RNA is the brain. I spent nearly 5 years trying to get my Institute to understand that, but they couldn't see past pValue mining.
February 13, 2026 at 2:48 PM
RNA is the brain. I spent nearly 5 years trying to get my Institute to understand that, but they couldn't see past pValue mining.
Вот и настал момент на работе когда пригодилось знание определения pvalue, которое так любят обсуждать на собесах.
Разработчик спросил, что это за чиселка в табличке.
Разработчик спросил, что это за чиселка в табличке.
January 9, 2025 at 12:05 PM
Вот и настал момент на работе когда пригодилось знание определения pvalue, которое так любят обсуждать на собесах.
Разработчик спросил, что это за чиселка в табличке.
Разработчик спросил, что это за чиселка в табличке.
5%levelofsignificance Randomsample pvalue Normalityassumption ?
(Par contre, je vais ajouter Turing dans mes noms potentiels de chat 😁)
(Par contre, je vais ajouter Turing dans mes noms potentiels de chat 😁)
Et vous, comment appelleriez-vous vos enfants si leurs prénoms devaient être en lien avec votre travail ?
T’imagines si tout le monde faisait ça ? Mes enfants s’appelleraient diphtongue et apocope.
June 15, 2025 at 4:42 PM
5%levelofsignificance Randomsample pvalue Normalityassumption ?
(Par contre, je vais ajouter Turing dans mes noms potentiels de chat 😁)
(Par contre, je vais ajouter Turing dans mes noms potentiels de chat 😁)
The unprecedented times just keep coming!
This looks like a textbook figure on what a pvalue is 🙃 — maybe we are in a whole new distribution.
This looks like a textbook figure on what a pvalue is 🙃 — maybe we are in a whole new distribution.
How bad was today's stock market decline?
Of the 11,406 trading days since January 1980, only 29 had larger declines.
Of the 11,406 trading days since January 1980, only 29 had larger declines.
April 3, 2025 at 10:36 PM
The unprecedented times just keep coming!
This looks like a textbook figure on what a pvalue is 🙃 — maybe we are in a whole new distribution.
This looks like a textbook figure on what a pvalue is 🙃 — maybe we are in a whole new distribution.
pValue mining is a special case of Goodhart's Law.
(It's amazing how much Goodhart's Law shows up once you know what to look for.)
(It's amazing how much Goodhart's Law shows up once you know what to look for.)
February 13, 2026 at 3:13 PM
pValue mining is a special case of Goodhart's Law.
(It's amazing how much Goodhart's Law shows up once you know what to look for.)
(It's amazing how much Goodhart's Law shows up once you know what to look for.)
i have access to instagram and reddit again and oooooooo boy. let’s just say the regression coefficient of my mental health vs access to those apps has a pvalue<0.05.
February 5, 2025 at 11:11 PM
i have access to instagram and reddit again and oooooooo boy. let’s just say the regression coefficient of my mental health vs access to those apps has a pvalue<0.05.
Sometimes my pet peeve is when the casual gene is NOT the closest gene.
May I introduce you to HERC2,
reported here for the trait "retinal pigment score" with a pvalue of 0 (?!)
www.nature.com/articles/s41...
May I introduce you to HERC2,
reported here for the trait "retinal pigment score" with a pvalue of 0 (?!)
www.nature.com/articles/s41...
January 7, 2025 at 10:50 PM
Sometimes my pet peeve is when the casual gene is NOT the closest gene.
May I introduce you to HERC2,
reported here for the trait "retinal pigment score" with a pvalue of 0 (?!)
www.nature.com/articles/s41...
May I introduce you to HERC2,
reported here for the trait "retinal pigment score" with a pvalue of 0 (?!)
www.nature.com/articles/s41...
is the pvalue significant? if so i would say frost causes shadow.
November 23, 2025 at 8:18 PM
is the pvalue significant? if so i would say frost causes shadow.
Is pvalue worshiping really the fault of statisticians, or is it the fault of biologists that want black and white answers to questions that are inherently grey?
February 5, 2025 at 2:37 PM
Is pvalue worshiping really the fault of statisticians, or is it the fault of biologists that want black and white answers to questions that are inherently grey?
День начался с очередного вопроса от очередного менеджера, не виновато ли pvalue в том, что эксперимент серый.
Даже не знаю, что отвечать на такое, хоть доку заготовить и кидать. Но вроде для продакта, постоянно крутящего экспы, это базовые знания.
Даже не знаю, что отвечать на такое, хоть доку заготовить и кидать. Но вроде для продакта, постоянно крутящего экспы, это базовые знания.
February 12, 2025 at 6:25 AM
День начался с очередного вопроса от очередного менеджера, не виновато ли pvalue в том, что эксперимент серый.
