Polytherapy and amputation recommended course.
March 31, 2026 at 4:33 PM
Polytherapy and amputation recommended course.
Interesting new analysis of ADHD meds in schizophrenia-spectrum disorders: reduced risk of psychosis with atomoxetine and reduced risk for somatic hospitalizations with lisdexamphetamine.
Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky
Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky
July 5, 2025 at 8:11 AM
Interesting new analysis of ADHD meds in schizophrenia-spectrum disorders: reduced risk of psychosis with atomoxetine and reduced risk for somatic hospitalizations with lisdexamphetamine.
Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky
Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky
Congrats to Jeremy Lum, Justin Yerbury and Team for their new paper, "A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis', that also involved the CMR's A/P Peter Crouch
#ALS
www.thelancet.com/journals/ebi...
#ALS
www.thelancet.com/journals/ebi...
A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis
These findings support CET polytherapy as an advantageous alternative compared to
CuATSM monotherapy and highlight the potential of utilising small molecules targeting
SOD1 as a polytherapy avenue for...
www.thelancet.com
May 1, 2025 at 11:45 PM
Congrats to Jeremy Lum, Justin Yerbury and Team for their new paper, "A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis', that also involved the CMR's A/P Peter Crouch
#ALS
www.thelancet.com/journals/ebi...
#ALS
www.thelancet.com/journals/ebi...
i should’ve done polytherapy a few years back after having a situationship with this shitty poly guy
March 31, 2026 at 4:31 PM
i should’ve done polytherapy a few years back after having a situationship with this shitty poly guy
Stiripentol add-on to clobazam and valproic acid significantly reduced spontaneous seizure frequency in Scn1aA1783V/WT mice.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedications #Dravetsyndrome #hyperthermiainducedseizures #polytherapy #spontaneousrecurrentseizures
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedications #Dravetsyndrome #hyperthermiainducedseizures #polytherapy #spontaneousrecurrentseizures
July 21, 2025 at 2:21 PM
Stiripentol add-on to clobazam and valproic acid significantly reduced spontaneous seizure frequency in Scn1aA1783V/WT mice.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedications #Dravetsyndrome #hyperthermiainducedseizures #polytherapy #spontaneousrecurrentseizures
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedications #Dravetsyndrome #hyperthermiainducedseizures #polytherapy #spontaneousrecurrentseizures
There's also a bunch of other issues like not meaningfully differentiating between different types of E, mono versus polytherapy, etc. A lot of studies are also either old ones exclusively on binary trans women from previous generations of HRT, or on teens through age 18, etc.
July 31, 2024 at 4:18 PM
There's also a bunch of other issues like not meaningfully differentiating between different types of E, mono versus polytherapy, etc. A lot of studies are also either old ones exclusively on binary trans women from previous generations of HRT, or on teens through age 18, etc.
polytherapy! your mental health is gonna be 200%
December 4, 2025 at 6:57 PM
polytherapy! your mental health is gonna be 200%
Authors stress that there is no evidence on polytherapy otherwise and that this information needs to be collected over time. The authors list the many predosing tests that need to take place (Table 3) and also stress that patients and families need to be aware of the risks.
October 7, 2025 at 8:08 AM
Authors stress that there is no evidence on polytherapy otherwise and that this information needs to be collected over time. The authors list the many predosing tests that need to take place (Table 3) and also stress that patients and families need to be aware of the risks.
Letter to the Editor
doi.org/10.1111/epi....
Read the original article - onlinelibrary.wiley.com/doi/10.1111/...
#epilepsy #epilepsia #ILAE #statusepilepticus #acuteseizures #classification #Treatment #Polytherapy
doi.org/10.1111/epi....
Read the original article - onlinelibrary.wiley.com/doi/10.1111/...
#epilepsy #epilepsia #ILAE #statusepilepticus #acuteseizures #classification #Treatment #Polytherapy
June 29, 2025 at 4:22 PM
Letter to the Editor
doi.org/10.1111/epi....
Read the original article - onlinelibrary.wiley.com/doi/10.1111/...
#epilepsy #epilepsia #ILAE #statusepilepticus #acuteseizures #classification #Treatment #Polytherapy
doi.org/10.1111/epi....
Read the original article - onlinelibrary.wiley.com/doi/10.1111/...
