🦠🗺️ Sleeping Sickness Spreading?
Parasites causing sleeping sickness are evolving to spread without tsetse flies, thanks to key gene mutations. This allows them to infect new regions and animals, posing a potential threat beyond Africa.
🔗 www.nature.com/articles/s41...
#GlobalHealth #SciComm 🧪
Parasites causing sleeping sickness are evolving to spread without tsetse flies, thanks to key gene mutations. This allows them to infect new regions and animals, posing a potential threat beyond Africa.
🔗 www.nature.com/articles/s41...
#GlobalHealth #SciComm 🧪
Mechanisms of life cycle simplification in African trypanosomes - Nature Communications
African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory selected lines has identified a...
www.nature.com
December 28, 2024 at 9:25 PM
🦠🗺️ Sleeping Sickness Spreading?
Parasites causing sleeping sickness are evolving to spread without tsetse flies, thanks to key gene mutations. This allows them to infect new regions and animals, posing a potential threat beyond Africa.
🔗 www.nature.com/articles/s41...
#GlobalHealth #SciComm 🧪
Parasites causing sleeping sickness are evolving to spread without tsetse flies, thanks to key gene mutations. This allows them to infect new regions and animals, posing a potential threat beyond Africa.
🔗 www.nature.com/articles/s41...
#GlobalHealth #SciComm 🧪
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes
Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...
www.biorxiv.org
May 27, 2025 at 10:28 AM
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
Fernino et al. (2013) studied DNA from trypanosomes affecting S. Am & African crocodilids (including Nile Croc). Results = SA & Afr croc trypanosomes show relationships consistent w/ 4-5 MY croc dispersal across Atlantic & then host switch to infect alligatorids! doi.org/10.1186/1756... #2026MMM
March 27, 2026 at 1:34 AM
Fernino et al. (2013) studied DNA from trypanosomes affecting S. Am & African crocodilids (including Nile Croc). Results = SA & Afr croc trypanosomes show relationships consistent w/ 4-5 MY croc dispersal across Atlantic & then host switch to infect alligatorids! doi.org/10.1186/1756... #2026MMM
Comparative lipidomic profiling of African trypanosomes reveals metabolic distinctions impacting pan-species drug development pubmed.ncbi.nlm.nih.gov/42784629/
September 25, 2026 at 9:01 AM
Comparative lipidomic profiling of African trypanosomes reveals metabolic distinctions impacting pan-species drug development pubmed.ncbi.nlm.nih.gov/42784629/
Having done research in trypanosomes in my former life, all I can say is: YIKES. Cc: @peterhotezmdphd.bsky.social
“In the heart of Illinois, while researching wildlife disease, I made a discovery that stunned me: More than half of the raccoons I sampled were infected with Trypanosoma cruzi, the parasite that causes Chagas’ disease… It’s here, in the United States, spreading silently in wildlife.”
A ‘tropical’ disease is spreading in American wildlife
This neglected tropical disease is no longer confined to the tropics. It’s here, in the United States, spreading silently in wildlife.
www.statnews.com
August 8, 2025 at 1:27 PM
Having done research in trypanosomes in my former life, all I can say is: YIKES. Cc: @peterhotezmdphd.bsky.social
It is a great honour to invite you to a symposium to celebrate the career of Mark Carrington. An exciting set of talks, particularly if you are fascinated by trypanosomes.
January 13, 2025 at 10:32 AM
It is a great honour to invite you to a symposium to celebrate the career of Mark Carrington. An exciting set of talks, particularly if you are fascinated by trypanosomes.
Beautiful cartoons on the grids of the Institute illustrating our future research centre on vector-borne diseases @pasteur.fr with lovely #trypanosomes and a tsetse fly 😉
Many thanks to Céleste Gangolphe for the exceptional work!
Many thanks to Céleste Gangolphe for the exceptional work!
July 4, 2025 at 11:27 AM
Beautiful cartoons on the grids of the Institute illustrating our future research centre on vector-borne diseases @pasteur.fr with lovely #trypanosomes and a tsetse fly 😉
Many thanks to Céleste Gangolphe for the exceptional work!
