To evaluate the primary efficacy and safety of satralizumab, an anti–interleukin-6 receptor antibody, in patients with thyroid eye disease (TED).

SYCUME® Significantly Improved Proptosis (Response Rate 60.4% / LS Mean Change from Baseline -1.88 mm) with Favorable Safety Profile in Participants with Inactive Thyroid Eye Disease(TED) SAN FRANCISCO and SUZHOU, China, Oct. 8, 2026 /PRNewswire/ -- Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high-quality medicines for the treatment of oncologic, autoimmune, cardiovascular and metabolic, ophthalmologic and other major diseases, announced today that its independently developed recombinant anti-insulin-like growth factor 1 receptor (IGF-1R) antibody, SYCUME® (Teprotumumab N01 Injection, R&D code: IBI311), has achieved its primary study endpoint at Week 24 in a multicenter, randomized, double-blind, placebo-controlled Phase 3 clinical study (RESTORE-3) in Chinese participants with inactive thyroid eye disease (TED). In this study, SYCUME® demonstrated remarkable efficacy in reducing proptosis in participants with inactive TED, with a favorable safety profile. SYCUME® is the first IGF-1R antibody drug in China and the second one approved worldwide, filling a 70-year treatment gap in the domestic TED field. Officially included in China's National Reimbursement Drug List on January 1, 2026, SYCUME® substantially alleviates the financial burden on patients compared to the high cost of overseas counterparts, significantly enhancing drug accessibility. Patients with inactive TED account for...

Orbital fat decompression via a sutureless transconjunctival approach achieved improvement in proptosis and lower eyelid position in pediatric TED

Subcutaneous satralizumab improves proptosis, clinical activity, and diplopia in patients with active or inactive thyroid eye disease.

A 30-year-old woman with Crohn disease presented with progressive bilateral periocular swelling, ptosis, conjunctival injection and chemosis, severe proptosis, ophthalmoplegia, and periorbital pain (A1–A3). Magnetic resonance imaging demonstrated diffuse infiltration of the lacrimal glands, orbital fat, extraocular muscles, and periorbital soft tissues (B). After orbital biopsy (C), histopathology (D) revealed granulomatous vasculitis with palisading epithelioid histiocytes (arrows), fibrinoid necrosis (asterisk), and necrotizing and nonnecrotizing granulomas in a background of fibrosis (not shown).

A 70-year-old man presented with left periorbital pain. He had a history of frontal lobe meningioma resection 9 years prior. Examination revealed left proptosis, inferior globe displacement, and restricted upward motility. Computed tomography showed a mixed-density lesion in the superior left orbit, with a partial defect of the superior orbital wall. Magnetic resonance imaging demonstrated a cystic extraconal lesion, isointense on T1 (A), hyperintense on T2 (B), with peripheral enhancement (C) and inferior globe displacement.

Introduction: Acute myeloid leukemia (AML), constituting 30% of pediatric malignancies, is the most common childhood cancer. This paper explores the rare presentation of AML with extramedullary…

This case report describes a 58-year-old man with a 10-day history of left eye redness, proptosis, blurred vision, and left-sided head pressure.

An 80-year-old woman presented with 4-mm relative left-sided proptosis over several years. Approximately 30 years previously, a pleomorphic adenoma of the left lacrimal gland had been excised via lateral orbitotomy with intraoperative frozen section. Computed tomography showed multiple discrete nodules involving the left orbital roof, lateral wall, and temporal fossa (arrows) with bony remodeling and focal defects of the frontal sinus and anterior cranial fossa (A–D). The multifocal distribution was attributed to seeding secondary to violation of the original tumor’s capsule.

Los hamsters pueden desarrollar problemas oculares como conjuntivitis, ulceras corneales o el llamado "ojo caido" (proptosis), comun en la especie por tener las

The short answer is no; a pug dog's eyes do not fall out or roll across the floor on their own. Their eyes are held in place by muscles and the optic nerve. However, flat-faced breeds like Pugs can experience ocular proptosis, a serious veterinary emergency where facial pressure or trauma forces the eyeball forward past the eyelids, making it appear as though the eye has popped out.

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This page contains presentations for ophthalmology residents to use in studying for the OKAP and Board exams.

Every year, there are approximately 25,000 people in the U.S. receiving care to manage their Thyroid Eye Disease (TED), an autoimmune condition where the immune system mistakenly attacks the muscle and fat tissue behind the eyes, leading to symptoms like proptosis (bulging eyes) and diplopia (double vision). TED can look different from person to person, […]