🗺️ The most comprehensive atlas of healthy human tissue has been launched to help understand disease. Researchers at @harvardmed.bsky.social led the development of the HuBMAP Data Portal.
Abstract: https://go.nature.com/4zyBieT
News: https://bit.ly/4z8BRea
#OpenScience #OpenAccess
Abstract: https://go.nature.com/4zyBieT
News: https://bit.ly/4z8BRea
#OpenScience #OpenAccess
November 9, 2026 at 1:25 PM
🗺️ The most comprehensive atlas of healthy human tissue has been launched to help understand disease. Researchers at @harvardmed.bsky.social led the development of the HuBMAP Data Portal.
Abstract: https://go.nature.com/4zyBieT
News: https://bit.ly/4z8BRea
#OpenScience #OpenAccess
Abstract: https://go.nature.com/4zyBieT
News: https://bit.ly/4z8BRea
#OpenScience #OpenAccess
Early endothelial cell immunogenic/pro-inflammatory features in🐭Heart failure with preserved ejection fraction #HFpEF
Transcriptomic evidence of 2 🐭models
1️⃣L-NAME + #HighFatDiet
2️⃣Mild #TransverseAorticConstriction + HFD
+Re-analysis of 👤HFpEF snRNAseq
bioRxiv 2026
www.biorxiv.org/content/10.6...
Transcriptomic evidence of 2 🐭models
1️⃣L-NAME + #HighFatDiet
2️⃣Mild #TransverseAorticConstriction + HFD
+Re-analysis of 👤HFpEF snRNAseq
bioRxiv 2026
www.biorxiv.org/content/10.6...
October 13, 2026 at 12:34 PM
Early endothelial cell immunogenic/pro-inflammatory features in🐭Heart failure with preserved ejection fraction #HFpEF
Transcriptomic evidence of 2 🐭models
1️⃣L-NAME + #HighFatDiet
2️⃣Mild #TransverseAorticConstriction + HFD
+Re-analysis of 👤HFpEF snRNAseq
bioRxiv 2026
www.biorxiv.org/content/10.6...
Transcriptomic evidence of 2 🐭models
1️⃣L-NAME + #HighFatDiet
2️⃣Mild #TransverseAorticConstriction + HFD
+Re-analysis of 👤HFpEF snRNAseq
bioRxiv 2026
www.biorxiv.org/content/10.6...
external-careers.jobs.unsw.edu.au/cw/en/job/54...
Postdoc position to spearhead the snRNAseq project in the lab
Postdoc position to spearhead the snRNAseq project in the lab
Research Associate
This position is specifically required to contribute towards a research program leveraging single-cell transcriptomics (snRNAseq) of brain tissue to understand differences in animal behaviour.
external-careers.jobs.unsw.edu.au
October 12, 2026 at 1:36 AM
external-careers.jobs.unsw.edu.au/cw/en/job/54...
Postdoc position to spearhead the snRNAseq project in the lab
Postdoc position to spearhead the snRNAseq project in the lab
Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle fiber-type gene expression, Ciotlos et al.
snRNA-seq of skeletal muscle from 263 people
🧬 🖥️🧪 #snRNAseq #RNAseq #SingleNucleus #SingleCell
www.sciencedirect.com/science/arti...
snRNA-seq of skeletal muscle from 263 people
🧬 🖥️🧪 #snRNAseq #RNAseq #SingleNucleus #SingleCell
www.sciencedirect.com/science/arti...
September 30, 2026 at 12:10 PM
Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle fiber-type gene expression, Ciotlos et al.
snRNA-seq of skeletal muscle from 263 people
🧬 🖥️🧪 #snRNAseq #RNAseq #SingleNucleus #SingleCell
www.sciencedirect.com/science/arti...
snRNA-seq of skeletal muscle from 263 people
🧬 🖥️🧪 #snRNAseq #RNAseq #SingleNucleus #SingleCell
www.sciencedirect.com/science/arti...
