Cassie Spracklen
@cnspracklen.bsky.social
Assistant Professor of Epidemiology | Genetic Epidemiology | Statistical Genetics | wine and coffee addict | Women in STEM advocate | Scientist by day, quilter and book worm by night
Reposted by Cassie Spracklen
The best rates for #ASHG26 close TODAY at 5 PM U.S. ET. Secure your spot before rates increase and join the researchers, clinicians, and industry professionals shaping the future of human genetics and genomics in Montréal: https://bit.ly/4o3wfxM #ASHG #HumanGenetics
September 15, 2026 at 2:53 PM
The best rates for #ASHG26 close TODAY at 5 PM U.S. ET. Secure your spot before rates increase and join the researchers, clinicians, and industry professionals shaping the future of human genetics and genomics in Montréal: https://bit.ly/4o3wfxM #ASHG #HumanGenetics
Reposted by Cassie Spracklen
I want to give a special shoutout to the #ASHG26 program committee member who came up with the session title “Uptown Funk(tion): Don’t Believe Me, Just Perturb.”
Robert Redford as Jeremiah Johnson Nodding
Alt: Robert Redford as Jeremiah Johnson Nodding, here indicating respect
static.klipy.com
August 19, 2026 at 4:11 PM
I want to give a special shoutout to the #ASHG26 program committee member who came up with the session title “Uptown Funk(tion): Don’t Believe Me, Just Perturb.”
Reposted by Cassie Spracklen
📢Late-Breaking Abstracts are open for #ASHG26!
Share impactful discoveries, new findings & datasets, and research advancing human genetics, genomics & clinical care.
Accepted abstracts may be featured in an oral session or poster.
📅 Aug. 26, 5 PM U.S. ET
🔗 https://bit.ly/3PKPMpZ #ASHG
Share impactful discoveries, new findings & datasets, and research advancing human genetics, genomics & clinical care.
Accepted abstracts may be featured in an oral session or poster.
📅 Aug. 26, 5 PM U.S. ET
🔗 https://bit.ly/3PKPMpZ #ASHG
August 10, 2026 at 8:26 PM
📢Late-Breaking Abstracts are open for #ASHG26!
Share impactful discoveries, new findings & datasets, and research advancing human genetics, genomics & clinical care.
Accepted abstracts may be featured in an oral session or poster.
📅 Aug. 26, 5 PM U.S. ET
🔗 https://bit.ly/3PKPMpZ #ASHG
Share impactful discoveries, new findings & datasets, and research advancing human genetics, genomics & clinical care.
Accepted abstracts may be featured in an oral session or poster.
📅 Aug. 26, 5 PM U.S. ET
🔗 https://bit.ly/3PKPMpZ #ASHG
Reposted by Cassie Spracklen
So tired of him shitting all over people who are doing their best in hard times. Just let them use some damn condensed soup. Some canned fish. Basic pasta. Stop guilting parents for getting to 75% instead of 100. And ffs, stop cutting programs *that people use to buy food*.
August 7, 2026 at 2:15 AM
So tired of him shitting all over people who are doing their best in hard times. Just let them use some damn condensed soup. Some canned fish. Basic pasta. Stop guilting parents for getting to 75% instead of 100. And ffs, stop cutting programs *that people use to buy food*.
Reposted by Cassie Spracklen
I co-sign this great summary from @dereklowe.bsky.social .
The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
July 24, 2026 at 5:10 AM
I co-sign this great summary from @dereklowe.bsky.social .
The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
Reposted by Cassie Spracklen
okay i change my mind, THIS is one of the best and most beautiful images from artemis ii
April 9, 2026 at 11:48 PM
okay i change my mind, THIS is one of the best and most beautiful images from artemis ii
Reposted by Cassie Spracklen
Our multi-ancestry, multi-tissue MR study for type 2 diabetes is out in Nature Metabolism!
Amazing collab with the Type 2 Diabetes Global Genetics Initiative.
We showed that causal effects are mostly shared across ancestries but are highly heterogeneous across tissues.
www.nature.com/articles/s42...
Amazing collab with the Type 2 Diabetes Global Genetics Initiative.
We showed that causal effects are mostly shared across ancestries but are highly heterogeneous across tissues.
www.nature.com/articles/s42...
Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues
Nature Metabolism - Analysing the causal links of gene expression and protein abundance on type 2 diabetes risk in blood and seven tissues related to the disease from individuals of four...
rdcu.be
January 27, 2026 at 10:36 PM
Our multi-ancestry, multi-tissue MR study for type 2 diabetes is out in Nature Metabolism!
Amazing collab with the Type 2 Diabetes Global Genetics Initiative.
We showed that causal effects are mostly shared across ancestries but are highly heterogeneous across tissues.
www.nature.com/articles/s42...
Amazing collab with the Type 2 Diabetes Global Genetics Initiative.