Many thanks to Céleste Gangolphe for the exceptional work!
Avian trypanosomes in Thai bulbuls: an integrative study combining morphology and molecular analyses.
Molecular screening revealed substantially more infections than microscopy and uncovered mixed infections involving multiple trypanosome strains and/or species.🧪
🔗 doi.org/10.1051/para...
Molecular screening revealed substantially more infections than microscopy and uncovered mixed infections involving multiple trypanosome strains and/or species.🧪
🔗 doi.org/10.1051/para...
September 23, 2026 at 1:00 PM
Avian trypanosomes in Thai bulbuls: an integrative study combining morphology and molecular analyses.
Molecular screening revealed substantially more infections than microscopy and uncovered mixed infections involving multiple trypanosome strains and/or species.🧪
🔗 doi.org/10.1051/para...
Molecular screening revealed substantially more infections than microscopy and uncovered mixed infections involving multiple trypanosome strains and/or species.🧪
🔗 doi.org/10.1051/para...
@chrisgirardb.bsky.social Christine’s first manuscript is on BioRXiv! She investigated the CCDC40 protein in trypanosomes with superb expansion images and unexpected findings!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
June 11, 2026 at 7:02 AM
@chrisgirardb.bsky.social Christine’s first manuscript is on BioRXiv! She investigated the CCDC40 protein in trypanosomes with superb expansion images and unexpected findings!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Intersection between Art and Science: The minicircle network of the kinetoplast DNA from trypanosomes. - Trypanosomes have arguably the most complicated mitochondrial genome.
December 21, 2024 at 7:57 PM
Intersection between Art and Science: The minicircle network of the kinetoplast DNA from trypanosomes. - Trypanosomes have arguably the most complicated mitochondrial genome.
How do African trypanosomes regulate the complement system? Check out our new study from @BiochemCook, in which he identified a new trypanosome receptor which binds to the core C3bBb convertase of the complement system and blocks its activity. Real all about it! doi.org/10.64898/202...
August 20, 2026 at 7:55 PM
How do African trypanosomes regulate the complement system? Check out our new study from @BiochemCook, in which he identified a new trypanosome receptor which binds to the core C3bBb convertase of the complement system and blocks its activity. Real all about it! doi.org/10.64898/202...
What good way to start with Bluesky!
Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !
rdcu.be/d13YK
Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !
rdcu.be/d13YK
Mechanisms of life cycle simplification in African trypanosomes
Nature Communications - African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory...
rdcu.be
December 2, 2024 at 3:53 PM
What good way to start with Bluesky!
Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !
rdcu.be/d13YK
Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !
rdcu.be/d13YK
IFT imaging in trypanosomes was made possible thanks to Spencer and his team who trained Johanna Buisson and many others, for example for FRAP development
See @jcellsci.bsky.social for more videos
doi.org/10.1242/jcs....
See @jcellsci.bsky.social for more videos
doi.org/10.1242/jcs....
January 29, 2026 at 7:52 AM
IFT imaging in trypanosomes was made possible thanks to Spencer and his team who trained Johanna Buisson and many others, for example for FRAP development
See @jcellsci.bsky.social for more videos
doi.org/10.1242/jcs....
See @jcellsci.bsky.social for more videos
doi.org/10.1242/jcs....
Excited to share our work on life cycle simplification (monomorphism) in Trypanosoma brucei in Nature Comms @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechanisms of life cycle simplification in African trypanosomes - Nature Communications
African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory selected lines has identified a...
www.nature.com
December 2, 2024 at 4:32 PM
Excited to share our work on life cycle simplification (monomorphism) in Trypanosoma brucei in Nature Comms @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A factor integrating transcription and repression of surface antigen genes in African trypanosomes pubmed.ncbi.nlm.nih.gov/41632842/
February 4, 2026 at 11:33 AM
A factor integrating transcription and repression of surface antigen genes in African trypanosomes pubmed.ncbi.nlm.nih.gov/41632842/
Are you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York!