Research Technician role at UCL supporting FTD and ALS research using FANS, snRNAseq library preparation and bioinformatic analysis. Closing date: 7th October
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Technician - DEMENTIA RESEARCHER
UCL seeks a Research Technician to support FTD and ALS research using FANS, snRNAseq library preparation and bioinformatic analysis.
www.dementiaresearcher.nihr.ac.uk
September 18, 2026 at 9:22 AM
Research Technician role at UCL supporting FTD and ALS research using FANS, snRNAseq library preparation and bioinformatic analysis. Closing date: 7th October
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
One reason a gene may appear lowly-expressed in bulk RNAseq is that it is only expressed in a few cells. So we mapped the lowest-expressed genes onto our published snRNAseq data, and saw that many of these genes are expressed in specific cell clusters. The new filter enriches for DEGs too!
8/12
8/12
September 15, 2026 at 6:05 PM
One reason a gene may appear lowly-expressed in bulk RNAseq is that it is only expressed in a few cells. So we mapped the lowest-expressed genes onto our published snRNAseq data, and saw that many of these genes are expressed in specific cell clusters. The new filter enriches for DEGs too!
8/12
8/12
Research Technician role at UCL supporting FTD and ALS research using FANS, snRNAseq library preparation and bioinformatic analysis. Closing date: 28th September
www.dementiaresearcher.nihr.ac.uk/job/neurodeg...
www.dementiaresearcher.nihr.ac.uk/job/neurodeg...
Neurodegenerative Diseases Research Lab Technician
UCL seeks a Research Technician to support FTD and ALS research using FANS, snRNAseq library preparation and bioinformatic analysis.
www.dementiaresearcher.nihr.ac.uk
September 9, 2026 at 8:10 PM
Research Technician role at UCL supporting FTD and ALS research using FANS, snRNAseq library preparation and bioinformatic analysis. Closing date: 28th September
www.dementiaresearcher.nihr.ac.uk/job/neurodeg...
www.dementiaresearcher.nihr.ac.uk/job/neurodeg...
Floored by the news that I got a Future Fellowship to dig into brain mechanisms behind why individuals differ so much in avoiding bad choices
The project builds on prelim snRNAseq and whole-brain cFos data in mice. PhD/postdoc openings to work on this coming soon.
The project builds on prelim snRNAseq and whole-brain cFos data in mice. PhD/postdoc openings to work on this coming soon.
September 8, 2026 at 9:35 AM
Floored by the news that I got a Future Fellowship to dig into brain mechanisms behind why individuals differ so much in avoiding bad choices
The project builds on prelim snRNAseq and whole-brain cFos data in mice. PhD/postdoc openings to work on this coming soon.
The project builds on prelim snRNAseq and whole-brain cFos data in mice. PhD/postdoc openings to work on this coming soon.
📣 Job alert! 2 Positions starting 2027.
PhD position with me and @bayerlab.bsky.social on Robustness of embryonic and stomatal development, part of @greenrobust.de
Postdoc position on the regulation of cell state, following up on some exciting snRNAseq dat!
Apply now or share!
#PlantSciJob
PhD position with me and @bayerlab.bsky.social on Robustness of embryonic and stomatal development, part of @greenrobust.de
Postdoc position on the regulation of cell state, following up on some exciting snRNAseq dat!
Apply now or share!
#PlantSciJob
August 24, 2026 at 12:47 PM
📣 Job alert! 2 Positions starting 2027.
PhD position with me and @bayerlab.bsky.social on Robustness of embryonic and stomatal development, part of @greenrobust.de
Postdoc position on the regulation of cell state, following up on some exciting snRNAseq dat!
Apply now or share!
#PlantSciJob
PhD position with me and @bayerlab.bsky.social on Robustness of embryonic and stomatal development, part of @greenrobust.de
Postdoc position on the regulation of cell state, following up on some exciting snRNAseq dat!
