Warum ist in meiner Creme Kojisäure enthalten? 🤔
Kojisäure wird aus dem Reis-Schimmelpilz gewonnen und hemmt das Enzym Tyrosinase, das für die Bildung des Hautpigments Melanin zuständig ist.
#DerApotheker 🥷 1
Kojisäure wird aus dem Reis-Schimmelpilz gewonnen und hemmt das Enzym Tyrosinase, das für die Bildung des Hautpigments Melanin zuständig ist.
#DerApotheker 🥷 1
January 21, 2025 at 5:45 PM
Warum ist in meiner Creme Kojisäure enthalten? 🤔
Kojisäure wird aus dem Reis-Schimmelpilz gewonnen und hemmt das Enzym Tyrosinase, das für die Bildung des Hautpigments Melanin zuständig ist.
#DerApotheker 🥷 1
Kojisäure wird aus dem Reis-Schimmelpilz gewonnen und hemmt das Enzym Tyrosinase, das für die Bildung des Hautpigments Melanin zuständig ist.
#DerApotheker 🥷 1
It's colored in our tyrosinase transgenic mice! Does that make you feel better?
January 7, 2025 at 4:04 AM
It's colored in our tyrosinase transgenic mice! Does that make you feel better?
Great to see so many new people on #chemsky!
Time for a re-introduction of me and my group working @rwth.bsky.social in #inorganicchemistry . Research topics are #tyrosinase and #entaticstate models, iron #coordinationchemistry , #bioplastics, #recycling of plastics, #FAIRdata in chemistry, #InChI
Time for a re-introduction of me and my group working @rwth.bsky.social in #inorganicchemistry . Research topics are #tyrosinase and #entaticstate models, iron #coordinationchemistry , #bioplastics, #recycling of plastics, #FAIRdata in chemistry, #InChI
November 16, 2024 at 10:01 PM
Great to see so many new people on #chemsky!
Time for a re-introduction of me and my group working @rwth.bsky.social in #inorganicchemistry . Research topics are #tyrosinase and #entaticstate models, iron #coordinationchemistry , #bioplastics, #recycling of plastics, #FAIRdata in chemistry, #InChI
Time for a re-introduction of me and my group working @rwth.bsky.social in #inorganicchemistry . Research topics are #tyrosinase and #entaticstate models, iron #coordinationchemistry , #bioplastics, #recycling of plastics, #FAIRdata in chemistry, #InChI
A new publication is now out from @commsbio.bsky.social:
"The small molecule ML233 is a direct inhibitor of tyrosinase function" by R.Menard, A.Baanannou, C.Halluin, D.Morse, S.Kuhn, @jhgrabermdibl.bsky.social, J.Strickland & R.Madelaine.
🧪 🤝 🐟🎸 👩🔬 #ScientificResearchPublishing #ResearchPublishing
"The small molecule ML233 is a direct inhibitor of tyrosinase function" by R.Menard, A.Baanannou, C.Halluin, D.Morse, S.Kuhn, @jhgrabermdibl.bsky.social, J.Strickland & R.Madelaine.
🧪 🤝 🐟🎸 👩🔬 #ScientificResearchPublishing #ResearchPublishing
The small molecule ML233 is a direct inhibitor of tyrosinase function - Communications Biology
In vivo, in vitro and in silico validation of the direct inhibition of Tyrosinase activity by the ML233 small molecule reveal a therapeutic candidate for skin disorders.
www.nature.com
March 28, 2025 at 2:11 PM
A new publication is now out from @commsbio.bsky.social:
"The small molecule ML233 is a direct inhibitor of tyrosinase function" by R.Menard, A.Baanannou, C.Halluin, D.Morse, S.Kuhn, @jhgrabermdibl.bsky.social, J.Strickland & R.Madelaine.
🧪 🤝 🐟🎸 👩🔬 #ScientificResearchPublishing #ResearchPublishing
"The small molecule ML233 is a direct inhibitor of tyrosinase function" by R.Menard, A.Baanannou, C.Halluin, D.Morse, S.Kuhn, @jhgrabermdibl.bsky.social, J.Strickland & R.Madelaine.
🧪 🤝 🐟🎸 👩🔬 #ScientificResearchPublishing #ResearchPublishing
Week 4 of HTGAA (Protein Design) is done & I'm amazed!
