#proteome
LightNews LightNews
natbiotech.nature.com
Scientists mining the ‘dark proteome’ are uncovering thousands of previously missed proteins, including promising new targets for cancer immunotherapies www.nature.com/articles/s41...
rdcu.be/YxZrAghhPmsa
Startups mine ‘dark proteome’ for new drug targets - Nature Biotechnology
Scientists uncover thousands of previously missed proteins, many of which appear to be relevant to human health — including promising new targets for cancer immunotherapies.
www.nature.com
November 2, 2026 at 9:01 PM
plant-sci.bsky.social
🌱🧬Plant mitochondria mix conserved & unique features. Using serial enrichment, MS, and protein correlation profiling, researchers built AtMitoCarta—1,609 mitochondrial proteins, including 236 new and 147 unknown.

About 15% of families are plant specific. #plantscience www.cell.com/cell/fulltex...
A high-confidence plant mitochondrial proteome via protein correlation profiling
A high-confidence mitochondrial proteome inventory of Arabidopsis thaliana (AtMitoCarta) is defined using serial enrichment of mitochondria, mass spectrometry, and protein correlation profiling.
www.cell.com
November 3, 2026 at 9:21 AM
Proteome: the ribosome retention
October 31, 2026 at 9:00 PM
robertosaezm.bsky.social
The proteome of Middle Pleistocene Xujiayao and common Denisovan morphology www.nature.com/articles/s41...
The proteome of Middle Pleistocene Xujiayao and common Denisovan morphology - Nature
Denisovans from the Xujiayao and other East Asian sites are morphologically distinctive, with a low cranial profile with near-parallel lateral walls, a massive supraorbital torus, a flat…
www.nature.com
November 2, 2026 at 7:31 AM
renesugar.bsky.social
Investigation into the Plasma Proteome Signature in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ( #MECFS )

publications.ersnet.org/content/erj/...

"Selectin E (SELE), ATP Synthase Subunit F6 (ATP5PF), and Transcobalamin 2 (TCN2) were identified as top candidates."
November 1, 2026 at 6:39 PM
bffo.bsky.social
From Ali F. Alsulami in #OUP 's #DATABASE journal | MERS-CoV-3D: integrating whole-genome variation, proteome mapping, and structural annotation of MERS-CoV mutations | #OpenScience #BioCuration #Proteomics #3D #Genomics #MERS-CoV | 🧬🖥️🧪🔓🇸🇦 🦠
⬇️
doi.org/10.1093/data...
MERS-CoV-3D: integrating whole-genome variation, proteome mapping, and structural annotation of MERS-CoV mutations
Abstract. Middle East respiratory syndrome coronavirus (MERS-CoV) remains a high-consequence zoonotic pathogen with recurrent outbreak potential and substa
doi.org
October 30, 2026 at 6:14 PM
lancedenes.bsky.social
New preprint.

We extend generative protein design to the disordered proteome…

A collaboration between the Lionnet, Holt, and Holehouse labs.

@successprocess.bsky.social
@liamholt.bsky.social
@alexholehouse.bsky.social
@remenecker.bsky.social

www.biorxiv.org/content/10.6...
October 28, 2026 at 12:39 PM
psb-vib.bsky.social
PAPER from @therhizolab.bsky.social #PlantScience
www.frontiersin.org/journals/pla...
Frontiers | Systemic proteome remodeling in soybean during early nodulation: distinct responses in roots and leaves
Here, we aimed to deepen our understanding of the integration between root and shoot signaling during early nodulation by jointly analyzing proteome-level dy...
www.frontiersin.org
October 30, 2026 at 2:59 PM
abioticstress.bsky.social
Dissecting #wheat epitranscriptome & #proteome under #salt stress characterizes an m6A reader gene vital for #salinity adaptation

academic.oup.com/plphys/artic...

