Metal Free Birch Reduction!
No ammonia either
This is VERY cool collab from ICIQ, U. Bologna and J&J on a most excellent #Photochem reaction
Nice scope too and added spirocycle bonus! @jacs.acspublications.org ASAP
#ChemSky
No ammonia either
This is VERY cool collab from ICIQ, U. Bologna and J&J on a most excellent #Photochem reaction
Nice scope too and added spirocycle bonus! @jacs.acspublications.org ASAP
#ChemSky
Light-Driven Organocatalytic Birch Reduction for Late-Stage Drug Modification and sp3-Rich Spirocycle Synthesis
The Birch reduction is a cornerstone transformation in synthetic chemistry, yet its widespread application is limited by harsh conditions, poor functional group tolerance, and safety concerns. Recent ...
pubs.acs.org
January 28, 2026 at 6:46 PM
Metal Free Birch Reduction!
No ammonia either
This is VERY cool collab from ICIQ, U. Bologna and J&J on a most excellent #Photochem reaction
Nice scope too and added spirocycle bonus! @jacs.acspublications.org ASAP
#ChemSky
No ammonia either
This is VERY cool collab from ICIQ, U. Bologna and J&J on a most excellent #Photochem reaction
Nice scope too and added spirocycle bonus! @jacs.acspublications.org ASAP
#ChemSky
A cool spirocycle will always make me have a look at a paper and this one from #Novartis in #JMedChemASAP has that look - spiropiperidine with an “ortho” amide linkage. It’s cool stuff, but it’s the neat reaction in the synthetic scheme tag at caught my eye…1/2
Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase
Leukotriene C4 synthase (LTC4S) is a glutathione S-transferase that mediates the biosynthesis of cysteinyl leukotriene C4 (LTC4). Cysteinyl leukotrienes (CysLTs) are lipid mediators that drive type 2 ...
pubs.acs.org
February 18, 2025 at 6:45 PM
A cool spirocycle will always make me have a look at a paper and this one from #Novartis in #JMedChemASAP has that look - spiropiperidine with an “ortho” amide linkage. It’s cool stuff, but it’s the neat reaction in the synthetic scheme tag at caught my eye…1/2
I am happy to share my latest publication from my PhD in the Melchiorre group, published in @jacs.acspublications.org, in which we present a simple organocatalyst to realize the Birch reductions of electron-rich benzenes under mild photocatalytic conditions.
#ChemSky
pubs.acs.org/doi/10.1021/...
#ChemSky
pubs.acs.org/doi/10.1021/...
Light-Driven Organocatalytic Birch Reduction for Late-Stage Drug Modification and sp3-Rich Spirocycle Synthesis
The Birch reduction is a cornerstone transformation in synthetic chemistry, yet its widespread application is limited by harsh conditions, poor functional group tolerance, and safety concerns. Recent ...
pubs.acs.org
January 29, 2026 at 8:51 PM
I am happy to share my latest publication from my PhD in the Melchiorre group, published in @jacs.acspublications.org, in which we present a simple organocatalyst to realize the Birch reductions of electron-rich benzenes under mild photocatalytic conditions.
#ChemSky
pubs.acs.org/doi/10.1021/...
#ChemSky
pubs.acs.org/doi/10.1021/...
New spirocycle molecules for medicines are being made faster using computers and robots at Caltech.
https://newsletter.tf/caltech-scientist-makes-new-medicine-molecules/
https://newsletter.tf/caltech-scientist-makes-new-medicine-molecules/
Caltech Scientist Uses Computers and Robots to Make New Medicine Molecules
Caltech scientist Melissa Ramirez uses computers and robots to create new spirocycle molecules for potential medicines. Learn how technology speeds up drug discovery.
newsletter.tf
March 2, 2026 at 10:12 AM
New spirocycle molecules for medicines are being made faster using computers and robots at Caltech.
https://newsletter.tf/caltech-scientist-makes-new-medicine-molecules/
https://newsletter.tf/caltech-scientist-makes-new-medicine-molecules/
Unlock novel bioactives - Iain Coldham et la. describe the formation of #spirooxindoles using an intermolecular nitrone #cycloaddition reaction.
🔗 https://www.beilstein-journals.org/bjoc/articles/21/146?B=y
#cascade #oxindoles #spirocycle #stereochemistry
#BJOC 💎🔓
🔗 https://www.beilstein-journals.org/bjoc/articles/21/146?B=y
#cascade #oxindoles #spirocycle #stereochemistry
#BJOC 💎🔓
December 19, 2025 at 2:02 PM
Unlock novel bioactives - Iain Coldham et la. describe the formation of #spirooxindoles using an intermolecular nitrone #cycloaddition reaction.
🔗 https://www.beilstein-journals.org/bjoc/articles/21/146?B=y
#cascade #oxindoles #spirocycle #stereochemistry
#BJOC 💎🔓
🔗 https://www.beilstein-journals.org/bjoc/articles/21/146?B=y
#cascade #oxindoles #spirocycle #stereochemistry
#BJOC 💎🔓
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders https://covalentmodifiers.blogspot.com/2024/04/proteomic-ligandability-maps-of.html
April 4, 2024 at 3:00 PM
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders https://covalentmodifiers.blogspot.com/2024/04/proteomic-ligandability-maps-of.html