I was always intimidated by 3D protein models in papers & never thought I'd understand them one day!
Today, I loaded a PDB file into PyMOL, saw the alpha helices & beta sheets of my Tyrosinase enzyme.
This is so cool. 🚀
#HTGAA #proteindesign
I was always intimidated by 3D protein models in papers & never thought I'd understand them one day!
Today, I loaded a PDB file into PyMOL, saw the alpha helices & beta sheets of my Tyrosinase enzyme.
This is so cool. 🚀
#HTGAA #proteindesign
November 11, 2025 at 2:27 AM
Week 4 of HTGAA (Protein Design) is done & I'm amazed!
I was always intimidated by 3D protein models in papers & never thought I'd understand them one day!
Today, I loaded a PDB file into PyMOL, saw the alpha helices & beta sheets of my Tyrosinase enzyme.
This is so cool. 🚀
#HTGAA #proteindesign
I was always intimidated by 3D protein models in papers & never thought I'd understand them one day!
Today, I loaded a PDB file into PyMOL, saw the alpha helices & beta sheets of my Tyrosinase enzyme.
This is so cool. 🚀
#HTGAA #proteindesign
The enzyme responsible for his darker coloration is tyrosinase, which is one of the most important enzymes controlling the rate of production of melanin. When tyrosinase is hot, it binds tightly to an inhibitor, and can no longer perform its role in synthesis of melanin.
3/6
3/6
May 17, 2025 at 2:29 PM
The enzyme responsible for his darker coloration is tyrosinase, which is one of the most important enzymes controlling the rate of production of melanin. When tyrosinase is hot, it binds tightly to an inhibitor, and can no longer perform its role in synthesis of melanin.
3/6
3/6
Interested in understanding why Siamese cats look like they do? My just published research demonstrates the structural relationship between mutant & normal tyrosinase gene. First of its kind study for cats.
#siamesecats #catsofbluesky #felinescience
www.techscience.com/biocell/onli...
#siamesecats #catsofbluesky #felinescience
www.techscience.com/biocell/onli...
Tyrosinase; signal peptide; translation; feline; endoplasmic reticulum (ER) stress; melanin
Objective: Tyrosinase is the rate-limiting enzyme in the generation of melanin. The feline tyrosinase mutation, G302R, confers temperature-sensitive loss of function, resulting in the familiar Siamese...
www.techscience.com
November 28, 2025 at 7:18 PM
Interested in understanding why Siamese cats look like they do? My just published research demonstrates the structural relationship between mutant & normal tyrosinase gene. First of its kind study for cats.
#siamesecats #catsofbluesky #felinescience
www.techscience.com/biocell/onli...
#siamesecats #catsofbluesky #felinescience
www.techscience.com/biocell/onli...
Plating a plant optimized tyrosinase plasmid onto LB with kanamycin 25mg/L, L-Tyrosine 500mg/L and Copper Sulfate 40mg/L. Let's see if it perks up melanin production in a day or two. Patched 4 colonies to start.
March 20, 2025 at 5:56 PM
Plating a plant optimized tyrosinase plasmid onto LB with kanamycin 25mg/L, L-Tyrosine 500mg/L and Copper Sulfate 40mg/L. Let's see if it perks up melanin production in a day or two. Patched 4 colonies to start.
🔵 Interesting new work from @davidweinshenker.bsky.social on why locus coeruleus neurons might be vulnerable to degeneration in humans (Alzheimer's) but not in mice. And a new approach on how this could be modelled in mice through human tyrosinase overexpression: www.biorxiv.org/content/10.1...
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
The locus coeruleus (LC), the major source of norepinephrine (NE) in the brain, is among the earliest site of pathology in both Alzheimers disease (AD) and Parkinsons disease (PD), and it undergoes ca...
www.biorxiv.org
April 9, 2025 at 7:25 PM
🔵 Interesting new work from @davidweinshenker.bsky.social on why locus coeruleus neurons might be vulnerable to degeneration in humans (Alzheimer's) but not in mice. And a new approach on how this could be modelled in mice through human tyrosinase overexpression: www.biorxiv.org/content/10.1...
Prof. Dr. Sonja Herres-Pawlis from RWTH Aachen University gave a talk on “News on the electron transfer at Tyrosinase models”, followed by an informal exchange with female early-career researchers on gender-related career topics. Many thanks for the valuable insights!