#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @plant-sci.bsky.social @sciplant.bsky.social @plantgenetics.bsky.social
Dissecting wheat epitranscriptome and proteome under salt stress characterizes an m6A reader gene vital for salinity adaptation
Abstract. Soil salinization is a major abiotic stress limiting wheat production. Although transcriptional responses to salt stress are well-studied, the ro
academic.oup.com
October 29, 2026 at 1:41 PM
harvardcellbio.bsky.social
Work from the @harperlabhms.bsky.social & Johannes Walter labs reveals a structural interactome resource for the Golgi apparatus that combines crosslinking organelle proteomics with structural predictions across the Golgi proteome.@asapresearch.parkinsonsroadmap.org www.biorxiv.org/content/10.6...
GolgiFold: A Structural Predictome of Human Golgi Protein Complexes
The Golgi apparatus is a central hub for protein secretion and endolysosomal biogenesis, coordinating protein and vesicular trafficking pathways that maintain cellular homeostasis. Although hundreds o...
www.biorxiv.org
October 30, 2026 at 4:43 PM
ericchevet.bsky.social
Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: A nanoscale map of the human cell surface proteome reveals spatial and functional organization www.nature.com/articles/s41...
bims-proteo 2026-11-01 papers
biomed.news
November 1, 2026 at 6:26 AM
gmj-georgia.bsky.social
Age 50 marks a major proteome restructuring—the critical inflection point transitioning aging from slow drift to accelerated change.

https://news.gmj.ge/briefs/the-age-50-threshold-when-your-bodys-proteins-shift-dramatically/
The Age 50 Threshold: When Your Body’s Proteins Shift Dramatically
Age 50 marks a major proteome restructuring—the critical inflection point transitioning aging from slow drift to accelerated change.
news.gmj.ge
November 3, 2026 at 5:27 AM
plant-sci.bsky.social
🌱🧬A new experimental pipeline defines the Arabidopsis mitoproteome: 1,609 proteins, 236 newly identified, 147 uncharacterized. 15% of mitochondrial families are plant specific, including expanded PPR proteins.

A resource for comparative mitochondrial biology. #plantsci www.cell.com/cell/fulltex...
A high-confidence plant mitochondrial proteome via protein correlation profiling
A high-confidence mitochondrial proteome inventory of Arabidopsis thaliana (AtMitoCarta) is defined using serial enrichment of mitochondria, mass spectrometry, and protein correlation profiling.
www.cell.com
October 28, 2026 at 10:09 AM
drmuth.bsky.social
What if de novo peptide sequencing uses a proteome as a guide without being constrained by it?

Unlike DB search, PepPr, a peptide language model improves variant peptide identification and enhances AB sequencing hypervariable regions.

Preprint by the Gagneur lab: www.biorxiv.org/content/10.6...
PepPr: De Novo peptide sequencing with peptide priors
Mass spectrometry-based peptide sequencing underpins proteomics. Database search confines to predefined candidates, whereas de novo peptide sequencing (DNPS) struggles with incomplete spectra. Existin...
www.biorxiv.org
November 2, 2026 at 9:26 PM
plantphys.bsky.social
Dissecting wheat epitranscriptome and proteome under salt stress characterizes an m6A reader gene vital for salinity adaptation (Jie Zang , Qian Zhang , Yuyu Zhang , Zheng Wang , Yuxiu Dong , Yongming Chen , Xian Sheng Zhang , Yifeng Hou) doi.org/10.1093/plph... #PlantScience @aspbofficial
Dissecting wheat epitranscriptome and proteome under salt stress characterizes an m6A reader gene vital for salinity adaptation
Abstract. Soil salinization is a major abiotic stress limiting wheat production. Although transcriptional responses to salt stress are well-studied, the ro
doi.org
October 28, 2026 at 2:50 PM
rna-guy.bsky.social
1/n
Our paper is out in Nature today. Our immune systems learn to label our expressed proteome as self, but what if the proteome changes and novel peptides are made that the immune system has never seen before? Our immune systems are programmed to consider such peptides as non-self and attack them,
T and B cells recognize splicing-derived neutrophil neoantigens in lupus - Nature
In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody r...
www.nature.com
October 29, 2026 at 12:47 AM
bejalab.bsky.social
SAR11 HTCC1062. The functional proteome landscape of a cosmopolitan oceanic bacterium academic.oup.com/proteincell/...
The functional proteome landscape of a cosmopolitan oceanic bacterium
Abstract. SAR11 bacteria, the most abundant organisms in the global ocean, are an extensively studied example of streamlining, an adaptation to extremely l
academic.oup.com
October 28, 2026 at 7:04 AM
ausarchosaur.bsky.social
The proteome of Middle Pleistocene Xujiayao and common Denisovan morphology

