![Comic. [Person with shoulder-length hair talking to a second person. She is gesturing at a dinosaur skeleton with a machine mounted on its back.] PERSON 1: Although Bazookasaurus’s distinctive structure was long assumed to be a weapon, vascularization studies show that it was very fragile and could only have been used for display.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreidp3zjc4e2d44eanl64r6gctwkqlzkg2lvwl4gik7eyn4kownucxy)
March 10, 2026 at 8:22 PM
Beautiful review on embryonic brain vascularization!
Central nervous system vascularization in human embryos and neural organoids
Human pluripotent stem cell-derived neural organoids are promising models for studying central nervous system development and disease. However, few have successfully been vascularized, and none truly recapitulate in vivo vascularization patterns. Here, developmental anatomy and bioengineering principles are discussed to chart a path toward enhancing vascularized neural organoid biomimicry.
www.cell.com
December 17, 2024 at 8:42 PM
Beautiful review on embryonic brain vascularization!
Pluripotent stem cells that differentiate into vascularized cardiac and hepatic organoids. Wow! www.science.org/doi/10.1126/...
Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularization
Although model organisms have provided insight into the earliest stages of cardiac and hepatic vascularization, we know very little about this process in humans because of ethical restrictions and the...
www.science.org
June 6, 2025 at 2:25 AM
Pluripotent stem cells that differentiate into vascularized cardiac and hepatic organoids. Wow! www.science.org/doi/10.1126/...
The less vascularization the connective tissue has, the shittier its healing and recovery process will be.
September 21, 2024 at 6:24 AM
The less vascularization the connective tissue has, the shittier its healing and recovery process will be.
Really pleased to see reviews like this, expanding on our discoveries that #cerebrovascular dysregulation during development contributes to autism spectrum disorders. physoc.onlinelibrary.wiley.com/doi/10.1113/...
Dysregulation of neural tube vascular development as an aetiological factor in autism spectrum disorder: Insights from valproic acid exposure
Abstract figure legend Relationship between neural tube vascularization and behavioural outcomes. This figure illustrates the proposed link between neural tube vascularization and behavioural develop....
physoc.onlinelibrary.wiley.com
January 3, 2025 at 11:55 PM
Really pleased to see reviews like this, expanding on our discoveries that #cerebrovascular dysregulation during development contributes to autism spectrum disorders. physoc.onlinelibrary.wiley.com/doi/10.1113/...
I've been anticipating this for a while now. It's a big deal for organoids. It might also accelerate complicated ethical questions about brain organoids, which until now have been partly limited in size by lack of vascularization.
Researchers are making ever more sophisticated mini organs in the lab — and now they can grow their own blood vessels
go.nature.com/4nNF3ri
go.nature.com/4nNF3ri
Mini hearts, lungs and livers made in lab now grow their own blood vessels
These sophisticated models will be used for human-development studies and drug testing.
go.nature.com
July 11, 2025 at 11:51 AM
I've been anticipating this for a while now. It's a big deal for organoids. It might also accelerate complicated ethical questions about brain organoids, which until now have been partly limited in size by lack of vascularization.
What do they mean cancer cannot survive in an oxygenated environment? Part of tumor development is vascularization. God they’re all so stupid
January 11, 2025 at 4:24 PM
What do they mean cancer cannot survive in an oxygenated environment? Part of tumor development is vascularization. God they’re all so stupid
Tendons and ligaments, the things that you are way more likely to injure than muscle or bone, are poorly vascularized.
Tendons connect muscle to bone, ligaments connect bone to bone.
The rotator cuff tendons lack vascularization, this is why they heal so poorly and slowly.
Tendons connect muscle to bone, ligaments connect bone to bone.
The rotator cuff tendons lack vascularization, this is why they heal so poorly and slowly.
September 21, 2024 at 6:22 AM
Tendons and ligaments, the things that you are way more likely to injure than muscle or bone, are poorly vascularized.
Tendons connect muscle to bone, ligaments connect bone to bone.