Даже не знаю, что отвечать на такое, хоть доку заготовить и кидать. Но вроде для продакта, постоянно крутящего экспы, это базовые знания.
Даже не знаю, что отвечать на такое, хоть доку заготовить и кидать. Но вроде для продакта, постоянно крутящего экспы, это базовые знания.
Cooomunque, stanotte ho sognato che la mia febbre aveva un pvalue. E per chi non ha idea di cosa sto dicendo: buon per voi.
@coriolanus-snow.bsky.social secondo me merito un aumento per dedizione alla causa.
@coriolanus-snow.bsky.social secondo me merito un aumento per dedizione alla causa.
July 12, 2025 at 12:33 PM
Cooomunque, stanotte ho sognato che la mia febbre aveva un pvalue. E per chi non ha idea di cosa sto dicendo: buon per voi.
@coriolanus-snow.bsky.social secondo me merito un aumento per dedizione alla causa.
@coriolanus-snow.bsky.social secondo me merito un aumento per dedizione alla causa.
Aargh. The curse of the underflow p value strikes the MVP study.
In picking the lead snps the authors (inadvertantly) picked the first SNP with an underflow pvalue. This can be up to 500kb from the true lead snp.
All the strong pvalues listed from verma et al in @gwascatalog.bsky.social are suspect
In picking the lead snps the authors (inadvertantly) picked the first SNP with an underflow pvalue. This can be up to 500kb from the true lead snp.
All the strong pvalues listed from verma et al in @gwascatalog.bsky.social are suspect
See now this is what I'm talking about. A massive study (MVP) with 80,000 GWAS associations and the 1,000 most significant are corrupted because the authors didn't provide their actual p-values.
www.ebi.ac.uk/gwas/publica...
Don't do this
www.ebi.ac.uk/gwas/publica...
Don't do this
February 11, 2025 at 2:52 PM
Aargh. The curse of the underflow p value strikes the MVP study.
In picking the lead snps the authors (inadvertantly) picked the first SNP with an underflow pvalue. This can be up to 500kb from the true lead snp.
All the strong pvalues listed from verma et al in @gwascatalog.bsky.social are suspect
In picking the lead snps the authors (inadvertantly) picked the first SNP with an underflow pvalue. This can be up to 500kb from the true lead snp.
All the strong pvalues listed from verma et al in @gwascatalog.bsky.social are suspect
I like the paradigm of things being maladaptive attractor states in dynamic systems. But I don't see why omics isn't/ couldn't be part of studying those states. It just requires analysis more subtle than a pvalue on an enrichment analysis.
January 23, 2025 at 12:47 PM
I like the paradigm of things being maladaptive attractor states in dynamic systems. But I don't see why omics isn't/ couldn't be part of studying those states. It just requires analysis more subtle than a pvalue on an enrichment analysis.
Data without discussion is dead data 🧐 @simonegastaldon.bsky.social & I think #LinguisticAlignment needs #OpenScience & #multiverse debate!
🔥 Our re-analysis goes beyond the #pvalue to #collectively build solid #theory & valid #measurement in #cognitive #sciences
🔗 doi.org/10.1016/j.co...
🔥 Our re-analysis goes beyond the #pvalue to #collectively build solid #theory & valid #measurement in #cognitive #sciences
🔗 doi.org/10.1016/j.co...
March 1, 2025 at 11:32 AM
Data without discussion is dead data 🧐 @simonegastaldon.bsky.social & I think #LinguisticAlignment needs #OpenScience & #multiverse debate!
🔥 Our re-analysis goes beyond the #pvalue to #collectively build solid #theory & valid #measurement in #cognitive #sciences
🔗 doi.org/10.1016/j.co...
🔥 Our re-analysis goes beyond the #pvalue to #collectively build solid #theory & valid #measurement in #cognitive #sciences
🔗 doi.org/10.1016/j.co...
I'm afraid that my background biochemistry knowledge is not sufficient to understand that. I understand pValue shenanigans, but not the specific field you're in.
February 13, 2026 at 3:50 PM
I'm afraid that my background biochemistry knowledge is not sufficient to understand that. I understand pValue shenanigans, but not the specific field you're in.
I have been asked: how come the pvalue changed when I added/removed samples. Not infrequently
People do think it exists in the world as a thing to be estimated
People do think it exists in the world as a thing to be estimated
January 27, 2025 at 12:50 PM
I have been asked: how come the pvalue changed when I added/removed samples. Not infrequently
People do think it exists in the world as a thing to be estimated
People do think it exists in the world as a thing to be estimated
Eg: "using the best pvalue from preliminary measurements n=50 it is clear that the n=200 is well powered across all 1000 metabolites even with bonferroni correction".
Don't make me, the reviewer, do your power calculations.
Don't make me, the reviewer, do your power calculations.
