Pp1ab is a large non-structural protein in #SARSCoV2, crucial for #viralreplication & transcription. It is unique to #SARSCoV2 & not found in uninfected human cells. After being translated from the #viralRNA, Pp1ab is cleaved into 16 nonstructural proteins (nsps)

#Medsky🧪 #IDsky #immunosky #virosky #publichealth @cidjournal.bsky.social A repeated 5 d course of #paxlovid was safe & well tolerated & associated with a faster decline in #viralRNA levels. However there was no clear benefit of retreatment ➡️ rebound was transient & did not lead to severe #COVID

#MedSky🧪#IDSky #ImmunoSky Overview the host-🦠 interactions mediated by #viralRNA & the importance of vRNA in regulating protein function through riboregulation & Uncovering the vRNA #interactome

www.cell.com/molecular-ce...

3
Ivermectin: pubmed is full of it. e.g.:

"Caly et al.showed the in vitro benefit of ivermectin in Vero-hSLAM cells infected with SARS-CoV-2.The authors found that a single dose of ivermectin was able to effect ∼5000-fold reduction in viralRNA at48h[4]."
source: pmc.ncbi.nlm.nih.gov/articles/PMC...

@ViralRNA

Italiassa oli eilen noin 10% potilaista teholla.
2/x

#korona="/hashtag/koronavirus" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#koronavirusshtag/koronavirusfi" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#koronavirusfi #korona #koronavirus #covid2019fi @lasleh @hsfi @uusisuomi

https://x.com/ViralRNA/status/1239257906366812165

Finland's planned ICU levels are way too low. Italy has 30-80x more people in ICU when compared to what Finland is planning to get ready for.
1/x

#covid2019 #covid19 @ViralRNA...

@ViralRNA and @DrDenaGrayson, here is China's guide for Covid-19 best practises, financed by Alibaba. PDF or online.

#COVID2019 thx to @MikaelJungner

https://covid-19.alibabacloud.com/

Italia eilen 19.3.
4/x

#korona="/hashtag/koronavirus" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#koronavirusshtag/koronavirusfi" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#koronavirusfi #korona #koronavirus #covid19fi #covid2019

https://x.com/ViralRNA/status/1240408437516877824

Where did these Chinese subscribers go?

Chinese operators' subscribers are down 13 million m/m in February, and Unicom hasn't even reported yet.
1/x

#koronavirusfi #COVID2019italia #Covid19usa #COVID19US #COVID2019uk #COVID19de @ViralRNA @realDonaldTrump @T_Inglesby

Month/month change in percent. China Unicom has lost more than 2 percent of its subscribers.

#koronavirusfi #COVID2019italia #Covid19usa #COVID19US #COVID2019uk #COVID19de
@ViralRNA @T_Inglesby

Chinese mobile operators have lost 1.6m subscribers m/m in January and 19.5m more in February. Total 21.1 million. China Unicom's Feb numbers now included.
1/x

#koronavirusfi #COVID2019italia #Covid19usa #COVID19US #COVID2019uk #COVID19de
@ViralRNA @T_Inglesby

Tuberculosis vaccination might help. Many countries don't do that. Disclaimer: not peer reviewed.

#korona="/hashtag/koronavirusfi" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#koronavirusfi #korona #covid19fi #covid19finland #covid2019 #covid19italy #Covid19usa #COVID19US @ViralRNA ...

Terminal Loop Sequences in Viral Double-Stranded RNAs Modulate RIG-I Signaling
Gnazzo, V., Hackbart, M. et al.
Paper
Details
#RIGISignaling #ViralRNA #ImmuneResponse

Next-Gen Fluorosensor Detects Viral RNA in Real Time #Science #HealthandMedicine #InfectiousDiseases #Fluoresensor #ViralRNA #HealthTech