We showed that causal effects are mostly shared across ancestries but are highly heterogeneous across tissues.
www.nature.com/articles/s42...
Can’t wait for #ASHG26 in Montreal!
That’s a wrap on #ASHG25!
In just 5 days, we:
🧬Showcased groundbreaking science
🤝Sparked powerful connections
🏆Celebrated excellence
📸Captured unforgettable moments
Thank you for the energy, ideas, and inspiration. We look forward to seeing you in Montreal, CA for #ASHG26!
In just 5 days, we:
🧬Showcased groundbreaking science
🤝Sparked powerful connections
🏆Celebrated excellence
📸Captured unforgettable moments
Thank you for the energy, ideas, and inspiration. We look forward to seeing you in Montreal, CA for #ASHG26!
October 22, 2025 at 11:19 AM
Can’t wait for #ASHG26 in Montreal!
Reposted by Cassie Spracklen
AI is transforming #humangenetics & genomics research. Head to the Distinguished Speakers Symposium to explore the breakthroughs & the ethical challenges of implementing AI systems in research.
Don’t miss this powerful closing session of #ASHG25!📲 https://bit.ly/474ALFu #ASHG
Don’t miss this powerful closing session of #ASHG25!📲 https://bit.ly/474ALFu #ASHG
October 18, 2025 at 3:38 PM
AI is transforming #humangenetics & genomics research. Head to the Distinguished Speakers Symposium to explore the breakthroughs & the ethical challenges of implementing AI systems in research.
Don’t miss this powerful closing session of #ASHG25!📲 https://bit.ly/474ALFu #ASHG
Don’t miss this powerful closing session of #ASHG25!📲 https://bit.ly/474ALFu #ASHG
Reposted by Cassie Spracklen
📣New from @klmohlke.bsky.social & co!
📄Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
www.cell.com/ajhg/fulltex...
📄Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
www.cell.com/ajhg/fulltex...
Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
To investigate the underlying mechanisms of complex traits, we performed an eQTL meta-analysis
in skeletal muscle and identified 18,818 conditionally distinct signals for 12,283
genes. Colocalization ...
www.cell.com
September 23, 2025 at 5:06 PM
📣New from @klmohlke.bsky.social & co!
📄Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
www.cell.com/ajhg/fulltex...
📄Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
www.cell.com/ajhg/fulltex...
Reposted by Cassie Spracklen
This ought to be engraved somewhere.
September 23, 2025 at 2:56 AM
This ought to be engraved somewhere.
Reposted by Cassie Spracklen
I have a message to the staff at CDC who have dedicated their careers to protecting Americans from health threats of all kinds: Thank you.
Your courage and dedication have improved or saved the lives of people who may not even know it.
We’re with you.
Your courage and dedication have improved or saved the lives of people who may not even know it.
We’re with you.
August 29, 2025 at 5:39 PM
I have a message to the staff at CDC who have dedicated their careers to protecting Americans from health threats of all kinds: Thank you.
Your courage and dedication have improved or saved the lives of people who may not even know it.
We’re with you.
Your courage and dedication have improved or saved the lives of people who may not even know it.
We’re with you.
Some good news: just found out my PhD student @rachelwacks.bsky.social won our College Outstanding Graduate Teaching Award for 2024-2025! So happy that her awesomeness has been recognized!! #ProudPI #EpiSky
March 25, 2025 at 9:01 PM
Some good news: just found out my PhD student @rachelwacks.bsky.social won our College Outstanding Graduate Teaching Award for 2024-2025! So happy that her awesomeness has been recognized!! #ProudPI #EpiSky
Well…don’t I feel old now…
Apropos of nothing, 2025 marks 25 years since Linkin Park's Hybrid Theory, which is as far back as Zeppelin's Physical Graffiti (1975) was to teenage me at the time.
That is to say, Linkin Park is objectively classic rock.
💀
That is to say, Linkin Park is objectively classic rock.
💀
March 5, 2025 at 10:48 PM
Well…don’t I feel old now…
Reposted by Cassie Spracklen
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Science Homecoming
sciencehomecoming.com
February 18, 2025 at 5:12 PM
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Recent work from my lab, led by PhD student Chi Zhao, demonstrating just how much of an impact modifiable risk factors can have on T2D risk, no matter how high your genetic risk may be.
Associations of Combined Genetic and Lifestyle Risks with Incident Type 2 Diabetes in the UK Biobank https://www.medrxiv.org/content/10.1101/2024.12.16.24319115v1
December 31, 2024 at 2:27 AM
Recent work from my lab, led by PhD student Chi Zhao, demonstrating just how much of an impact modifiable risk factors can have on T2D risk, no matter how high your genetic risk may be.
Reposted by Cassie Spracklen
www.biorxiv.org/content/10.1...
Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
www.biorxiv.org
December 28, 2024 at 9:02 PM
www.biorxiv.org/content/10.1...
Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!