January 22, 2026 at 10:37 AM
Prof. Dr. Sonja Herres-Pawlis from RWTH Aachen University gave a talk on “News on the electron transfer at Tyrosinase models”, followed by an informal exchange with female early-career researchers on gender-related career topics. Many thanks for the valuable insights!
Tyrosinase expressing cells growing nicely at 30C! About 21 hours into growth. My experience back in 2020 was that it took a few days to really get melanin going. Fingers crossed for nice dark patches soon 🍫🦠
March 21, 2025 at 1:51 PM
Tyrosinase expressing cells growing nicely at 30C! About 21 hours into growth. My experience back in 2020 was that it took a few days to really get melanin going. Fingers crossed for nice dark patches soon 🍫🦠
Fuck you
Cat facts with Kasane Teto
Cat facts with Kasane Teto
September 25, 2025 at 8:55 PM
Fuck you
Cat facts with Kasane Teto
Cat facts with Kasane Teto
Letzten Freitag wurden an der RWTH Aachen die Friedrich-Wilhelm-Preise verliehen. Dominik Steden wurde für seine hervorragende Masterarbeit zu Elektronentransferprozessen an Tyrosinase-Modellen geehrt - herzlichen Glückwunsch! #bioinorganicchemistry
November 20, 2023 at 9:52 PM
Letzten Freitag wurden an der RWTH Aachen die Friedrich-Wilhelm-Preise verliehen. Dominik Steden wurde für seine hervorragende Masterarbeit zu Elektronentransferprozessen an Tyrosinase-Modellen geehrt - herzlichen Glückwunsch! #bioinorganicchemistry
Im Rahmen des @gdch.de Kolloquiums freuen wir uns HEUTE auf den Besuch von Prof. Sonja Herres-Pawlis @herreslab.bsky.social von der @rwth.bsky.social. Ihr Vortragstitel lautet:
"New tyrosinase models and the recycling of plastics - coordination chemistry in application"
📍 Haus 25/ F1.01
⌚ 14.00 c.t.
"New tyrosinase models and the recycling of plastics - coordination chemistry in application"
📍 Haus 25/ F1.01
⌚ 14.00 c.t.
July 14, 2025 at 7:59 AM
Im Rahmen des @gdch.de Kolloquiums freuen wir uns HEUTE auf den Besuch von Prof. Sonja Herres-Pawlis @herreslab.bsky.social von der @rwth.bsky.social. Ihr Vortragstitel lautet:
"New tyrosinase models and the recycling of plastics - coordination chemistry in application"
📍 Haus 25/ F1.01
⌚ 14.00 c.t.
"New tyrosinase models and the recycling of plastics - coordination chemistry in application"
📍 Haus 25/ F1.01
⌚ 14.00 c.t.
Das endoplasmatische Retikulum kam gerade endlich mal mit einer Funktion vor und nicht nur das gibt's und klingt witzig wie sonst immer!
Es synthetisiert zum Beispiel Tyrosinase.
Es synthetisiert zum Beispiel Tyrosinase.
May 16, 2024 at 9:50 AM
Das endoplasmatische Retikulum kam gerade endlich mal mit einer Funktion vor und nicht nur das gibt's und klingt witzig wie sonst immer!
Es synthetisiert zum Beispiel Tyrosinase.
Es synthetisiert zum Beispiel Tyrosinase.
If RUBY works then all tyrosinases will work too, because the first coding sequence in the RUBY P2A transcript is an arabi tyrosinase :)
March 18, 2025 at 11:45 PM
If RUBY works then all tyrosinases will work too, because the first coding sequence in the RUBY P2A transcript is an arabi tyrosinase :)
References
onlinelibrary-wiley-com/doi/chapter-...
onlinelibrary-wiley-com/doi/epdf/10....
onlinelibrary-wiley-com/doi/epdf/10....
www.sciencedirect.com/science/arti...
onlinelibrary-wiley-com/doi/chapter-...
onlinelibrary-wiley-com/doi/epdf/10....
onlinelibrary-wiley-com/doi/epdf/10....
www.sciencedirect.com/science/arti...