The rotator cuff tendons lack vascularization, this is why they heal so poorly and slowly.
Tendons connect muscle to bone, ligaments connect bone to bone.
The rotator cuff tendons lack vascularization, this is why they heal so poorly and slowly.
Heart #Assembloid Vascularization (+pericyte coverage) & Innervation
1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid
Beautiful vascular network!
Can we further differentiate it into A-C-V microcirculatory unit?😁
bioRxiv 2025
www.biorxiv.org/content/10.1...
1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid
Beautiful vascular network!
Can we further differentiate it into A-C-V microcirculatory unit?😁
bioRxiv 2025
www.biorxiv.org/content/10.1...
January 18, 2025 at 12:44 PM
Heart #Assembloid Vascularization (+pericyte coverage) & Innervation
1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid
Beautiful vascular network!
Can we further differentiate it into A-C-V microcirculatory unit?😁
bioRxiv 2025
www.biorxiv.org/content/10.1...
1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid
Beautiful vascular network!
Can we further differentiate it into A-C-V microcirculatory unit?😁
bioRxiv 2025
www.biorxiv.org/content/10.1...
#MarfanSyndrome Retina #Angiogenesis
Fbn1 C1041G/+🐭have defective postnatal retinal vascularization
⏬Tip cell (Fibrillin-1 is deposited along the sprouts🤩), filopodia
An interesting microvascular re-appraisal of Fibrillin-1 suppression of BMP signal
#PNASNews 2023
www.pnas.org/doi/10.1073/...
Fbn1 C1041G/+🐭have defective postnatal retinal vascularization
⏬Tip cell (Fibrillin-1 is deposited along the sprouts🤩), filopodia
An interesting microvascular re-appraisal of Fibrillin-1 suppression of BMP signal
#PNASNews 2023
www.pnas.org/doi/10.1073/...
November 13, 2024 at 1:09 PM
#MarfanSyndrome Retina #Angiogenesis
Fbn1 C1041G/+🐭have defective postnatal retinal vascularization
⏬Tip cell (Fibrillin-1 is deposited along the sprouts🤩), filopodia
An interesting microvascular re-appraisal of Fibrillin-1 suppression of BMP signal
#PNASNews 2023
www.pnas.org/doi/10.1073/...
Fbn1 C1041G/+🐭have defective postnatal retinal vascularization
⏬Tip cell (Fibrillin-1 is deposited along the sprouts🤩), filopodia
An interesting microvascular re-appraisal of Fibrillin-1 suppression of BMP signal
#PNASNews 2023
www.pnas.org/doi/10.1073/...
Nanodelivery/Nanoengineering/Nanozyme strategies for skeletal muscle repair & regeneration
Tuning inflammation, oxidative stress, muscularization, vascularization, innervation
#JNanobiotech 2026
link.springer.com/article/10.1...
Tuning inflammation, oxidative stress, muscularization, vascularization, innervation
#JNanobiotech 2026
link.springer.com/article/10.1...
June 21, 2026 at 12:30 PM
Nanodelivery/Nanoengineering/Nanozyme strategies for skeletal muscle repair & regeneration
Tuning inflammation, oxidative stress, muscularization, vascularization, innervation
#JNanobiotech 2026
link.springer.com/article/10.1...
Tuning inflammation, oxidative stress, muscularization, vascularization, innervation
#JNanobiotech 2026
link.springer.com/article/10.1...
✨ December 2025 #ImageOfTheMonth ✨
Whole rat hearts cleared with iDISCO reveal sympathetic innervation (orange) and vascularization (green). 💛💚
Work by S. Bertrand & A. Bonilla (INCIA) with S. Martin & I. Brunet (CIRB), imaged by J. Teillon (BIC).
#Microscopy #iDISCO #BICBordeaux
Whole rat hearts cleared with iDISCO reveal sympathetic innervation (orange) and vascularization (green). 💛💚
Work by S. Bertrand & A. Bonilla (INCIA) with S. Martin & I. Brunet (CIRB), imaged by J. Teillon (BIC).