May 10, 2026 at 9:26 AM
Eg: "using the best pvalue from preliminary measurements n=50 it is clear that the n=200 is well powered across all 1000 metabolites even with bonferroni correction".
Don't make me, the reviewer, do your power calculations.
Don't make me, the reviewer, do your power calculations.
#statstab #468 Confidence Distribution, the Frequentist Distribution Estimator of a Parameter: A Review
Thoughts: Frequentist stats must move beyond point and interval estimators, and adopt "distribution estimators".
#concurve #fisher #fiducial #pvalue
onlinelibrary.wiley.com/doi/full/10....
Thoughts: Frequentist stats must move beyond point and interval estimators, and adopt "distribution estimators".
#concurve #fisher #fiducial #pvalue
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
January 21, 2026 at 7:06 PM
Non ho visto se c’era un intervallo di confidenza al 95%, ma penso che il pvalue fosse >0.05 perché la febbre non ce l’ho 😂
July 12, 2025 at 4:36 PM
Non ho visto se c’era un intervallo di confidenza al 95%, ma penso che il pvalue fosse >0.05 perché la febbre non ce l’ho 😂
www.nature.com/articles/506...
The fallacy of p values..a significant part of our research uses p value..but with very little knowledge of how to interpret it
#statistics #pvalue #science
The fallacy of p values..a significant part of our research uses p value..but with very little knowledge of how to interpret it
#statistics #pvalue #science
Scientific method: Statistical errors - Nature
P values, the 'gold standard' of statistical validity, are not as reliable as many scientists assume.
www.nature.com
November 26, 2024 at 9:16 AM
www.nature.com/articles/506...
The fallacy of p values..a significant part of our research uses p value..but with very little knowledge of how to interpret it
#statistics #pvalue #science
The fallacy of p values..a significant part of our research uses p value..but with very little knowledge of how to interpret it
#statistics #pvalue #science
In the current case the authors listed a pvalue of 1e-323 when the real number is 1e-1500, an error of over one thousand orders of magnitude. By that measure I'm over one mile tall. I also would have over 5000 sons...
January 31, 2025 at 9:14 PM
In the current case the authors listed a pvalue of 1e-323 when the real number is 1e-1500, an error of over one thousand orders of magnitude. By that measure I'm over one mile tall. I also would have over 5000 sons...
given all the factors, context, limitations of how to study a problem like this, the stakes, etc etc i certainly interpret this as pretty compelling evidence
(also: thats just not what a pvalue means its a not uncommon misunderstanding;
(also: thats just not what a pvalue means its a not uncommon misunderstanding;
July 30, 2025 at 4:25 AM
given all the factors, context, limitations of how to study a problem like this, the stakes, etc etc i certainly interpret this as pretty compelling evidence
(also: thats just not what a pvalue means its a not uncommon misunderstanding;
(also: thats just not what a pvalue means its a not uncommon misunderstanding;
#statstab #557 The widespread misinterpretation of p-values as error probabilities
Thoughts: Well written & clear on the issue of p's and alpha's. I like "discrepancy" as a description of p-value.
#pvalue #nhst #fisher #alpha #hypothesis #testing #error
www.tandfonline.com/doi/full/10....
Thoughts: Well written & clear on the issue of p's and alpha's. I like "discrepancy" as a description of p-value.
#pvalue #nhst #fisher #alpha #hypothesis #testing #error
www.tandfonline.com/doi/full/10....
The widespread misinterpretation of p-values as error probabilities
The anonymous mixing of Fisherian (p-values) and Neyman–Pearsonian (α levels) ideas about testing, distilled in the customary but misleading p < α criterion of statistical significance, has led re...
www.tandfonline.com
June 22, 2026 at 5:27 PM
#statstab #557 The widespread misinterpretation of p-values as error probabilities
Thoughts: Well written & clear on the issue of p's and alpha's. I like "discrepancy" as a description of p-value.
#pvalue #nhst #fisher #alpha #hypothesis #testing #error
www.tandfonline.com/doi/full/10....
Thoughts: Well written & clear on the issue of p's and alpha's. I like "discrepancy" as a description of p-value.
#pvalue #nhst #fisher #alpha #hypothesis #testing #error
www.tandfonline.com/doi/full/10....
I want one with a low pvalue
August 16, 2026 at 8:35 PM
I want one with a low pvalue
what I am missing from the p.value discourse are applied examples of when a p.value less then or greater than .05 is approporiate. Eg, given the questions outcomes / applications/ sensitivities/ use cases, how they determined what is the more appropriate pvalue for that test would help alot
September 20, 2026 at 8:24 PM
what I am missing from the p.value discourse are applied examples of when a p.value less then or greater than .05 is approporiate. Eg, given the questions outcomes / applications/ sensitivities/ use cases, how they determined what is the more appropriate pvalue for that test would help alot