New Essay: 'Resistance potentiators: Evolutionary catalysts of antibiotic resistance'
To understand the evolutionary drivers of #AMR we need to move beyond resistance genes to thinking about the ability of genomes to generate AMR variants. #microsky
journals.plos.org/plosbiology/...
To understand the evolutionary drivers of #AMR we need to move beyond resistance genes to thinking about the ability of genomes to generate AMR variants. #microsky
journals.plos.org/plosbiology/...
Resistance potentiators: Evolutionary catalysts of antibiotic resistance
How do bacteria evolve resistance to antibiotics? Drawing on evidence from experimental evolution, pathogen genomics, and molecular microbiology, this Essay argues that the evolution of antibiotic res...
journals.plos.org
July 6, 2026 at 9:17 PM
New Essay: 'Resistance potentiators: Evolutionary catalysts of antibiotic resistance'
To understand the evolutionary drivers of #AMR we need to move beyond resistance genes to thinking about the ability of genomes to generate AMR variants. #microsky
journals.plos.org/plosbiology/...
To understand the evolutionary drivers of #AMR we need to move beyond resistance genes to thinking about the ability of genomes to generate AMR variants. #microsky
journals.plos.org/plosbiology/...
How do #bacteria evolve resistance to antibiotics ? This Essay by @craigmaclean.bskyb.social &co argues that the evolution of #AntibioticResistance is catalyzed by ‘resistance potentiators’ that accelerate evolution in a trait-specific manner.
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
July 7, 2026 at 3:55 PM
How do #bacteria evolve resistance to antibiotics ? This Essay by @craigmaclean.bskyb.social &co argues that the evolution of #AntibioticResistance is catalyzed by ‘resistance potentiators’ that accelerate evolution in a trait-specific manner.
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
How do #bacteria evolve resistance to antibiotics ? This Essay by @craigmaclean.bskyb.social &co argues that the evolution of #AntibioticResistance is catalyzed by ‘resistance potentiators’ that accelerate evolution in a trait-specific manner.
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
July 7, 2026 at 7:55 AM
How do #bacteria evolve resistance to antibiotics ? This Essay by @craigmaclean.bskyb.social &co argues that the evolution of #AntibioticResistance is catalyzed by ‘resistance potentiators’ that accelerate evolution in a trait-specific manner.
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
BARI is celebrating Kevan Shokat’s new ACS Chem Biol study! They designed long-acting CFTR potentiators by tweaking the protein-membrane interface, longer lipophilic chains dramatically extend activity via enhanced membrane retention. Exciting for CF and membrane drug design!
May 26, 2026 at 4:56 PM
BARI is celebrating Kevan Shokat’s new ACS Chem Biol study! They designed long-acting CFTR potentiators by tweaking the protein-membrane interface, longer lipophilic chains dramatically extend activity via enhanced membrane retention. Exciting for CF and membrane drug design!
How do #bacteria evolve resistance to antibiotics ? This Essay by @craigmaclean.bskyb.social &co argues that the evolution of #AntibioticResistance is catalyzed by ‘resistance potentiators’ that accelerate evolution in a trait-specific manner.
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
July 7, 2026 at 11:55 AM
How do #bacteria evolve resistance to antibiotics ? This Essay by @craigmaclean.bskyb.social &co argues that the evolution of #AntibioticResistance is catalyzed by ‘resistance potentiators’ that accelerate evolution in a trait-specific manner.
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
🧪 #AcademicSky @biology.ox.ac.uk
plos.io/4flYKnF
Blaskovich & Cooper review the pipeline of conventional antibiotics and highlight in depth numerous promising alternatives—including potentiators of antibiotic action, bacteriophage, lysins and microbiome modulation—the impact of CARB-X on innovation is patently clear
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Antibiotics re-booted—time to kick back against drug resistance - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Antibiotics re-booted—time to kick back against drug resistance
www.nature.com
May 31, 2025 at 2:12 AM
Blaskovich & Cooper review the pipeline of conventional antibiotics and highlight in depth numerous promising alternatives—including potentiators of antibiotic action, bacteriophage, lysins and microbiome modulation—the impact of CARB-X on innovation is patently clear
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators - Kanyo - British Journal of Pharmacology bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
June 14, 2026 at 5:28 PM
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators - Kanyo - British Journal of Pharmacology bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
We propose that this function of microvilli as potentiators of cellular plasticity evolved before animal multicellularity. While it initially allowed fast adaptation to unpredictable, hostile natural environments, it has now been co-opted for animal development and cell physiology.