#Microscopy #iDISCO #BICBordeaux
December 4, 2025 at 11:29 AM
✨ December 2025 #ImageOfTheMonth ✨
Whole rat hearts cleared with iDISCO reveal sympathetic innervation (orange) and vascularization (green). 💛💚
Work by S. Bertrand & A. Bonilla (INCIA) with S. Martin & I. Brunet (CIRB), imaged by J. Teillon (BIC).
#Microscopy #iDISCO #BICBordeaux
Whole rat hearts cleared with iDISCO reveal sympathetic innervation (orange) and vascularization (green). 💛💚
Work by S. Bertrand & A. Bonilla (INCIA) with S. Martin & I. Brunet (CIRB), imaged by J. Teillon (BIC).
#Microscopy #iDISCO #BICBordeaux
#SodiumTungstate (NaW), a pharmacological protein phosphatase inhibitor, is shown to enhance vascularization and survival of human #BetaCell grafts
by A. García-Alamán, R. Gasa & colleagues @isciiisalud.bsky.social @ciberisciii.bsky.social
👉 doi.org/10.1038/s44321-026-00523-4
by A. García-Alamán, R. Gasa & colleagues @isciiisalud.bsky.social @ciberisciii.bsky.social
👉 doi.org/10.1038/s44321-026-00523-4
September 25, 2026 at 12:50 PM
#SodiumTungstate (NaW), a pharmacological protein phosphatase inhibitor, is shown to enhance vascularization and survival of human #BetaCell grafts
by A. García-Alamán, R. Gasa & colleagues @isciiisalud.bsky.social @ciberisciii.bsky.social
👉 doi.org/10.1038/s44321-026-00523-4
by A. García-Alamán, R. Gasa & colleagues @isciiisalud.bsky.social @ciberisciii.bsky.social
👉 doi.org/10.1038/s44321-026-00523-4
Epigenetic regulation of placental vascularization - now published in Developmental Cell (www.sciencedirect.com/science/arti...). Congratulations & thanks to Stephanie Gehrs for fantastic work and paving the way of the www.augustinlab.de into the world of vascular epigenetics. There’s more to come!
January 14, 2025 at 7:52 PM
Epigenetic regulation of placental vascularization - now published in Developmental Cell (www.sciencedirect.com/science/arti...). Congratulations & thanks to Stephanie Gehrs for fantastic work and paving the way of the www.augustinlab.de into the world of vascular epigenetics. There’s more to come!
Chinese research from 2025, but relevant pubs.aip.org/aip/apb/arti...
Injectable photosensitive bone cement enhancing angiogenesis and osteogenic differentiation for the treatment of bone nonunion
Nonunion fractures present a significant clinical challenge because of their complex microenvironment, which includes poor vascularization, insufficient osteoge
pubs.aip.org
October 1, 2025 at 3:35 AM
Chinese research from 2025, but relevant pubs.aip.org/aip/apb/arti...
Here's the thing: the estrogen injections cause a lot of growth in a certain region for me, which means a ton of increased vascularization in the very region in which I inject, which makes the shots hurt more.
Transphobic.
Transphobic.
June 25, 2025 at 4:37 PM
Here's the thing: the estrogen injections cause a lot of growth in a certain region for me, which means a ton of increased vascularization in the very region in which I inject, which makes the shots hurt more.
Transphobic.
Transphobic.
More vascularization, morning wood, general regaining of some lost territory
September 22, 2025 at 5:48 PM
More vascularization, morning wood, general regaining of some lost territory
return of atrophied tissue, increased vascularization, increased muscle building, increased libido
October 6, 2025 at 5:58 PM
return of atrophied tissue, increased vascularization, increased muscle building, increased libido
The absolute dream paper for any #cerebrovascular developmental biologist !! Congrats to @nicolasrenier.bsky.social, @alexdubrac.bsky.social and their teams !
