The Fentanyl Fold: Neurobiological Mechanisms of Opioid-Induced Postural Deformity and Reticulospinal Collapse www.noeris.media/the-fentanyl...
The Fentanyl Fold: Neurobiological Mechanisms of Opioid-Induced Postural Deformity and Reticulospinal Collapse
Fentanyl's potency, lipophilicity, and full mu-agonist action disrupt reticulospinal and basal ganglia control, causing forward flexion, rigidity, myoclonus, and foaming. Xylazine worsens it. Naloxone...
www.noeris.media
September 30, 2026 at 5:33 PM
The Fentanyl Fold: Neurobiological Mechanisms of Opioid-Induced Postural Deformity and Reticulospinal Collapse www.noeris.media/the-fentanyl...
Latest from the lab. Beautiful work from Joanna Lau and a fantastic collaboration with James Fitzgerald.
www.cell.com/current-biol...
www.cell.com/current-biol...
Supraspinal commands have a modular organization that is behavioral context specific
Lau et al. use calcium imaging and statistical modeling to comprehensively survey
reticulospinal activity during diverse locomotor behaviors. They find that a small
set of functional modules act combi...
www.cell.com
August 23, 2025 at 12:48 PM
Latest from the lab. Beautiful work from Joanna Lau and a fantastic collaboration with James Fitzgerald.
www.cell.com/current-biol...
www.cell.com/current-biol...
Next up from our group at @northumbriauni.bsky.social is @jandrushko.bsky.social presenting work on the contribution of the reticulospinal tract to concentric, Isometric, and eccentric muscle actions at @ecssofficial.bsky.social in Rimini, Italy 🇮🇹
July 4, 2025 at 9:34 AM
Next up from our group at @northumbriauni.bsky.social is @jandrushko.bsky.social presenting work on the contribution of the reticulospinal tract to concentric, Isometric, and eccentric muscle actions at @ecssofficial.bsky.social in Rimini, Italy 🇮🇹
Downstream @etlunsford.bsky.social mapped how the corresponding interneurons in the brainstem project onto reticulospinal neurons to select the steering command eliciting either forward or turns ... recalling the pioneering work of @daniobrain.bsky.social on optical motor response to flow! (5)
July 2, 2025 at 3:37 PM
Downstream @etlunsford.bsky.social mapped how the corresponding interneurons in the brainstem project onto reticulospinal neurons to select the steering command eliciting either forward or turns ... recalling the pioneering work of @daniobrain.bsky.social on optical motor response to flow! (5)
In this study, Nicole Sarah Holliger and collaborators from @uzh-ch.bsky.social investigated the involvement of the #reticulospinal system in the control of #locomotion 🧠 🔊
Read the paper👇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read the paper👇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
September 28, 2026 at 1:00 PM
In this study, Nicole Sarah Holliger and collaborators from @uzh-ch.bsky.social investigated the involvement of the #reticulospinal system in the control of #locomotion 🧠 🔊
Read the paper👇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read the paper👇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Breathing-Driven Modulation of Reticulospinal Tract Activity https://www.biorxiv.org/content/10.1101/2025.03.02.641029v1
March 7, 2025 at 7:16 PM
Breathing-Driven Modulation of Reticulospinal Tract Activity https://www.biorxiv.org/content/10.1101/2025.03.02.641029v1
For #MicroscopyMonday: 3D reconstructions of lamprey reticulospinal synapses
🐉: Petromyzon marinus
🥼: Jaqulin Wallace, @mblscience.bsky.social
🔬: JEOL JEM-200CX, MBL’s Central Microscopy Facility
📄: doi.org/10.1091/mbc....
#Neurodegeneration #ElectronMicroscopy #MBL #Microscopy #Parkinsons #NESM
🐉: Petromyzon marinus
🥼: Jaqulin Wallace, @mblscience.bsky.social
🔬: JEOL JEM-200CX, MBL’s Central Microscopy Facility
📄: doi.org/10.1091/mbc....
#Neurodegeneration #ElectronMicroscopy #MBL #Microscopy #Parkinsons #NESM
May 12, 2025 at 1:33 PM
For #MicroscopyMonday: 3D reconstructions of lamprey reticulospinal synapses
🐉: Petromyzon marinus
🥼: Jaqulin Wallace, @mblscience.bsky.social
🔬: JEOL JEM-200CX, MBL’s Central Microscopy Facility
📄: doi.org/10.1091/mbc....
#Neurodegeneration #ElectronMicroscopy #MBL #Microscopy #Parkinsons #NESM
🐉: Petromyzon marinus
🥼: Jaqulin Wallace, @mblscience.bsky.social
🔬: JEOL JEM-200CX, MBL’s Central Microscopy Facility
📄: doi.org/10.1091/mbc....
#Neurodegeneration #ElectronMicroscopy #MBL #Microscopy #Parkinsons #NESM
For #MicroscopyMonday, meet our #NESM President, Jaqulin! She studies how alpha-synuclein affects synapses in sea lamprey at @mblscience.bsky.social, and is passionate about microscopy education & outreach.