September 2, 2026 at 9:19 PM
We propose that this function of microvilli as potentiators of cellular plasticity evolved before animal multicellularity. While it initially allowed fast adaptation to unpredictable, hostile natural environments, it has now been co-opted for animal development and cell physiology.
I'm assuming these are all orgone potentiators like I think we gotta be starting with the base assumption that backyard pyramids are getting built primarily for orgone type reasons
August 13, 2026 at 5:12 PM
I'm assuming these are all orgone potentiators like I think we gotta be starting with the base assumption that backyard pyramids are getting built primarily for orgone type reasons
Excited to be attending the second Global Antimicrobial Resistance Innovators Conference (GAMRIC) in sunny Lisbon this week.
Come see my research on #antibiotic #potentiators against #pseudomonas #aeruginosa infections in people with #cysticfibrosis at poster 031!
#GAMRIC2026
@escmid.bsky.social
Come see my research on #antibiotic #potentiators against #pseudomonas #aeruginosa infections in people with #cysticfibrosis at poster 031!
#GAMRIC2026
@escmid.bsky.social
September 22, 2026 at 12:37 PM
Excited to be attending the second Global Antimicrobial Resistance Innovators Conference (GAMRIC) in sunny Lisbon this week.
Come see my research on #antibiotic #potentiators against #pseudomonas #aeruginosa infections in people with #cysticfibrosis at poster 031!
#GAMRIC2026
@escmid.bsky.social
Come see my research on #antibiotic #potentiators against #pseudomonas #aeruginosa infections in people with #cysticfibrosis at poster 031!
#GAMRIC2026
@escmid.bsky.social
Aha! I knew I'd seen a paper on this. Abstract in comments.
- Set and setting
- Drug dosage
- Trait absorption
- Drug type
- Intention
- Surrender state
- Acceptance
Possible potentiators:
- Music
- Meditation and spiritual practices
- Nature-based settings
#psychedelics
doi.org/10.1556/2054...
- Set and setting
- Drug dosage
- Trait absorption
- Drug type
- Intention
- Surrender state
- Acceptance
Possible potentiators:
- Music
- Meditation and spiritual practices
- Nature-based settings
#psychedelics
doi.org/10.1556/2054...
Predictors and potentiators of psychedelic-occasioned mystical experiences
Abstract Mystical experiences are often described as being among the most profound and meaningful events of a person’s life. Their occurrence, while a normal but uncommon phenomenon, is reliably occas...
doi.org
June 3, 2025 at 5:17 PM
Aha! I knew I'd seen a paper on this. Abstract in comments.
- Set and setting
- Drug dosage
- Trait absorption
- Drug type
- Intention
- Surrender state
- Acceptance
Possible potentiators:
- Music
- Meditation and spiritual practices
- Nature-based settings
#psychedelics
doi.org/10.1556/2054...
- Set and setting
- Drug dosage
- Trait absorption
- Drug type
- Intention
- Surrender state
- Acceptance
Possible potentiators:
- Music
- Meditation and spiritual practices
- Nature-based settings
#psychedelics
doi.org/10.1556/2054...
Potentiators INCREASE the potency of other psychoactive plants or substances
Here are 5 potentiator herbs to add to your smoking rotation
A THREAD: Potentiator Herbs
Here are 5 potentiator herbs to add to your smoking rotation
A THREAD: Potentiator Herbs
July 4, 2023 at 4:08 PM
Potentiators INCREASE the potency of other psychoactive plants or substances
Here are 5 potentiator herbs to add to your smoking rotation
A THREAD: Potentiator Herbs
Here are 5 potentiator herbs to add to your smoking rotation
A THREAD: Potentiator Herbs
Indeed. Things like fresh ginger and black pepper and mustard seed work as potentiators for the chiles and vice versa.
October 9, 2025 at 10:38 AM
Indeed. Things like fresh ginger and black pepper and mustard seed work as potentiators for the chiles and vice versa.
I think practically that this will just be an efficient substitute for the other potentiators of psychosis, and marginally grab some more with the tendency but with weaker attachment to the traditional ones. A lot of the insane e/acc crap reaches across that spectrum.
