What is a good way to represent a protein structure? I would argue that graphs provide some of the most expressive ways we have today. #scicommUU26 #GNN #computationalchemistry #machinelearning #proteinstability

With graphs you can capture a bunch of cool features, such as weight, charges, polarizability, distances and angles.
A graph neural network (GNN) can then be trained to predict the effect of mutations! #scicommUU26 #GNN #computationalchemistry #machinelearning #proteinstability

New Discovery Rewrites the Rules of Protein Stability and Evolution #Science #Biology #MolecularBiology #ProteinStability #Evolution #BiologyResearch

SPIRRIG is required for BRICK1 stability and salt stress induced root hair developmental plasticity in Arabidopsis
Chi Zhang, Jingyu Zeng ... John Schiefelbein, Fei Yu & Lijun An

link.springer.com/article/10.1...

#Actin #cytoskeleton #Proteinstability

🚨 New study reveals amino acids stabilize proteins, offering potential solutions to manage particle stability in pharmaceuticals. This breakthrough opens paths to enhance drug formulation efficacy. Link: https://tinyurl.com/23zkrsad #ProteinStability #Pharmaceuticals #BiotechInnovation

🧱 Crystal structure shows binding on the opposite face to CDK, enabling ternary complex formation.
🧪 In cells, nanobodies act as pharmacological chaperones to restore p16 function!

#StructuralBiology #CellCycle #Nanobodies #CancerResearch #ProteinStability

Read the full application note determining the stability of common growth factors > zurl.co/lZy0j

#growthfactors #proteinstability

This application note reviews the stability of @Qkine growth factors (GM-CSF, IL-6, IGF-1, IGF1 LR3, GDNF, BMP-4, HGF NK1 and TGF-ß1 PLUS) under cell culture-like conditions.

Read the full application note > zurl.co/XG5cN

#growthfactors #proteinstability

Antibody Therapeutics (IF=4.5, Oxford University Press)
🔹 Preventing Physical and Chemical Degradation of the LABL-fc-MOGR5, a Bifunctional Peptide Inhibitor, with Formulation Development Approaches.
academic.oup.com/abt/advance-...
#DrugFormulation #Biologics #ProteinStability #CMC