David B. Sauer
@davidbsauer.bsky.social
Membrane Transporters, Ion Channels, Structural Biology, Bioinformatics... and other bits of fun
Purdue BS, UTSW PhD, NYUSoM PostDoc, Univ. of Oxford PI
davidbsauer.com
Purdue BS, UTSW PhD, NYUSoM PostDoc, Univ. of Oxford PI
davidbsauer.com
Pinned
Wonderful 2026 group picnic with the amazing membrane protein scientists at the @cmd.ox.ac.uk!
Reposted by David B. Sauer
Researchers @oxfordchemistry.bsky.social and @kavlioxford.bsky.social how that phospholipid transfer proteins are not redundant: each prefers different acyl chains, while tissue-specific expression and phosphorylation help fine-tune membrane composition
Differential lipid selectivity of StARD phospholipid transporters revealed by native MS - Nature Communications
Lipid transfer proteins organize intracellular lipid distribution. Here, the authors show that seemingly redundant phospholipid transfer proteins have distinct acyl chain preferences, and suggest that their tissue-specific expression levels and phosphorylation fine-tune membrane composition.
dlvr.it
August 31, 2026 at 12:48 PM
Researchers @oxfordchemistry.bsky.social and @kavlioxford.bsky.social how that phospholipid transfer proteins are not redundant: each prefers different acyl chains, while tissue-specific expression and phosphorylation help fine-tune membrane composition
Reposted by David B. Sauer
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...
Treat biological databases as infrastructure, not projects
Letter to the Editor
www.nature.com
August 20, 2026 at 12:46 PM
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...
Reposted by David B. Sauer
Try for your protein at py2dmol.solab.org
(Style → Cartoon)
(Style → Cartoon)
August 15, 2026 at 2:13 AM
Try for your protein at py2dmol.solab.org
(Style → Cartoon)
(Style → Cartoon)
Reposted by David B. Sauer
UT Southwestern Medical Center is hiring:
Instructor – Structural Biology – Rosenbaum Lab
#structuralbiology #biochemistry
Instructor – Structural Biology – Rosenbaum Lab
#structuralbiology #biochemistry
August 13, 2026 at 4:22 AM
UT Southwestern Medical Center is hiring:
Instructor – Structural Biology – Rosenbaum Lab
#structuralbiology #biochemistry
Instructor – Structural Biology – Rosenbaum Lab
#structuralbiology #biochemistry
Reposted by David B. Sauer
Learn the foundations of Python and discover how coding can unlock new approaches to biochemical data analysis and research, launching on 5 October 2026! https://ow.ly/t0KG50ZypQA 🧪
August 12, 2026 at 12:45 PM
Learn the foundations of Python and discover how coding can unlock new approaches to biochemical data analysis and research, launching on 5 October 2026! https://ow.ly/t0KG50ZypQA 🧪
Reposted by David B. Sauer
Happy to see our NHE6 story published today in @natcomms.nature.com!
Led by @lukasfeilen.bsky.social we reveal the #cryoEM structure, ion selectivity and regulation of the endosomal Na+/H+ exchanger NHE6, providing a framework for understanding Christianson syndrome.
www.nature.com/articles/s41...
Led by @lukasfeilen.bsky.social we reveal the #cryoEM structure, ion selectivity and regulation of the endosomal Na+/H+ exchanger NHE6, providing a framework for understanding Christianson syndrome.
www.nature.com/articles/s41...
August 12, 2026 at 12:39 PM
Happy to see our NHE6 story published today in @natcomms.nature.com!
Led by @lukasfeilen.bsky.social we reveal the #cryoEM structure, ion selectivity and regulation of the endosomal Na+/H+ exchanger NHE6, providing a framework for understanding Christianson syndrome.
www.nature.com/articles/s41...
Led by @lukasfeilen.bsky.social we reveal the #cryoEM structure, ion selectivity and regulation of the endosomal Na+/H+ exchanger NHE6, providing a framework for understanding Christianson syndrome.
www.nature.com/articles/s41...
Reposted by David B. Sauer
1/ The toolkit behind the discovery is out.
In @natcomms.nature.com, we report the selective NUDT5 degrader toolkit that helped uncover NUDT5’s hidden biology - and show antagonistic roles for NUDT5 and NUDT15 in 6-TG response. doi.org/10.1038/s414...
In @natcomms.nature.com, we report the selective NUDT5 degrader toolkit that helped uncover NUDT5’s hidden biology - and show antagonistic roles for NUDT5 and NUDT15 in 6-TG response. doi.org/10.1038/s414...
Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response - Nature Communications
Thiopurines are widely used drugs whose activity depends on cellular metabolism. Here, the authors develop chemical tools to remove NUDT5 and show that protein loss, but not inhibition, alters drug re...
doi.org
August 12, 2026 at 2:03 PM
1/ The toolkit behind the discovery is out.
In @natcomms.nature.com, we report the selective NUDT5 degrader toolkit that helped uncover NUDT5’s hidden biology - and show antagonistic roles for NUDT5 and NUDT15 in 6-TG response. doi.org/10.1038/s414...
In @natcomms.nature.com, we report the selective NUDT5 degrader toolkit that helped uncover NUDT5’s hidden biology - and show antagonistic roles for NUDT5 and NUDT15 in 6-TG response. doi.org/10.1038/s414...
Wonderful 2026 group picnic with the amazing membrane protein scientists at the @cmd.ox.ac.uk!
August 5, 2026 at 12:24 PM
Wonderful 2026 group picnic with the amazing membrane protein scientists at the @cmd.ox.ac.uk!
Reposted by David B. Sauer
Curious about how drugs are designed?
Check out this seminar for non-scientists by Chris Tate, Group Leader in the LMB’s Structural Studies Division. He covers how drugs work and how researchers are working to design drugs better, faster and with fewer side effects.
youtu.be/fOzwbmiKNKI
Check out this seminar for non-scientists by Chris Tate, Group Leader in the LMB’s Structural Studies Division. He covers how drugs work and how researchers are working to design drugs better, faster and with fewer side effects.
youtu.be/fOzwbmiKNKI
Drugs! How they work and how to design them. Seminar for non-scientists by Chris Tate
YouTube video by MRC Laboratory of Molecular Biology
youtu.be
July 8, 2026 at 4:11 PM
Curious about how drugs are designed?
Check out this seminar for non-scientists by Chris Tate, Group Leader in the LMB’s Structural Studies Division. He covers how drugs work and how researchers are working to design drugs better, faster and with fewer side effects.
youtu.be/fOzwbmiKNKI
Check out this seminar for non-scientists by Chris Tate, Group Leader in the LMB’s Structural Studies Division. He covers how drugs work and how researchers are working to design drugs better, faster and with fewer side effects.
youtu.be/fOzwbmiKNKI
Reposted by David B. Sauer
@wheelerlab.org is talking about his effort to build a resource for protein dynamics (PDB for MD). MDRepo is a repository to store simulation data. This is really needed to push the needle in design, function and more. Please help make it successful by sharing your MD data. #ismb2026
🌐 mdrepo.org
🌐 mdrepo.org
July 16, 2026 at 6:53 PM
@wheelerlab.org is talking about his effort to build a resource for protein dynamics (PDB for MD). MDRepo is a repository to store simulation data. This is really needed to push the needle in design, function and more. Please help make it successful by sharing your MD data. #ismb2026
🌐 mdrepo.org
🌐 mdrepo.org
A water molecule is crucial to maintaining the structure and transport activity of VcINDY!
academic.oup.com/pnasnexus/ad...
Fantastic collaboration by the groups of @danengw.bsky.social (NYUSoM) and @chrismulligan.bsky.social (Univ. of Kent)
academic.oup.com/pnasnexus/ad...
Fantastic collaboration by the groups of @danengw.bsky.social (NYUSoM) and @chrismulligan.bsky.social (Univ. of Kent)
Functional role of a structural water in the elevator domain of dicarboxylate transporter VcINDY
Abstract. The divalent anion sodium symporter (DASS) family mediates the uptake of Krebs cycle intermediates and sulfate, and influences adiposity, insulin
academic.oup.com
July 17, 2026 at 7:25 AM
A water molecule is crucial to maintaining the structure and transport activity of VcINDY!
academic.oup.com/pnasnexus/ad...
Fantastic collaboration by the groups of @danengw.bsky.social (NYUSoM) and @chrismulligan.bsky.social (Univ. of Kent)
academic.oup.com/pnasnexus/ad...
Fantastic collaboration by the groups of @danengw.bsky.social (NYUSoM) and @chrismulligan.bsky.social (Univ. of Kent)
Thank you to @wehi-research.bsky.social for squeezing me in for a quick visit!
Fascinating chats about targeting membrane proteins and structural biology for drug development!
Fascinating chats about targeting membrane proteins and structural biology for drug development!