Apply now or share!
#PlantSciJob
Working on some sex specific snRNAseq analyses and the next SABV frontier is definitely going to be validating cell types in terms of sex differences.
The “atlas era” might be over but the atlases are full of brains from white guys with liver cirrhosis that got into car accidents.
The “atlas era” might be over but the atlases are full of brains from white guys with liver cirrhosis that got into car accidents.
August 23, 2026 at 8:56 PM
Working on some sex specific snRNAseq analyses and the next SABV frontier is definitely going to be validating cell types in terms of sex differences.
The “atlas era” might be over but the atlases are full of brains from white guys with liver cirrhosis that got into car accidents.
The “atlas era” might be over but the atlases are full of brains from white guys with liver cirrhosis that got into car accidents.
El TFM es sobre el Análisis y validación funcional de genes y elementos cis reguladores (enhancers) involucrados en la especificación de territorios de la copa óptica del pez cebra, identificados mediante snRNAseq y snATACseq
July 9, 2025 at 4:07 PM
El TFM es sobre el Análisis y validación funcional de genes y elementos cis reguladores (enhancers) involucrados en la especificación de territorios de la copa óptica del pez cebra, identificados mediante snRNAseq y snATACseq
@libdrstats.bsky.social videos and blog posts continue to be a great resource for me as I delve into snRNAseq analyses, and for lots of other bioinformatics-related topics! Learn more here: research.libd.org/rstatsclub/
LIBD rstats club
Continuous rstats learning
research.libd.org
March 26, 2026 at 6:18 PM
@libdrstats.bsky.social videos and blog posts continue to be a great resource for me as I delve into snRNAseq analyses, and for lots of other bioinformatics-related topics! Learn more here: research.libd.org/rstatsclub/
Check out my first @libdrstats.bsky.social presentation on one strategy our team @lcolladotor.bsky.social at @lieberinstitute.bsky.social is taking to deal with doublets during quality control for single nucleus RNA-sequencing data:
www.youtube.com/watch?v=SMA-...
www.youtube.com/watch?v=SMA-...
[2026-02-27] Strategy to drop doublets during snRNAseq QC steps
YouTube video by Leonardo Collado Torres
www.youtube.com
March 26, 2026 at 6:18 PM
Check out my first @libdrstats.bsky.social presentation on one strategy our team @lcolladotor.bsky.social at @lieberinstitute.bsky.social is taking to deal with doublets during quality control for single nucleus RNA-sequencing data:
www.youtube.com/watch?v=SMA-...
www.youtube.com/watch?v=SMA-...
Excited to share our latest paper from a collab w Patrick Sullivan and others where results from two different data-driven approaches (GWAS/human-snRNAseq and fMRI) converge on the amygdala and hippocampus as key regions for schizophrenia: nature.com/articles/s41...
Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity - Nature Communications
Circuit and cell type prioritization for complex disorders is crucial to direct future efforts. Here the authors integrate GWAS, human single-cell RNA-seq and fMRI analysis suggesting multi-modality c...
nature.com
January 7, 2025 at 2:09 PM
Excited to share our latest paper from a collab w Patrick Sullivan and others where results from two different data-driven approaches (GWAS/human-snRNAseq and fMRI) converge on the amygdala and hippocampus as key regions for schizophrenia: nature.com/articles/s41...