#epilepsy #epilepsia #ILAE #statusepilepticus #acuteseizures #classification #Treatment #Polytherapy
ICYMI: a new EURAP study investigates the risks of poor fetal growth in infants exposed prenatally to antiseizure medications, comparing monotherapy versus polytherapy, different monotherapies, and common antiseizure medication combinations
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Antiseizure medication use in pregnancy and the risk of poor fetal growth in the EURAP international registry: a prospective cohort study
In addition to congenital malformations and neurodevelopmental effects, poor fetal
growth should be regarded as an important adverse outcome of prenatal antiseizure
medication exposure. Risk varies ac...
www.thelancet.com
September 4, 2026 at 7:54 AM
ICYMI: a new EURAP study investigates the risks of poor fetal growth in infants exposed prenatally to antiseizure medications, comparing monotherapy versus polytherapy, different monotherapies, and common antiseizure medication combinations
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Well, cannot be excluded. Maybe one should specify the importance to follow the right polytherapy.
In the shown case I would suggest to add some lithium salt...
In the shown case I would suggest to add some lithium salt...
May 1, 2026 at 1:09 PM
Well, cannot be excluded. Maybe one should specify the importance to follow the right polytherapy.
In the shown case I would suggest to add some lithium salt...
In the shown case I would suggest to add some lithium salt...
RRIDs were included in this eBioMedicine paper. We value the author's support of reproducibility. #reproducibility #methodsmatter #RRID
A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis
doi.org
April 19, 2025 at 7:00 AM
RRIDs were included in this eBioMedicine paper. We value the author's support of reproducibility. #reproducibility #methodsmatter #RRID
Late-onset epilepsy of unknown etiology (LOEU) is less likely to receive ASM polytherapy than acquired lesional late-onset epilepsy (LOE).
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaOpen #Alzheimersdisease #cerebrovasculardisease #elderly #lateonsetepilepsy #neurodegenerativedisease
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaOpen #Alzheimersdisease #cerebrovasculardisease #elderly #lateonsetepilepsy #neurodegenerativedisease
October 15, 2025 at 8:00 PM
Late-onset epilepsy of unknown etiology (LOEU) is less likely to receive ASM polytherapy than acquired lesional late-onset epilepsy (LOE).
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaOpen #Alzheimersdisease #cerebrovasculardisease #elderly #lateonsetepilepsy #neurodegenerativedisease
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaOpen #Alzheimersdisease #cerebrovasculardisease #elderly #lateonsetepilepsy #neurodegenerativedisease
✅ Lisdexamfetamine was linked to reduced hospitalisation and mortality
✅ Moderate-dose methylphenidate: reduced risk
⚠️ High-dose methylphenidate increased risks
🤝 Atomoxetine showed some benefit
❗Polytherapy raised concerns
A valuable study for clinicians & policymakers:
🔗 buff.ly/BrKjOqd
✅ Moderate-dose methylphenidate: reduced risk
⚠️ High-dose methylphenidate increased risks
🤝 Atomoxetine showed some benefit
❗Polytherapy raised concerns
A valuable study for clinicians & policymakers:
🔗 buff.ly/BrKjOqd
buff.ly
October 6, 2025 at 6:41 AM
✅ Lisdexamfetamine was linked to reduced hospitalisation and mortality
✅ Moderate-dose methylphenidate: reduced risk
⚠️ High-dose methylphenidate increased risks
🤝 Atomoxetine showed some benefit
❗Polytherapy raised concerns
A valuable study for clinicians & policymakers:
🔗 buff.ly/BrKjOqd
✅ Moderate-dose methylphenidate: reduced risk
⚠️ High-dose methylphenidate increased risks
🤝 Atomoxetine showed some benefit
❗Polytherapy raised concerns
A valuable study for clinicians & policymakers:
🔗 buff.ly/BrKjOqd
Risk of poor fetal growth in infants exposed prenatally to antiseizure medications: a new study from EURAP investigates the risks associated with monotherapy versus polytherapy, across different monotherapies, and across common antiseizure medication combinations
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Antiseizure medication use in pregnancy and the risk of poor fetal growth in the EURAP international registry: a prospective cohort study
In addition to congenital malformations and neurodevelopmental effects, poor fetal
growth should be regarded as an important adverse outcome of prenatal antiseizure
medication exposure. Risk varies ac...