August 21, 2026 at 12:45 PM
I think practically that this will just be an efficient substitute for the other potentiators of psychosis, and marginally grab some more with the tendency but with weaker attachment to the traditional ones. A lot of the insane e/acc crap reaches across that spectrum.
ie, in people taking GLP-1s, people with low stomach acid, people who take H2 antihistamines, people who can't take it with potentiators like vitamin C, yadda, ferrous gluconate may work better. My wife has been having iron issues for a while and we have done Much Research
February 3, 2026 at 12:16 AM
ie, in people taking GLP-1s, people with low stomach acid, people who take H2 antihistamines, people who can't take it with potentiators like vitamin C, yadda, ferrous gluconate may work better. My wife has been having iron issues for a while and we have done Much Research
【2025年7月 岡山大学/東京理科大学/京都大学】調査論文
インゲン豆のそばにブッシュバジルを植えるとハダニ対策になるよ！
ブッシュバジル（シソ科の矮性種一年草）が出す揮発性有機化合物（VOC）がインゲン豆の抵抗力を高め、さらにはハダニの天敵も呼び寄せる
pubs.acs.org/doi/10.1021/...
〜東京理科大学・有村源一郎
著作は『植物のたくらみ』『植物アロマサイエンスの最前線』
インゲン豆のそばにブッシュバジルを植えるとハダニ対策になるよ！
ブッシュバジル（シソ科の矮性種一年草）が出す揮発性有機化合物（VOC）がインゲン豆の抵抗力を高め、さらにはハダニの天敵も呼び寄せる
pubs.acs.org/doi/10.1021/...
〜東京理科大学・有村源一郎
著作は『植物のたくらみ』『植物アロマサイエンスの最前線』
Bush Basil Companion Plants Act as Plant Defense Potentiators for Cultivated Plants
Interplant interactions mediated by plant-emitted volatile organic compounds (VOCs) occur with heterospecific neighboring plants, making VOC-emitting companion plants a practical tool for pest managem...
pubs.acs.org
July 26, 2025 at 12:33 AM
【2025年7月 岡山大学/東京理科大学/京都大学】調査論文
インゲン豆のそばにブッシュバジルを植えるとハダニ対策になるよ！
ブッシュバジル（シソ科の矮性種一年草）が出す揮発性有機化合物（VOC）がインゲン豆の抵抗力を高め、さらにはハダニの天敵も呼び寄せる
pubs.acs.org/doi/10.1021/...
〜東京理科大学・有村源一郎
著作は『植物のたくらみ』『植物アロマサイエンスの最前線』
インゲン豆のそばにブッシュバジルを植えるとハダニ対策になるよ！
ブッシュバジル（シソ科の矮性種一年草）が出す揮発性有機化合物（VOC）がインゲン豆の抵抗力を高め、さらにはハダニの天敵も呼び寄せる
pubs.acs.org/doi/10.1021/...
〜東京理科大学・有村源一郎
著作は『植物のたくらみ』『植物アロマサイエンスの最前線』
like i'm talking "panera lemonade that kills you" levels of caffeine and potentiators in those shits. last year in provo they were getting teenagers into the hospital with arrhythmias from drinking too many mlm energy shakes.
February 15, 2026 at 6:40 AM
like i'm talking "panera lemonade that kills you" levels of caffeine and potentiators in those shits. last year in provo they were getting teenagers into the hospital with arrhythmias from drinking too many mlm energy shakes.
"Need for caution in screening for mitophagy activators in the presence of mitochondrial stressors because seemingly silent mitochondrial toxins may appear as promising pharmacological mitophagy potentiators", even if initial hits were obtained using purified enzyme targets 'sans cells'
August 28, 2025 at 9:42 AM
"Need for caution in screening for mitophagy activators in the presence of mitochondrial stressors because seemingly silent mitochondrial toxins may appear as promising pharmacological mitophagy potentiators", even if initial hits were obtained using purified enzyme targets 'sans cells'
Harvard Kennedy School researchers argue the real antibiotic crisis is not rare superbugs but common treatment failures.
A new class of drugs called pathogen-general potentiators could fix this and make antibiotic R&D profitable again.
www.nature.com/articles/s41...
A new class of drugs called pathogen-general potentiators could fix this and make antibiotic R&D profitable again.
www.nature.com/articles/s41...
Rethinking the unmet need for novel antibiotics - The Journal of Antibiotics
The Journal of Antibiotics - Rethinking the unmet need for novel antibiotics
www.nature.com
January 7, 2026 at 2:32 PM
Harvard Kennedy School researchers argue the real antibiotic crisis is not rare superbugs but common treatment failures.
