Background/Purpose: Rheumatoid arthritis (RA) amplifies the risk of multimorbidity and polypharmacy, even in relatively younger patients, via chronic systemic inflammation and the increased burden of ...

ABSTRACT Quetiapine, a second-generation atypical antipsychotic, has broad indications and considerable variation in daily prescribed doses across different diseases, yet its therapeutic window remains narrow (100–500 ng/mL). In clinical practice, quetiapine is frequently co-administered with other psychotropic drugs. To evaluate the impact of commonly co-administered medications on quetiapine plasma concentrations, we developed and validated a rapid and sensitive ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous quantification of quetiapine and 16 commonly co-administered psychotropic drugs in human plasma. Method validation demonstrated good linearity for all analytes, with precision (CV 

Patients receiving home-based medical care are often older adults with multiple chronic conditions, and polypharmacy, commonly defined as the concurrent use of multiple medications, is prevalent in this population. However, the challenges of medication management extend beyond the number of prescribed medications.

Aims Polypharmacy exists in children and young people (CYP), generating clinician concern and a desire to deprescribe. This study validated and applied a questionnaire to assess the attitudes of CYP...

Taking lithium in addition to other psychiatric medications may lower the risk of hyponatremia (low blood sodium) but increase the risk of conditions such as tremor, ataxia (poor muscle control), and myoclonus (twitching or spasms).

This study uses a nationally representative sample to estimate changes in the use and concurrent use of prescription and over-the-counter (OTC) medications and dietary supplements among older adults in the US between 2015-2016 and 2021-2023, including use of potentially major drug-drug interactions.