Highlights from an exciting Day 2 at @endocrinesociety.bsky.social #ENDO2025 including my talk on #snRNAseq in #ACC at the #adrenalcancer symposium! @unibirmingham.bsky.social @uhbtrust.bsky.social
July 14, 2025 at 5:35 AM
Highlights from an exciting Day 2 at @endocrinesociety.bsky.social #ENDO2025 including my talk on #snRNAseq in #ACC at the #adrenalcancer symposium! @unibirmingham.bsky.social @uhbtrust.bsky.social
Hi! Check my journal club talk: smart ML method to deconvolute pooled snRNA-seq using sex-specific expression🧬
Thanks @daylab.bsky.social & @rphillips3.bsky.social for this approach🙌
🎥 youtu.be/zpeCFwYfV3o
🛝 speakerdeck.com/manishabarse
#snRNAseq #ML #Bioinformatics @lieberinstitute.bsky.social
Thanks @daylab.bsky.social & @rphillips3.bsky.social for this approach🙌
🎥 youtu.be/zpeCFwYfV3o
🛝 speakerdeck.com/manishabarse
#snRNAseq #ML #Bioinformatics @lieberinstitute.bsky.social
[2025-04-23] Journal club on "[...] deconvolution of pooled snRNA-seq using sex-dependent gene expr"
YouTube video by Leonardo Collado Torres
youtu.be
May 22, 2025 at 9:51 PM
Hi! Check my journal club talk: smart ML method to deconvolute pooled snRNA-seq using sex-specific expression🧬
Thanks @daylab.bsky.social & @rphillips3.bsky.social for this approach🙌
🎥 youtu.be/zpeCFwYfV3o
🛝 speakerdeck.com/manishabarse
#snRNAseq #ML #Bioinformatics @lieberinstitute.bsky.social
Thanks @daylab.bsky.social & @rphillips3.bsky.social for this approach🙌
🎥 youtu.be/zpeCFwYfV3o
🛝 speakerdeck.com/manishabarse
#snRNAseq #ML #Bioinformatics @lieberinstitute.bsky.social
snRNASeq of Early IPF lungs reveals emergence of aberrant basaloid cells & alveolar intermediate epithelial states & marked loss of AT2 and AT1 cells in early IPF.
These changes associate with subsequent disease progression 🙀
#EarlyIPFisIPF www.biorxiv.org/content/10.6...
These changes associate with subsequent disease progression 🙀
#EarlyIPFisIPF www.biorxiv.org/content/10.6...
June 1, 2026 at 2:35 AM
snRNASeq of Early IPF lungs reveals emergence of aberrant basaloid cells & alveolar intermediate epithelial states & marked loss of AT2 and AT1 cells in early IPF.
These changes associate with subsequent disease progression 🙀
#EarlyIPFisIPF www.biorxiv.org/content/10.6...
These changes associate with subsequent disease progression 🙀
#EarlyIPFisIPF www.biorxiv.org/content/10.6...
The first snRNASeq and spatial transcriptomic analysis of bronchoscopic cryobiopsies from patients with Early IPF & preserved pulmonary functions is out on @biorxivpreprint
and take home message is SIMPLE: Early IPF is IPF‼️
www.biorxiv.org/content/10.6... x.com
and take home message is SIMPLE: Early IPF is IPF‼️
www.biorxiv.org/content/10.6... x.com
June 1, 2026 at 2:35 AM
The first snRNASeq and spatial transcriptomic analysis of bronchoscopic cryobiopsies from patients with Early IPF & preserved pulmonary functions is out on @biorxivpreprint
and take home message is SIMPLE: Early IPF is IPF‼️
www.biorxiv.org/content/10.6... x.com
and take home message is SIMPLE: Early IPF is IPF‼️
www.biorxiv.org/content/10.6... x.com
Finally out! The largest ever multiomics COPD study. 1.5M lung cells. 141 individuals. snRNAseq, spatial, blood proteomics reveal shifting cell states & biomarkers across COPD stages, disease endotypes.
Kudos Dr. Sauler & team for this Herculean effort.
www.nature.com/articles/s41...
Kudos Dr. Sauler & team for this Herculean effort.
www.nature.com/articles/s41...
Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease - Nature Genetics
This study uses single-nucleus RNA sequencing to analyze lung tissue from 141 individuals with chronic obstructive pulmonary disease. Distinct patterns of spatially resolved changes in cell compositio...
www.nature.com
January 24, 2026 at 8:00 PM
Finally out! The largest ever multiomics COPD study. 1.5M lung cells. 141 individuals. snRNAseq, spatial, blood proteomics reveal shifting cell states & biomarkers across COPD stages, disease endotypes.