Regulation of mammalian melanogenesis by tyrosinase inhibition
Melanocyte stimulating hormone (MSH) specifically induces differentiation of mammalian melanocytes. To further define the biochemical events elicited …
www.sciencedirect.com
May 17, 2025 at 2:29 PM
The small molecule ML233 is a direct inhibitor of tyrosinase function https://www.biorxiv.org/content/10.1101/2025.02.16.638443v1
February 21, 2025 at 7:02 AM
The small molecule ML233 is a direct inhibitor of tyrosinase function https://www.biorxiv.org/content/10.1101/2025.02.16.638443v1
💬 Behind the Science Interview with Rosalie Dalhoff (RWTH Aachen University)
She discusses a robust dicopper peroxido complex that mimics tyrosinase activity while tolerating water, temperature, and non‑dried solvents
www.chemistryviews.org/unusually-st...
She discusses a robust dicopper peroxido complex that mimics tyrosinase activity while tolerating water, temperature, and non‑dried solvents
www.chemistryviews.org/unusually-st...
Unusually Stable Yet Reactive Cu₂O₂ Side-on Peroxido Tyrosinase Model Complex - ChemistryViews
Rosalie Dalhoff, RWTH Aachen, discusses a robust dicopper peroxido complex that mimics tyrosinase activity while tolerating water, temperature, and non‑dried solvents
www.chemistryviews.org
July 8, 2026 at 9:10 AM
💬 Behind the Science Interview with Rosalie Dalhoff (RWTH Aachen University)
She discusses a robust dicopper peroxido complex that mimics tyrosinase activity while tolerating water, temperature, and non‑dried solvents
www.chemistryviews.org/unusually-st...
She discusses a robust dicopper peroxido complex that mimics tyrosinase activity while tolerating water, temperature, and non‑dried solvents
www.chemistryviews.org/unusually-st...
Another perfect Siamese. If you want to know more about your Siamese cat colorpoint pattern; here is a link to my research published in Dec 2025.
doi.org/10.32604/bio...
doi.org/10.32604/bio...
Computational Tools Identify Novel Mechanisms for Feline Color-Pointed Phenotypes Based on Tyrosinase Mutations
Objective: Tyrosinase is the rate-limiting enzyme in the generation of melanin. The feline tyrosinase mutation, G302R, confers temperature-sensitive loss of function, resulting in the familiar Siamese...
doi.org
January 19, 2026 at 8:42 PM
Another perfect Siamese. If you want to know more about your Siamese cat colorpoint pattern; here is a link to my research published in Dec 2025.
doi.org/10.32604/bio...
doi.org/10.32604/bio...
Fortunately, most skin bleaching products don't involve caustic bases that turn skin cells into soap. They're things that exfoliate and/or block melanin or tyrosinase, as far as I know, and sometimes anti-inflammatories.
May 22, 2026 at 4:24 PM
Fortunately, most skin bleaching products don't involve caustic bases that turn skin cells into soap. They're things that exfoliate and/or block melanin or tyrosinase, as far as I know, and sometimes anti-inflammatories.
SNAKES ARE CUTE AF I will die on this hill, I will slaughter on this hill
November 22, 2024 at 4:55 AM
SNAKES ARE CUTE AF I will die on this hill, I will slaughter on this hill
Working on that! The tyrosinase i have has a rubisco small subunit chloroplast tag, since tyr is mostly in cp. But if RUBY works then why not! Both run off Tyr. Vicia faba has a weird nitrogen-free alomelankn that looks black.
March 18, 2025 at 9:59 PM
Working on that! The tyrosinase i have has a rubisco small subunit chloroplast tag, since tyr is mostly in cp. But if RUBY works then why not! Both run off Tyr. Vicia faba has a weird nitrogen-free alomelankn that looks black.
I suppose the petunia petals don’t have chloroplasts, but rather leucoplasts. Maybe the tyrosinase still gets in and does the job 🤔
March 18, 2025 at 11:20 PM
I suppose the petunia petals don’t have chloroplasts, but rather leucoplasts. Maybe the tyrosinase still gets in and does the job 🤔
FYI - we find it very hard / impossible to clone a tyrosinase in E.coli with a medium or strong constitutive promoter on high copy plasmid.
March 20, 2025 at 7:18 PM
FYI - we find it very hard / impossible to clone a tyrosinase in E.coli with a medium or strong constitutive promoter on high copy plasmid.