A new class of drugs called pathogen-general potentiators could fix this and make antibiotic R&D profitable again.
www.nature.com/articles/s41...
A new class of drugs called pathogen-general potentiators could fix this and make antibiotic R&D profitable again.
www.nature.com/articles/s41...
'Bush Basil Companion Plants Act as Plant Defense Potentiators for Cultivated Plants' in Journal of Agricultural and Food Chemistry was featured as an ACS Science Release.
Read the release: buff.ly/p1ZHnU0
Read the article: buff.ly/sfkgjn2
Read the release: buff.ly/p1ZHnU0
Read the article: buff.ly/sfkgjn2
August 7, 2025 at 3:04 PM
'Bush Basil Companion Plants Act as Plant Defense Potentiators for Cultivated Plants' in Journal of Agricultural and Food Chemistry was featured as an ACS Science Release.
Read the release: buff.ly/p1ZHnU0
Read the article: buff.ly/sfkgjn2
Read the release: buff.ly/p1ZHnU0
Read the article: buff.ly/sfkgjn2
In other cases resistance potentiators do not provide any direct benefits - these are probably element that have accumulated because they provide some other function, or simply as a result of genetic drift.
Here is a brilliant example:
www.nature.com/articles/s41...
Here is a brilliant example:
www.nature.com/articles/s41...
CanB is a metabolic mediator of antibiotic resistance in Neisseria gonorrhoeae - Nature Microbiology
Metabolic variation via a single substitution in the β-carbonic anhydrase CanB determines CO2 dependence and influences fluoroquinolone resistance in Neisseria gonorrhoeae.
www.nature.com
July 6, 2026 at 9:17 PM
In other cases resistance potentiators do not provide any direct benefits - these are probably element that have accumulated because they provide some other function, or simply as a result of genetic drift.
Here is a brilliant example:
www.nature.com/articles/s41...
Here is a brilliant example:
www.nature.com/articles/s41...
Terpenes are powerful potentiators.
Terpenes & synergistic herbs can be part of a whole flower tincture, after FIRST checking for herbal interactions & a Physician’s Desk Reference for Rx.
Agent Orange (4 tours, wartime) caused my dad DECADES of heart problems & too many dementia-causing Rx meds.
Terpenes & synergistic herbs can be part of a whole flower tincture, after FIRST checking for herbal interactions & a Physician’s Desk Reference for Rx.
Agent Orange (4 tours, wartime) caused my dad DECADES of heart problems & too many dementia-causing Rx meds.
Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t
The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of a bioactive endocannabinoid. As a hypothetical afterthought, this was proposed to hold general ...
pmc.ncbi.nlm.nih.gov
January 22, 2026 at 5:32 AM
Terpenes are powerful potentiators.
Terpenes & synergistic herbs can be part of a whole flower tincture, after FIRST checking for herbal interactions & a Physician’s Desk Reference for Rx.
Agent Orange (4 tours, wartime) caused my dad DECADES of heart problems & too many dementia-causing Rx meds.
Terpenes & synergistic herbs can be part of a whole flower tincture, after FIRST checking for herbal interactions & a Physician’s Desk Reference for Rx.
Agent Orange (4 tours, wartime) caused my dad DECADES of heart problems & too many dementia-causing Rx meds.
Resistance potentiators is a topic that we kept on 're-discovering' in the lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
elifesciences.org/articles/62474
elifesciences.org/articles/78834
And it was lots of fun writing this with Adam Mulkern and Liam Shaw!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
elifesciences.org/articles/62474
elifesciences.org/articles/78834
And it was lots of fun writing this with Adam Mulkern and Liam Shaw!
Identifying and exploiting genes that potentiate the evolution of antibiotic resistance - Nature Ecology & Evolution
The ability to evolve resistance to the antibiotic ceftazidime is shown to vary across the Pseudomonas genus because the AmpR global transcriptional regulator potentiates evolution. Blocking this path...
www.nature.com
July 6, 2026 at 9:17 PM
Resistance potentiators is a topic that we kept on 're-discovering' in the lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
elifesciences.org/articles/62474
elifesciences.org/articles/78834
And it was lots of fun writing this with Adam Mulkern and Liam Shaw!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
elifesciences.org/articles/62474
elifesciences.org/articles/78834
And it was lots of fun writing this with Adam Mulkern and Liam Shaw!