www.thelancet.com
August 20, 2026 at 8:23 AM
Risk of poor fetal growth in infants exposed prenatally to antiseizure medications: a new study from EURAP investigates the risks associated with monotherapy versus polytherapy, across different monotherapies, and across common antiseizure medication combinations
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
📰 #Finance
"Six presentations planned, including encore oral presentation of topline X-TOLE2 efficacy and safety results New poster will highlight the mechanistic characterization of azetukalner, including its potential additive effects when used with commonly prescribed ASMs VANCOUVER, BC…"
"Six presentations planned, including encore oral presentation of topline X-TOLE2 efficacy and safety results New poster will highlight the mechanistic characterization of azetukalner, including its potential additive effects when used with commonly prescribed ASMs VANCOUVER, BC…"
Xenon to Highlight Phase 3 X-TOLE2 Clinical Data and Rational Polytherapy Potential for Azetukalner at EEC 2026
financialpost.com
August 26, 2026 at 9:21 PM
📰 #Finance
"Six presentations planned, including encore oral presentation of topline X-TOLE2 efficacy and safety results New poster will highlight the mechanistic characterization of azetukalner, including its potential additive effects when used with commonly prescribed ASMs VANCOUVER, BC…"
"Six presentations planned, including encore oral presentation of topline X-TOLE2 efficacy and safety results New poster will highlight the mechanistic characterization of azetukalner, including its potential additive effects when used with commonly prescribed ASMs VANCOUVER, BC…"
"uses non-invasive digital polytherapy, combining active and gamified sound therapy through a smartphone app and earbuds. Clinician-prescribed daily activities guide patients through personalised 90-day programmes to help them manage their tinnitus." www.auckland.ac.nz/en/news/2026... #tinnitus
Sound thinking: how 30 years of tinnitus research became a start-up – University of Auckland
Professor Grant Searchfield spent 30 years tackling the “gnarly problem” of tinnitus. His University of Auckland research is behind TrueSilence Therapeutics, a digital health start-up taking a persona...
www.auckland.ac.nz
August 25, 2026 at 4:11 PM
"uses non-invasive digital polytherapy, combining active and gamified sound therapy through a smartphone app and earbuds. Clinician-prescribed daily activities guide patients through personalised 90-day programmes to help them manage their tinnitus." www.auckland.ac.nz/en/news/2026... #tinnitus
“Recommendations for clinical study protocols for immune and inflammatory profiling in Parkinson's disease”
->Nature | More from Lil' Dr Glen EcoChat at BigEarthData.ai
->Nature | More from Lil' Dr Glen EcoChat at BigEarthData.ai
“Recommendations for clinical study protocols for immune and inflammatory profiling in Parkinson's disease”
Clinical studies in PD are usually hampered by a long duration and slow progressive course of the disease, the clinical heterogeneity and the variability of symptoms and signs over the day related to the time of medication and polytherapy. In...
www.nature.com
October 21, 2025 at 1:04 AM
26% of patients with #epilepsy have intellectual disability.
How can you navigate drug resistance, polytherapy, and complex care needs in these patients?
Find out here 👉 buff.ly/7gUP7sb
#NeuroSky
How can you navigate drug resistance, polytherapy, and complex care needs in these patients?
Find out here 👉 buff.ly/7gUP7sb
#NeuroSky
People with epilepsy and intellectual disability
26% of patients with epilepsy have intellectual disability. How can you navigate drug resistance, polytherapy, and complex care needs in these patients?
buff.ly
October 1, 2025 at 12:41 PM
26% of patients with #epilepsy have intellectual disability.
How can you navigate drug resistance, polytherapy, and complex care needs in these patients?
Find out here 👉 buff.ly/7gUP7sb
#NeuroSky
How can you navigate drug resistance, polytherapy, and complex care needs in these patients?
Find out here 👉 buff.ly/7gUP7sb
#NeuroSky
They emphasize no single treatment is 100% effective on its own.
Instead, using multiple treatments together (polytherapy) yields better results.
In their analysis, combining treatments roughly doubled effectiveness (68% vs 33%).
Instead, using multiple treatments together (polytherapy) yields better results.
In their analysis, combining treatments roughly doubled effectiveness (68% vs 33%).
January 13, 2026 at 7:33 AM
They emphasize no single treatment is 100% effective on its own.
Instead, using multiple treatments together (polytherapy) yields better results.
In their analysis, combining treatments roughly doubled effectiveness (68% vs 33%).
Instead, using multiple treatments together (polytherapy) yields better results.
In their analysis, combining treatments roughly doubled effectiveness (68% vs 33%).
A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis.
https://pubmed.ncbi.nlm.nih.gov/40222103/
#neurodegeneration #SOD1
https://pubmed.ncbi.nlm.nih.gov/40222103/
#neurodegeneration #SOD1
April 14, 2025 at 1:39 PM
A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis.
https://pubmed.ncbi.nlm.nih.gov/40222103/
#neurodegeneration #SOD1
https://pubmed.ncbi.nlm.nih.gov/40222103/
#neurodegeneration #SOD1