial) peuvent s'écarter de la moyenne (intersexuation) ou évoluer (personnes trans). Prétendre que les causes distales *constituent* des catégories (dans lesquelles les phénotypes seraient fixés) est faux.
right, there is something of a motte and bailey here. like, if “race has some biological reality” just means that phenotypes are biological, then you’re just stating a banal observation. but that is not what people mean.
May 24, 2025 at 1:19 PM
right, there is something of a motte and bailey here. like, if “race has some biological reality” just means that phenotypes are biological, then you’re just stating a banal observation. but that is not what people mean.
This is the same bullshit as “sex is in every cell of the body”.
Genotypes are not a more accurate representation of phenotypes than phenotypes themselves
Genotypes are not a more accurate representation of phenotypes than phenotypes themselves
But my whole point is that this demonstrates how absolutely ridiculous of a scientific and biological proposition this understanding of sex is.
Somehow no amount of her womanhood and female experience counts anymore because of a DNA test? Bullshit!
Somehow no amount of her womanhood and female experience counts anymore because of a DNA test? Bullshit!
June 4, 2025 at 6:34 AM
This is the same bullshit as “sex is in every cell of the body”.
Genotypes are not a more accurate representation of phenotypes than phenotypes themselves
Genotypes are not a more accurate representation of phenotypes than phenotypes themselves
Quand au sexe, Bronner ne comprend pas que le sexe en biologie est une cause distale (une stratégie évolutive, une cause abstraite donc) qui *explique* des régularités dans les phénotypes de la population, mais pas un mécanisme proximal *causant* la réalité observable (=les phénotypes individuels).
August 24, 2025 at 5:30 PM
Quand au sexe, Bronner ne comprend pas que le sexe en biologie est une cause distale (une stratégie évolutive, une cause abstraite donc) qui *explique* des régularités dans les phénotypes de la population, mais pas un mécanisme proximal *causant* la réalité observable (=les phénotypes individuels).
Huge congrats to Rayyan Gorashi on her first author Science Advances @science.org paper! She discovered the Y-linked UTY gene modulates male-specific valve myofibroblast phenotypes - both X and Y chromosomes modulate cell phenotypes! 🤯
Link: www.science.org/doi/10.1126/...
@jacobsschool.bsky.social
Link: www.science.org/doi/10.1126/...
@jacobsschool.bsky.social
March 12, 2025 at 6:35 PM
Huge congrats to Rayyan Gorashi on her first author Science Advances @science.org paper! She discovered the Y-linked UTY gene modulates male-specific valve myofibroblast phenotypes - both X and Y chromosomes modulate cell phenotypes! 🤯
Link: www.science.org/doi/10.1126/...
@jacobsschool.bsky.social
Link: www.science.org/doi/10.1126/...
@jacobsschool.bsky.social
or, as i put it in talks: "we can observe the sexual phenotypes of a turtle. we can't ask the turtle its gender- and even if we could, its answer would like be incomprehensible to us"
July 12, 2026 at 2:33 AM
or, as i put it in talks: "we can observe the sexual phenotypes of a turtle. we can't ask the turtle its gender- and even if we could, its answer would like be incomprehensible to us"
how hard is it to say there are two major reproductive phenotypes with infinite variations and that humans often associate cultural gender with one or the other major types
July 12, 2026 at 12:22 PM
how hard is it to say there are two major reproductive phenotypes with infinite variations and that humans often associate cultural gender with one or the other major types
No matter the crime, no matter the context:
Disneyfication for some phenotypes, thugification for others.
Disneyfication for some phenotypes, thugification for others.
February 7, 2025 at 5:13 PM
No matter the crime, no matter the context:
Disneyfication for some phenotypes, thugification for others.
Disneyfication for some phenotypes, thugification for others.
"we find that models progressively converge toward generic phenotypes regardless of the model architecture. Specifically, rare but critical findings...vanish from the synthetic content generated by AI models, while demographic representations skew heavily toward middle aged male phenotypes."
"AI is rapidly populating medical records with synthetic content, creating a feedback loop [that] drives a rapid erosion of pathological variability and diagnostic reliability...this renders AI generated documentation clinically useless after just two generations" www.medrxiv.org/content/10.6...
AI-generated data contamination erodes pathological variability and diagnostic reliability
Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are increasingly at risk of training on uncurated AI ...
www.medrxiv.org
February 3, 2026 at 8:05 AM
"we find that models progressively converge toward generic phenotypes regardless of the model architecture. Specifically, rare but critical findings...vanish from the synthetic content generated by AI models, while demographic representations skew heavily toward middle aged male phenotypes."
Given that there are people whose chromosomes do not align with their sexual phenotypes, you cannot actually know the chromosomal sex of any historic figure to a certainty
September 25, 2026 at 7:38 PM
Given that there are people whose chromosomes do not align with their sexual phenotypes, you cannot actually know the chromosomal sex of any historic figure to a certainty
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
What you're looking at here isn't an AI glitch. These are "Sishui Fur sheep" with 2- and 4-horn phenotypes. The sheep on the right is polycerate: "multi-horned".
Let's talk about the why/how of polycerate bovids. But first, a brief departure into homeotic (Hox) genes.
Let's talk about the why/how of polycerate bovids. But first, a brief departure into homeotic (Hox) genes.
March 16, 2025 at 2:37 PM
What you're looking at here isn't an AI glitch. These are "Sishui Fur sheep" with 2- and 4-horn phenotypes. The sheep on the right is polycerate: "multi-horned".
Let's talk about the why/how of polycerate bovids. But first, a brief departure into homeotic (Hox) genes.
Let's talk about the why/how of polycerate bovids. But first, a brief departure into homeotic (Hox) genes.
l'écrasement des phénotypes ? on savait le mec dingue, pas raciste à ce point...
July 16, 2026 at 7:26 PM
l'écrasement des phénotypes ? on savait le mec dingue, pas raciste à ce point...
Absolutely delighted to have been awarded an NHMRC Investigator Grant to continue my work on using fine-grained phenotypes to advance psychopathology research for FIVE MORE YEARS!! ✨✨✨
February 24, 2025 at 10:34 PM
Absolutely delighted to have been awarded an NHMRC Investigator Grant to continue my work on using fine-grained phenotypes to advance psychopathology research for FIVE MORE YEARS!! ✨✨✨
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
1/9
1/9
July 7, 2025 at 2:44 AM
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
1/9
1/9
Oh my fucking god she started talking about phenotypes. This is so fucking gross
November 18, 2025 at 11:43 PM
Oh my fucking god she started talking about phenotypes. This is so fucking gross
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
www.nature.com
November 12, 2025 at 5:57 PM
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1
January 2, 2026 at 3:19 AM
I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1
Circular RNA aptamers dampen Alzheimer disease phenotypes in mouse models go.nature.com/4jgtKVA
rdcu.be/fa3yp
rdcu.be/fa3yp
Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models - Nature Biotechnology
Circular RNA aptamers dampen Alzheimer disease phenotypes in mouse models
go.nature.com
April 1, 2026 at 2:05 AM
Circular RNA aptamers dampen Alzheimer disease phenotypes in mouse models go.nature.com/4jgtKVA
rdcu.be/fa3yp
rdcu.be/fa3yp