Antimicrobial resistance, responsible for an estimated 35,000 deaths each year in the European Union, is spreading across humans, animals and the environment, prompting calls for a broader approach to tackling one of public health's biggest challenges.

Antimicrobial resistance, responsible for an estimated 35,000 deaths each year in the European Union, is spreading across humans, animals and the environment, prompting calls for a broader approach to tackling one of public health's biggest challenges.

Antimicrobial resistance, responsible for an estimated 35,000 deaths each year in the European Union, is spreading across humans, animals and the environment, prompting calls for a broader approach to tackling one of public health's biggest challenges.

Antimicrobial resistance, responsible for an estimated 35,000 deaths each year in the European Union, is spreading across humans, animals and the environment, prompting calls for a broader approach to...

A study of surveillance data shows an increase in carbapenem-resistant Enterobacterales infections in medically vulnerable pediatric patients.

Antimicrobial resistance, responsible for an estimated 35,000 deaths each year in the European Union, is spreading across humans, animals and the environment, prompting calls for a broader approach to

Antimicrobial resistance, responsible for an estimated 35,000 deaths each year in the European Union, is spreading across humans, animals and the environment, prompting calls for a broader approach to...

PhD Project - Evolution of antimicrobial resistance: how faulty replication supercharges a superbug at University of Sheffield, listed on FindAPhD.com

An increase in superbug infections in US hospitals appears to be affecting children with complex medical needs, US researchers reported this week in the Journal of the Pediatric Infectious Diseases Society. Recent surveillance studies by the Centers for Disease Control and Prevention (CDC) have shown a significant increase in hospital infections caused by carbapenem-resistant Enterobacterales (CRE), a family of bacterial pathogens that has become resistant to most antibiotics. The increase has been driven by carbapenemase-producing (CP)-CRE that carry the carbapenemase gene New Delhi metallo-beta-lactamase (NDM). But data on CRE and CP-CRE infections in pediatric patients have been limited. To assess trends in pediatric CRE and CP-CRE incidence in US hospitals, a team led by researchers with the CDC analyzed CRE clinical isolates from patients aged 18 and under that were submitted to the CDC’s Antimicrobial Resistance Laboratory Network from 2019 through 2024. “Recent increases in the incidence of NDM-producing CRE pose new challenges for managing CRE infections,” the study authors wrote. “These challenges are accentuated in pediatric populations, where approval and age-specific safety data are limited or unavailable for newer therapies that have expanded CP-CRE treatment options in adults.” A 4-fold rise in NDM-CRE infections Overall, researchers identified 1,845 CRE...

Researchers have discovered that vaccinating mouse mothers transfers antibodies that defend vulnerable newborns against Klebsiella pneumoniae. Klebsiella pneumoniae is a dangerous bacterium that kills thousands of infants in low- and middle-income countries each year and is the leading killer of children globally. Such infections can be difficult to treat due to the bacterium’s growing resistance to antibiotics and there is currently no vaccine available to prevent infection. The study in Science Advances points to a promising new strategy for protecting vulnerable infants from the drug-resistant superbug by harnessing maternal immunity. “Klebsiella pneumoniae is a serious threat to newborns who have not yet developed their own immune defenses,” says the study’s senior author, David A. Rosen, an associate professor of pediatrics and of molecular microbiology at Washington University School of Medicine in St. Louis. “Our study shows that maternal immunization can effectively bridge that critical window of vulnerability, giving newborns the protection they need right from birth.” K. pneumoniae is a big problem around the world, especially in the hospital where it can cause pneumonia and other infections among adults and children. In low- and middle-income countries, where children often get exposed to the bacterium in their environment, it drives severe...

Researchers have discovered that vaccinating mouse mothers transfers antibodies that defend vulnerable newborns against Klebsiella pneumoniae. Klebsiella pneumoniae is a dangerous bacterium that kills thousands of infants in low- and middle-income countries each year and is the leading killer of children globally. Such infections can be difficult to treat due to the bacterium’s growing resistance to antibiotics and there is currently no vaccine available to prevent infection. The study in Science Advances points to a promising new strategy for protecting vulnerable infants from the drug-resistant superbug by harnessing maternal immunity. “Klebsiella pneumoniae is a serious threat to newborns who have not yet developed their own immune defenses,” says the study’s senior author, David A. Rosen, an associate professor of pediatrics and of molecular microbiology at Washington University School of Medicine in St. Louis. “Our study shows that maternal immunization can effectively bridge that critical window of vulnerability, giving newborns the protection they need right from birth.” K. pneumoniae is a big problem around the world, especially in the hospital where it can cause pneumonia and other infections among adults and children. In low- and middle-income countries, where children often get exposed to the bacterium in their environment, it drives severe...

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