July 14, 2026 at 11:50 PM
Thank you to @wehi-research.bsky.social for squeezing me in for a quick visit!
Fascinating chats about targeting membrane proteins and structural biology for drug development!
Fascinating chats about targeting membrane proteins and structural biology for drug development!
Fun fact: Human NaCT/SLC13A5's mechanism for coupling sodium & substrate co-transport is distinct from its bacterial homolog VcINDY!
A fascinating question to tease apart with @danengw.bsky.social
and colleagues at NYU School of Medicine!
A fascinating question to tease apart with @danengw.bsky.social
and colleagues at NYU School of Medicine!
Structures of the human sodium-citrate cotransporter NaCT with and without substrates https://www.biorxiv.org/content/10.64898/2026.07.08.737274v1
July 13, 2026 at 4:20 AM
Fun fact: Human NaCT/SLC13A5's mechanism for coupling sodium & substrate co-transport is distinct from its bacterial homolog VcINDY!
A fascinating question to tease apart with @danengw.bsky.social
and colleagues at NYU School of Medicine!
A fascinating question to tease apart with @danengw.bsky.social
and colleagues at NYU School of Medicine!
Thank you @rosemaryjcater.bsky.social for a fantastic visit to UQ’s Institute for Molecular Bioscience!!
Wonderful day chatting about the spectacular science in Brisbane, and squeezing in some time to visit the local fauna.
Wonderful day chatting about the spectacular science in Brisbane, and squeezing in some time to visit the local fauna.
July 12, 2026 at 12:26 AM
Thank you @rosemaryjcater.bsky.social for a fantastic visit to UQ’s Institute for Molecular Bioscience!!
Wonderful day chatting about the spectacular science in Brisbane, and squeezing in some time to visit the local fauna.
Wonderful day chatting about the spectacular science in Brisbane, and squeezing in some time to visit the local fauna.
Reposted by David B. Sauer
Kicking Arsenic to the Curb: a paper from the labs of Douglas Reese & Bill Clemons of @caltech.edu that describe cryo-EM structure of a bacterial metalloid pump & the mechanisms that could offer more insight into ridding environments of toxic metalloids.
Read more here: buff.ly/dnyw7U1
#SBGrid
Read more here: buff.ly/dnyw7U1
#SBGrid
Kicking Arsenic to the Curb
This publication highlight is part of the SBGrid Communities Project focused on science education and demonstrating how structural biology…
buff.ly
July 10, 2026 at 4:05 PM
Kicking Arsenic to the Curb: a paper from the labs of Douglas Reese & Bill Clemons of @caltech.edu that describe cryo-EM structure of a bacterial metalloid pump & the mechanisms that could offer more insight into ridding environments of toxic metalloids.
Read more here: buff.ly/dnyw7U1
#SBGrid
Read more here: buff.ly/dnyw7U1
#SBGrid
Reposted by David B. Sauer
Interested in joining our group in Oxford? We are looking for a PDRA with single particle Cryo-EM experience to help us figure out how sphingolipids are transported to the cell surface of Gram-negative bacteria.
The deadline is 31st July.
Informal enquires are welcome. Please share!
The deadline is 31st July.
Informal enquires are welcome. Please share!
Job Details
my.corehr.com
July 10, 2026 at 7:57 AM
Interested in joining our group in Oxford? We are looking for a PDRA with single particle Cryo-EM experience to help us figure out how sphingolipids are transported to the cell surface of Gram-negative bacteria.
The deadline is 31st July.
Informal enquires are welcome. Please share!
The deadline is 31st July.
Informal enquires are welcome. Please share!
Reposted by David B. Sauer
Take a look at the fantastic lineup of speakers we have assembled for the 2026 Kuo Symposium in Beijing!
The workshop is already FULL, but symposium registration is still open, and early-bird rates are still available.
See you in Beijing! www.bsc.org.cn/KuoSymposium...
The workshop is already FULL, but symposium registration is still open, and early-bird rates are still available.
See you in Beijing! www.bsc.org.cn/KuoSymposium...
June 24, 2026 at 6:08 AM
Take a look at the fantastic lineup of speakers we have assembled for the 2026 Kuo Symposium in Beijing!
The workshop is already FULL, but symposium registration is still open, and early-bird rates are still available.
See you in Beijing! www.bsc.org.cn/KuoSymposium...
The workshop is already FULL, but symposium registration is still open, and early-bird rates are still available.
See you in Beijing! www.bsc.org.cn/KuoSymposium...
Reposted by David B. Sauer
Less than two weeks to register for the ion channel meeting. Please RT!