Please share!
jobs.york.ac.uk/vacancy/post...
Please share!
jobs.york.ac.uk/vacancy/post...
January 16, 2025 at 7:54 AM
Are you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York!
Please share!
jobs.york.ac.uk/vacancy/post...
Please share!
jobs.york.ac.uk/vacancy/post...
Introducing @bethbs.bsky.social who is working out what makes trypanosomes able to infect humans!
December 5, 2024 at 8:32 AM
Introducing @bethbs.bsky.social who is working out what makes trypanosomes able to infect humans!
Fancy RNA processing - Here is the structure of the Editosome from Trypanosomes doing U insertions and deletions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of the RNA-editing cascade in trypanosome mitochondria - Nature
Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uri...
www.nature.com
September 25, 2026 at 6:53 AM
Fancy RNA processing - Here is the structure of the Editosome from Trypanosomes doing U insertions and deletions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SHERLOCK4HAT: a CRISPR-RNA test rapidly spots animal trypanosomes, boosting sleeping-sickness surveillance and protecting herds. Led by Institut Pasteur & partners, study in eLife.
Details: www.pasteur.fr/en/home/rese...
Details: www.pasteur.fr/en/home/rese...
September 23, 2025 at 11:39 AM
SHERLOCK4HAT: a CRISPR-RNA test rapidly spots animal trypanosomes, boosting sleeping-sickness surveillance and protecting herds. Led by Institut Pasteur & partners, study in eLife.
Details: www.pasteur.fr/en/home/rese...
Details: www.pasteur.fr/en/home/rese...
January 22, 2026 at 9:02 PM
Tsetse flies are the cyclical vectors of African trypanosomes.
To separate the sexes is a major goal for tsetse management programmes with Sterile Insect Technique.
This automatic sorting machine can do that! 🧪
doi.org/10.1051/para...
To separate the sexes is a major goal for tsetse management programmes with Sterile Insect Technique.
This automatic sorting machine can do that! 🧪
doi.org/10.1051/para...
January 12, 2025 at 2:45 PM
Tsetse flies are the cyclical vectors of African trypanosomes.
To separate the sexes is a major goal for tsetse management programmes with Sterile Insect Technique.
This automatic sorting machine can do that! 🧪
doi.org/10.1051/para...
To separate the sexes is a major goal for tsetse management programmes with Sterile Insect Technique.
This automatic sorting machine can do that! 🧪
doi.org/10.1051/para...
[Podcast] Avec Sciences | "Maladies tropicales : une nouvelle cible thérapeutique potentielle identifiée chez les trypanosomes " par @alexandremorales.bsky.social
Maladies tropicales : une nouvelle cible thérapeutique potentielle identifiée chez les trypanosomes
Une publication parue dans Nature Communications précise la structure de l’ARN des parasites trypanosomes, à l'origine de pathologies comme la maladie du sommeil. Ils pourraient constituer une cible t...
www.radiofrance.fr
February 9, 2025 at 7:58 AM
[Podcast] Avec Sciences | "Maladies tropicales : une nouvelle cible thérapeutique potentielle identifiée chez les trypanosomes " par @alexandremorales.bsky.social
www.nature.com/articles/s41...
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
www.nature.com
July 5, 2025 at 9:08 AM
www.nature.com/articles/s41...
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
An Auxin-Inducible Degron System for Trypanosomes pubmed.ncbi.nlm.nih.gov/42573698/
August 11, 2026 at 3:22 PM
An Auxin-Inducible Degron System for Trypanosomes pubmed.ncbi.nlm.nih.gov/42573698/
NYU MS student Rafael Baez is doing super cool work with urban frogs in NYC! Trypanosomes, chytrid, immune function, and natural history. Some truly integrative research! #SICB2025
January 5, 2025 at 1:49 PM
NYU MS student Rafael Baez is doing super cool work with urban frogs in NYC! Trypanosomes, chytrid, immune function, and natural history. Some truly integrative research! #SICB2025