🔬: @jeolusa.bsky.social 120i TEM
🐍: Sea lamprey reticulospinal synapse
🥼: Jaqulin Wallace
🔬: @jeolusa.bsky.social 120i TEM
🐍: Sea lamprey reticulospinal synapse
🥼: Jaqulin Wallace
January 26, 2026 at 2:57 PM
For #MicroscopyMonday, meet our #NESM President, Jaqulin! She studies how alpha-synuclein affects synapses in sea lamprey at @mblscience.bsky.social, and is passionate about microscopy education & outreach.
🔬: @jeolusa.bsky.social 120i TEM
🐍: Sea lamprey reticulospinal synapse
🥼: Jaqulin Wallace
🔬: @jeolusa.bsky.social 120i TEM
🐍: Sea lamprey reticulospinal synapse
🥼: Jaqulin Wallace
Corticospinal, reticulospinal, and motoneuronal contributions to fatigability during a sustained contraction of the elbow flexors https://www.biorxiv.org/content/10.1101/2025.02.17.637601v1
February 23, 2025 at 5:15 PM
Corticospinal, reticulospinal, and motoneuronal contributions to fatigability during a sustained contraction of the elbow flexors https://www.biorxiv.org/content/10.1101/2025.02.17.637601v1
We are kicking off the afternoon sessions at #ASNR2024 with a Scientific Symposium examining the reticulospinal contributions to movement after #stroke or #SpinalCordInjury. Dr. Stuart Baker starts with a discussion of the reticulospinal tract & functional recovery after injury. #neurorehabilitation
April 12, 2024 at 7:01 PM
We are kicking off the afternoon sessions at #ASNR2024 with a Scientific Symposium examining the reticulospinal contributions to movement after #stroke or #SpinalCordInjury. Dr. Stuart Baker starts with a discussion of the reticulospinal tract & functional recovery after injury. #neurorehabilitation
Breathing-Driven Modulation of Reticulospinal Tract Activity https://www.biorxiv.org/content/10.1101/2025.03.02.641029v1
March 7, 2025 at 7:16 PM
Breathing-Driven Modulation of Reticulospinal Tract Activity https://www.biorxiv.org/content/10.1101/2025.03.02.641029v1
guys there's a spinoreticular tract and a reticulospinal tract. one of them is involved in the emotional and arousal aspects of pain and the other one in automatic posture and gait related movements . HELP MEEEEE
December 12, 2024 at 8:05 PM
guys there's a spinoreticular tract and a reticulospinal tract. one of them is involved in the emotional and arousal aspects of pain and the other one in automatic posture and gait related movements . HELP MEEEEE
Transient effects in corticospinal and reticulospinal tract excitability induced by motor skill and isometric resistance training https://www.biorxiv.org/content/10.1101/2025.05.21.655351v1
May 27, 2025 at 8:15 AM
Transient effects in corticospinal and reticulospinal tract excitability induced by motor skill and isometric resistance training https://www.biorxiv.org/content/10.1101/2025.05.21.655351v1
Dr. Monica Perez shared insights on reticulospinal contributions to movement after spinal cord injury, including reorganization that occurs in the nervous system and considerations relevant for motor recovery. #ASNR2024 #neurorehabilitation
April 12, 2024 at 7:50 PM
Dr. Monica Perez shared insights on reticulospinal contributions to movement after spinal cord injury, including reorganization that occurs in the nervous system and considerations relevant for motor recovery. #ASNR2024 #neurorehabilitation
4️⃣
🧠 Extrapyramidal Tracts:
Function: Regulate posture, balance, & involuntary movements.
Key Players:
Rubrospinal: Fine motor control (upper limbs).
Vestibulospinal: Balance & posture.
Reticulospinal: Automatic movements (e.g., walking).
🧠 Extrapyramidal Tracts:
Function: Regulate posture, balance, & involuntary movements.
Key Players:
Rubrospinal: Fine motor control (upper limbs).
Vestibulospinal: Balance & posture.
Reticulospinal: Automatic movements (e.g., walking).
February 22, 2025 at 6:51 AM
4️⃣
🧠 Extrapyramidal Tracts:
Function: Regulate posture, balance, & involuntary movements.
Key Players:
Rubrospinal: Fine motor control (upper limbs).
Vestibulospinal: Balance & posture.
Reticulospinal: Automatic movements (e.g., walking).
🧠 Extrapyramidal Tracts:
Function: Regulate posture, balance, & involuntary movements.
Key Players:
Rubrospinal: Fine motor control (upper limbs).
Vestibulospinal: Balance & posture.
Reticulospinal: Automatic movements (e.g., walking).
Antonia Maria Eilfort, Lennart Carlson Neumann and Linard Filli (Spinal Cord Injury Center, Balgrist University Hospital) present the first comprehensive assessment of reticulospinal drive across 14 upper and lower extremity muscles.
📜 buff.ly/qqvF8mA
📜 buff.ly/qqvF8mA
December 21, 2025 at 3:16 PM
Antonia Maria Eilfort, Lennart Carlson Neumann and Linard Filli (Spinal Cord Injury Center, Balgrist University Hospital) present the first comprehensive assessment of reticulospinal drive across 14 upper and lower extremity muscles.