Kudos Dr. Sauler & team for this Herculean effort.
www.nature.com/articles/s41...
Kudos Dr. Sauler & team for this Herculean effort.
www.nature.com/articles/s41...
1/n
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
#CureIPF
www.biorxiv.org/content/10.1...
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
#CureIPF
www.biorxiv.org/content/10.1...
June 15, 2025 at 1:11 PM
1/n
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
#CureIPF
www.biorxiv.org/content/10.1...
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
#CureIPF
www.biorxiv.org/content/10.1...
Super excited to share this new preprint from our lab describing the Jamaican fruit bat placenta! 🦇
Here we analyzed the bat placenta by snRNAseq, compared it to the human and murine placenta to identify unique features, and developed bat placental & decidual organoids for use as models!
Here we analyzed the bat placenta by snRNAseq, compared it to the human and murine placenta to identify unique features, and developed bat placental & decidual organoids for use as models!
Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats https://www.biorxiv.org/content/10.1101/2025.05.15.654282v1
May 19, 2025 at 3:20 PM
Super excited to share this new preprint from our lab describing the Jamaican fruit bat placenta! 🦇
Here we analyzed the bat placenta by snRNAseq, compared it to the human and murine placenta to identify unique features, and developed bat placental & decidual organoids for use as models!
Here we analyzed the bat placenta by snRNAseq, compared it to the human and murine placenta to identify unique features, and developed bat placental & decidual organoids for use as models!
Watch a new webinar showcasing how Lite Yang (Washington University in St. Louis) harnessed the power of Xenium #singlecellspatial and multiomic #snRNAseq to create detailed, multimodal maps of cell projections in the mouse #brain: bit.ly/4je4uiB
April 1, 2025 at 4:00 PM
Watch a new webinar showcasing how Lite Yang (Washington University in St. Louis) harnessed the power of Xenium #singlecellspatial and multiomic #snRNAseq to create detailed, multimodal maps of cell projections in the mouse #brain: bit.ly/4je4uiB
Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social
March 20, 2025 at 1:38 AM
Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social
Nagler, Sud, and Ghannam et al. developed a droplet-based single-nucleus spatial transcriptomics platform, Slide-GoTags, that integrates genotyping, TCR sequencing, and snRNAseq from the same frozen section to map [...] @amitsud.bsky.social @harvardmed.bsky.social
bit.ly/4fPg8jO
bit.ly/4fPg8jO
August 9, 2026 at 2:00 PM
Nagler, Sud, and Ghannam et al. developed a droplet-based single-nucleus spatial transcriptomics platform, Slide-GoTags, that integrates genotyping, TCR sequencing, and snRNAseq from the same frozen section to map [...] @amitsud.bsky.social @harvardmed.bsky.social
bit.ly/4fPg8jO
bit.ly/4fPg8jO
tl;dr more people should use combined pathological models, it seems we might have been missing a LOT of stuff you only see when both pathologies are present! 🔍
We hope you enjoy exploring/leveraging these data. (: Thanks for all coauthors for their contributions! #blueskyence #Alzheimer's #snRNAseq
We hope you enjoy exploring/leveraging these data. (: Thanks for all coauthors for their contributions! #blueskyence #Alzheimer's #snRNAseq
August 11, 2026 at 4:40 PM
tl;dr more people should use combined pathological models, it seems we might have been missing a LOT of stuff you only see when both pathologies are present! 🔍
We hope you enjoy exploring/leveraging these data. (: Thanks for all coauthors for their contributions! #blueskyence #Alzheimer's #snRNAseq
We hope you enjoy exploring/leveraging these data. (: Thanks for all coauthors for their contributions! #blueskyence #Alzheimer's #snRNAseq