The spatiotemporal dynamics of postnatal vascularization in the mouse brain
Whole-brain tissue clearing and spatial transcriptomics were applied to map postnatal
vascular development in the mouse brain, identifying three coordinated phases that
link vascular growth to neurona...
www.cell.com
April 15, 2026 at 3:02 PM
The absolute dream paper for any #cerebrovascular developmental biologist !! Congrats to @nicolasrenier.bsky.social, @alexdubrac.bsky.social and their teams !
there's vascularization in there, right? deciduous organs are wild
September 13, 2026 at 5:05 PM
there's vascularization in there, right? deciduous organs are wild
Most patients with this pattern who do not undergo coronary re-vascularization, ultimately develop extensive anterior wall myocardial infarction within a few weeks
Easy to miss if you don't see it "often". Be aware!
Easy to miss if you don't see it "often". Be aware!
November 16, 2024 at 11:58 PM
Most patients with this pattern who do not undergo coronary re-vascularization, ultimately develop extensive anterior wall myocardial infarction within a few weeks
Easy to miss if you don't see it "often". Be aware!
Easy to miss if you don't see it "often". Be aware!
Just a slight clarification: Are they only saying slow/prevent, or is there a possibility to reverse abnormal vascularization?
March 29, 2026 at 5:49 PM
Just a slight clarification: Are they only saying slow/prevent, or is there a possibility to reverse abnormal vascularization?
#HereditaryHemorrhagicTelangiectasia #ArterioVenousMalformation
Bi-specific agonist antibody (DIAG100 DIAG723) clustering ALK1 + BMPRII
-> ⏫BMP-SMAD1/5/8 signal
-> ⏬retinal AVM, joint vascularization, cardiac hypertrophy in HHT🐭1⃣BMP9/10ib 2⃣Eng iECKO
bioRxiv 2025
www.biorxiv.org/content/10.1...
Bi-specific agonist antibody (DIAG100 DIAG723) clustering ALK1 + BMPRII
-> ⏫BMP-SMAD1/5/8 signal
-> ⏬retinal AVM, joint vascularization, cardiac hypertrophy in HHT🐭1⃣BMP9/10ib 2⃣Eng iECKO
bioRxiv 2025
www.biorxiv.org/content/10.1...
September 3, 2025 at 7:08 PM
#HereditaryHemorrhagicTelangiectasia #ArterioVenousMalformation
Bi-specific agonist antibody (DIAG100 DIAG723) clustering ALK1 + BMPRII
-> ⏫BMP-SMAD1/5/8 signal
-> ⏬retinal AVM, joint vascularization, cardiac hypertrophy in HHT🐭1⃣BMP9/10ib 2⃣Eng iECKO
bioRxiv 2025
www.biorxiv.org/content/10.1...
Bi-specific agonist antibody (DIAG100 DIAG723) clustering ALK1 + BMPRII
-> ⏫BMP-SMAD1/5/8 signal
-> ⏬retinal AVM, joint vascularization, cardiac hypertrophy in HHT🐭1⃣BMP9/10ib 2⃣Eng iECKO
bioRxiv 2025
www.biorxiv.org/content/10.1...
Intrauterine growth restriction impacts ~30% of pregnancies in low- to middle-income countries w/ few treatment options
Here, germ-free mouse model reveals maternal microbiome influences placental vascularization (thus, a therapeutic target)
www.pnas.org/doi/10.1073/...
Here, germ-free mouse model reveals maternal microbiome influences placental vascularization (thus, a therapeutic target)
www.pnas.org/doi/10.1073/...
July 27, 2025 at 4:18 PM
Intrauterine growth restriction impacts ~30% of pregnancies in low- to middle-income countries w/ few treatment options
Here, germ-free mouse model reveals maternal microbiome influences placental vascularization (thus, a therapeutic target)
www.pnas.org/doi/10.1073/...
Here, germ-free mouse model reveals maternal microbiome influences placental vascularization (thus, a therapeutic target)
www.pnas.org/doi/10.1073/...