Only 2.5 weeks left to register to the Ion Channel meeting that will take place in September in Sète (France)! Whether you want to connect with the #Ionchannel community or extend your summer on the Mediterrean sea (or both!), this conference is for you. Registration deadline July 3rd. Pls share!
June 23, 2026 at 7:27 PM
Less than two weeks to register for the ion channel meeting. Please RT!
Little one is obsessed with "Random Walks in Biology" (deceptively small as most biophysicists know)
We should start with something easier, like partial differential equations?!
We should start with something easier, like partial differential equations?!
June 18, 2026 at 6:47 PM
Little one is obsessed with "Random Walks in Biology" (deceptively small as most biophysicists know)
We should start with something easier, like partial differential equations?!
We should start with something easier, like partial differential equations?!
Reposted by David B. Sauer
Structural basis of substrate recognition and allosteric inhibition in human B0AT2 www.biorxiv.org/content/10.64898/2026.06.16.732524v1 #cryoem
June 17, 2026 at 10:28 AM
Structural basis of substrate recognition and allosteric inhibition in human B0AT2 www.biorxiv.org/content/10.64898/2026.06.16.732524v1 #cryoem
Reposted by David B. Sauer
How did animal senses evolve? Max Coyle et al. used choanoflagellates to uncover TRPW, ancient ion channels predating animal somatosensory receptors. TRPW links microbial prey ecology to evolution of receptor structure, sensory organelles, & multicellular processing.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
June 16, 2026 at 4:59 PM
How did animal senses evolve? Max Coyle et al. used choanoflagellates to uncover TRPW, ancient ion channels predating animal somatosensory receptors. TRPW links microbial prey ecology to evolution of receptor structure, sensory organelles, & multicellular processing.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by David B. Sauer
Ready to start coding? Practical Python for Beginners begins 5 Oct 2026 and will help biochemists develop core Python skills for analysing and visualising complex biochemical data. https://ow.ly/FwKT50ZbyAM
June 17, 2026 at 2:01 PM
Ready to start coding? Practical Python for Beginners begins 5 Oct 2026 and will help biochemists develop core Python skills for analysing and visualising complex biochemical data. https://ow.ly/FwKT50ZbyAM
Reposted by David B. Sauer
🔬 We’ll be at the 6th NY Area #CryoEM Meeting on May 27, presenting recent developments in #CryoSPARC for Homogeneous Ab Initio Refinement and workflows for small proteins. bit.ly/4dYMUze
We’re also proud to support the meeting as a sponsor — stop by our poster to learn more!
We’re also proud to support the meeting as a sponsor — stop by our poster to learn more!
May 25, 2026 at 12:13 PM
🔬 We’ll be at the 6th NY Area #CryoEM Meeting on May 27, presenting recent developments in #CryoSPARC for Homogeneous Ab Initio Refinement and workflows for small proteins. bit.ly/4dYMUze
We’re also proud to support the meeting as a sponsor — stop by our poster to learn more!
We’re also proud to support the meeting as a sponsor — stop by our poster to learn more!
Reposted by David B. Sauer
We have a late opening for postbac in my lab starting this summer. Please reshare, repost.
Interested in chemical mechanisms of membrane proteins ?We have an opening for postbac fellows. Please share and repost. Thanks !
Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters.
bit.ly/42jWXYD.
/n
Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters.
bit.ly/42jWXYD.
/n
May 25, 2026 at 3:26 PM
We have a late opening for postbac in my lab starting this summer. Please reshare, repost.
Reposted by David B. Sauer
The OpenBind consortium’s first release of experimental data marks a milestone in efforts to improve how artificial intelligence (AI) is used in drug discovery.
Find out more ⬇️
https://www.ox.ac.uk/news/2026-05-12-openbind-releases-first-open-dataset-and-ai-model-for-drug-discovery
Find out more ⬇️
https://www.ox.ac.uk/news/2026-05-12-openbind-releases-first-open-dataset-and-ai-model-for-drug-discovery
May 14, 2026 at 10:47 AM
The OpenBind consortium’s first release of experimental data marks a milestone in efforts to improve how artificial intelligence (AI) is used in drug discovery.
Find out more ⬇️
https://www.ox.ac.uk/news/2026-05-12-openbind-releases-first-open-dataset-and-ai-model-for-drug-discovery
Find out more ⬇️
https://www.ox.ac.uk/news/2026-05-12-openbind-releases-first-open-dataset-and-ai-model-for-drug-discovery