📜 buff.ly/qqvF8mA
📜 buff.ly/qqvF8mA
We're looking forward to this #ASNR2024 session with Drs. Monica Perez, Stuart Baker, and Jules Dewald. Join us to learn more about reticulospinal contributions to movement after stroke and spinal cord injury! www.asnr.com/i4a/pages/in...
#neurorehabilitation 🧠📈
#neurorehabilitation 🧠📈
April 6, 2024 at 2:34 PM
We're looking forward to this #ASNR2024 session with Drs. Monica Perez, Stuart Baker, and Jules Dewald. Join us to learn more about reticulospinal contributions to movement after stroke and spinal cord injury! www.asnr.com/i4a/pages/in...
#neurorehabilitation 🧠📈
#neurorehabilitation 🧠📈
The art of wandering in vertebrates:
New mapping of neurons involved in locomotion
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish 🧪
www.nature.com/articles/s41...
New mapping of neurons involved in locomotion
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish 🧪
www.nature.com/articles/s41...
September 6, 2023 at 3:03 PM
The art of wandering in vertebrates:
New mapping of neurons involved in locomotion
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish 🧪
www.nature.com/articles/s41...
New mapping of neurons involved in locomotion
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish 🧪
www.nature.com/articles/s41...
Yeah subcortical motor pathways such as reticulospinal and vestibulospinal tracts as well as central pattern generators in the spine still mediate posture and locomotion to some extent in healthy people. Corticospinal input (ie what’s damaged in the stroke) helps shape more complex motor behaviors
January 30, 2026 at 4:52 PM
Yeah subcortical motor pathways such as reticulospinal and vestibulospinal tracts as well as central pattern generators in the spine still mediate posture and locomotion to some extent in healthy people. Corticospinal input (ie what’s damaged in the stroke) helps shape more complex motor behaviors
Authors published a paper in Biorxiv, they used ImageJ in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
Characterisation of transgenic lines labelling reticulospinal neurons in larval zebrafish
www.biorxiv.org
May 31, 2025 at 12:01 PM
Authors published a paper in Biorxiv, they used ImageJ in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
Supraspinal commands have a modular organization that is #behavioral context specific CurrentBiology
Supraspinal commands have a modular organization that is #behavioral context specific
Lau et al. use calcium imaging and statistical modeling to comprehensively survey reticulospinal activity during diverse locomotor behaviors. They find that a small set of functional modules act combinatorially to generate descending commands, and unexpectedly, this control architecture is stratified according to behavioral context.
dlvr.it
September 26, 2025 at 5:42 AM
Supraspinal commands have a modular organization that is #behavioral context specific CurrentBiology
Supraspinal commands have a modular organization that is #behavioral context specific CurrentBiology
Supraspinal commands have a modular organization that is #behavioral context specific
Lau et al. use calcium imaging and statistical modeling to comprehensively survey reticulospinal activity during diverse locomotor behaviors. They find that a small set of functional modules act combinatorially to generate descending commands, and unexpectedly, this control architecture is stratified according to behavioral context.
dlvr.it
September 24, 2025 at 4:41 PM
Supraspinal commands have a modular organization that is #behavioral context specific CurrentBiology
We all know how long-term training changes your outside… but what about your inside?
Our new study shows that long-term resistance training leads to different neural adaptations.
🔗 link.springer.com/article/10.1...
Our new study shows that long-term resistance training leads to different neural adaptations.
🔗 link.springer.com/article/10.1...
Reticulospinal and corticospinal responses in long-term strength-trained and untrained adults - European Journal of Applied Physiology
Purpose Studies investigating neural adaptation to strength training have yet to determine the loci of previously observed improvements in motor pathway function. While transcranial magnetic stimulati...
link.springer.com
June 13, 2025 at 5:25 PM
We all know how long-term training changes your outside… but what about your inside?
Our new study shows that long-term resistance training leads to different neural adaptations.
🔗 link.springer.com/article/10.1...
Our new study shows that long-term resistance training leads to different neural adaptations.
🔗 link.springer.com/article/10.1...
Loud acoustic stimulation reveals an online reticulospinal contribution to long-latency reflexes in humans #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.08.10.743894v1
https://www.biorxiv.org/content/10.64898/2026.08.10.743894v1
August 15, 2026 at 4:01 AM
Loud acoustic stimulation reveals an online reticulospinal contribution to long-latency reflexes in humans #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.08.10.743894v1
https://www.biorxiv.org/content/10.64898/2026.08.10.743894v1
Loud acoustic stimulation reveals an online reticulospinal contribution to long-latency reflexes in humans https://www.biorxiv.org/content/10.64898/2026.08.10.743894v1
August 15, 2026 at 2:15 AM
Loud acoustic stimulation reveals an online reticulospinal contribution to long-latency reflexes in humans https://www.biorxiv.org/content/10.64898/2026.08.10.743894v1