www.nature.com/articles/s41...
The proteome of Middle Pleistocene Xujiayao and common Denisovan morphology - Nature
Denisovans from the Xujiayao and other East Asian sites are morphologically distinctive, with a low cranial profile with near-parallel lateral walls, a massive supraorbital torus, a fla...
www.nature.com
October 27, 2026 at 11:32 AM
biorxiv-biophys.bsky.social
ProtoPure: Literature Mining and Analysis of Protein Purification Protocols at Proteome Scale https://www.biorxiv.org/content/10.64898/2026.10.26.762056v1
October 30, 2026 at 10:48 PM
biorxivpreprint.bsky.social
ProtoPure: Literature Mining and Analysis of Protein Purification Protocols at Proteome Scale https://www.biorxiv.org/content/10.64898/2026.10.26.762056v1
October 30, 2026 at 10:48 PM
drtimos.bsky.social
Signal or noise? > IGF-I Gene Therapy Reshapes the Proteome of
Cartilage-Forming Stem Cells from Osteoarthritis Patients -
Bioengineer.org >> Comment below! #strategy #competitiveintelligence #marketing #healthcare #biotech #pharma #competitivemarketing #pharmaceutical
IGF-I Gene Therapy Reshapes the Proteome of Cartilage-Forming Stem Cells from Osteoarthritis Patients - Bioengineer.org
IGF-I Gene Therapy Reshapes the Proteome of Cartilage-Forming Stem Cells from Osteoarthritis Patients  Bioengineer.org
dlvr.it
October 30, 2026 at 5:59 AM
natsmb.nature.com
ICYMI: New online: A nanoscale map of the human cell surface proteome reveals spatial and functional organization
A nanoscale map of the human cell surface proteome reveals spatial and functional organization
Nature Structural & Molecular Biology, Published online: 28 October 2026; doi:10.1038/s41594-026-01914-4Floyd et al. use proximity labeling, mass spectrometry and machine learning to map the spatial organization of the human surfaceome, revealing functional protein modules, surface-localized mitochondrial proteins and regulators of immune signaling.
dlvr.it
October 29, 2026 at 12:19 PM
shihcheng.bsky.social
Nuclear proteome analysis reveals MAP1B, a microtubule-associated protein, in neural stem cells. It shuttles to the nucleus, influencing fate and disease. Fascinating implications for neuroscience! PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7
No description available
www.cell.com
October 30, 2026 at 2:00 PM
drtimos.bsky.social
Signal or noise? > IGF-I Gene Therapy Reshapes the Proteome of
Cartilage-Forming Stem Cells from Osteoarthritis Patients -
Bioengineer.org >> Comment below! #strategy #competitiveintelligence #marketing #healthcare #biotech #pharma #competitivemarketing #pharmaceutical
IGF-I Gene Therapy Reshapes the Proteome of Cartilage-Forming Stem Cells from Osteoarthritis Patients - Bioengineer.org
IGF-I Gene Therapy Reshapes the Proteome of Cartilage-Forming Stem Cells from Osteoarthritis Patients  Bioengineer.org
dlvr.it
October 30, 2026 at 5:59 AM