The synthesis of the hindered and polyfluorinated dialkyl ethers poses challenges owing to the bulkiness of tertiary alcohols and the low nucleophilicity of polyfluorinated alcohols. Additionally, associated competitive side reactions always provide poor reactivities. Although certain strategies, such as electrocatalytic decarboxylation and hydroalkoxylation, have been explored, a straightforward method for obtaining ethers with structural diversity remains elusive. In this study, we have exploited the photoinduced approach that involves the in situ formation of singlet carbenes followed by O–H insertions to access the hindered and polyfluorinated ethers with congested or polyfluorinated alcohols. Moreover, other nucleophiles such as phenols, H2O, thiols, silanols, tributyltin hydride, etc., are also tolerable to obtain valuable products. The gram-scale synthesis of marketed drugs and the modification of complex molecules demonstrate the practicality of this approach. The detailed mechanistic studies have elucidated the key intermediates and reaction mechanism, which were distinct from traditional metal-carbenoid O–H insertions.

University at Buffalo researchers reveal molecular insights into the neurotoxic effects of PFAS. Per- and polyfluorinated alkyl substances (PFAS), often referred to as "forever chemicals," are known f...

Per- and polyfluorinated alkyl substances (PFAS) earn their "forever chemical" moniker by persisting in water, soil and even the human brain. This unique ability to cross the blood-brain barrier and a...

Per- and polyfluorinated alkyl substances (PFAS) earn their "forever chemical" moniker by persisting in water, soil and even the human brain. This unique ability to cross the blood-brain barrier and a...

The widespread use of organofluorides in modern society has inadvertently led to the bioaccumulation of harmful pollutants, most prominently per- and polyfluorinated alkyl substances (PFAS). In princi...

In this proof-of-concept study, we show that polyfluorinated trityl radicals with the, to this date, highest fluorination grade can be accessed in quantitative yields in a straightforward manner start...

Per-and polyfluorinated substances (PFAS) are synthetic chemicals that are used to make fluoropolymer coatings found in many products, such as non-stick pans, clothing, cosmetics, and food packaging. ...

The widespread use of organofluorides in modern society has inadvertently led to the bioaccumulation of harmful pollutants, most prominently per- and polyfluorinated alkyl substances (PFAS). In princi...

Background Per- and polyfluorinated alkyl substances (PFAS) have received increasing scientific and political attention in recent years. Several thousand commercially produced compounds are used in nu...

Per- and Polyfluorinated Substances (PFAS) are chemicals used to make coatings and products that resist heat, oil, stains, grease, and water and they are killing everything, including humans.

TFA is a highly mobile, water-soluble chemical that resists degradation in nature. Classified within the group of per- and polyfluorinated alkyl substances

There are more than 9,000 polyfluorinated compounds developed for commercial use, some negatively impacting human health, and they are generally considered to be resistant to biodegradation. Only a li...

Per- and polyfluorinated alkyl substances (PFAS) earn their "forever chemical" moniker by persisting in water, soil and even the human brain. This unique ability to cross the blood-brain barrier and a...

When scientists first discovered the chemistry of per- and polyfluorinated alkyl substances, PFAS, in the 1930s, they didn’t know we’d be struggling to remove them from the environment and human bodie...

The Environmental Protection Agency has approved the highly persistent pesticide trifludimoxazin for use on wheat, oats, oranges, apples and almonds. The pesticide is a “forever chemical” — often call...

Per- and polyfluoroalkyl substances (PFAS), a group of synthetic chemicals that have been produced for over fifty years, are of significant concern du…

Per-and polyfluorinated substances (PFAS) are synthetic chemicals that are used to make fluoropolyme

Fluoropolymers are the state-of-the-art materials for flexible electromechanical conversion. However, they present environmental challenges through the release of polyfluorinated alkyl substances (PF....

University at Buffalo researchers reveal molecular insights into the neurotoxic effects of PFAS. Per- and polyfluorinated alkyl substances (PFAS), often referred to as "forever chemicals," are known f...